15 research outputs found
A human MAP kinase interactome.
- Author
- A Friedman
- A Karydis
- A Lunardi
- AA Reszka
- AC Gavin
- AJ Whitmarsh
- BP Kelley
- C Widmann
- Chih-yuan Chiang
- Christopher H Martin
- Cornelia Kurschner
- D Wang
- Diane L Barber
- DJ LaCount
- GD Bader
- GL Johnson
- J Kim
- J Ptacek
- JV Olsen
- Jyoti Srivastava
- K Hayashi
- K Venkatesan
- KC Gunsalus
- L Chang
- L Collin
- M Baumgartner
- M Karin
- M Qi
- M Rothe
- Merril Gersten
- Mike Smoot
- P Uetz
- PJ Cullen
- R Hooley
- R Konig
- R Konig
- R Konig
- Russell Bell
- S Peri
- SA Johnson
- SK Chanda
- Sourav Bandyopadhyay
- SP Denker
- Sudhir Sahasrabudhe
- Suhaila White
- Sumit K Chanda
- T Ito
- T Reguly
- Trey Ideker
- W Kolch
- W Kolch
- Y Ho
- Publication venue
- eScholarship, University of California
- Publication date
- 01/10/2010
- Field of study
Mitogen-activated protein kinase (MAPK) pathways form the backbone of signal transduction in the mammalian cell. Here we applied a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other cellular machinery and to assemble these data into functional modules. Multiple lines of evidence including conservation with yeast supported a core network of 641 interactions. Using small interfering RNA knockdowns, we observed that approximately one-third of MAPK-interacting proteins modulated MAPK-mediated signaling. We uncovered the Na-H exchanger NHE1 as a potential MAPK scaffold, found links between HSP90 chaperones and MAPK pathways and identified MUC12 as the human analog to the yeast signaling mucin Msb2. This study makes available a large resource of MAPK interactions and clone libraries, and it illustrates a methodology for probing signaling networks based on functional refinement of experimentally derived protein-interaction maps
Studies on diversity of soil microfungi in the Hornsund area, Spitsbergen
- Author
- ABYZOV
- ABYZOV
- ADAMS
- ADAMS
- ALIAS
- ALIAS
- AMICO
- AMICO
- ARENZ
- ARENZ
- ARENZ
- ARENZ
- ARENZ
- ARENZ
- ARNEBRANT
- ARNEBRANT
- BAZZIGHER
- BAZZIGHER
- BERGERO
- BERGERO
- BLANCHETTE
- BLANCHETTE
- BUTINAR
- BUTINAR
- CAPDET
- CAPDET
- Cephalosporium
- Cephalosporium
- CHAVERRI
- CHAVERRI
- CHLEBICKI
- CHLEBICKI
- DAVEY
- DAVEY
- FELLER
- FELLER
- FIEDUREK
- FIEDUREK
- FRATE
- FRATE
- GAWAS SAKHALKAR
- GAWAS SAKHALKAR
- GUNDE CIMERMEN
- GUNDE CIMERMEN
- HART
- HART
- HARTIG
- HARTIG
- Hii Yii Siang
- IZZO
- IZZO
- JALINK
- JALINK
- Jerzy Smykla
- JONASSON
- JONASSON
- Ka−Lai Pang
- KRISHNAN
- KRISHNAN
- KUREK
- KUREK
- LAICHMANOVA
- LAICHMANOVA
- LUDWIG
- LUDWIG
- MAGAN
- MAGAN
- MARSHALL
- MARSHALL
- MEDARDI
- MEDARDI
- MERCANTINI
- MERCANTINI
- MIGAŁA
- MIGAŁA
- MILLER
- MILLER
- MORITA
- MORITA
- OMAR
- OMAR
- ONOFRI
- ONOFRI
- OZERSKAYA
- OZERSKAYA
- PANG
- PANG
- PANG
- PANG
- Peter Convey
- QUINN
- QUINN
- RAO
- RAO
- ROBINSON
- ROBINSON
- SAMUELS
- SAMUELS
- Sheng−Yu Guo
- SINCLAIR
- SINCLAIR
- SINGH
- SINGH
- SINGH
- SINGH
- Siti Aisyah Alias
- Siti Hafizah Hafizah
- SMITH
- SMITH
- SMYKLA
- SMYKLA
- STEMPNIEWICZ
- STEMPNIEWICZ
- SUHAILA
- SUHAILA
- THORMANN
- THORMANN
- TOSI
- TOSI
- WANG
- WANG
- WARCUP
- WARCUP
- WATLING
- WATLING
- WEISER
- WEISER
- White
- White
- WHITE
- WHITE
- YUKI
- YUKI
- ZIMMERMANN
- ZIMMERMANN
- ZMUDCZYŃSKA
- ZMUDCZYŃSKA
- Publication venue
- 'Walter de Gruyter GmbH'
- Publication date
- 27/02/2013
- Field of study
We assessed culturable soil microfungal diversity in various habitats around Hornsund, Spitsbergen in the High Arctic, using potato dextrose agar (PDA) medium. Thermal growth classification of the fungi obtained was determined by incubating them in 4°C and 25°C, permitting separation of those with psychrophilic, psychrotolerant and mesophilic char− acteristics. In total, 68 fungal isolates were obtained from 12 soil samples, and grouped into 38 mycelial morphotypes. Intergenic spacer regions of these morphotypes were sequenced, and they represented 25 distinct taxonomic units, of which 21 showed sufficient similarity with available sequence data in NCBI to be identified to species level. Soil under ornithogenic influence showed the highest species diversity, including sequences assigned to Mortierella macrocystis, M. elongata, Mortierella sp., Cudoniella sp., Varicosporium elodeae, Beauveria bassiana, Geomyces pannorum, Penicillium sp. and Atradidymella muscivora. Fourteen taxa were classified as psychrophilic, seven mesophilic, and four psychrotolerant
A human MAP kinase interactome
- Author
- A Friedman
- A Karydis
- A Lunardi
- AA Reszka
- AC Gavin
- AJ Whitmarsh
- BP Kelley
- C Widmann
- Chih-yuan Chiang
- Christopher H Martin
- Cornelia Kurschner
- D Wang
- Diane L Barber
- DJ LaCount
- GD Bader
- GL Johnson
- J Kim
- J Ptacek
- JV Olsen
- Jyoti Srivastava
- K Hayashi
- K Venkatesan
- KC Gunsalus
- L Chang
- L Collin
- M Baumgartner
- M Karin
- M Qi
- M Rothe
- Merril Gersten
- Mike Smoot
- P Uetz
- PJ Cullen
- R Hooley
- R Konig
- R Konig
- R Konig
- Russell Bell
- S Peri
- SA Johnson
- SK Chanda
- Sourav Bandyopadhyay
- SP Denker
- Sudhir Sahasrabudhe
- Suhaila White
- Sumit K Chanda
- T Ito
- T Reguly
- Trey Ideker
- W Kolch
- W Kolch
- Y Ho
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Improvement of tissue culture, genetic transformation, and applications of biotechnology to Brassica
- Author
- Baillie A. M. R.
- Bano R.
- Burnett L.
- Cao J.
- Cardoza V.
- Christey M. C.
- Christianson M. L.
- Dale J.
- Deane C. R.
- Duijs J. G.
- Engineer C. B.
- George E. F.
- Guang M. A.
- Gupta V.
- Hartmann H. T.
- Hu C. Y.
- Janick J.
- Kaur N. D.
- Khachatourians G. C.
- Kole C.
- Komari T.
- Kong F.
- Kranthi S.
- Kuta D. D.
- Lal R.
- Li X. B.
- Lin C. Y.
- Litz R. E.
- Luehrsen K. R.
- Maheshwari P.
- Moghaieb R. E. A.
- Munir M.
- Munshi M. K.
- Nagaharu U.
- Pental D.
- Pierik R. L. M.
- Ravanfar S. A.
- Ravanfar S. A.
- Ravanfar S. A.
- Ravanfar S. A.
- Ravanfar S. A.
- Razdan M. K.
- Riva D. G. A.
- Rodriguez C. R.
- Roostika I. T.
- Siti Suhaila A. R.
- Sparrow P. A. C.
- Vasil I. K.
- Venkatachalam P.
- Verhoeven D. T.
- Verma R.
- White P. R.
- Yong W. T. L.
- Young J. M.
- Zhao S.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity
- Author
- Aasiyah Rashan
- Abid Khatak
- Abigail Beane
- Adrian Streinu-Cercel
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Agnes Meybeck
- Agnes Sommet
- Agnieszka Oldakowska
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Rahman
- Ahmed Farooq
- Aidan Burrell
- Albert Groenendijk
- Albert Sotto
- Albertus Beishuizen
- Aldric Manuel
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J Mentzer
- Alexandra Bedossa
- Alexandra Coelho
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Ali Hachemi
- Alif Adlan Thabit
- Alison M. Meynert
- Alistair Nichol
- Alpha Diallo
- Alphonsine Diouf
- AM Udara Attanyake
- Amanda Corley
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amina Meziane
- Amirul Asyraf
- Amna Faheem
- Amélie Valran
- Ana Freitas Ribeiro
- Ana L Rios
- Ana Martins
- Ana Silva Filipe
- Anant Kataria
- Anca Streinu-Cercel
- Andrea Angheben
- Andrea Rossanese
- Andrew Dagens
- Andrew Udy
- Andrey Svistunov
- André Cabié
- André Dias
- Andy Law
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anja Grosse Lordemann
- Anjellica Chen
- Anna Beltrame
- Anne Conrad
- Anne Guillaumot
- Anne McCarthy
- Anne-Hélène Boivin
- Anne-Marie Guerguerian
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B. Docherty
- Annmarie O'Callaghan
- Ansley Hamer
- Anthony L. Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Antonia Ho
- Antonio Lalueza
- António Mesquita
- Arabella Fahy
- Ardiyan Apriyana
- Arfan Ikram
- Aria Kekalih
- Arianne Joy Corpuz
- Arjen M Dondorp
- Arnaud Scherpereel
- Arsene Kpangon
- Ary Serpa Neto
- Asgar Rishu
- Ashraf Sheharyar
- Asma Moin
- Astarini Hidayah
- Attaur Rehman
- Audrey Barrelet
- Aurore Bousquet
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Axelle Braconnier
- Azlan Mat Soom
- B. P Edouard Soum
- Barbara Wanjiru Citarella
- Basri Mat Nor
- Beatrice Alex
- Benedict Sim Heng
- Benjamin Bach
- Benjamin Lefèvre
- Benjamine Sarton
- Benoit Thill
- Benoit Visseaux
- Benoît Roze
- Bernard Cholley
- Bernardo Ferreira
- Bertrand Dussol
- Bharath Kumar Vijayaraghavan
- Bianca Boxma
- Biing Horng Lee
- Blandine Rammaert
- Bouchra Loufti
- Brenda Reeve
- Brigitte Elharrar
- Bronner P Gonçalves
- Bronner P. Gonçalves
- Bruno Levy
- Bruno Lina
- Bruno Pastene
- Bénédicte Lefebvre
- Bénédicte Rossignol
- Calum Semple
- Calvin Wong
- Cameron J. Fairfield
- Camile Bouisse
- Camille Couffignal
- Carine Roy
- Carlo Giaquinto
- Carlos Alexandre Brito
- Carlos Lumbreras Bermejo
- Carlos Pimentel
- Carola Pierobon
- Carolien van Netten
- Caroline Martins Rego
- Caroline Mudara
- Caroline Semaille
- Carolline Araujo
- Carrol Gamble
- Catarina Espírito Santo
- Catarina Pires
- Catherine A. Shaw
- Catherine Chakveatze
- Catherine Chirouze
- Catherine L. Hough
- Cecile Azoulay
- Cecile Yelnik
- Cedric Laouenan
- Ceila Sant'Ana Malaque
- Celina Turchi Martelli
- Chamira Kodippily
- Chan Chee Eng
- Charlene Da Silveira
- Charline Vauchy
- Charlotte Salmon Gandonniere
- Charlotte Summers
- Chian Hui Yeoh
