A Pre-experimental Study to Assess the Effect of Structured Teaching Program on Knowledge regarding Intravenous Cannulation and Its Complications among Staff Nurses Working in a Selected Hospital of Bhopal, M.P.

Intravenous therapy is important in modern medicine. Millions of patients are receiving infusion therapy for life saving and for correcting the metabolic disorders through drugs, nutrition, solutions and blood products

A Descriptive Study to Assess the Opinion Regarding Virtual Classes among B.Sc. Nursing Students of Selected Colleges of Bhopal, Madhya Pradesh India

In the modern world there is an increasing use of networkcomputers, the Internet and advances in telecommunicationtechnology, e-Learning has been widely recognized as avaluable tool for learning and training

Stress responsive gene bioprospecting studies from extremophilic and extremotolerant microalgae: characterization and functional validation of genes involved in acid, salt and thermal stress

Micro algae are diverse group of microscopic photo-autotrophic nonvascular plants with photosynthesizing pigments. They are unicellular and sometimes form extended chains with simple reproductive structures. These unicellular primary producers are dispersed throughout the photic zones of the ocean and accomplish major share of the primary production in the marine environment and account half of the primary production in the earth. They belong to both prokaryotes (Blue Green algae, Cyanobacteria) and eukaryotes (True algae). The phylogeny of microalgae basically depends on the traditional morphological identification. Morphological identification, based on the structure and arrangement of cell organelles, has limited application when environmental condition like salinity, pH, light, temperature, nutrient condition can change the structure of the cell. Recently more research has been carried out in the field of algal taxonomy, wherein many exciting molecular and ultrastuctural evidences has emerged. Due to its diverse distribution, only about 40,000 to 60,000 species of microalgae have been described. There are many species yet to be described including the extremophiles (Norton et al., 1996; Sastre and Posten, 2010)

REVIEW ON EVALUATING THE ROLE OF NSAIDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

Recently, several studies have been reported that nonsteroidal anti-inflammatory drugs can fight against neurodegenerative disorders by various mechanisms. Currently, available therapies of neurodegenerative disorders (NDs) provide only symptomatic relief. This is the point at which we need an alternative that acts on the root cause of disease. Parkinson’s disease and Alzheimer’s disease are the two NDs concentrated here. Since the drug profile is already known, drug repurposing is a promising technique in research, thereby reducing the cost and period effectively. Epidemiological studies on various nonsteroidal anti-inflammatory drugs (NSAIDs) showed good results, but when it came to clinical studies the results are found to be poor. Hence, it can be concluded that NSAIDs provide its neuroprotective activity on its long-term use only, as the brain accessibility of this kind of drug is poor due to its lower lipophilicity

Status of sea cucumber resources and impact of fishing ban on the livelihood of fishers in Gulf of Mannar and Palk Bay

The sea cucumbers constitute an important part of non-fish income source for thousands of fishers along Gulf of Mannar and Palk Bay of south east coast of India. The fishery which is more than thousand years old was introduced by the Chinese stationed at Ramanathapuram, for preparing a dried sea cucumber product Beche-de-mer. The sea cucumber fishery in Gulf of Mannar and Palk Bay was artisanal in nature and consisted of fishermen who were good divers, the processors who acted as middlemen and the exporters. The sea cucumbers were chiefly collected by skin diving to a depth of 1.5 to 6.0 m in the shallow seas using nonmechanised country crafts. They were also caught as by-catch in trawlers locally known as Thallu madi (an indigenous modified trawler operating on wind power in shallow waters), besides the Chanku madi and Attai madi which were operated in deeper coastal waters

Sea cucumber conservation in Palk Bay and Gulf of Mannar, India "An evaluation of the current conservation measures on sea cucumber stocks in Palk Bay and Gulf of Mannar of India"

Sea cucumber fishery and trade were one of the top non-finfish income streams for the coastal people of Palk Bay and Gulf of Mannar in the South East coast of India. As there was no regulation to control the fishery, there was a concern on decline in sea cucumber populations. In order to conserve the over-exploited stocks, the Ministry of Environment, Forestry and Climate Change, Government of India banned the fishery and trade of sea cucumbers by including them under Wild Life Protection Act 1972 since 2001. The enforcement of a blanket ban of sea cucumber fishing over the last 14 years might have helped in reviving their populations; at the same time, the ban would possibly had a social and economic impact on scores of people, who were dependent on the sea cucumber fishery. To understand the situation, the Bay of Bengal Large Marine Ecosystem (BOBLME) project approved a short term project to Central Marine Fisheries Research Institute (India). The project was intended to understand the sea cucumber stocks and implications of the ban on the livelihood of fishers in Palk Bay and Gulf of Mannar. The purpose of the project was also to suggest management options for conservation and sustainable use of sea cucumber resources

