8 research outputs found
Biological investigations of ruthenium(III) 3-(Benzothiazol-2-liminomethyl)-phenol Schiff base complexes bearing PPh3 / AsPh3 coligand
New ruthenium(III) complexes with 3-(Benzothiazol-2-yliminomethyl)-phenol (HL) ligand have been synthesized and characterized with the aid of elemental analysis, IR, electronic, and electron paramagnetic resonance spectroscopic techniques. The binding mode of the ligand and complexes with DNA and their ability to bind DNA have been investigated by UV-vis absorption titration. In addition, the ligand and complexes have been subjected to antioxidant activity tests which showed that HL and its ruthenium(III) complexes possess significant scavenging effect against DPPH and OH radicals. Cytotoxic activities of the ligand and ruthenium(III) complexes showed that the ruthenium(III) complexes exhibited more effective cytotoxic activity against HeLa and MCF-7 cells than the corresponding ligand
Synthesis, spectral, dna binding and cleavage properties of ruthenium(II) Schiff base complexes containing PPh3/AsPh3 as co-ligands
A dihydroxybenzaldehyde Schiff base ligands (L1-L3) and its ruthenium(II)
complexes, have been synthesized and characterized on the basis of elemental
analysis, 1H, 13C, 31P NMR, mass spectra, UV-vis and IR spectra. The binding
of ruthenium(II) complexes have been investigated by UV-vis absorption
spectroscopy. The experiment reveals that all the compounds can bind to DNA
through an electrostatic mode and intrinsic binding constant (Kb) has been
estimated under similar set of experimental conditions. Absorption spectral
study indicate that the ruthenium(II) complexes has intrinsic binding
constant in the range of 1.6-8.6 X 104 M-1. The complex [Ru(CO)(PPh3)2(L3)]
bind more strongly than that of the other complexes. In addition, DNA
cleavage property were tested for all ruthenium(II) complexes