- Chiara Simona Cardellino
- Chloe Donohue
- Christel Arnold-Day
- Christelle Chantalat Auger
- Christelle Delmas
- Christelle Paul
- Christelle Tual
- Christian Rabaud
- Christiana Kartsonaki
- Christl A Donnelly
- Christophe Fraser
- Christophe Rapp
- Christopher A. Green
- Claire Andrejak
- Claire Lévy-Marchal
- Clara Flateau
- Clara Mouton Perrot
- Clare Jackson
- Clark D. Russell
- Claudia Figueiredo-Mello
- Claudia Milena Orozco-Chamorro
- Claudia Montes
- Claudina Cruz
- Claudine Badr
- Claudio Duarte Fonseca
- Clotilde Allavena
- Clément Le Bihan
- Colin McArthur
- Coline Jaud-Fischer
- Coralie Khan
- Coralie Tardivon
- Corine Delsing
- Corinne Daniel
- Cornelius Rau
- Courtney Greene
- Cynthia Braga
- Cyril Cadoz
- Cyril Le Bris
- Cécile Goujard
- Cécile Mear-Passard
- Cécile Tromeur
- Cédric Joseph
- Céline Dorival
- Céline Ficko
- Céline Michelanglei
- César Vieira
- Dafsah Juzar
- Damien Bouhour
- Daniel Glikman
- Daniel Haber
- Daniel Marino
- Daniel Mathieu
- Daniel Munblit
- Daniel Perez
- Daniela Guerreiro
- Danielle Jaafar
- David L. Robertson
- David Maslove
- David Richardson
- David S.Y. Ong
- David Stuart
- David Thomson
- David Zucman
- Debby Bogaert
- Deepashankari Suppiah
- Dehbia Benkerrou
- Delphine Bachelet
- Delphine Bergeaud
- Delphine Lariviere
- Demetrios Kutsogiannis
- Denis Butnaru
- Denis Garot
- Denis Malvy
- Denisa Khoo
- Desy Rusmawatiningtyas
- Detlef Kindgen-Milles
- Dewi Guellec
- Diana Adrião
- Diana Hernández
- Diana Póvoas
- Diane Descamps
- Diane Ponscarme
- Didier Laureillard
- Diego Fernando Rincon
- Diogo Borges
- Diogo Lopes
- Diptesh Aryal
- Djura Piersma
- Dominique Deplanque
- Dominique Luton
- Dounia Bouhmani
- Douwe F. Postma
- Duc Nguyen
- Dyah Kanya Wati
- Dzawani Muhamad
- Eder Caceres
- Edmund Manning
- Eglantine Ferrand Devouge
- Egle Saviciute
- Elias Iosifidis
- Elisa Demonchy
- Elisabeth Botelho-Nevers
- Elise Artaud-Macari
- Ellen Shadowitz
- Elodie Curlier
- Elsa Nyamankolly
- Ema Leal
- Eman Al Qasim
- Emma C. Thomson
- Emma Clarke
- Emma Costigan
- Emmanuel Roilides
- Emmanuelle A Dankwa
- Emmanuelle Denis
- Emmanuelle Mercier
- Eric D'ortenzio
- Eric Delaveuve
- Eric Oziol
- Eric Senneville
- Erlina Burhan
- Ernita Akmal
- Erwan Fourn
- Erwan L'her
- Esteban Garcia-Gallo
- Etienne De Montmollin
- Eva Geraud
- Eva Miranda Marwali
- Eve Defous
- Evert-Jan Wils
- Ewa Talarek
- Ewen M. Harrison
- Fabio S. Taccone
- Fabrice Laine
- Fakhir Haidri
- Fanny Vuotto
- Fara Diop
- Farah Nadiah Bidin
- Felwa Bin Humaid
- Fernando Augusto Bozza
- Fernando Maltez
- Filipa Cardoso
- Filipe Cardoso
- Fiona Griffiths
- Firouzé Bani-Sadr
- Florence Jego
- Florent Peelman
- Florentia Kaguelidou
- France Mentré
- François Angoulvant
- François Bissuel
- François Bompart
- François Dubos
- François Goehringer
- François Lellouche
- François Martin Carrier
- François Téoulé
- François-Xavier Catherine
- François-Xavier Ferrand
- François-Xavier Lescure
- Félix Djossou
- Gabriel Macheda
- Gail Carson
- Gamage Dona Priyadarshani
- Gan Ee Xian
- Ganesh Kumar
- Gary Leeming
- Geoffrey Liegeon
- Georges Le Falher
- Georgios Pollakis
- Geraldine Goco
- Gianluigi Li Bassi
- Gilles Peytavin
- Giri Shan Rajahram
- Giulia Bertoli
- Graham S. Cooke
- Grazielle Viana Ramos
- Gry Kloumann Bekken
- Grégory Corvaisier
- Gugapriyaa Muyandy
- Guillame Louis
- Guillaume Lingas
- Guillaume Martin-Blondel
- Guillermo Giordano
- Guillermo Maestro de la Calle
- Guylaine Castor-Alexandre
- Gwenaël Le Moal
- Gwenhaël Colin
- Ha Sha Lene
- Hajnal-Gabriela Illes
- Hanan Fateena
- Hanna Renk
- Hannah Habraken
- Hans Martin Bosse
- Harald Vonkeman
- Hashmi Madiha
- Hayley Hardwick
- Heidi Dalton
- Heidi Gruner
- Heidi Jean Dalton
- Heng Gee Lee
- Hervé Le Nagard
- Hiba Zayyad
- Hikombo Hitoto
- Himasha Muvindi
- Himed Musaab
- Hiu Jian Chua
- Hodane Yonis
- Hon Shen Png
- Hongru Ren
- Hubert Tessier-Grenier
- Huda Alfoudri
- Hugo Inácio
- Hugo Mouquet Ben Morton
- Hugues Aumaître
- Hugues Cordel
- Husna Begum
- Hwa Jin Cho
- Hélène Espérou
- Hélène Salvator
- Ikram Houas
- Ilka Engelmann
- Ilonka van Veen
- Ingrid G Bustos
- Irfan Khan
- Isabela Bolaños
- Isabelle Delacroix
- Isabelle Enderle
- Isabelle Fabre
- Isabelle Gorenne
- Isabelle Hoffmann
- Isabelle Michelet
- Isabelle Pironneau
- Ithan D. Peltan
- Ivy Cerelia Valerie
- J. Kenneth Baillie
- Jacky Y. Suen
- Jade Ghosn
- Jaganathan Selvanayagam
- Jaime Cruz Rojo
- Jake Dunning
- James Joshua Douglas
- James Lee
- James Scott-Brown
- James Vickers
- Jananee Thirumanickam
- Janet Harrison
- Janet T. Scott
- Jaques Sztajnbok
- Jarne Van Hattem
- Jason Bouziotis
- Jean Baptiste Assie
- Jean Christophe Lucet
- Jean-Benoît Arlet
- Jean-Charles Gagnard
- Jean-Charles Preiser
- Jean-Christophe Goffard
- Jean-Daniel Lelievre
- Jean-François Payen
- Jean-François Timsit
- Jean-Luc Diehl
- Jean-Marc Chapplain
- Jean-Marie Turmel
- Jean-Sébastien Hulot
- Jeanne Sibiude
- Jeanne Truong
- Jee Yan Ong
- Jennifer Lee
- Jenny Lennon
- Jeremie Guedj
- Jess Gibson
- Jia Shyi Loy
- Jia Wei
- Jillian Deacon
- Jimmy Ming-Yang Hsu
- Jimmy Mullaert
- Jin Yi Goh
- Jo Dalton
- Joana Alves Cabrita
- Joana Ferrão
- Joaquín Baruch
- Job van der Palen
- Johann Auchabie
- John F Fraser
- John Marshall
- Jolanta Popielska
- Jonathan Bitton
- Jonathan Chua
- Jonathan Remppis
- Jordan Zhien Toh
- Jorge Dantas
- Jorge Fernandes
- Jorge Paulos
- Jose Andres Calvache
- Jose M. Mandei
- Joshua Solomon
- José Casimiro
- José Ernesto Vidal
- José Luis Sobrino
- José Ramalho
- João Estevão
- João Teixeira
- Juan Luis Bermúdez
- Jules Bauer
- Julian Chica
- Juliana Damas
- Julie Chas
- Julie Mankikian
- Julien Jabot
- Julien Moyet
- Julien Poissy
- Juliette Patrier
- Juliette Romaru
- Justine Pages Maïder Pagadoy
- Jérémie Pasquier
- Jérôme Dimet
- Kah Chuan Lim
- Kalaiarasu Peariasamy
- Kalynn Kennon
- Karen Delavigne
- Karine Bezulier
- Karine Faure
- Karine Risso
- Karisha Sivam
- Karl Erik Müller
- Karolina Nowicka
- Katharina Weil
- Kathy Brickell
- Katie O'Hearn
- Kazali Enagnon Alidjnou
- Kenneth A McLean
- Ker Hong Bee
- Kevin Katz
- Khor How Kiat
- Kim Keat Tan
- Kok Wei Hao
- Kong Yeow Kang
- Konrad Zawadka
- Krishna Bhavsar
- Kuan Pei Xuan
- Kusum Menon
- Kévin Alexandre
- Kévin Bouiller
- Kévin Didier
- Laetitia Bodenes
- Lai Hui Pang
- Lance C.W. Turtle
- Lara Absil
- Lars Heggelund
- Laura Marsh
- Laura Merson
- Laure Goubert
- Lauren Deconninck
- Laurence Bouillet
- Laurence Maulin
- Laurent Abel
- Laurent Bitker
- Laurent Guilleminault
- Laurent Lefebvre
- Laurent Mandelbrot
- Laurent Plantier
- Laurent Richier
- Laurène Azemar
- Lee Lee Low
- Leong Chee Loon
- Leong Chin Tho
- Liem Luong
- Lila Bouadma
- Lim Lina
- Lim Saio Xian
- Lim Yuen Han
- Lina Morales Cely
- Linda O'Shea
- Lionel Eric Benjiman
- Lionel Piroth
- Lisa Norman
- Louis Gerbaud Morlaes
- Louise Sigfrid
- Lucia Moro
- Lucie Le Fevre
- Lucille Blumberg
- Luis Felipe Reyes
- Luís Val-Flores
- Lysa Tagherset
- M Azhari Taufik
- Mageswari Selvarajoo
- Mahdad Noursadeghi
- Maire-Laure Casanova
- Malcolm G. Semple
- Malte Kohns Vasconcelos
- Malte Kohns Vasconcelos
- Manuel Etienne
- Manuel Rosa-Calatrava
- Maram Zahran
- Marc Fabre
- Marc Lambert
- Marc Leone
- Marcel van den Berge
- Marcela Vieira Freire
- Margarida Torres
- Margaux Isnard
- Maria Amaral
- Maria Donnelly
- Maria Pokorska-Spiewak
- Maria Zambon
- Mariana Cascão
- Marie Bartoli
- Marie Connor
- Marie Gominet
- Marie Lachatre
- Marie Lacoste
- Marie Lagrange
- Marie Langelot-Richard
- Marie Rafiq
- Marie-Capucine Tellier
- Marie-Charlotte Chopin
- Marie-Christine Carret
- Marie-Pierre Debray
- Marieke Haalboom
- Marielle Boyer-Besseyre
- Marielle Buisson
- Marije Lowik
- Marina Esposito-Farèse
- Marina Lanza
- Marine Beluze
- Marine Livrozet
- Marion Le Maréchal
- Marion Noret
- Marion Schneider
- Marion Zabbe
- Marjolein Brusse-Keizer
- Mark G. Pritchard
- Mark Joseph
- Marlene Murris
- Marsilla Marzukie
- Marta Leal Santos
- Marta Torre
- Martin Guego
- Martin Martinot
- Martina Escher
- Martine Remy
- Mary Copland
- Marília Andreia Fernandes
- Masliza Zahid
- Massimo Palmarini
- Mathieu Blot
- Mathieu Lesouhaitier
- Mathieu Mattei
- Mathilde Desvallées
- Matthew Hall
- Matthew Pellan Cheng
- Matthieu Revest
- Maude Bouscambert
- Maureen Masha
- Maxime Hentzien
- Maximilien Saint-Gilles
- Mayka Mergeay-Fabre
- Meera Chand
- Megan Coles
- Mehdi Mezidi
- Melissa Parker
- Menaldi Rasmin
- Merce Jourdain
- Mical Paul
- Michael Rose
- Michele Petrovic
- Michelle Girvan
- Miguel Pedrera Jiménez
- Minerva Cervantes-Gonzalez
- Minh Le
- Mirjam Evers
- Mohammad Shamsah
- Mohammed El Sanharawi
- Mohammed Quraishi
- Mohan Dass Pathmanathan
- Mohanaprasanth Balakrishnan
- Mohd Nazlin Kamarudin
- Mohiuddin Shiekh
- Morgane Gilg
- Morgane Snacken
- Moshe Matan
- Moïse Machado
- Muhammad Aisar Kamaluddin
- Muhammad Ashraf
- Muhammad Fadhli Basri
- Muhammad Rayhan
- Murray Dryden
- Murray Wham
- Musharaf Sadat
- Mylène Maillet
- Mário Ferraz
- Mélanie Roriz
- Nadia Ettalhaoui
- Nadia Malik
- Nadia Ouamara
- Nadiah Ismail
- Nadiah Kamarudin
- Nadir Hadri
- Nadirah Abdul Wahid
- Nadège Neant
- Nagarajan Ramakrishnan
- Nassima Si Mohammed
- Nathalie Allou
