Athmanathan, Sreedharan

Chandramouli, BA

Kamble, Ravindra

Mathew, Subin

Raghavendra, S

Rao, Ravi Mohan

English

PubMed

Mathew Subin

Rao Ravi

Raghavendra S

Chandramouli BA

Kamble Ravindra

Athmanathan Sreedharan

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BMC Infectious Diseases

Rare case of multiple brain abscess <it>– Scedosporium apiospermum</it>

Subin Mathew

Ravi Rao

S Raghavendra

BA Chandramouli

Ravindra Kamble

Sreedharan Athmanathan

Springer - Publisher Connector

Rare case of multiple brain abscess – Scedosporium apiospermum

Ravi Mohan Rao

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POSTER PRESENTATION Open Access
Rare case of multiple brain abscess –
Scedosporium apiospermum
Subin Mathew1*, Ravi Mohan Rao1, S Raghavendra1, BA Chandramouli1, Ravindra Kamble2,
Sreedharan Athmanathan3
From First International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2012)
Chennai, India. 20-22 January 2012
Introduction
Scedosporium apiospermum is the asexual form of fun-
gus Pseudallescheria boydii which is commonly found in
soil and sewage. It usually causes cutaneous infection
(mycetoma) and otitis externa and in rare circumstances
causes invasive disease in immunocompromised
patients, which can involve the central nervous system
with devastating prognosis. We report a case of brain
abscess caused by S. apiospermum.
Case presentation
A 9 year old boy with a history of hydrocephalus with
multiple VP shunt surgeries, presented to us with his-
tory of unsteadiness of gait since ten days, headache and
vomiting for a period of 5 days with an episode of fall.
Initial MRI showed trapped fourth ventricle with dilated
left occipital horn. Endoscopic fenestration of lateral
ventricle cyst and microsurgical fenestration of trapped
fourth ventricle was performed. A repeat MRI done on
the fourth day of admission showed multiple small ring
enhancing lesions scattered in right cerebral hemisphere.
He was started on antibiotics. MRI done on the sixth
day revealed increase in size of the lesions for which he
underwent decompressive craniectomy, anterior tem-
poral lobectomy and the specimen studded with multi-
ple hemorrhagic lesion was sent for histopathology and
microbiological evaluation. His condition worsened and
he succumbed to the illness on the eight day after
admission. Culture revealed S. apiospermum.
Discussion
Intracranial fungal infections due to S. apiospermum are
difficult to treat and are often fatal. Maintaining a high
clinical suspicion, early diagnosis, appropriate antifungal
therapy (e.g. voriconazole) and combined surgical inter-
ventions may improve prognosis.
Author details
1Department of Neuroscience, Vikram Hospital, Bangalore, India.
2Department of Radiology, Vikram Hospital, Bangalore, India. 3Department of
Microbiology, Vikram Hospital, Bangalore, India.
Published: 4 May 2012
doi:10.1186/1471-2334-12-S1-P59
Cite this article as: Mathew et al.: Rare case of multiple brain abscess –
Scedosporium apiospermum. BMC Infectious Diseases 2012 12(Suppl 1):P59.
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* Correspondence: matthew.subin@gmail.com
1Department of Neuroscience, Vikram Hospital, Bangalore, India
Full list of author information is available at the end of the article
Mathew et al. BMC Infectious Diseases 2012, 12(Suppl 1):P59
http://www.biomedcentral.com/1471-2334/12/S1/P59
© 2012 Mathew et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.


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Rare case of multiple brain abscess – Scedosporium apiospermum

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