Liver Resection after Downstaging Hepatocellular Carcinoma with Sorafenib

Background. Sorafenib is a molecular-targeted therapy used in palliative treatment of advanced hepatocellular carcinoma in Child A patients. Aims. To address the question of sorafenib as neoadjuvant treatment. Methods. We describe the cases of 2 patients who had surgery after sorafenib. Results. The patients had a large hepatocellular carcinoma in the right liver with venous neoplastic thrombi (1 in the right portal branch, 1 in the right hepatic vein). After 9 months of sorafenib, reassessment showed that tumours had decreased in size with a necrotic component. A right hepatectomy with thrombectomy was performed, and histopathology showed 35% to 60% necrosis. One patient had a recurrence after 6 months and had another liver resection; they are both recurrence-free since then. Conclusion. Sorafenib can downstage hepatocellular carcinoma and thus could represent a bridge to surgery. It may be possible to select patients in good general condition with partial regression of the tumour with sorafenib for a treatment in a curative intent

The Mass-Radius Relationship for Very Low Mass Stars: Four New Discoveries from the HATSouth Survey

We report the discovery of four transiting F-M binary systems with companions between 0.1-0.2 Msun in mass by the HATSouth survey. These systems have been characterised via a global analysis of the HATSouth discovery data, combined with high-resolution radial velocities and accurate transit photometry observations. We determined the masses and radii of the component stars using a combination of two methods: isochrone fitting of spectroscopic primary star parameters, and equating spectroscopic primary star rotation velocity with spin-orbit synchronisation. These new very low mass companions are HATS550-016B (0.110 -0.006/+0.005 Msun, 0.147 -0.004/+0.003 Rsun), HATS551-019B (0.17 -0.01/+0.01 Msun, 0.18 -0.01/+0.01 Rsun), HATS551-021B (0.132 -0.005/+0.014 Msun, 0.154 -0.008/+0.006 Rsun), HATS553-001B (0.20 -0.02/+0.01 Msun, 0.22 -0.01/+0.01 Rsun). We examine our sample in the context of the radius anomaly for fully-convective low mass stars. Combining our sample with the 13 other well-studied very low mass stars, we find a tentative 5% systematic deviation between the measured radii and theoretical isochrone models.Comment: 17 pages, 8 figures, accepted for publication in MNRA

HATS-3b: An inflated hot Jupiter transiting an F-type star

We report the discovery by the HATSouth survey of HATS-3b, a transiting extrasolar planet orbiting a V=12.4 F-dwarf star. HATS-3b has a period of P = 3.5479d, mass of Mp = 1.07MJ, and radius of Rp = 1.38RJ. Given the radius of the planet, the brightness of the host star, and the stellar rotational velocity (vsini = 9.0km/s), this system will make an interesting target for future observations to measure the Rossiter-McLaughlin effect and determine its spin-orbit alignment. We detail the low/medium-resolution reconnaissance spectroscopy that we are now using to deal with large numbers of transiting planet candidates produced by the HATSouth survey. We show that this important step in discovering planets produces logg and Teff parameters at a precision suitable for efficient candidate vetting, as well as efficiently identifying stellar mass eclipsing binaries with radial velocity semi-amplitudes as low as 1 km/s.Comment: 11 pages, 10 figures, submitted to A

HATS-5b: A Transiting hot-Saturn from the HATSouth Survey

We report the discovery of HATS-5b, a transiting hot-Saturn orbiting a G type star, by the HAT-South survey. HATS-5b has a mass of Mp=0.24 Mj, radius of Rp=0.91 Rj, and transits its host star with a period of P=4.7634d. The radius of HATS-5b is consistent with both theoretical and empirical models. The host star has a V band magnitude of 12.6, mass of 0.94 Msun, and radius of 0.87 Rsun. The relatively high scale height of HATS-5b, and the bright, photometrically quiet host star, make this planet a favourable target for future transmission spectroscopy follow-up observations. We reexamine the correlations in radius, equilibrium temperature, and metallicity of the close-in gas-giants, and find hot Jupiter-mass planets to exhibit the strongest dependence between radius and equilibrium temperature. We find no significant dependence in radius and metallicity for the close-in gas-giant population.Comment: 10 pages, submitted to A

HATS-11b and HATS-12b: Two transiting Hot Jupiters orbiting sub-solar metallicity stars selected for the K2 Campaign 7

We report the discovery of two transiting extrasolar planets from the HATSouth survey. HATS-11, a V=14.1 G0-star shows a periodic 12.9 mmag dip in its light curve every 3.6192 days and a radial velocity variation consistent with a Keplerian orbit. HATS-11 has a mass of 1.000 $\pm$ 0.060 M$_{\odot}$, a radius of 1.444 $\pm$ 0.057 M$_{\odot}$ and an effective temperature of 6060 $\pm$ 150 K, while its companion is a 0.85 $\pm$ 0.12 M$_J$, 1.510 $\pm$ 0.078 R$_J$ planet in a circular orbit. HATS-12 shows a periodic 5.1 mmag flux decrease every 3.1428 days and Keplerian RV variations around a V=12.8 F-star. HATS-12 has a mass of 1.489 $\pm$ 0.071 M$_{\odot}$, a radius of 2.21 $\pm$ 0.21 R$_{\odot}$, and an effective temperature of 6408 $\pm$ 75 K. For HATS-12, our measurements indicate that this is a 2.38 $\pm$ 0.11 M$_J$, 1.35 $\pm$ 0.17 R$_J$ planet in a circular orbit. Both host stars show sub-solar metallicity of -0.390 $\pm$ 0.060 dex and -0.100 $\pm$ 0.040 dex, respectively and are (slightly) evolved stars. In fact, HATS-11 is amongst the most metal-poor and, HATS-12 is amongst the most evolved stars hosting a hot Jupiter planet. Importantly, HATS-11 and HATS-12 have been observed in long cadence by Kepler as part of K2 campaign 7 (EPIC216414930 and EPIC218131080 respectively).Comment: 14 pages, 7 figures, 6 tables, submitted to A