- Nathalie DeCastro
- Nathalie Dournon
- Nathalie Gault
- Nathalie Pansu
- Nathan Peiffer-Smadja
- Navy Lolong
- Nazreen Abu Bakar
- Neerusha Kaisbain
- Neurinda Permata Kusumastuti
- Ng Yong Muh
- Ng Yong Siang
- Nicholas Sedillot
- Nicholas Yee Hing
- Nick Daneman
- Nicolas Benech
- Nicolas Carlier
- Nicolas Ferriere
- Nicolas Terzi
- Nicole White
- Nidyanara Castanheira
- Nik Nur Mohamed
- Nikita Nekliudov
- Nina Jamieson
- Noelia García Barrio
- Noor Hidayu Wahab
- Nor Arisah Misnan
- Nor Zaila Zaidan
- Nowneet Kumar Bhat
- NoéMie Mercier
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- Nur Amira
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- Nurul Najmee Abdulkadir
- Nurul Zaynah
- Oana Sândulescu
- Obada Yousif
- Odile Launay
- Ogechukwu Menkiti
- Oleksa Rewa
- Olivia V Swann
- Olivier Bouchaud
- Olivier Epaulard
- Olivier Lairez
- Olivier Lesens
- Olivier Picone
- Olivier Robineau
- Olivier Sanchez
- Olivier Terrier
- Ong Yiaw Joe
- Oriane Puechal
- Oryane Mabiala
- Ouifiya Kafif
- Pablo Serrano Balazote
- Pamela Combs
- Paola Rodari
- Paolo Cattaneo
- Parthena Savvidou
- Pascal Granier
- Pathik Dhanger
- Patricia Fontela
- Patricia Gordon
- Patricia Lizotte
- Patrick Archambault
- Patrick Imbert
- Patrick Rispal
- Patrick Rossignol
- Paul Campbell
- Paul Dunand
- Paul Henri Wicky
- Paul Klenerman
- Paul Le Turnier
- Paul Loubet
- Paul McNally
- Paul Tierney
- Paul van der Valk
- Paula Custodio
- Pauline Caraux-Paz
- Pavan Kumar Vecham
- Pedro Faria
- Peter de Vries
- Peter Horby
- Peter Kiiza
- Peter Openshaw
- Peter S Timashev
- Peter Van der Voort
- Petr Glybochko
- PG Ishara Udayanga
- Philippe Jouvet
- Philippine Eloy
- Phoebe Ampaw
- Piero L Olliaro
- Piero L. Olliaro
- Pierre Delobel
- Pierre Jaquet
- Pierre Tattevin
- Pierre-Adrien Bolze
- Pierre-François Sandrine
- Pierre-Marie Roger
- Pieter Depuydt
- Polina Bugaeva
- Prasan Kumar Panda
- Pratap Karpayah
- Quentin Le Hingrat
- Quentin Lepiller
- Quratul Ain Khan
- Rachael Parke
- Rachel Cregan
- Rachida Ouissa
- Rafael Freitas França
- Rafael Mahieu
- Raphael Favory
- Raphaël Borie
- Raquel Pinto
- Rashan Haniffa
- Rasidah Bt Senian
- Raul Neto
- Rebecca Hamidfar
- Renata Barbalho
- Richard S. Tedder
- Riinu Pius
- Rima Song
- Rita Alves
- Rob Klont
- Robert A Fowler
- Robert A. Fowler
- Roberta Cavalin
- Robin Kobbe
- Rodrigo Díaz
- Romain Basmaci
- Romain Decours
- Romain Guery
- Romans Matulevics
- Ross Hendry
- Rostane Gaci
- Roxane Courtois
- Rozanah Abd Rahman
- Rui Caetano Garcês
- Rui Pereira
- Rupert Higgins
- Ruth Lyons
- Ryadh Pokeerbux
- Ryan Khoo
- Ryan S Thwaites
- Saad Nseir
- Sabelline Bouchez
- Sabina Kali
- Sabina Mason
- Sabine Cornelis
- Sabine Croonen
- Sadie Kelly
- Saef Umar Barnett
- Saijad Orakzai
- Sally Shrapnel
- Salma Jaafoura
- Samantha Lissauer
- Samira Laribi
- Samreen Ijaz
- Samuel Hinton
- Samuel Markowicz
- Sandrine Couffin-Cadiergues
- Sanka Sri Darshana
- Sanne Wesselius
- Santi Dewayanti
- Saptadi Yuliarto
- Sara Clohisey
- Sara Machado
- Sarah E McDonald
- Sarah Isgett
- Sarah Moore
- Sarah Redl
- Sarah Stabler
- Sarah Syahrin
- Sarah Tubiana
- Saye Khoo
- Scott Pharand
- Sebastien Preau
- Segolène Greffe
- Seán Keating
- Shahdattul Mawarni Taib
- Shaikh Sharjeel
- Shaminee Veeran
- Sharma Keshav
- Sheryl Ann Abdukahil
- Shiranee Sriskandan
- Shirin Tabrizi
- Shirley Sarfo-Mensah
- Shoban Raj Vasudayan
- Shona C Moore
- Sia Loong Tonnii
- Sim Choon Ean
- Simon Bessis
- Simon Forsyth
- Simon-Djamel Thiberville
- Siri Goepel
- Siti Nurul Ridzuan
- Siti Rohani Yakop
- Siti Zubaidah Othman
- Sivanesen Anthonidass
- Sobia Masood
- Sofia Cardoso
- Soizic Le Mestre
- Sophie Halpin
- Sophie Mahy
- Srinivas Murthy
- Stanislas Rebaudet
- Stella Rousset
- Stephanie Roberts
- Stephanie Yerkovich
- Stephen R Knight
- Steve Webb
- Stéphane Jaureguiberry
- Stéphane Lasry
- Stéphane Sallaberry
- Stéphanie Cousse
- Stéphanie Fry
- Subhash Acharya
- Sue Smith
- Suhaila Abdul Wahab
- Surain Raaj Thurai
- Suresh Kumar Chidambaram
- Sushil Khanal
- Suvintheran Thangavelu
- Swosti Joshi
- Syamin Asyraf Shahidan
- Sybille Bevilcaqua
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Sze Kye Teoh
- Séverine Ansart
- Tae Song
- Tahira Jamal Mohamed
- Tala Al-Dabbous
- Tan Pei Wen
- Tatiana Fonseca
- Teck Fung Wong
- Teresa Lawrence
- Thalha Rashan
- Tharmini Ravi
- Thavamany Kaleesvran
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thushan de Silva
- Théo Treoux
- Tiago Isidoro
- Tiffany Trouillon
- Timo Brandenburger
- Timothy M. Uyeki
- Ting Soo Chow
- Tiphaine Goulenok
- Todd C Lee
- Todd Karsies
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Tony Trapani
- Tristan Gigante
- Tze Vee Soh
- Tze Yuan Tee
- Tânia Sequeira
- Valentine Campana
- Valeria Balan
- Valla Sahraei
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Vanessa Sancho-Shimizu
- Vanina Meysonnier
- Ventzislava Petrov-Sanchez
- Victor Fomin
- Victoria Manda
- Victoria Shaw
- Vilmaris Quinones-Cardona
- Vincent Dinot
- Vincent Dubée
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinod Kumar
- Vinothini Krishnan
- Véronique Lemee
- Víctor Quirós González
- Waasila Jassat
- Walter Picard
- Wei Han Hoh
- Wei Shen Lim
- Wendy S. Barclay
- William A. Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Wim Dieperink
- Xavier Duval
- Xin Ci Wong
- Yael Dishon
- Yan Chyi Tan
- Yaseen Arabi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Ymkje Stienstra
- Yoan Lavie-Badie
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yusing Gu
- Yvelynne Kelly
- Yves Levy
- Zhang Duan Tham
- Zul Amali Kamaruddin
- Zulfiqar Sandhu
- Publication venue
- 'BMJ'
- Publication date
- 01/10/2022
- Field of study
Background The impact of the COVID-19 pandemic on paediatric populations varied between high-income countries (HICs) versus low-income to middle-income countries (LMICs). We sought to investigate differences in paediatric clinical outcomes and identify factors contributing to disparity between countries.Methods The International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) COVID-19 database was queried to include children under 19 years of age admitted to hospital from January 2020 to April 2021 with suspected or confirmed COVID-19 diagnosis. Univariate and multivariable analysis of contributing factors for mortality were assessed by country group (HICs vs LMICs) as defined by the World Bank criteria.Results A total of 12 860 children (3819 from 21 HICs and 9041 from 15 LMICs) participated in this study. Of these, 8961 were laboratory-confirmed and 3899 suspected COVID-19 cases. About 52% of LMICs children were black, and more than 40% were infants and adolescent. Overall in-hospital mortality rate (95% CI) was 3.3% [=(3.0% to 3.6%), higher in LMICs than HICs (4.0% (3.6% to 4.4%) and 1.7% (1.3% to 2.1%), respectively). There were significant differences between country income groups in intervention profile, with higher use of antibiotics, antivirals, corticosteroids, prone positioning, high flow nasal cannula, non-invasive and invasive mechanical ventilation in HICs. Out of the 439 mechanically ventilated children, mortality occurred in 106 (24.1%) subjects, which was higher in LMICs than HICs (89 (43.6%) vs 17 (7.2%) respectively). Pre-existing infectious comorbidities (tuberculosis and HIV) and some complications (bacterial pneumonia, acute respiratory distress syndrome and myocarditis) were significantly higher in LMICs compared with HICs. On multivariable analysis, LMIC as country income group was associated with increased risk of mortality (adjusted HR 4.73 (3.16 to 7.10)).Conclusion Mortality and morbidities were higher in LMICs than HICs, and it may be attributable to differences in patient demographics, complications and access to supportive and treatment modalities
Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19
- Author
- Abdukahil heryl Ann
- Abdulkadir Nurul Najmee
- Abe Ryuzo
- Abel Laurent
- Abrous Amal
- Absil Lara
- Acker Andrew
- Adachi Shingo
- Adrião Diana
- Ahmed Shakeel
- Ainscough Kate
- Airlangga Eka
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Akwani Chika
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alberti Angela
- Alegesan Senthilkumar
- Alessi Marta
- Alex Beatrice
- Alexandre Kévin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Amira Nur
- Ampaw Phoebe
- Andini Roberto
- Andrey
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart Séverine
- Anthonidass Sivanesen
- Antonelli Massimo
- Antunes de Brito Carlos Alexandre
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Arancibia Francisco
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Asensio Angel
- Ashraf Muhammad
- Assie Jean Baptiste
- Asyraf Amirul
- Atif Minahel
- Atikah Ahmad Ridzuan Siti Nurul
- Atique Anika
- Auchabie Johann
- Aumaitre Hugues
- Auvet Adrien
- Ayadi Kamaluddin Muhammad Aisar
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baillie J. Kenneth
- Baird J Kevin
- Bak Erica
- Bakakos Agamemnon
- Bakar Nazreen Abu
- Bal Andriy
- Balakrishnan Mohanaprasanth
- Balan Valeria
- Balazote Pablo Serrano
- Bani-Sadr Firouzé
- Barbalho Renata
- Barbosa Nicholas Yuri
- Barclay Wendy S.