DETAILED VIEW ON REPURPOSED DRUGS, TRACKING OF VACCINES,AND BRIEF VIEW ON PROPHYLACTIC NANOMEDICINES AS AN ALTERNATIVE APPROACH AND PATIENT CARE FOR COVID-19

In December 2019, a rare case of pneumonia was reported in Wuhan, China. This was later analyzed and known to have similar characteristics as viral pneumonia caused by a novel coronavirus. Later, on 11 February 2020, the World Health Organization (WHO) officially named the disease as COVID19. The Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) ought to taint both the upper respiratory tract and the lower respiratory tract. This COVID-19 is spreading quickly with an immense rise in cases around the world. This infection's mechanism stays obscure, and the medications explicit for the infection were not grown at this point. Infection is highly contagious. Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) is one of seven kinds of crown infection, including the one which causes severe maladies like Middle East respiratory disorder (MERS) and abrupt, intense respiratory syndrome(SARS). Since its revelation, the infection has spread and has caused anxiety and fear among people. Recent vaccines are tracked, and clinical trials can bring an immediate protocol on a medication approach. By including different therapeutic approaches, it is easier to combat the disease quickly. With very low mortality and high transmission rate, new approaches to vaccines and nanomedicines bring down the spread. Controlled patient care is also crucial. On 11 March, the World Health Organization (WHO) declared the disease as 'global pandemic’. COVID-19, therefore, poses a significant threat to global public health. This article reviews the epidemiology, pathogenesis, and diagnostic methods. The review also focuses on repurposed drugs, traced vaccines, and a quick view of prophylactic nanomedicines as an alternative for COVID 19. For this review, the complete database has been collected from various search engines such as PubMed, ScienceDirect, Scopus, Elsevier, etc., from the year 2001-2020 using the following keywords

Bioactive Molecules Against Malarial Dihydroorotate Dehydrogenase: An in silico Approach

Malaria, caused by Plasmodium falciparum, remains a major cause of mortality among children in African countries. Due to the parasite's resistance against existing malarial drugs, there is a contemporary need for the exploration of potent compounds possessing anti-malarial properties. Plasmodium falciparum dihydroorotate dehydrogenase (pfDHODH) is one of the promising targets (PDB ID: 6GJG) for treating malaria. This study aims to incorporate computational approaches to explore potent phytochemicals with reported biological activity as inhibitors of pfDHODH and to investigate the molecular-level details. The results showed that acetylmontrifoline, retusin, montrifoline, ealamine D, rhamnazin, and canaliculin stand out as potential inhibitors of the enzyme with binding affinities of -11.308 kcal/mol, -11.251 kcal/mol, -11.221 kcal/mol, -10.938 kcal/mol, -10.920 kcal/mol, and -10.827 kcal/mol, respectively, better than that of the native ligand with -9.873 kcal/mol. The adducts exhibited significant geometrical stability, with good RMSD of ligands below 5 Å from 200 ns molecular dynamics simulation, and sustained thermodynamic stability from the MMPBSA method. All other geometrical evaluators also supported the stability of the complexes. The pharmacokinetics and pharmacodynamics predicted moderate drug-likeness, and the hit candidates could be proposed for further in vivo and in vitro experiments to validate the computational results

Ferromagnetic Kitaev interaction and the origin of large magnetic anisotropy in α\alpha-RuCl3_3

$\alpha$-RuCl$_3$ is drawing much attention as a promising candidate Kitaev quantum spin liquid. However, despite intensive research efforts, controversy remains about the form of the basic interactions governing the physics of this material. Even the sign of the Kitaev interaction (the bond-dependent anisotropic interaction responsible for Kitaev physics) is still under debate, with conflicting results from theoretical and experimental studies. The significance of the symmetric off-diagonal exchange interaction (referred to as the $\Gamma$ term) is another contentious question. Here, we present resonant elastic x-ray scattering data that provides unambiguous experimental constraints to the two leading terms in the magnetic interaction Hamiltonian. We show that the Kitaev interaction ($K$) is ferromagnetic, and that the $\Gamma$ term is antiferromagnetic and comparable in size to the Kitaev interaction. Our findings also provide a natural explanation for the large anisotropy of the magnetic susceptibility in $\alpha$-RuCl$_3$ as arising from the large $\Gamma$ term. We therefore provide a crucial foundation for understanding the interactions underpinning the exotic magnetic behaviours observed in $\alpha$-RuCl$_3$.Comment: 5 pages, two-column, 3 figure