Central giant cell lesion of mandible managed by intralesional triamcinolone injections : a report of two cases and literature review

Central giant cell lesion (CGCL) is a benign lesion which has unpredictable biologic behaviour and is amenable to a plethora of treatment alternatives. We describe our experience in managing this lesion by intralesional triamcinolone. The mainstay of treatment of CGCL in our centre until now has been surgical curettage or resection. We chose two patients for this pilot endeavour at our hands. Case I is a 10 year old girl having CGCL of left side mandible. Case II is a 20 yr old man with CGCL affecting the left side posterior mandible. Both patients responded well to intralesional administration of triamcinolone acetonide (Kenacort-10®) with no obvious recurrences to date. Successful application of this conservative drug therapy for managing CGCL can not only save the patient from a mutilating procedure but also has significant financial implications. The amount of triamcinolone injected ranged from 85mg to 180mg by 5-6 injections at weekly intervals

Analysis of cosmological bias within spherical collapse model

The goal of our research work is to analyze cosmological bias parameter. Parametric equations of spherical collapse model are used to calculate the values of spherical collapse over density and mass variance, which is further used in bias formulae to find the values of cosmological bias. Spherical collapse over density has been calculated in the range of redshift 0 to 1. Also, it is compared with the value according to the spherical collapse model. Bias is one of the parameters which are utilized to infer cosmological parameters. Extracting the cosmological parameters is very much useful to know and understand about the birth and evolution of our universe. As there is no direct probe to get the idea about the existence of dark matter. Bias factor helps to analyze about dark matter. The bias coefficient of higher order terms in Taylor series expansion are found to be in ascending order. Increasing values of bias indicate the large-scale structure formation at current epoch is more and more clustered. Values of bias are discussed in result. Also, bias values have been analyzed for redshift in the range 2 to 0. The graph has been plotted bias versus redshift. Let’s found bias decreases with decrease of redshift. That means bias evolves with redshift. Bias value less than one and negative value of bias implies that structure formation is in linear region and higher values of bias indicates the structure formation occurs in nonlinear region. Negative value of bias is also called as antibias. That means the structure formation has not started yet. It is still in linear region. The bias value nearly equal to one indicates that the structure formation has been transformed from linear region to nonlinear region. So, the result showing bias values greater than one indicates that evolution of structure formation occurs in nonlinear region

A Secure Short Signature Scheme Based upon Biometric Security

This paper presents a short signature scheme whose security is based upon two computationally hard problems, namely, discrete logarithm problem (DLP) and Integer factorization problem (IFP). In this scheme, biometric feature values of the signer are used to compute biometric cryptographic key, which is further used in signature generation. As biometric data is unique to a person, the signature cannot be forged. Also the length of the signature is short, which helps to reduce communication overhead. The verification cost of the proposed scheme is low, thus applicable in real life scenarios, such as e-voting, e-cash and e-commerce

A comparative study on performance of MM5 and WRF models in simulation of tropical cyclones over Indian seas

Tropical cyclone is one of the most devastating and deadly weather phenomenon worldwide. It is a result of organized intense convective activities over warm tropical oceans. In recent years mesoscale models are extensively used for simulation of genesis, intensification and movement of tropical cyclones. In this study, the recent three very severe cyclonic storms generated over Indian seas (Bay of Bengal and Arabian Sea) are considered. During 26-29 April 2006, a very severe tropical cyclone, known as Mala, developed over the Bay of Bengal and crossed the Arakan coast of Myanmar on 29 April 2006. During 2-7 June 2007, a super cyclonic storm, known as Gonu, developed over the Arabian sea and crossed the Makran coast on 7 June 2007. During 11-16 November 2007, a very severe cyclonic storm, known as Sidr, developed over the Bay of Bengal and crossed the Khulna-Barisal coast of Bangladesh on 15 November 2007. In the present study, two state-ofthe- art mesoscale models, MM5 and WRF, developed at the National Center for Atmospheric Research (NCAR), USA, have been used to evaluate the performances of both the models in the simulation of the above-mentioned tropical cyclones. The performances of both the models have been calculated by integrating with 15 different initial conditions, i.e. each case with five different initial conditions. A number of meteorological fields, viz. central pressure, wind and precipitation have been verified against observations/ verification analyses. The vector displacement error in track forecast has also been calculated using the best track provided by the India Meteorological Department. The results indicate that the WRF model has better performance in respect of track and intensity prediction than the MM5 model