- Barnett Saef Umar
- Barnikel Michaela
- Barrelet Audrey
- Barrigoto Cleide
- Barrio Noelia García
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Bautista Rincon Diego Fernando
- Beane Abigail
- Bedossa Alexandra
- Bee Ker Hong
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beltrão Beatriz Amorim
- Beluze Marine
- Benech Nicolas
- Benjiman Lionel Eric
- Benkerrou Dehbia
- Bennett Suzanne
- Benny Binny
- Bento Luís
- Berdal Jan-Erik
- Bergeaud Delphine
- Bergin Hazel
- Bermejo Carlos Lumbreras
- Bernal Sobrino José Luis
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bidin Farah Nadiah
- Bin Kamarudin Mohd Nazlin
- Binti Mohd Yakop Siti Rohani
- Binti Zaidan Nor Zaila
- Bisoffi Zeno
- Bissuel François
- Biston Patrick
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Blumberg Lucille
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-Hélène
- Bolaños Isabela
- Bolze Pierre-Adrien
- Bompart François
- Borges Diogo
- Borie Raphaël
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camile
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando Augusto
- Braconnier Axelle
- Braga Cynthia
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brewster David
- Brickell Kathy
- Brien Fionnuala O.
- Browne Shaunagh
- Brusse-Keizer Marjolein
- Bryda Petra
- Buchtele Nina
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O.
- Calligy Kate
- Calvache Jose Andres
- Campana Valentine
- Campbell Paul
- Campisi Josie
- Camões João
- Cantero Mireia
- Caraux-Paz Pauline
- Cardellino Chiara Simona
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja Inês
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Casanova Maire-Laure
- Cascão Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castor-Alexandre Guylaine
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavayas Alexandros
- Cely Lina Morales
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chantalat Auger Christelle
- Chapplain Jean-Marc
- Charpentier Charlotte
- Chas Julie
- Chavez-Iniquez Jonathan Samuel
- Che Kamaruddin Zul Amali
- Chen Anjellica
- Chen Yih-Sharng
- Chenard Léo
- Cheng Matthew Pellan
- Cheret Antoine
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chidambaram Suresh Kumar
- Chirouze Catherine
- Chiumello Davide
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chopin Marie-Charlotte
- Chow Ting Soo
- Chow Yock Ping
- Chua Hiu Jian
- Chua Jonathan
- Chávez Iñiguez Jonathan Samuel
- Cidade Jose Pedro
- Citarella Barbara Wanjiru
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Jennifer
- Claure-Del Granado Rolando
- Claure-Del Granado Rolando
- Clohisey Sara
- Cobb Perren J.
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Coles Jennifer
- Coles Megan
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Combs Pamela
- Connolly Jennifer
- Connor Marie
- Conrad Anne
- Conway Elaine
- Cooke Graham S.
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
- Cortegiani Andrea
- Corvaisier Grégory
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Cousse Stéphanie
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Bermúdez Juan Luis
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Curley Gerard
- Curlier Elodie
- Curran Colleen
- Custodio Paula
- D'Ortenzio Eric
- da Silva Filipe Ana
- Da Silva Fernanda Dias
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew
- Dahly Darren
- Dai Danyang
- Dai Danyang
- Dalton Heidi
- Dalton Jo
- Daly Seamus
- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A.
- Dantas Jorge
- de Loughry Gillian
- De Montmollin Etienne
- De Rosa Rosanna
- de Silva Thushan
- de Vries Peter
- Dean David
- Debard Alexa
- DeBenedictis Bianca
- Debray Marie-Pierre
- DeCastro Nathalie
- Dechert William
- Deconninck Lauren
- Decours Romain
- Defous Eve
- Delacroix Isabelle
- Delaveuve Eric
- Delavigne Karen
- Dell'Amore Andrea
- Delmas Christelle
- Delobel Pierre
- Delsing Corine
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Desai Mehul
- Descamps Diane
- Desvallées Mathilde
- Devouge Eglantine Ferrand
- Dewayanti Santi
- Dhanger Pathik
- Diallo Alpha
- Diamantis Sylvain
- Diaz Juan Jose
- Diaz Rodrigo
- Didier Kévin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet Jérôme
- Dinot Vincent
- Diop Fara
- Diouf Alphonsine
- Dishon Yael
- Djossou Félix
- Docherty Annemarie B.
- Doherty Helen
- Donnelly Christl A.
- Donnelly Maria
- Donohue Chloe
- Donohue Sean
- Donohue Yoann
- Doran Peter
- Dorival Céline
- Douglas James Joshua
- Dournon Nathalie
- Downer Triona
- Downey Joanne
- Downing Mark
- Drake Tom
- Driscoll Aoife
- Dryden Murray
- Dubee Vincent
- Dubos François
- Ducancelle Alexandre
- Duculan Toni
- Dudman Susanne
- Duggal Abhijit
- Dunand Paul
- Dunning Jake
- Duplaix Mathilde
- Durante-Mangoni Emanuele
- Durham Lucian
- Dussol Bertrand
- Duthoit Juliette
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- Ean Sim Choon
- Echeverria-Villalobos Marco
- Edwards Eleanor
- Egan Siobhan
- El Sanharawi Mohammed
- Elapavaluru Subbarao
- Elharrar Brigitte
- Eliza Mohamed Nik Nur
- Eloy Philippine
- Elshazly Tarek
- Enderle Isabelle
- Endo Tomoyuki
- Eng Chan Chee
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Escher Martina
- Esperatti Mariano
- Esperou Hélène
- Esposito-Farese Marina
- Estevão João
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Evers Mirjam
- Fabre Isabelle
- Fabre Marc
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J.
- Faria Pedro
- Fateena Hanan
- Fatoni Arie Zainul
- Faure Karine
- Favory Raphaël
- Fayed Mohamed
- Feely Niamh
- Feeney Laura
- Fernandes Jorge
- Fernandes Marília Andreia
- Fernandes Susana
- Ferrand François-Xavier
- Ferraz Mário
- Ferreira Benigno
- Ferreira Bernardo
- Ferreira Sílvia
- Ferriere Nicolas
- Ferrão Joana
- Ficko Céline
- Figueiredo-Mello Claudia
- Fiorda Juan
- Flament Thomas
- Flanagan Emily
- Flateau Clara
- Fletcher Tom
- Florence Aline-Marie
- Florio Letizia Lucia
- Flynn Deirdre
- Foley Jean
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Tatiana
- Forsyth Simon
- Foster Denise
- Foti Giuseppe
- Fourn Erwan
- Fowler Robert A.
- Fraher Marianne
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John F.
- Freire Marcela Vieira
- Freitas de Oliveira França Rafael
- Friedrich Caren
- Fritz Ricardo
- Fry Stéphanie
- Fuentes Nora
- Fukuda Masahiro
- G Argin
- Gaborieau Valérie
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- Gaião Sérgio
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- Gandonniere Charlotte Salmon
- Gani Yasmin
- Garan Arthur
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- Gavin Aisling
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- Gaymard Alexandre
- Gebauer Johannes
- Geraud Eva
- Germano Nuno
- Ghadimi Moji
- Ghosn Jade
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- Gigante Tristan
- Gilg Morgane
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- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goehringer François
- Goffard Jean-Christophe
- Goh Jin Yi
- Golob Jonathan
- Gominet Marie
- Gonzalez Alicia
- González Víctor Quirós
- Gordon Patricia
- Gorenne Isabelle
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- Goujard Cécile
- Goulenok Tiphaine
- Grable Margarite
- Grandin Edward Wilson
- Granerud Beathe Kiland
- Granier Pascal
- Grasselli Giacomo
- Green Christopher A.
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Griffee Matthew
- Griffiths Fiona
- Grigoras Ioana
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj Jérémie
- Guego Martin
- Guellec Dewi
- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
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- Guimard Thomas
- Guimarães de Castro Maisa
- Haalboom Marieke
- Haber Daniel
- Habraken Hannah
- Hachemi Ali
- Hadri Nadir
- Haji Ab Rahman Ahmad Kashfi
- Hakak Sheeba
- Hall Adam
- Hall Matthew
- Halpin Sophie
- Hamer Ansley
- Hamers Raph L.
- Hamidfar Rebecca
- Hammond Naomi
- Hammond Terese
- Han Lim Yuen
- Hao Kok Wei
- Hardwick Hayley
- Harrison Ewen M.
- Harrison Janet
- Hartman Alan
- Hashmi Junaid
- Hassin Basri Muhammad Fadhli
- Hayes Ailbhe
- Hays Leanne
- Heerman Jan
- Heggelund Lars
- Hendry Ross
- Hennessy Martina
- Hentzien Maxime
- Hernandez Diana
- Hershey Andrew
- Hesstvedt Liv
- Higgins Dawn
- Higgins Eibhlin
- Higgins Rupert
- Hinchion Rita
- Hinton Samuel
- Hiraiwa Hiroaki
- Hitoto Hikombo
- Ho Antonia
- Ho Yi Bin
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- Hoffmann Isabelle
- Hoh Wei Han
- Hoiting Oscar
- Holt Rebecca
- Holten Aleksander Rygh
- Holter Jan Cato
- Horby Peter
- Hoshino Kota
- Houas Ikram
- Hough Catherine L.
- Houltham Stuart
- Hssain Ali Ait
- Hulot Jean-Sébastien
- Humaid Felwa Bin
- Hurd Abby
- Ijaz Samreen
- Ikram M. Arfan
- Illes Hajnal-Gabriela
- Imbert Patrick
- Ing Yun Sii
- Inácio Hugo
- Ippolito Mariachiara
- Isgett Sarah
- Isidoro Tiago
- Ismail Nadiah
- Isnard Margaux
- Itai Junji
- Ivulich Daniel
- Izzati Norharizam Nurul Faten
- Jaafar Danielle
- Jaafoura Salma
- Jabot Julien
- Jackson Clare
- Jaquet Pierre
- Jassat Waasila
- Jaud-Fischer Coline
- Jaureguiberry Stéphane
- Jego Florence
- Jelani Anilawati Mat
- Jenum Synne
- Jiménez Miguel Pedrera
- Joe Ong Yiaw
- Johnson David W.
- Jorge García Ruth N.
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- Tawfik Hassan
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- Tho Leong Chin
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- Thomson David
- Thomson Emma C.
- Thorpe Mathew
- Thwaites Ryan S.
- Tierney Paul
- Tieroshyn Vadim
- Timashev Peter S.
- Timsit Jean-François
- Tirupakuzhi Vijayaraghavan Bharath Kumar
- Tissot Noémie
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- Truong Jeanne
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- Tubiana Sarah
- Tuite Helen
- Turgeon Alexis F.
- Turmel Jean-Marie
- Turtle Lance C. W.
- Tveita Anders
- Twardowski Pawel
- Téoulé François
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M.
- Vajdovics Cristinava
- Val-Flores Luís
- Valran Amélie
- Van de Velde Stijn
- van den Berge Marcel
- van der Palen Job
- van der Valk Paul
- Van Der Vekens Nicky
- Van der Voort Peter
- Van Der Werf Sylvie
- van Gulik Laura
- Van Hattem Jarne
- van Netten Carolien
- van Veen Ilonka
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Varrone Michael
- Vasudayan Shoban Raj
- Vauchy Charline
- Vecham Pavan Kumar
- Veeran Shaminee
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vidal José Ernesto
- Vieira César
- Villanueva Joy Ann
- Villoldo Andrea
- Visseaux Benoit
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wahab Noor Hidayu
- Wahab Suhaila Abdul
- Wahid Nadirah Abdul
- Wainstein Marina
- Wainstein Marina
- Walsh Laura
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Wen Tan Pei
- Wesselius Sanne
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Sue
- Williams Bailey
- Williams Patricia J.
