CMOS Logic Design with FINFETS Using 32nm TECHNOLOGY

In this paper we propose double gate transistor i.e. FINFETS circuits. It is the substitute of bulk CMOS that mean without any compromise in fabrication process except one or two changes. Actually bulk CMOS suffers high power consumption and high leakage currents .so we implement a various novel circuits i.e FINFETS logic design style in 32nm technology and analyzing various parameters like power dissipation, delay, frequency are observed in this paper. In here we notice that less power consumption in FINFETS when compared to ordinary bulk CMOS. We also check the other submicron technology compared to that this submicron technology got less power consumption

A modified sensitive palladium-copper oxide and multiwalled carbon nanotubes electrochemical sensor for detection of ametridione pesticide

Glassy carbon electrode modified sensitive Pd-CuO/MWCNTs electrochemical nanosensor was used for detection of ametridione pesticide in water samples. The morphology characteristics of Pd-CuO/MWCNTs are examined by scanning electron microscopy and EDX. The ametridione pesticide under voltammetric investigation involves irreversible, 4e? electron reduction based on the protonation of the two carbonyl groups (>C=O). The voltammetric method was applied for the detection of ametridione in BR buffer solution at pH 5.0 as a supporting electrolyte. The detection limit, limit of quantification and concentration ranges of the proposed method were 0.0796 ?g?mL?1 (signal/noise=3), 0.5560 ?g?mL?1 and 0.1 to 10.0 ?g?mL?1, respectively. The electrochemical sensor was successfully applied for the detection of ametridione in tap, agricultural run-off and river water samples showing >98% mean recoveries.   &nbsp

FABRICATION AND TESTING OF HEMP FIBRE REINFORCED EPOXY COMPOSITES

Over the last decennium, composites of polymers reinforced with natural fibers have attracted field both from the academic world and from various industries. The most important of the natural fibers used in composite materials are flax, hemp, kenaf and sisal due to their properties and availability. Natural fibers based on cellulose have a low density, high stiffness and strong compared to those of glass fibers. For the automotive industry, where weight reduction always is an issue, this was said to be the original reason for the development of interior parts with natural fibers as fillers. The works evaluate study of mechanical behavior and develop a polymer matrix composite using hemp fiber by varying percentage weight fraction of hemp fibers by using hand lay-up method. The fabricated composite samples were trimmed according to the ASTM standards for different experiments and its characterization is performed

Protective effect of Picrorhiza kurroa on Alzheimer’s disease induced by aluminium chloride in rats

Background: Alzheimer’s disease is a progressive neurodegenerative disorder characterized by cognitive deterioration together with declining activities of daily living and behavioural changes. The present work is aimed to investigate the effect of methanolic extract of rhizomes of Picrorhiza kurroa against aluminum chloride induced Alzheimer’s disease.Methods: Wistar rats were selected in this study and were divided into 5 groups (6 each). Group I served as normal control. Group II received aluminum chloride (300mg/kg, P.O.). Group III and IV received ethanolic extract of Picrorhiza kurroa (200mg/kg, 400mg/kg, P.O. respectively) and inducing agent (AlCl3 300mg/kg, P.O.). Group V received rivastigmine (0.3mg/kg, I.P.) and inducing agent (AlCl3 300mg/kg, P.O.). The rats were given respective treatment for 20 days and behavioural parameters were determined on 20th day. After 20th day rats were sacrificed and anti-oxidant parameters, brain acetylcholinesterase content were determined.Results: Oral administration of ethanolic extract of Picrorhiza kurroa at doses 200, 400mg/kg body weight showed improve in behavioural parameters when compared to AlCl3 induced rats, showed increase in superoxide dismutase, catalase, reduced glutathione and decreased levels of malondialdehyde and showed decrease in brain acetylcholinesterase content when compared to AlCl3 induced rats.Conclusions: The study clearly demonstrated the beneficial effects of Picrorhiza kurroa by improving biochemical and behavioural parameters

A Revised Novel Approach of Ischemic Stroke through Thrombolytic Therapy and Thrombectomy

This comprehensive overview analyses the development of ischemic stroke therapy, emphasizing the critical significance that thrombolytic therapy and thrombectomy techniques have played. With a particular set of difficulties, thrombolytic therapy tissue plasminogen activator, or tPA has revolutionized acute stroke care by breaking up clots in a crucial window of time. Simultaneously, thrombectomy has become a revolutionary intervention, especially for large-vessel occlusions, offering a localized, effective approach and expanding therapy windows. This review guides you through the historical events, technological developments, and continuing research that have shaped these methods. The importance of individualized treatment plans, the use of telemedicine, and the bright future prospects for the management of ischemic strokes are emphasized