POPULATION STRUCTURE OF KAEMPFERIA GALANGA L. FROM EASTERN INDIA

Objective: India has been a producer of a large number of aromatic medicinal plants which serves as a valuable genetic resource for future quality improvement to meet the ever-growing demand of human essential products. Thus, an urgent need arises for germplasm conservation of these high yielding varieties to help the pharmaceutical and other industries. For this understanding, the population structure is essential in order to explore their genetic identification by fingerprinting and molecular characterization. Methods: In the present study DNA was isolated using modified Cetyl Trimethyl Ammonium Bromide (CTAB) method and Polymerase Chain Reaction (PCR) was performed according to standardized method along with its data analysis. This study was undertaken to characterize the highly medicinal Kaempferia galanga collected from 4 different populations of Odisha using the molecular markers as Random Amplified Polymorphic DNA and Inter-Simple Sequence Repeats for the first time. Results: A dendrogram constructed through Sequential Agglomerative Hierarchical and Nested (SAHN) clustering and Unweighted Pair Group Method with Arithmetic mean (UPGMA) analysis showed an average similarity of 0.993 ranging between 0.967 to 1.000. Jaccard’s similarity coefficient of combined markers segregated the genotypes into two main clusters, 1 with six samples and the others at 0.98 similarity coefficient. Conclusion: Hence, the molecular analysis could be further used for the identification of important novel gene present in Kaempferia galanga which can be utilized for future crop improvement as well as pharmacological activities

Assessment of genetic diversity of Curcuma aromatica from eastern India using ISSR and RAPD markers

Application of Inter Simple Sequence Repeats and Random Amplified Polymorphic DNA markers in Curcuma aromatica collected from 4 different populations of Odisha. A dendrogram was constructed through sequential agglomerative hierarchial and nested (SAHN) clustering and unweighted pair group method with arithmetic mean (UPGMA) analysis using Jaccard’s similarity coefficient of combined markers using this particular species. Two major clusters were found i.e., cluster-I (Koraput-1, Koraput-2, Koraput-3, G.Udaigiri-1, G.Udaigiri-2, G.Udaigiri-3 and Phulabani-1, Phulabani-2, Phulabani-3) and cluster-II (Raikia-1, Raikia-2 and Raikia-3). The clustering pattern also revealed moreover the extent of genetic similarity between germplasms collected from those populations. This technique would be further utilized for identification and tagging of important novel gene present in different taxa or improvement work in family Zingiberaceae. This study would be of immense significance for conservation and characterization of important medicinal plant species

Mesenchymal Stem Cells Modulate the Immune System in Developing Therapeutic Interventions

Mesenchymal stem cells (MSCs) are emerging as key players in regenerative medicine for the treatment of various diseases associated with the inflammation and degeneration, thereby aiding in therapeutic advancements. Several tissues have been identified as potential sources of MSCs including the bone marrow, cord blood, dental pulp, umbilical cord, adipose tissue, peripheral blood, and fetal liver, of which some are clinically recognized. MSCs are capable of differentiating into cells of multiple lineages and therefore established as suitable candidates for transplantation in damaged organs. They have added advantage of higher proliferation, easy expansion, and, more importantly, the absence of HLA class II receptors, with potential applications extending toward allogenic settings. MSCs are actively involved in different mechanisms related to repair and regeneration of tissues via immunomodulation, transdifferentiation, paracrine factors, etc. They are known to exhibit profound immunomodulatory effect on T and B cells and natural killer (NK) cells mediated via soluble factors and direct cell-cell contact. The MSCs activate the immune responses and inhibit proliferation, maturation, and differentiation of T and B cells. The MSC-activated immune responses induce the expression of regulatory T cells (Tregs). A plethora of studies have established that MSCs suppress immune responses via immunomodulation that makes them a preferred cell source for the use in clinical trials

