3 research outputs found
The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma
We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) based on multidimensional and comprehensive characterization, including mitochondrial DNA (mtDNA) and whole genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared to other kidney cancers with more proximal origins. Combined mtDNA and gene expression analysis implicates changes in mitochondrial function as a component of the disease biology, while suggesting alternative roles for mtDNA mutations in cancers relying on oxidative phosphorylation. Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT up-regulation in cancer distinct from previously-observed amplifications and point mutations
Unprecedented Synergistic Effects of Nanoscale Nutrients on Growth, Productivity of Sweet Sorghum [Sorghum bicolor (L.) Moench], and Nutrient Biofortification
Evidence-based synergistic effects
of nanoscale materials (size of <100 nm in at least one dimension)
were scantly documented in agriculture at field scale. Herein, we
report for the first time on effects of nanoscale zinc oxide (n-ZnO),
calcium oxide (n-CaO), and magnesium oxide (n-MgO) on growth and productivity
of sweet sorghum [Sorghum bicolor (L.)
Moench]. A modified sol–gel method was used to prepare nanoscale
materials under study. Characterization was performed using transmission
and scanning electron microscopies, X-ray diffraction, and dynamic
light scattering. Average sizes (25, 53.7, and 53.5 nm) and ζ
potentials (−10.9, −28.2, and −16.2 mV) of n-ZnO,
n-CaO, and n-MgO were measured, respectively. The significant grain
yield (17.8 and 14.2%), cane yield (7.2 and 8.0%), juice yield (10
and 12%), and higher sucrose yield (21.8 and 20.9%) were recorded
with the application of nanoscale materials in the years 2014 and
2015, respectively. Nutrient uptake was significant with foliar application
of nanoscale nutrients
The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma
We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) on the basis of multidimensional and comprehensive characterization, including mtDNA and whole-genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared with other kidney cancers with more proximal origins. Combined mtDNA and gene expression analysis implicates changes in mitochondrial function as a component of the disease biology, while suggesting alternative roles for mtDNA mutations in cancers relying on oxidative phosphorylation. Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT upregulation in cancer distinct from previously observed amplifications and point mutationsclose5