- Williams Virginie
- Wils Evert-Jan
- Wittman Jessica
- Wong Calvin
- Wong Teck Fung
- Wong Xin Ci
- Wong Yew Sing
- Xian Gan Ee
- Xian Lim Saio
- Xynogalas Ioannis
- Yamazaki Masaki
- Yang Toh Jordan Zhien
- Yarad Elizabeth
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yeoh Chian Hui
- Yerkovich Stephanie
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Zaaqoq Akram
- Zabbe Marion
- Zahid Masliza
- Zahran Maram
- Zambon Maria
- Zambrano Miguel
- Zanella Alberto
- Zaynah Nurul
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- Elsevier BV
- Publication date
- 26/05/2023
- Field of study
Introduction: Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population. Methods: This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay. Results: Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity. Conclusions: AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes
Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
- Author
- Abdukahil Sheryl Ann
- Abdulkadir Nurul Najmee
- Abe Ryuzo
- Abel Laurent
- Abrous Amal
- Absil Lara
- Acker Andrew
- Adam Elisabeth
- Adrião Diana
- Ahmed Shakeel
- Ainscough Kate
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Akwani Chika
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alberti Angela
- Alegesan Senthilkumar
- Alessi Marta
- Alex Beatrice
- Alexander Peta MA
- Alexandre Kévin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Amira Nur
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart Séverine
- Anthonidass Sivanesen
- Antonelli Massimo
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Arancibia Francisco
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Asensio Angel
- Ashraf Muhammad
- Assie Jean Baptiste
- Asyraf Amirul
- Atif Minahel
- Atikah Ahmad Ridzuan Siti Nurul
- Atique Anika
- Auchabie Johann
- Aumaitre Hugues
- Auvet Adrien
- Ayadi Kamaluddin Muhammad Aisar
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J Kenneth
- Bak Erica
- Bakakos Agamemnon
- Bakar Nazreen Abu
- Bal Andriy
- Balakrishnan Mohanaprasanth
- Balan Valeria
- Balazote Pablo Serrano
- Bani-Sadr Firouzé
- Barbalho Renata
- Barbosa Nicholas Yuri
- Barclay Wendy S
- Barnett Saef Umar
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Barrio Noelia García
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Basri Muhammad Fadhli Hassin
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beltrão Beatriz Amorim
- Beluze Marine
- Benech Nicolas
- Benjiman Lionel Eric
- Benkerrou Dehbia
- Bennett Suzanne
- Benny Binny
- Bento Luís
- Berdal Jan-Erik
- Bergeaud Delphine
- Bergin Hazel
- Bermejo Carlos Lumbreras
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bidin Farah Nadiah
- Binti Mohd Yakop Siti Rohani
- Binti Zaidan Nor Zaila
- Bisoffi Zeno
- Bissuel François
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Blumberg Lucille
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-Hélène
- Bolaños Isabela
- Bolze Pierre-Adrien
- Bompart François
- Borges Diogo
- Borie Raphaël
- Bosse Hans Martin
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camile
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando Augusto
- Bozza Patricia T
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brewster David
- Brickell Kathy
- Brien Fionnuala O
- Browne Alex
- Browne Shaunagh
- Brozzi Nicolas
- Brusse-Keizer Marjolein
- Bryda Petra
- Buchtele Nina
- Buisson Marielle
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
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- Callaghan Annmarie O
- Calligy Kate
- Calvache Jose Andres
- Campana Valentine
- Campbell Paul
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- Canepa Cecilia
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- Chair Anissa
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- Cheret Antoine
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- Chiarabini Thibault
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- Chin Tho Leong
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- Chiumello Davide
- Cho Sung-Min
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- Cholley Bernard
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- Chow Ting Soo
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- Cidade Jose Pedro
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- Citarella Barbara Wanjiru
- Citarella Barbara Wanjiru
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- Colin Gwenhaël
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- Combs Pamela
- Connolly Jennifer
- Connor Marie
- Conrad Anne
- Conway Elaine
- Cooke Graham S
- Copland Mary
- Cordel Hugues
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- Dankwa Emmanuelle A
- Dantas Jorge
- de Brito Carlos Alexandre Antunes
- de Castro Maisa Guimarães
- de Jong Menno
- de la Calle Guillermo Maestro
- de Loughry Gillian
- De Montmollin Etienne
- de Oliveira França Rafael Freitas
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- Delacroix Isabelle
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- Delfos Nathalie M
- Deligiannis Ionna
- Dell'Amore Andrea
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- Dimet Jérôme
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- Diop Fara
- Diouf Alphonsine
- Dishon Yael
- Djossou Félix
- Docherty Annemarie B
- Doherty Helen
- Donnelly Christl A
- Donnelly Maria
- Donohue Chloe
- Donohue Sean
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- Doran Peter
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- Dournon Nathalie
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- Dussol Bertrand
- Duthoit Juliette
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- Dyrhol-Riise Anne Margarita
- Ean Sim Choon
- Echeverria-Villalobos Marco
- Eddington Devin P
- Egan Siobhan
- Eira Carla
- Ekow Harrison Samuel Bernard
- El Sanharawi Mohammed
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- Everding Anna Greti
- Evers Mirjam
- Fabre Isabelle
- Fabre Marc
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J
- Fanning Jonathon P
- Faria Pedro
- Fateena Hanan
- Fatoni Arie Zainul
- Faure Karine
- Favory Raphaël
- Fayed Mohamed
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- Foley Claire
- Foley Jean
- Fonseca Claudio Duarte
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- Forsyth Simon
- Foster Denise
- Foti Giuseppe
- Fourn Erwan
- Fowler Robert A
- Fraher Marianne
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John
- Fraser John F
- Freire Marcela Vieira
- Fritz Ricardo
- Fry Stéphanie
- Fuentes Nora
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- Gaborieau Valérie
- Gaci Rostane
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- Goh Jin Yi
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- Goulenok Tiphaine
- Grable Margarite
- Graf Jeronimo
- Grandin Edward Wilson
- Granerud Beathe Kiland
- Granier Pascal
- Grasselli Giacomo
- Green Christopher A
- Greene Courtney
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Griffee Matthew
- Griffee Matthew J
- Griffiths Fiona
- Grigoras Ioana
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj Jérémie
- Guego Martin
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- Hamer Ansley
- Hamidfar Rebecca
- Hammond Naomi
- Hammond Terese
- Han Lim Yuen
- Haniffa Rashan
- Hao Kok Wei
- Hardwick Hayley
- Harrison Ewen M
- Harrison Janet
- Hartman Alan
- Hashmi Junaid
- Hayes Ailbhe
- Hays Leanne
- Heerman Jan
- Heggelund Lars
- Hendry Ross
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- Holter Jan Cato
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- Hoshino Koji
- Houas Ikram
- Hough Catherine L
- Houltham Stuart
- Hssain Ali Ait
- Hulot Jean-Sébastien
- Humaid Felwa Bin
- Hurd Abby
- Ijaz Samreen
- Ikram M Arfan
- Illes Hajnal-Gabriela
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- Jego Florence
- Jelani Anilawati Mat
- Jenum Synne
- Jimbo-Sotomayor Ruth
- Jiménez Miguel Pedrera
- Joe Ong Yiaw
- Jorge García Ruth N
- Joseph Cédric
- Joseph Mark
- Jourdain Mercé
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- Jung Anna
- Jung Hanna
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- Kafif Ouifiya
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- Keshav Sharma
- Khalid Imrana
- Khalil Antoine
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- Kho Michelle E
- Khoo Denisa
- Khoo Ryan
- Khoo Saye
- Kiat Khor How
- Kida Yuri
- Kiiza Peter
- Kildal Anders Benjamin
- Kimmoun Antoine
- Kindgen-Milles Detlef
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- Kitamura Nobuya
- Klenerman Paul
- Klont Rob
- Knight Stephen R
- Komatsu Mamoru
- Kosgei Caroline
- Kpangon Arsène
- Krawczyk Karolina
- Krishnan Sudhir
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- Kurtzman Ethan
- Kutsogiannis Demetrios
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- Kyriakoulis Konstantinos
- L'Her Erwan
- Lachatre Marie
- Lacoste Marie
- Laffey John G
- Lafhej Nadhem
- Lagrange Marie
- Laine Fabrice
- Lairez Olivier
- Lalueza Antonio
- Lambert Marc
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- Langelot-Richard Marie
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- Leathlobhair Niamh Ni
- Lee Low Lee
- Lee Biing Horng
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- Lee James
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- Lee Su Hwan
- Lee Todd C
- Lee Yi Lin
- Leeming Gary
- Lefebvre Bénédicte
- Lefebvre Laurent
- Lefèvre Benjamin
- LeGac Sylvie
- Lelievre Jean-Daniel
- Lellouche François
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- Liang Hing Nicholas Yee
- Liegeon Geoffrey
- Lim Heng Benedict Sim
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- Liu Keibun
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- Lizotte Patricia
- Lolong Navy
- Loon Leong Chee
- Lopes Diogo
- Lopez-Colon Dalia
- Loschner Anthony L
- Loubet Paul
- Loufti Bouchra
- Louis Guillame
- Lourenco Silvia
- Lowik Marije
- Loy Jia Shyi
- Lucet Jean-Christophe
- Luna Carlos M
- Lungu Olguta
- Luong Liem
- Luque Nestor
- Luton Dominique
- Lwin Nilar
- Lyons Ruth
- Maasikas Olavi
- Mabiala Oryane
- Machado Moïse
- Machado Sara
- Macheda Gabriel
- Madiha Hashmi
- Mahieu Rafael
- Mahy Sophie
- Maia Ana Raquel
- Maier Lars S
- Maillet Mylène
- Maitre Thomas
- Malfertheiner Maximilian
- Malik Nadia
- Mallon Paddy
- Maltez Fernando
- Malvy Denis
- Manda Victoria
- Mandelbrot Laurent
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- Markowicz Samuel
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- Martin-Blondel Guillaume
- Martin-Loeches Ignacio
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- Martinot Martin
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- Martins João
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- Martynenko Olga
- Marwali Eva Miranda
- Marzukie Marsilla
- Maslove David
- Mason Sabina
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- Mathieu Daniel
- Mattei Mathieu
- Maulin Laurence
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- Mazzoni Thierry