THE EFFECT OF LEAD TOXICITY ON GROWTH AND ANTIOXIDANT ENZYME EXPRESSION OF ABUTILON INDICUM L

Objective: The focus of the present study was to analyse the oxidative effects of lead nitrate on biosynthesis of antioxidant enzyme activities (superoxide dismutase (SOD) and glutathione peroxidase (GPX)) in Abutilon indicum. Methods: Seedlings of A. indicum were grown with supplementation of different concentrations (0, 25, 50, 75 and 100 μM) of lead nitrate for 15 and 30 days. The various growth parameters like shoot length, size and total number of leaves per plant were recorded. Extraction, assay and expression of super oxide dismutase (SOD) and glutathione peroxidase (GPX) were carried out with control (without metal salt) and lead nitrate treated plants.Results: The growth parameters exhibited a declining trend in the metal treated plants in a dose dependant manner. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of leaf and root protein extracts exhibited the appearance of some new proteins due to metal stress. At lower concentrations of the metal, antioxidant enzyme activity was enhanced with a gradual declination of higher concentration (75 and 100 μM). The enzyme activity reflects the deleterious impact of lead on the plants. Isoforms of SOD and GPX were separated using non-denaturing polyacrylamide gel electrophoresis and new isoforms were noticed in the stressed plants rather than the control during the investigation.Conclusion: Isoforms of the antioxidant enzymes synthesized due to Pb stress may be used as biomarkers for analysing the impact of heavy metals on other medicinal plants under metal stress condition.Â

Papillary cystic acinic cell carcinoma: report of a rare lesion with unusual presentation

Introduction: Acinic cell carcinoma is an uncommon low grade tumour of the salivary glands that constitutes 2.5 to 4% of parotid gland tumours. Acinic cell carcinoma -Papillary cystic variant (ACC-PCV) is histologically composed of tumor with papillary and cystic growth patterns, with varying proportions of one or more cell types. It has been conferred significance because it has a poorer prognosis and is reported to be universally fatal in ten years. Case Report: We present a case of ACC-PCV in a sixteen year old male with unusual unicystic gross appearance, benign cytological picture and characteristic histopathological features .Cystic areas with papillary projection of surrounding cells showing characteristic tombstone or hobnail arrangements were seen. Discussion: The histogenesis and myriad architectural and cellular variations of ACC-PCV have been discussed along with its variegated cytomorphology which may lead to pitfalls in cytodiagnosis. The tumor may pose difficulty in histodiagnosis due to its resemblance to papillary carcinoma of the thyroi

Post endodontic Aspergillosis in an immunocompetent individual

Non-invasive aspergillosis in immunocompetent individuals subsequent to post endodontic treatment can involve the maxillary antrum. An early and accurate diagnosis will aid in prompt and effective treatment. A 35 year old female patient reported with a painful nasomaxillary swelling. Previous records revealed the failure of the endodontic treatment of maxillary left second premolar which was subsequently extracted. Root piece was accidently left behind which resulted in a painful nasomaxillary swelling. The extraction socket was curetted and tissue was sent for histopathological examination, which revealed abundant septate fungal hyphae with numerous spores characteristic of Aspergillus . The patient showed marked improvement in the symptoms with systemic itraconazole at 3 months follow up and complete resolution occurred within 6 months. Inclusion of aspergilloma infections in the differential diagnosis is advocated when patients present with post-endodontic nasomaxillary swellin