Fracture strength and toughness of ultra high strength TRIP aided steels

The performance of hydrogen embrittlement, fatigue properties and impact toughness of ultra high strength transformation induced plasticity aided steels with bainitic ferrite matrix (TBF steels) has been discussed. Some characteristics and deformation transformation mechanism of the retained austenite has also been discussed. It has been observed that mechanical stability and volume fraction of the interlath retained austenite phase in the TBF steels play an important role in increasing delayed fracture strength, fatigue limit and impact toughness.ArticleMATERIALS SCIENCE AND TECHNOLOGY. 25(9):1108-1117 (2009)journal articl

Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition

Two large phosphatidylinositol 3-kinase-related protein kinases (PIKKs), ATM and ATR, play a central role in the DNA damage response pathway. PIKKs contain a highly conserved extreme C-terminus called the FRAP-ATM-TRRAP-C-terminal (FATC) domain. In budding yeast, ATM and ATR correspond to Tel1 and Mec1, respectively. In this study, we characterized functions of the FATC domain of Tel1 by introducing substitution or truncation mutations. One substitution mutation, termed tel1-21, and a truncation mutation, called tel1- Î"C, did not significantly affect the expression level. The tel1-21 mutation impaired the cellular response to DNA damage and conferred moderate telomere maintenance defect. In contrast, the tel1-Î"C mutation behaved like a null mutation, conferring defects in both DNA damage response and telomere maintenance. Tel1-21 protein localized to DNA ends as effectively as wild-type Tel1 protein, whereas Tel1-Î"C protein failed. Introduction of a hyperactive TEL1-hy mutation suppressed the tel1-21 mutation but not the tel1-Î"C mutation. In vitro analyses revealed that both Tel1-21 and Tel1-Î"C proteins undergo efficient autophosphorylation but exhibit decreased kinase activities toward the exogenous substrate protein, Rad53. Our results show that the FATC domain of Tel1 mediates localization to DNA ends and contributes to phosphorylation of target proteins. © 2015 Ogi, Goto, Ghosh, et al

Evolution of the Small Magellanic Cloud

Based on the results of N-body simulations on the last 2.5 Gyr evolution of the Large and Small Magellanic Clouds (LMC and SMC, respectively) interacting with the Galaxy, we firstly show when and where the leading arms (LAs) of the Magellanic stream (MS) can pass through the Galactic plane after the MS formation. We secondly show collisions between the outer Galactic HI disk and the LAs of the MS can create giant HI holes and chimney-like structures in the disk about 0.2 Gyr ago. We thirdly show that a large amount of metal-poor gas is stripped from the SMC and transfered to the LMC during the tidal interaction between the Clouds and the Galaxy about 0.2 and 1.3 Gyr ago. We thus propose that this metal-poor gas can closely be associated with the origin of LMC's young and intermediate-age stars and star clusters with distinctively low-metallicities with [Fe/H] < -0.6.Comment: 4 pages, 3 figures, to appear in the proceedings of ``Galaxies in the Local Volume'', Sydney, 8 to 13 July, 200

Global Update and Trends of Hidden Hunger, 1995-2011: The Hidden Hunger Index

Background Deficiencies in essential vitamins and minerals–also termed hidden hunger–are pervasive and hold negative consequences for the cognitive and physical development of children. Methods This analysis evaluates the change in hidden hunger over time in the form of one composite indicator–the Hidden Hunger Index (HHI)–using an unweighted average of prevalence estimates from the Nutrition Impact Model Study for anemia due to iron deficiency, vitamin A deficiency, and stunting (used as a proxy indicator for zinc deficiency). Net changes from 1995–2011 and population weighted regional means for various time periods are measured. Findings Globally, hidden hunger improved (-6.7 net change in HHI) from 1995–2011. Africa was the only region to see a deterioration in hidden hunger (+1.9) over the studied time period; East Asia and the Pacific performed exceptionally well (-13.0), while other regions improved only slightly. Improvements in HHI were mostly due to reductions in zinc and vitamin A deficiencies, while anemia due to iron deficiency persisted and even increased. Interpretation This analysis is critical for informing and tracking the impact of policy and programmatic efforts to reduce micronutrient deficiencies, to advance the global nutrition agenda, and to achieve the Millennium Development Goals (MDGs). However, there remains an unmet need to invest in gathering frequent, nationally representative, high-quality micronutrient data as we renew our efforts to scale up nutrition, and as we enter the post-2015 development agenda. Funding Preparation of this manuscript was funded by Sight and Life. There was no funding involved in the study design, data collection, analysis, or decision to publish

Constant-time Bilateral Filter using Spectral Decomposition

This paper presents an efficient constant-time bilateral filter where constant-time means that computational complexity is independent of filter window size. Many state-of-the-art constant-time methods approximate the original bilateral filter by an appropriate combination of a series of convolutions. It is important for this framework to optimize the performance tradeoff between approximate accuracy and the number of convolutions. The proposed method achieves the optimal performance tradeoff in a least-squares manner by using spectral decomposition under the assumption that images consist of discrete intensities such as 8-bit images. This approach is essentially applicable to arbitrary range kernel. Experiments show that the proposed method outperforms state-of-the-art methods in terms of both computational complexity and approximate accuracy