- McArthur Colin
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- McCarthy Aine
- McCarthy Anne
- McCloskey Colin
- McConnochie Rachael
- McDermott Sherry
- McDonald Sarah E
- McElroy Aine
- McElwee Samuel
- McEneany Victoria
- McEvoy Natalie
- McGeer Allison
- McKay Chris
- McKeown Johnny
- McLean Kenneth A
- McNally Paul
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- McPartlan Elaine
- Meaney Edel
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- Mechlin Maggie
- Mehkri Omar
- Mele Ferruccio
- Melo Luis
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- Menon Kusum
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- Mentzer Alexander J
- Mercier Emmanuelle
- Mercier Noémie
- Merckx Antoine
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- Mergler Blake
- Merson Laura
- Merson Laura
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- Mestre Soizic Le
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- Meyer Dan
- Meynert Alison M
- Meysonnier Vanina
- Meziane Amina
- Mezidi Mehdi
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- Mone Mary
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- Montes Claudia
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- Moore Sarah
- Moore Shona C
- Morlaes Louis Gerbaud
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- Morton Ben
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- Moyet Julien
- Mudara Caroline
- Muh Ng Yong
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- Müller Karl Erik
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- Nitayavardhana Prompak
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- Nowinski Adam
- Nseir Saad
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- Nyamankolly Elsa
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- Ogston Tawnya
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- Oh Tak-Hyuk
- Ohshimo Shinichiro
- Oliveira João
- Oliveira Larissa
- Olliaro Piero L
- Ong David SY
- Ong Jee Yan
- Oosthuyzen Wilna
- Opavsky Anne
- Openshaw Peter
- Orozco-Chamorro Claudia Milena
- Ortoleva Jamel
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- Paul Christelle
- Paul Mical
- Paulos Jorge
- Paxton William A
- Payen Jean-François
- Peake Sandra L
- Peariasamy Kalaiarasu
- Peek Giles J
- Peelman Florent
- Peiffer-Smadja Nathan
- Peigne Vincent
- Pejkovska Mare
- Pelosi Paolo
- Peltan Ithan D
- Pereira Rui
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- Ponscarme Diane
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- Postma Douwe F
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- Powis Jeff
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- Prebensen Christian
- Preiser Jean-Charles
- Prinssen Anton
- Pritchard Mark G
- Proença Lucia
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- Purcell Gregory
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- Ramalho José
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- Rapp Christophe
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- Reid Liadain
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- Reyes Tiago
- Ribeiro Ana Freitas
- Ribeiro Maria Ines
- Richardson David
- Richardson Denise
- Richier Laurent
- Rincon Diego Fernando Bautista
- Rios Ana L
- Rishu Asgar
- Rispal Patrick
- Risso Karine
- Rizer Nicholas
- Robba Chiara
- Roberto André
- Roberts Stephanie
- Robertson David L
- Robineau Olivier
- Roche-Campo Ferran
- Rodari Paola
- Rodeia Simão
- Roessler Bernhard
- Roger Claire
- Roger Pierre-Marie
- Roilides Emmanuel
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- Roriz Mélanie
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- Rosenberger Dorothea
- Rossanese Andrea
- Rossetti Matteo
- Rossignol Bénédicte
- Rossignol Patrick
- Rousset Stella
- Roy Carine
- Roze Benoît
- Russell Clark D
- Ryan Maeve
- Ryan Maria
- Ryckaert Steffi
- Rätsep Indrek
- Saba Isabela
- Sadat Musharaf
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- Saint-Gilles Maximilien
- Sakiyalak Pranya
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- Sallaberry Stéphane
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- Sanchez-Miralles Angel
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- Sandhu Gyan
- Sandhu Zulfiqar
- Sandrine Pierre-François
- Sandulescu Oana
- Sant`Ana Malaque Ceila Maria
- Santo Catarina Espírito
- Santos Marlene
- Santos Marta Leal
- Sarfo-Mensah Shirley
- Sarmento Banheiro Bruno
- Sarmiento Iam Claire E
- Sarton Benjamin
- Satyapriya Sree
- Satyawati Rumaisah
- Saviciute Egle
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- Saw Yen Tsen
- Schaffer Justin
- Schermer Tjard
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- Schneider Marion
- Schroll Stephan
- Schwameis Michael
- Scicluna Brendan
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- Seitz Tamara
- Selvarajoo Mageswari
- Semaille Caroline
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- Senneville Eric
- Sepulveda Claudia
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- Sequeira Tânia
- Shadowitz Ellen
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- Sharjeel Shaikh
- Sharma Pratima
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- Shaw Victoria
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- Shi Haixia
- Shime Nobuaki
- Shimizu Keiki
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- Shum Hoi Ping
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- Spinuzza Elisabetta
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- Steinsvik Trude
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- Stiksrud Birgitte
- Stolz Eva
- Stone Amy
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- Streinu-Cercel Anca
- Stuart Ami
- Stuart David
- Su Richa
- Suen Gabriel
- Suen Jacky Y
- Sukumar Prasanth
- Sultana Asfia
- Summers Charlotte
- Supic Dubravka
- Suppiah Deepashankari
- Surovcová Magdalena
- Sweeney Lisa Mc
- Syahrin Sarah
- Syrigos Konstantinos
- Sztajnbok Jaques
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- Taib Shahdattul Mawarni
- Taleb Sara
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- Tamlihat Younes Ait
- Tampubolon Maria Lawrensia
- Tan Kim Keat
- Tan Yan Chyi
- Tanaka Hiroyuki
- Tanaka Taku
- Taniguchi Hayato
- Tardivon Coralie
- Tattevin Pierre
- Taufik M Azhari
- Tawfik Hassan
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- Teixeira João
- Tejada Sofia
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- Teoh Sze Kye
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- Tieroshyn Vadim
- Timsit Jean-François
- Tissot Noémie
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- Toki Maria
- Tonby Kristian
- Tonnii Sia Loong
- Torre Marta
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- Torres Margarida
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- Towers Michael
- Trapani Tony
- Trioux Théo
- Tromeur Cécile
- Trontzas Ioannis
- Trouillon Tiffany
- Truong Jeanne
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turgeon Alexis F
- Turmel Jean-Marie
- Turtle Lance CW
- Tveita Anders
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M
- Vajdovics Cristinava
- Val-Flores Luís
- Valran Amélie
- Van de Velde Stijn
- van den Berge Marcel
- Van der Feltz Machteld
- van der Palen Job
- van der Valk Paul
- Van Der Vekens Nicky
- Van der Voort Peter
- Van Der Werf Sylvie
- van Gulik Laura
- Van Hattem Jarne
- van Netten Carolien
- van Someren Gréve Frank
- van Veen Ilonka
- Van Willigen Hugo
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Varrone Michael
- Vasconcelos Malte Kohns
- Vasudayan Shoban Raj
- Vauchy Charline
- Vecham Pavan Kumar
- Veeran Shaminee
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vidal José Ernesto
- Vieira César
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wahab Noor Hidayu
- Wahab Suhaila Abdul
- Wahid Nadirah Abdul
- Wainstein Marina
- Walsh Laura
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Weil Katharina
- Wen Tan Pei
- Wesselius Sanne
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Sue
- Williams Bailey
- Williams Patricia J
- Williams Virginie
- Wils Evert-Jan
- Wittman Jessica
- Wong Calvin
- Wong Teck Fung
- Wong Xin Ci
- Wong Yew Sing
- Xian Gan Ee
- Xian Lim Saio
- Xynogalas Ioannis
- Yamazaki Masaki
- Yang Toh Jordan Zhien
- Yarad Elizabeth
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yeoh Chian Hui
- Yerkovich Stephanie
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Zaaqoq Akram
- Zabbe Marion
- Zacharowski Kai
- Zahid Masliza
- Zahran Maram
- Zambon Maria
- Zambrano Miguel
- Zanella Alberto
- Zaynah Nurul
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- Elsevier BV
- Publication date
- 30/06/2023
- Field of study
Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were more frequent in HICs than in LMICs (developing countries). Increased mortality associated with coagulopathy complications was of a greater magnitude among patients in LMICs. Additional research is needed regarding timely diagnosis of and intervention for coagulation derangements associated with COVID-19, particularly for limited-resource settings
Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies
- Author
- Aage Christiansen
- Aaradhana Adhikari
- Aaron Venti
- Aayesha Qadeer
- Abdellatif Benslama
- Abigail Beane
- Abu Hena Mostafa Kamal
- Abul Faiz
- Adam B Schlichting
- Adam Bell Bell
- Adenilton M R Ampinelli
- Aditya Uppalapati
- Adrian Donnelly
- Adriana M Fernandez
- Adrien Robine
- Aftab Akhtar
- Agreta Gecaj-Gashi
- Ahmed Farooq
- Ahmed S Al Jabbary
- Ahmet Dilek
- Ahmet Sukru Denker
- Ai Y Hang
- Aiman Tulaimat
- Akihiro Takaba
- Akinori Uchiyama
- Akira Hirata
- Akm Shamsul Alam
- Akut Aytulun
- Alain Combes
- Alain M Dive
- Alain Mercat
- Alain U Alisasis
- Alan Zazu
- Alastair Rose
- Alberto Deicas
- Alec A Tallet Alfonso
- Alejandro A Saez
- Alejandro Ebeid
- Alejandro G Castro
- Alejandro R Bruhn
- Alek Kumar
- Alessandro Bacuzzi
- Alessandro Protti
- Alessia Mattei
- Alex Mcleod
- Alex Morton
- Alexandra Ceniceros-Barros
- Alexandra J Williams
- Alexandra Marcu
- Alexandra Siqueira Colombo
- Alexandre Biasi Cavalcanti
- Alexandre Biasi Cavalcanti
- Alexandre Chan
- Alexandre Demoule
- Alexandre Guilherme Ribeiro de Carvalho
- Alexandre Molin
- Alexandre Molin
- Alexey I Gritsan
- Alfons Arizmendi
- Aline Ascoli
- Alison Ghosh
- Alistair Nichol
- Alistair Roy Roy
- Alma Cani
- Alvaro Ramirez-Gutierrez
- Amadeu Martinez
- Amanda Cowton
- Amanda Krstevski
- Amanda Maria R R de Oliveira
- Amanda Skinner
- Amanda Whileman
- Amine Ali Zeggwagh
- Amine Ali Zeggwagh
- Amy McInerney
- Ana Carolina P Antônio
- Ana Carolina Peçanha
- Ana G França
- Ana M Araujo
- Ana M Pellicer
- Anais Briquet
- Anand Dongre
- Anatole Harrois
- Anders Aneman
- Anders Larsson
- Andre Japiassu
- Andre Luiz Baptiston Nunes
- Andre Luiz Baptiston Nunes
- Andre Vercueil
- Andrea Coppadoro
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Lombardo
- Andrea N Cracchiolo
