Biological investigations of ruthenium(III) 3-(Benzothiazol-2-liminomethyl)-phenol Schiff base complexes bearing PPh3 / AsPh3 coligand

New ruthenium(III) complexes with 3-(Benzothiazol-2-yliminomethyl)-phenol (HL) ligand have been synthesized and characterized with the aid of elemental analysis, IR, electronic, and electron paramagnetic resonance spectroscopic techniques. The binding mode of the ligand and complexes with DNA and their ability to bind DNA have been investigated by UV-vis absorption titration. In addition, the ligand and complexes have been subjected to antioxidant activity tests which showed that HL and its ruthenium(III) complexes possess significant scavenging effect against DPPH and OH radicals. Cytotoxic activities of the ligand and ruthenium(III) complexes showed that the ruthenium(III) complexes exhibited more effective cytotoxic activity against HeLa and MCF-7 cells than the corresponding ligand

Synthesis, spectral, dna binding and cleavage properties of ruthenium(II) Schiff base complexes containing PPh3/AsPh3 as co-ligands

A dihydroxybenzaldehyde Schiff base ligands (L1-L3) and its ruthenium(II) complexes, have been synthesized and characterized on the basis of elemental analysis, 1H, 13C, 31P NMR, mass spectra, UV-vis and IR spectra. The binding of ruthenium(II) complexes have been investigated by UV-vis absorption spectroscopy. The experiment reveals that all the compounds can bind to DNA through an electrostatic mode and intrinsic binding constant (Kb) has been estimated under similar set of experimental conditions. Absorption spectral study indicate that the ruthenium(II) complexes has intrinsic binding constant in the range of 1.6-8.6 X 104 M-1. The complex [Ru(CO)(PPh3)2(L3)] bind more strongly than that of the other complexes. In addition, DNA cleavage property were tested for all ruthenium(II) complexes