Potential signature of a quadrupolar Hubble expansion in Pantheon+ supernovae

The assumption of isotropy -- that the Universe looks the same in all directions on large scales -- is fundamental to the standard cosmological model. This model forms the building blocks of essentially all of our cosmological knowledge to date. It is therefore critical to empirically test in which regimes its core assumptions hold. Anisotropies in the cosmic expansion are expected on small scales due to nonlinear structures in the late Universe, however, the extent to which these anisotropies might impact our low-redshift observations remains to be fully tested. In this paper, we use fully general relativistic simulations to calculate the expected local anisotropic expansion and identify the dominant multipoles in cosmological parameters to be the quadrupole in the Hubble parameter and the dipole in the deceleration parameter. We constrain these multipoles simultaneously in the new Pantheon+ supernova compilation. The fiducial analysis is done in the rest frame of the CMB with peculiar velocity corrections. Under the fiducial range of redshifts in the Hubble flow sample, we find a $\sim 2\sigma$ deviation from isotropy. We constrain the eigenvalues of the quadrupole in the Hubble parameter to be $\lambda_1 =0.021\pm{ 0.011}$ and ${\lambda_2= 3.15\times 10^{-5}}\pm 0.012$ and place a $1\sigma$ upper limit on its amplitude of $2.88\%$. We find no significant dipole in the deceleration parameter, finding constraints of $q_{\rm dip} = 4.5^{+1.9}_{-5.4}$. However, in the rest frame of the CMB without corrections, we find $q_{ \rm dip} = 9.6^{+4.0}_{-6.9}$, a $>2\sigma$ positive amplitude. We also investigate the impact of these anisotropies on the Hubble tension. We find a maximal shift of $0.30$ km s$^{-1}$ Mpc$^{-1}$ in the monopole of the Hubble parameter and conclude that local anisotropies are unlikely to fully explain the observed tension.Comment: 12 pages, to be submitted to MNRA

Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress.

BackgroundCoenzyme Q10 (CoQ10) supplementation improves mitochondrial coupling of respiration to oxidative phosphorylation, decreases superoxide production in endothelial cells, and may improve functional cardiac capacity in patients with congestive heart failure. There are no studies evaluating the safety, tolerability and efficacy of varying doses of CoQ10 in chronic hemodialysis patients, a population subject to increased oxidative stress.MethodsWe performed a dose escalation study to test the hypothesis that CoQ10 therapy is safe, well-tolerated, and improves biomarkers of oxidative stress in patients receiving hemodialysis therapy. Plasma concentrations of F2-isoprostanes and isofurans were measured to assess systemic oxidative stress and plasma CoQ10 concentrations were measured to determine dose, concentration and response relationships.ResultsFifteen of the 20 subjects completed the entire dose escalation sequence. Mean CoQ10 levels increased in a linear fashion from 704 ± 286 ng/mL at baseline to 4033 ± 1637 ng/mL, and plasma isofuran concentrations decreased from 141 ± 67.5 pg/mL at baseline to 72.2 ± 37.5 pg/mL at the completion of the study (P = 0.003 vs. baseline and P < 0.001 for the effect of dose escalation on isofurans). Plasma F2-isoprostane concentrations did not change during the study.ConclusionsCoQ10 supplementation at doses as high as 1800 mg per day was safe in all subjects and well-tolerated in most. Short-term daily CoQ10 supplementation decreased plasma isofuran concentrations in a dose dependent manner. CoQ10 supplementation may improve mitochondrial function and decrease oxidative stress in patients receiving hemodialysis.Trial registrationThis clinical trial was registered on clinicaltrials.gov [NCT00908297] on May 21, 2009

Uncertainty inequalities as entanglement criteria for negative partial-transpose states

In this Letter, we show that the fulfillment of uncertainty relations is a sufficient criterion for a quantum-mechanically permissible state. We specifically construct two pseudo-spin observables for an arbitrary non-positive Hermitian matrix whose uncertainty relation is violated. This method enables us to systematically derive separability conditions for all negative partial-transpose states in experimentally accessible forms. In particular, generalized entanglement criteria are derived from the Schrodinger-Robertson inequalities for bipartite continuous-variable states.Comment: 4 pages, published version with minor change

A label-free biosensor based on graphene and reduced graphene oxide dual-layer for electrochemical determination of beta-amyloid biomarkers

A label-free biosensor is developed for the determination of plasma-based Aβ1–42 biomarker in Alzheimer’s disease (AD). The platform is based on highly conductive dual-layer of graphene and electrochemically reduced graphene oxide (rGO). The modification of dual-layer with 1-pyrenebutyric acid N-hydroxysuccinimide ester (Pyr-NHS) is achieved to facilitate immobilization of H31L21 antibody. The effect of these modifications were studied with morphological, spectral and electrochemical techniques. The response of the biosensor was evaluated using differential pulse voltammetry (DPV). The data was acquired at a working potential of ~ 180 mV and a scan rate of 50 mV s−1. A low limit of detection (LOD) of 2.398 pM is achieved over a wide linear range from 11 pM to 55 nM. The biosensor exhibits excellent specificity over Aβ1–40 and ApoE ε4 interfering species. Thus, it provides a viable tool for electrochemical determination of Aβ1–42. Spiked human and mice plasmas were used for the successful validation of the sensing platform in bio-fluidic samples. The results obtained from mice plasma analysis concurred with the immunohistochemistry (IHC) and magnetic resonance imaging (MRI) data obtained from brain analysis.This work was financially supported by H2020 MSCA-ITN-ETN BBDiag project under grant no. 721281.Peer reviewe

A Smart Under-Frequency Load Shedding Scheme based on Takagi-Sugeno Fuzzy Inference System and Flexible Load Priority

This paper proposes a new smart under frequency load shedding (UFLS) scheme, based on Takagi-Sugeno (TS) fuzzy inference system and flexible load priority. The proposed scheme consists of two parts. First part consists of fuzzy load shed amount estimation module (FLSAEM) which uses TS-fuzzy to estimate the amount of load shed and sends its value to accurate load shedding module (ALSM) to perform accurate load shedding using flexible load priority. The performance of the proposed scheme is tested for intentional islanding case and increment of sudden load in the system. Moreover, the response of the proposed scheme is compared with adaptive UFLS scheme to highlight its advantages. The simulation results show that the proposed UFLS scheme provides the accurate load shedding due to advantage of flexible priority whereas adaptive UFLS scheme due to fixed load priority does not succeed to achieve accurate load shedding.fi=vertaisarvioitu|en=peerReviewed