SIMULTANEOUS ESTIMATION OF MECLIZINE HYDROCHLORIDE AND NICOTINIC ACID IN PHARMACEUTICAL DOSAGE FORM BY RP-HPLC METHOD

A simple, selective, rapid, precise and economical reverse phase high performance liquid chromatographicmethod has been developed for the simultaneous estimation of meclizine hydrochloride and nicotinic Acid frompharmaceutical formulation using C18 (25 cm x 4.6 mm i.d.,

Promising Technologies for dry land Agriculture

Not AvailableNatural Resource Management has important research agenda in view of the climate change, degradation of land and declining productivity in greenrevolution areas. Efficient methods of soil and rain water conservation and water harvesting become important areas of dryland agriculture research to achieve sustainability. Variation in crop yields is more in dry lands due to non receipt of timely rainfall and prolonged dry spells during crop periods. Adoption of soil and moisture conservation measures and improved management practices will help in getting higher yields.A large number of location specific practices for insitu moisture conservation, water harvesting and supplemental irrigation have been developed and tested successfully at All India Co-ordinated Research Project for Dryland Agriculture (AICRPDA), Agricultural Research Station, Ananthapuramu. Dryland Agriculture occupies a prominent place in rural livelihoods of Andhra Pradesh. In Andhra Pradesh out of 92.04 lakh ha of cultivable land an area of 34.56 lakh ha is under rainfed agriculture, mainly in scarce rainfall and southern agro climatic zones. AICRPDA, ARS, Ananthapuramu is continuing efforts to generate location specific technologies in the areas of rain water management, integrated nutrient management, cropping systems, farming systems, alternate land use and energy management.Not Availabl

Exploring the Therapeutic Potential of Rosemary: An In-depth Review of its Pharmacological Properties

The pharmacological effects of rosemary plant period a wide range and include anti-inflammatory and antioxidant properties. Rosemary is shown to have its potential on Ischemic stroke because of its Anti-oxidant and Anti-inflammatory properties. It contains strong antioxidants such carnosol, which has anti-inflammatory properties, and Rosmarinus acid, which fights oxidative stress. Rosemary is an attractive possibility for treating disorders like oxidative-related diseases because of its dual activity. Additionally, Rosemary has shown neuroprotective qualities that aid in maintaining brain health and cognitive function. The aromatic components in its essential oil may improve concentration and memory. Rosemary has also been investigated for its potential in hair care, with research indicating that it can encourage hair growth. These rosemary Officinalis also have different chemical substances and compounds like Terpenes, Essential oils, Bicyclic monoterpenes, Monoterpenoids, Ester and also, we have different pharmacological activates they are Anti-oxidative, Anti-inflammatory, Anti-microbial, Anti-obesity, Anti-fungal, Anti-cancer, Anti-diabetic, Cardiovascular activity, Skin health, Neuroprotective, Gastrointestinal, Sperm motility, Anti-depressant, Anti-viral activity

Selected novel 5'-amino-2'-hydroxy-1,3-diaryl-2-propen-1-ones arrest cell cycle of HCT-116 in G0/G1 phase

A series of 5’-amino-2’-hydroxy-1,3-diaryl-2-propen-1-ones (AC1-AC15) were synthesized by Claisen-Schmidt condensation of 5'-acetamido-2’-hydroxy acetophenone with various substituted aromatic aldehydes. The synthesized compounds were characterized by FTIR, 1H NMR and mass spectrometry and evaluated for their selective cytotoxicity using MTT assay on two cancer cell lines namely breast cancer cell line (MCF-7), colon cancer cell line (HCT-116) and one normal kidney epithelial cell line (Vero). Among the tested compounds, AC-10 showed maximum cytotoxic effect on MCF-7 cell line with IC50 value 74.7 ± 3.5 μM. On HCT-116 cells, AC-13 exhibited maximum cytotoxicity with IC50 value 42.1 ± 4.0 μM followed by AC-14 and AC-10 with IC50 values 62 ± 2.3 μM and 95.4 ± 1.7 μM respectively. All tested compounds were found to be safe on Vero cell line with IC50 value more than 200 μM. Based on their highest efficacy on HCT-116, AC-10, AC-13 and AC-14 were selected for mechanistic study on this cell line by evaluating changes nucleomorphological characteristics using acridine orange-ethidium bromide (AOEB) dual stain and by analyzing cell cycle with flow cytometry using propidium iodide stain. In AOEB staining, all three tested compounds showed significant (p < 0.05) increase in percentage apoptotic nuclei compared to control cells, with highest increase in apoptotic nuclei by AC-13 treatment (31 %). Flow cytometric studies showed cell cycle arrest by AC-10 and AC-14 treatment in G0/G1 phase and by AC-13 in G0/G1 and G2/M phase. The study reflected the potential of AC-10, AC-13 and AC-14 to be the lead molecules for further optimization