HATS-13b and HATS-14b: two transiting hot Jupiters from the HATSouth survey

We report the discovery of HATS-13b and HATS-14b, two hot-Jupiter transiting planets discovered by the HATSouth survey. The host stars are quite similar to each other (HATS-13: V = 13.9 mag, M* = 0.96 Msun, R* = 0.89 Rsun, Teff = 5500 K, [Fe/H] = 0.05; HATS-14: V = 13.8 mag, M* = 0.97 Msun, R* = 0.93 Rsun, Teff = 5350 K, [Fe/H] = 0.33) and both the planets orbit around them with a period of roughly 3 days and a separation of roughly 0.04 au. However, even though they are irradiated in a similar way, the physical characteristics of the two planets are very different. HATS-13b, with a mass of Mp = 0.543 MJ and a radius of Rp = 1.212 RJ, appears as an inflated planet, while HATS-14b, having a mass of Mp = 1.071 MJ and a radius of Rp = 1.039 RJ, is only slightly larger in radius than Jupiter.Comment: 13 pages, 7 figures, Submitted to Astronomy & Astrophysics. arXiv admin note: text overlap with arXiv:1503.0006

HATS-9b and HATS-10b: Two Compact Hot Jupiters in Field 7 of the K2 Mission

We report the discovery of two transiting extrasolar planets by the HATSouth survey. HATS-9b orbits an old (10.8 $\pm$ 1.5 Gyr) V=13.3 G dwarf star, with a period P = 1.9153 d. The host star has a mass of 1.03 M$_{\odot}$, radius of 1.503 R$_\odot$ and effective temperature 5366 $\pm$ 70 K. The planetary companion has a mass of 0.837 M$_J$, and radius of 1.065 R$_J$ yielding a mean density of 0.85 g cm$^{-3}$ . HATS-10b orbits a V=13.1 G dwarf star, with a period P = 3.3128 d. The host star has a mass of 1.1 M$_\odot$, radius of 1.11 R$_\odot$ and effective temperature 5880 $\pm$ 120 K. The planetary companion has a mass of 0.53 M$_J$, and radius of 0.97 R$_J$ yielding a mean density of 0.7 g cm$^{-3}$ . Both planets are compact in comparison with planets receiving similar irradiation from their host stars, and lie in the nominal coordinates of Field 7 of K2 but only HATS-9b falls on working silicon. Future characterisation of HATS-9b with the exquisite photometric precision of the Kepler telescope may provide measurements of its reflected light signature.Comment: 15 pages, 10 figures, accepted for publication in A

HATS-17b: A Transiting Compact Warm Jupiter in a 16.3 Days Circular Orbit

We report the discovery of HATS-17b, the first transiting warm Jupiter of the HATSouth network. HATS-17b transits its bright (V=12.4) G-type (M$_{\star}$=1.131 $\pm$ 0.030 M$_{\odot}$, R$_{\star}$=1.091$^{+0.070}_{-0.046}$ R$_{\star}$) metal-rich ([Fe/H]=+0.3 dex) host star in a circular orbit with a period of P=16.2546 days. HATS-17b has a very compact radius of 0.777 $\pm$ 0.056 R$_J$ given its Jupiter-like mass of 1.338 $\pm$ 0.065 M$_J$. Up to 50% of the mass of HATS-17b may be composed of heavy elements in order to explain its high density with current models of planetary structure. HATS-17b is the longest period transiting planet discovered to date by a ground-based photometric survey, and is one of the brightest transiting warm Jupiter systems known. The brightness of HATS-17b will allow detailed follow-up observations to characterize the orbital geometry of the system and the atmosphere of the planet.Comment: 12 page, 8 figures, submitted to A

Increase of CXCR3+ T cells impairs Th17 cells recruitment in the small intestine mucosa through IFN-g and IL-18 during treated HIV-1 infection

The restoration of CD4+ T cells, especially T-helper type 17 (Th17) cells, remains incomplete in the gut mucosa of most human immunodeficiency virus type 1 (HIV-1)–infected individuals despite sustained antiretroviral therapy (ART). Herein, we report an increase in the absolute number of CXCR3+ T cells in the duodenal mucosa during ART. The frequencies of Th1 and CXCR3+ CD8+ T cells were increased and negatively correlated with CCL20 and CCL25 expression in the mucosa. In ex vivo analyses, we showed that interferon γ, the main cytokine produced by Th1 and effector CD8+ T cells, downregulates the expression of CCL20 and CCL25 by small intestine enterocytes, while it increases the expression of CXCL9/10/11, the ligands of CXCR3. Interleukin 18, a pro-Th1 cytokine produced by enterocytes, also contributes to the downregulation of CCL20 expression and increases interferon γ production by Th1 cells. This could perpetuate an amplification loop for CXCR3-driven Th1 and effector CD8+ T cells recruitment to the gut, while impairing Th17 cells homing through the CCR6-CCL20 axis in treated HIV-1–infected individuals