- Andrea Tinnirello
- Andreas Barratt-Due
- Andreas W Reske
- Andrej Sribar
- Andrew Bentley
- Andrew Corner
- Andrew Ferguson
- Andrew J Burtenshaw
- Andrey A Gazenkampf
- André Peretti Torelly
- Angela Delsing
- Angela Pinder
- Aniko D Frigyik
- Anil Hormis
- Anil P Hormis
- Anitha Shenoy
- Anna Hunt
- Anna Oscarsson Tibblin
- Anna Rossi
- Anna T Dowling
- Anna Walker
- Anna-Karin Morin
- Anne Adolfsson
- Anne B Guttormsen
- Annop Piriyapatsom
- Antero do Vale Fernandes
- Antoine Pronovost
- Antonino Giarratano
- Antonio Artigas
- Antonio Braschi
- Antonio Carlos Nogueira
- Antonio G Jimenez
- Antonio Jorge Pereira
- Antonio L Ruiz-Aguilar
- Antonio P Nassar Jr
- Antonio Paulo Nassar Junior
- António M Alvarez
- António M Messias
- Aogan C O'Muircheartaigh
- Areef Ahsan
- Areej Javeed
- Ariel Chena
- Arnaud Follin
- Arshad Taqi
- Arvind K Baronia
- Ary Serpa Neto
- Ashley Schomer
- Ashok S Raj
- Asisclo J Villagomez
- Asisclo Villagomez
- Asma Ben Souissi
- Asma Navasakulpong
- Asoka Gunaratne
- Atta Ur Rehman
- Aurelia M Martinho
- Aylin Seven
- Bao H Zhu
- Barbara Brunettini
- Barbara do Cs Martins
- Barrett T Kitch
- Barry Dixon
- Barry Kennedy
- Basak Ceyda Meco
- Batoul Khoundabi
- Beatriz C Tan
- Behzad Nadjm
- Ben Creagh-Brown
- Bernard Goubaux
- Bernhard Holzgraefe
- Bhagyesh Shah
- Bhuvana Krishna
- Bimal Kudavidanage
- Bin Li
- Bingyu Qin
- Bojan Jovanovic
- Boris G Villamagua
- Brenno Cardoso Gomes
- Brigit L Roberts
- Brit Å Sjøbø
- Bruno Franco Mazza
- Bruno Gelée
- Bruno S Oliveira
- Candelaria De Haro
- Carlo A Volta
- Carlo Alberto Volta
- Carlos A Pellegrini
- Carlos Eduardo Barboza
- Carlos Munhoz
- Carlos S Pereira
- Carly Brown
- Carmen Scott
- Carolina Quintana Grijalba
- Carolina S Insaurralde
- Carolina Serra
- Caroline Berghe
- Caroline C MacFie
- Caroline Wreybrown
- Cassia Righy
- Cassiano Teixeira
- Catalina Forteza
- Catherine Plowright
- Cecilia Carbayo-Gorriz
- Cecilia Hermosa
- Ceri E Battle
- Cesar A Cortez
- Cesar Milstein
- Cesar P Pere
- Chamila Pilimatalawwe
- Charlene Bigot
- Charlene Le Moal
- Charlotte Downes
- Chathurani Sigera
- Chern Min Voon
- Cheryl Padilla-Harris
- Chinni Krishna Kasi
- Chloe Hughes
- Christian C Rylander
- Christian Dellera
- Christian Frey
- Christian M Ramirez-Alfaro
- Christian Schlegel
- Christina Whitehead
- Christine Boyd
- Christine Brown
- Christine Ryan
- Christoph Muench
- Christopher J Scott
- Christopher Nutt
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- Christopher Tainter
- Chunting Wang
- Claine Judy
- Clair Harris
- Claire Kaloo
- Claire Matthews
- Claire Miller
- Claire Pegg
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- Clare Mellis
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- Claude Guérin
- Claudia A Ortiz
- Claudia R Estrella
- Claudio H Gonçalves
- Claudio Piras
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- Colette Seasman
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- Colin K Grissom
- Colin Mcarthur
- Colin S Black
- Cora Lavigne Moreira
- Corcoles G Virgilio
- Corinne Leemann-Refondini
- Cristiane Ritter
- Cristiane Tomasi Damiani
- Cristina M Cox
- Cristina Prata Amendola
- Cristina Santos
- Cristina Santos
- Cédric Daubin
- Daisuke Niimi
- Dale J Yeatts
- Dalton de Souza Barros
- Damien Roux
- Dan E Corneci
- Dan Hadfield
- Dana R Tomescu
- Daniel Aragão
- Daniel Beraldo
- Daniel Collins
- Daniel da Cunha Ribeiro
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- Daniel Hadfield
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- Daniel O Beraldo
- Daniel Prado
- Daniel R Crouch
- Daniel R Gonzalez
- Daniel V Collins
- Daniela Albiero
- Daniela M Palma
- Daniela N Vasquez
- Daniele M Combaux
- Danielle A Fawkes
- Danielle C Fontenele
- Danielle J Hacking
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- Dawn Trodd
- Debabrata Banik
- Debbie Weller
- Deborah M Inskip
- Deborah Smith
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- Deeban Ganesan
- Demet Aydin
- Denis Doyen
- Denise Donaldson
- Denise Griffin
- Dharshinie Dorasamy
- Diego Pastor Marcos
- Dimitrios Matamis
- Dina Gomaa
- Dina Gomaa
- Dina Ismail
- Dk Maizatul Aiman B Pg Hj Ismail
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- Donall O'Croinin
- Donatella Mestria
- Dora Mannarino
- Dorel Sandesc
- Dorothy M Breen
- Dorothée Carpentier
- Dulce M Dector
- Dyanne Moysés Dalcomune
- Dácil Parrilla Toribio
- Ed Bajwa
- Eddy Fan
- Edel A Meaney
- Edgardo E Tabhan
- Edgardo Nuñez
- Edgardo Tabhan
- Edison Moraes
- Eduardo Beck
- Eduardo Di Lauro
- Eduardo F Labarca
- Eimhin S Dunne
- Eizo Watanabe
- Elaine Ferreira
- Eldar Søreide
- Electra E Stamou
- Elena Frati
- Elena Gallego Curto
- Elena Perez Losada
- Eleni K Mouloudi
- Eleni V Massa
- Eliana Bernadete Caser
- Eliane Bernadete Caser
- Elie H Zogheib
- Eliezer Silva
- Elisa Estenssoro
- Elisa Seghelini
- Elisabetta Pecci
- Elise P Sauvadet
- Ellada V Kiourtzieva
- Elton Afonso Lopes
- Emanuel Cirstea
- Emilio M Osman
- Emma L Willett
- Emre Erbabacan
- Enrique A Piacentini
- Enrique Cereijo
- Eoin Young
- Erika E Borotto
- Erin Nishikawa
- Erna Alberts
- Esther Bermejo Lopez
- Esther Diaz-Rodriguez
- Ettore R Vascotto
- Eva O Nagy
- Evangelos Kalaitzis
- Evelin Drociunas Pacheco
- Evgeny Grigoriev
- Evren Senturk
- Ewan C Goligher
- Fa C Zhou
- Fabien Grelon
- Fabienne D Simonis
- Fabienne D Simonis
- Fabio Tarantino
- Fabrice Daviaud
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- Fan Zhang
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- Farshad Heidari
- Fatma Ulger
- Fayez M Kheir
- Feda Kahveci
- Federico Gordo
- Fekri Abroug
- Felipe A Aliaga
- Felipe Dal-Pizzol
- Felipe Saddy
- Felipe T Martinez
- Ferdinando Raimondi
- Fernanda Eugênia Fernandes
- Fernando Borges Rodriguez
- Fernando G George
- Fernando José da Silva Ramos
- Fernando Rios
- Ferran Roche-Campo
- Filipa M Barros
- Finn H Andersen
- Flavia A Loiacono
- Flavia Ribeiro Machado
- Francesco L Santoli
- Francesco Mojoli
- Francesco Raponi
- Francis Schneider
- Francisca G Cazorla-Barranquero
- Francisco Esteve
- Francisco Javier Flores Mejia
- Francisco P Huerta
- Francisco Soriano
- Francois Beloncle
- Frank Stansil
- Frank Van Haren
- Frank Van Haren
- Frantz Berkelmans
- Frederico Bruzzi Carvalho
- Fredrik Schiöler
- Fredy A Montes Oscanoa
- Fredy S Lora
- Fumihito Ito
- Fábio Poianas Giannini
- Gabriel Démpaire
- Gabriele Sales
- Gabrielle C Hanlon
- Gaetan Béduneau
- Galen Henderson
- Garcia M Elisabet
- Gareth P Sellors
- Gary H Mills
- Gautier Buzancais
- Gayle Clifford
- Ged Dempsey
- Gemma Rialp
- Gerard Curley
- Ghaleb Almekhlafi
- Ghanem M Mustafa
- Ghassan Kamel
- Giacomo Bellani
- Giacomo Monti
- Gianluca Zani
- Giannis A Zacharas
- Gilda Cinnella
- Giorgio A Iotti
- Giovana Colozza Mecatti
- Giovanna Occhipinti
- Giovanna Panarello
- Giulia Crapelli
- Giuseppe Foti
- Giuseppe Melchionda
- Gonzalo Navarro
- Greet Hermans
- Guilherme Schettino
- Guillaume Barberet
- Guillaume Carteaux
- Guillermo Bugedo
- Guillermo M Albaiceta
- Gulay Eren
- Gustavo A Plotnikow
- Gustavo Affonso de Oliveira
- Gustavo M Montanha
- Gustavo Pittini
- Guy M Francois
- Gyan Kayashta
- Gyorgy Frendl
- Güldem Turan
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- Haibo Qiu
- Haibo Qiu
- Haitao Liu
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- Hanane Ezzouine
- Hannah Crowther
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- Hans-Bernd F Hopf
- Hasan M Al Dorzi
- Hazel Spencer
- Heather Blaylock
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- Heera L Mahto
- Heidi Dawson
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- Helen Robertson
- Helen Rodgers
- Helen S Wong
- Helen Talbot
- Helen Wong
- Helena Barcraft-Barnes
- Helga Ceunen
- Helga Ceunen
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- Hernan Gianinetto
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- Hiroshi Imai
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- Hiroyuki Tanaka
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- Jonas Nielsen
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- Jun Zhao
- Junping Qin
- Juçara Gasparetto Maccari
- Kai Chen
- Kai D Zacharowski
- Kanishka Indraratna
- Kanokkarn Juntaping
- Kansuke Koyama
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- Karla Loureiro Meira
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- Katie H Mccalman
- Katie Lynch
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- Taohidul Majid Taohid
- Tarek Dendane
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- Terri-Ann Sewell
- Tharwat M Aisa
- Theonymfi G Papavasilopoulou
- Thiago Lisboa
- Thomas Baltus
- Thomas C Blakeman
- Thomas Collyer
- Thomas Kander
- Thomas Staudinger
- Thuy Duong Bich
- Théia Forny Wanderley Castellões
- Tiago Macruz
- Tie H Qin
- Tim Wenham
- Tom Hatton
- Tomas P Roser
- Tomaz Mesar
- Tomaz Mesar
- Tommaso Fossali
- Tomoaki Hashida
- Tomofumi Harasawa
- Tomoyuki Nakamura
- Toni E Mckenna
- Toshikazu Abe
- Tracey Evans
- Trevor W Oetting
- Troy S B Rowne
- Tài Pham
- Udomsak Silachamroon
- Ugur Goktas
- Ulysses V A Silva
- Una Poultney
- Unase Buyukkocak
- Upeka Samaranayake
- Ushio Higashijima
- Valeria I Cerrato
- Valerie M Banner-Goodspeed
- Vallish K Bhardwaj
- Vallverdu P Imma
- Valéria Maria Campos Rezende
- Vanessa Linnett
- Vanessa M Sales
- Vanessa Oliveira
- Vania A Brito
- Varsha Kadaba
- Vasilis Ourailogloy
- Venika Manoharan
- Venkatapura J Ramesh
- Veronica Villar
- Vesna Bumbasierevic
- Vesna Bumbasirevic
- Vicente Cés de Souza Dantas
- Vijayanand Palaniswamy
- Vincenzo Pota
- Vincenzo Russotto
- Vincenzo Schiavone
- Viratch Tangsujaritvijit
- Virginie Lemiale
- Visanthi Pinto
- Vivek Kakar
- Vladimir Cerny
- Vlasta Klaric
- Wahid Altaf
- Wajdi Maazouzi
- Wei H Zhu
- Wei Wang
- Weihua Lu
- Wenkui Yu
- Wenwen Li
- Werner Schmid
- William Stigler
- Xavier Wittebole
- Xian Y Zhao
- Xiao B Huang
- Xiao L Li
- Xiaoming Luo
- Xing Y Zhang
- Xinyu Li
- Y A Hasitha Dilhani
- Ya Q Wu
- Yaasen Arabi
- Yan Gao
- Yaseen M Arabi
- Yasuaki Ogino
- Yavuz Orak
- Yen Lam Minh
- Yi Han
- Yimin Li
- Yonghao Xu
- Yoshihiro Yamaji
- Yoshinobu Kameyama
- Youssef Haddad
- Youzhong An
- Yozo Kashiwa
- Yu D Di
- Yuan N Gao
- Yuan Y Li
- Yuanhua Lu
- Yves D Jarquin-Badiola
- Zerrin Demirtürk
- Zhe Zhai
- Zheng L Ye
- Zhenyang He
- Zhou Li-Xin
- Álvaro Réa-Neto
- Ángela Algaba
- Ángela González-Salamanca
- Çiler Zincircioglu
- Érica Aranha Suzumura
- Ênio Rego
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies.
Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality.
Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42·4% vs 44·2%; absolute difference -1·69 [-9·58 to 6·11] p=0·67; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5-8] vs 6 [5-8] cm H2O; p=0·0011). ICU mortality was higher in MICs than in HICs (30·5% vs 19·9%; p=0·0004; adjusted effect 16·41% [95% CI 9·52-23·52]; p<0·0001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0·80 [95% CI 0·75-0·86]; p<0·0001).
Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status
Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19
- Author
- A M Udara Lakshan Attanyake
- Aasiyah Rashan
- Aasmine Kaur
- Abby Hurd
- Abdulrahman Al-Fares
- Abhijit Duggal
- Abid Khatak
- Adam Ali
- Adam Hall
- Adam Nowinski
- Adrian Ceccato
- Adrian Streinu-Cercel
- Adrian Tey
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Aftab Imtiaz
- Agamemnon Bakakos
- Agnieszka Oldakowska
- Agnès Meybeck
- Agnès Sommet
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Haji Ab Rahman
- Ahmed Farooq
- Ailbhe Cullen
- Ailbhe Hayes
- Aine McCarthy
- Aine McElroy
- Aisha Kalsoom Mufti
- Aisling Gavin
- Aisling Murphy
- Aisling Murphy
- Akram Zaaqoq
- Al-Awwab Dabaliz
- Alan Hartman
- Alasdair Nazerali-Maitland
- Albert Groenendijk
- Alberto Sotto
- Alberto Uribe
- Alberto Zanella
- Albertus Beishuizen
- Aldo Rafael
- Aldric Manuel
- Alejandro Martin-Quiros
- Aleksander Rygh Holten
- Aleksandr Beljantsev
- Alessandra Notari
- Alex Browne
- Alex Nagrebetsky
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J Mentzer
- Alexander King
- Alexander Zoufaly
- Alexandra Bedossa
- Alexandra Coelho
- Alexandra Sperry
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Alexandros Cavayas
- Ali Ait Hssain
- Ali Hachemi
- Ali Liaquat
- Ali Raza
- Alice Bogaarts
- Alicia Gonzalez
- Alif Adlan Mohd Thabit
- Alina Kalicinska
- Alison M Meynert
- Allegra Chatterjee
- Allison McGeer
- Alpha Diallo
- Alphonsine Diouf
- Amanda Corley
- Amanda Palacios
- Amandine Gagneux-Brunon
- Amar Bhatt
- Ami Stuart
- Amin Khawaja
- Amina Meziane
- Amirul Asyraf
- Amna Faheem
- Amy Hackmann
- Amy Lester-Grant
- Amy Stone
- Amélie Valran
- Ana Catarino
- Ana Chora Sousa
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Ana Isabel de Pinho Oliveira
- Ana L Rios
- Ana Marques
- Ana Martins
- Ana Motos
- Ana Raquel Maia
- Anand Thakur
- Anant Kataria
- Anatoliy Gavrylov
- Anders Benjamin Kildal
- Anders Tveita
- Andra-Maris Post
- Andre Real
- Andrea Angheben
- Andrea Cortegiani
- Andrea Dell'Amore
- Andrea Kelly
- Andrea Rossanese
- Andrea Villoldo
- Andreas Lind
- Andrew Acker
- Andrew Hershey
- Andrew Udy
- Andrey Svistunov
- Andriy Bal
- André Cabie
- André Dias
- André Roberto
- Andy Dong
- Andy Law
- Aneela Altaf
- Angel Asensio
- Angel Sanchez-Miralles
- Angela Alberti
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anja Grosse Lordemann
- Anjellica Chen
- Ankana Satya
- Anna Beltrame
- Anna Ciullo
- Anna Greti Everding
- Anna Jung
- Anne Conrad
- Anne Guillaumot
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne Opavsky
- Anne-Hélène Boivin
- Anne-Marie Guerguerian
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B Docherty
- Annmarie O Callaghan
- Annmarie O'Callaghan
- Ansley Hamer
- Anthony L Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Anton Prinssen
- Antoni Torres
- Antonia Ricchiuto
- Antonio Arcadipane
- Antonio Lalueza
- Antonio Loforte
- Antonio Pesenti
- António Mesquita
- Anuraj Shankar
- Aoife Driscoll
- Aoife Kelly
- Aquiles Henriquez-Trujillo
- Arabella Fahy
- Ardiyan Apriyana
- Arianne Joy Corpuz
- Arie Zainul Fatoni
- Arjen M Dondorp
- Arnaud Scherpereel
- Arsalan Rahutullah
- Arshad Taqi
- Arsène Kpangon
- Arthur Garan
- Ary Serpa Neto
- Asad Usman
- Asfia Sultana
- Asgar Rishu
- Ashraf Sheharyar
- Asim Rana
- Asma Moin
- Astarini Hidayah
- Atif Siddiqui
- Attaur Rehman
- Audrey Barrelet
- Aurelius Bonfasius
- Aurore Bousquet
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Axelle Braconnier
- Ayodhia Pitaloka
- Azlan Mat Soom
- B P Sanka Ruwan Sri Darshana
- Bailey Cassandra
- Baillie J Kenneth
- Bairbre McNicholas
- Bambang Pujo Semedi
- Barrio Noelia García
- Baruch Joaquín
- Basanta Gauli
- Basri Mat Nor
- Beane Abigail
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- Paul Henri Wicky
- Paul Kambiya
- Paul Klenerman
- Paul Le Turnier
- Paul Loubet
- Paul McNally
- Paul Tierney
- Paul van der Valk
- Paula Custodio
- Pauline Caraux-Paz
- Pauline Yeung Ng
- Pawel Twardowski
- Pedrera Jiménez Miguel
- Pedro Faria
- Pedro Povoa
- Perren J Cobb
- Peter de Vries
- Peter Doran
- Peter Kiiza
- Peter Openshaw
- Peter S Timashev
- Peter Van der Voort
- Petr Glybochko
- Petrovic Michele
- Phil Gallagher
- Philippe Jouvet
- Philippine Eloy
- Phoebe Ampaw
- Piero Valentini
- Pierre Delobel
- Pierre Jaquet
- Pierre Tattevin
- Pierre-Adrien Bolze
- Pierre-François Sandrine
- Pierre-Marc Villeneuve
- Pierre-Marie Roger
- Pieter Depuydt
- Piret Sillaots
- Pleun Terpstra
- Polina Bugaeva
- Pompini Agustina Sitompul
- Pooja Varghese
- Pramesh Sundar Shrestha
- Pranya Sakiyalak
- Pratap Karpayah
- Pratheema Ramachandran
- Praveen Kumar Ghisulal
- Priscila Diaz
- Pritchard Mark G
- Prompak Nitayavardhana
- Pulak Kedia
- Punam Singh
- Qabas Alkhafajee
- Quentin Le Hingrat
- Quentin Lepiller
- Quratul Ain Khan
- Rachael McConnochie
- Rachael Parke
- Rachel Cregan
- Rachida Ouissa
- Rafael Freitas de Oliveira França
- Rafael León
- Rafael Mahieu
- Rajavardhan Rangappa
- Rajesh Mohan Shetty
- Rajyabardhan Pattnaik
- Rakesh Arora
- Ramakrishnan Nagarajan
- Ramos Grazielle Viana
- Rana Imran Sikander
- Raph L Hamers
- Raphaël Borie
- Raphaël Favory
- Raquel Pinto
- Rashan Haniffa
- Rashid Nasim Khan
- Rasidah Bt Senian
- Raul Neto
- Razi Alalqam
- Rebecca Hamidfar
- Rebecca Holt
- Rebekha Garcia
- Renata Barbalho
- Renato Reis
- Renaud Tamisier
- Renee Douma
- Ricard Ferrer-Roca
- Ricardo Fritz
- Richard S Tedder
- Riinu Pius
- Rima Song
- Rita Alves
- Rita Hinchion
- Ritika Ranjan
- Rob Klont
- Robert A Fowler
- Roberta Cavalin
- Roberta Meta
- Roberto Andini
- Roberto Roncon-Albuquerque
- Robin Kobbe
- Rodrigo Diaz
- Roger Claire
- Rogério Silva
- Rohan Shetty
- Rojek Amanda
- Rolando Claure-Del Granado
- Romain Basmaci
- Romain Decours
- Romain Guery
- Roman Ullrich
- Romans Matulevics
- Rosanna De Rosa
- Rosario Maria Torres Santos-Olmo
- Ross Hendry
- Rostane Gaci
- Roxane Courtois
- Rozanah Abd Rahman
- Rui Gomes
- Rui Pereira
- Rumaisah Satyawati
- Rupert Higgins
- Ruth Jimbo-Sotomayor
- Ruth Lyons
- Ruth N Jorge García
- Ryadh Pokeerbux
- Ryan Kennedy
- Ryan Khoo
- Ryan S Thwaites
- Ryuzo Abe
- Saad Nseir
- Sabelline Bouchez
- Sabin Koirala
- Sabina Kali
- Sabina Mason
- Sabine Cornelis
- Sabine Croonen
- Sadie Kelly
- Saef Umar Barnett
- Saijad Orakzai
- Sairah Sadaf
- Sakshi Lath
- Saleh Al Ageel
- Sally Shrapnel
- Salma Jaafoura
- Samira Laribi
- Samreen Ijaz
- Samuel Bernard Ekow Harrison
- Samuel Hinton
- Samuel Markowicz
- Samuel McElwee
- Sandrine Couffin-Cadiergues
- Sandulescu Oana
- Sanjay Lakhey
- Sanne Wesselius
- Santi Dewayanti
- Saptadi Yuliarto
- Sara Clohisey
- Sara Taleb
- Sara Ventura
- Sarah E McDonald
- Sarah Isgett
- Sarah Moore
- Sarah Redl
- Sarah Stabler
- Sarah Syahrin
- Sarah Tubiana
- Saye Khoo
- Scott Pharand
- Seamus Daly
- Sean Donohue
- Sebastian Vencken
- Sebastiano Maria Colombo
- Segolène Greffe
- Semple Malcolm G
- Senthilkumar Alegesan
- Sergio Poli
- Seán Keating
- Shahdattul Mawarni Taib
- Shaikh Sharjeel
- Shakeel Ahmed
- Shaminee Veeran
- Sharma Keshav
- Sharma Pratima
- Shaun Thompson
- Shaunagh Browne
- Sheeba Hakak
- Sheila Cárcel
- Sherry McDermott
- Sheryl Ann Abdukahil
- Shinichiro Ohshimo
- Shiranee Sriskandan
- Shirin Tabrizi
- Shirley Sarfo-Mensah
- Shoban Raj Vasudayan
- Shona C Moore
- Shubha Kalyan Shrestha
- Sia Loong Tonnii
- Sigfrid Louise
- Silvia Castañeda
- Silvia Lourenco
- Sim Choon Ean
- Sim Lim Heng Benedict
- Simon Bessis
- Simon Forsyth
- Simon-Djamel Thiberville
- Simone Carelli
- Simão Rodeia
- Singh Oinam Budha Charan
- Siobhan Casey
- Siobhan Egan
- Siri Goepel
- Siti Nurul Atikah Ahmad Ridzuan
- Siti Rohani Binti Mohd Yakop
- Siti Zubaidah Othman
- Sivanesen Anthonidass
- Smaragdi Kalomoiri
- Sobia Masood
- Sofia Cardoso
- Sofia Prapa
- Sofia Tejada
- Sofía Contreras
- Soizic Le Mestre
- Somers Emily C
- Sophie Halpin
- Sophie Mahy
- Sophie O'Halloran
- Sravya Pudota
- Sree Satyapriya
- Srinivas Murthy
- Stanislas Rebaudet
- Steffi Ryckaert
- Stella Huo
- Stella Rousset
- Stephan Schroll
- Stephanie Nonas
- Stephanie Roberts
- Stephanie Yerkovich
- Stephanie-Susanne Stecher
- Stephen R Knight
- Steve Webb
- Stijn Van de Velde
- Streinu-Cercel Anca
- Stuart Houltham
- Stéphane Jaureguiberry
- Stéphane Lasry
- Stéphane Sallaberry
- Stéphanie Cousse
- Stéphanie Fry
- Su Hwan Lee
- Subbarao Elapavaluru
- Subhash Acharya
- Sudhir Krishnan
- Sue Smith
- Suhaila Abdul Wahab
- Sung-Min Cho
- Surain Raaj Thanga Thurai
- Suresh Kumar Chidambaram
- Surya Otto Wijaya
- Susana Cabral
- Susana Fernandes
- Susanne Dudman
- Sushil Khanal
- Suvintheran Thangavelu
- Suwarti Suwarti
- Suzanne Bennett
- Suzette Willems
- Swosti Joshi
- Syamin Asyraf Shahidan
- Sybille Bevilcaqua
- Syed Muneeb
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Synne Jenum
- Sze Kye Teoh
- Sébastien Preau
- Sérgio Gaião
- Séverine Ansart
- Sílvia Ferreira
- T Eoin West
- Taccone Fabio
- Tae Song
- Taha Pasha
- Tahira Jamal Mohamed
- Tak-Hyuk Oh
- Takako Akimoto
- Takayuki Ogura
- Taku Tanaka
- Tala Al-Dabbous
- Tamara Seitz
- Tan Pei Wen
- Tarek Elshazly
- Tatiana Fonseca
- Tawnya Ogston
- Teck Fung Wong
- Teresa Lawrence
- Terese Hammond
- Thalha Rashan
- Tharmini Ravi
- Tharwat Aisa
- Thavamany Kaleesvran
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thomas Staudinger
- Thushan de Silva
- Théo Treoux
- Tiago Isidoro
- Tiago Reyes
- Tiffany Trouillon
- Timo Brandenburger
- Timothy M Uyeki
- Ting Soo Chow
- Tiphaine Goulenok
- Tjard Schermer
- Todd C Lee
- Todd Karsies
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Tomoyuki Endo
- Toni Duculan
- Tony Trapani
- Toshiki Yokoyama
- Triona Downer
- Tristan Gigante
- Trude Steinsvik
- Tze Vee Soh
- Tze Yuan Tee
- Tânia Sequeira
- Vadim Tieroshyn
- Valentine Campana
- Valeria Balan
- Valla Sahraei
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Vanessa Sancho-Shimizu
- Vanessa Teotonio
- Vanina Meysonnier
- Vecham Pavan Kumar
- Vegard Skogen
- Ventzislava Petrov-Sanchez
- Vicente Souza-Dantas
- Victor Fomin
- Victoria Janes
- Victoria Manda
- Victoria McEneany
- Victoria Shaw
- Vilmaris Quinones-Cardona
- Vincent Dinot
- Vincent Dubee
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinothini Krishnan
- Virginie Williams
- Vladislav Mihnovit
- Véronique Lemee
- Víctor Quirós González
- Wai Ching Sin
- Walter Picard
- Wan Fadzlina Wan Muhd Shukeri
- Wei Han Hoh
- Wei Shen Lim
- Wei Jia
- Wendy S Barclay
- William A Paxton
- William Dechert
- William Finlayson
- William Greenhalf
- Wilna Oosthuyzen
- Wils Evert-Jan
- Wim Dieperink
- Wing Yiu Ng
- Xavier Duval
- Yael Dishon
- Yan Chyi Tan
- Yaseen Arabi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Yih-Sharng Chen
- Ymkje Stienstra
- Yoan Lavie-Badie
- Yoann Donohue
- Yock Ping Chow
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yuri Kida
- Yusing Gu
- Yvelynne Kelly
- Yves Levy
- Zhang Duan Tham
- Zul Amali Che Kamaruddin
- Zul Fakar
- Zulfiqar Sandhu
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 28/02/2023
- Field of study
Background: We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world's largest international, standardized data sets concerning hospitalized patients. Methods: The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results: Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions: Age was the strongest determinant of risk of death, with a ∼30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who have a higher risk of death