Modelling take-up of Family Credit and Working Families' Tax Credit

Many people in the UK do not claim benefits to which they seem to be entitled. Amongst those of working-age, take-up rates for Family Credit ֠an in-work benefit available to those with children and working at least 16 hours a week ֠were the lowest of the main three means-tested benefits. In 1999, the UK Government replaced Family Credit with Working Families' Tax Credit, which was more generous, and delivered in a different way from FC. As a prelude to further work (now published as an update to this in the final report), we have analysed the decision to take up FC, and how take-up changed during the initial 6 month phase-in period of WFTC. Although there are differences in how well each records receipt of FC, we find reassuring similarities in comparable econometric models of take-up estimated on three different micro-data-sets. Entitlement, earnings, non-labour income, and education attainment are the most important determinants of FC take-up. We investigated FC take-up in greater detail using only the Family Resources Survey. Social renters are more likely to claim FC than owner occupiers or those in the private rental market, and we find that housing benefit recipients seem to under-value the potential fall in HB when considering whether to claim FC. We find that the Family Credit childcare disregard had little impact on the likelihood of take-up. Take-up of WFTC, conditional on entitlement, fell immediately after its introduction, compared to FC, but the majority of the effect is explained by the relatively low take-up rates of those families who were not previously entitled to FC. This is unsurprising, as we would not expect this group to have claimed WFTC on the first day of its existence. Work currently in progress is examining how take-up of WFTC, and the factors associated with take-up, changed between April 2000 and March 2003

Did working families' tax credit work? The final evaluation of the impact of in-work support on parents' labour supply and take-up behaviour in the UK

With micro-data from before and after a major reform in 1999 to the structure and form of in-work transfers in the UK, this paper uses a structural model of labour supply and programme participation to evaluate the labour market impact of Working Families' Tax Credit (WFTC). Estimates suggest that by 2002, WFTC had increased labour supply of lone mothers by around 5.11 percentage points, slightly reduced labour supply of mothers in couples by 0.57 percentage points, and increased the labour supply of fathers in couples by 0.75 percentage points, compared with the benefit that preceded it, called Family Credit. In aggregate, these changes are equivalent to a fall of 99,000 in the number of workless families with children, and a net increase in labour market participation of 81,000 workers. However, contemporaneous tax and benefit reforms acted to reduce the labour supply of parents, and so the overall impact of tax and benefit changes introduced since 1999 is lower than stated above. Participating in Family Credit, the UK's in-work programme before October 1999, conferred a utility loss as well as a utility gain from the extra income, but we find this utility cost of participation to be lower in the final year of WFTC than it was in the last year of Family Credit for lone mothers, and no different for individuals in couples: this in itself induced more lone mothers to work

Did Working Families' Tax Credit work? Analysing the impact of in-work support on labour supply and programme participation

With micro-data from before and after a major reform in 1999 to the structure and form of in-work transfers in the UK, this paper uses a structural model of labour supply and programme participation to show the impact of a reform to in-work support (Working Families' Tax Credit) on both labour supply and programme participation (or take-up). Estimates suggest that the changes in in-work incomes through the introduction of WFTC increased labour supply of lone mothers by around 4.6 percentage points, slightly reduced labour supply of mothers in couples by 0.2 percentage points, and increased the labour supply of fathers in couples by 0.8 percentage points, equivalent to a net increase in participation of 94,000 workers. Participating in Family Credit, the UK's in-work programme before October 1999, conferred a utility loss as well as a utility gain from the extra income, but we find this utility cost of participation to be lower under WFTC

Pathobiology and innate immune responses of gallinaceous poultry to clade 2.3.4.4A H5Nx highly pathogenic avian influenza virus infection

In the 2014-2015 Eurasian lineage clade 2.3.4.4A H5 highly pathogenic avian influenza (HPAI) outbreak in the U.S., backyard flocks with minor gallinaceous poultry and large commercial poultry (chickens and turkeys) operations were affected. The pathogenesis of the first H5N8 and reassortant H5N2 clade 2.3.4.4A HPAI U.S. isolates was investigated in six gallinaceous species: chickens, Japanese quail, Bobwhite quail, Pearl guinea fowl, Chukar partridges, and Ring-necked pheasants. Both viruses caused 80-100% mortality in all species, except for H5N2 virus that caused 60% mortality in chickens. The surviving challenged birds remained uninfected based on lack of clinical disease and lack of seroconversion. Among the infected birds, chickens and Japanese quail in early clinical stages (asymptomatic and listless) lacked histopathologic findings. In contrast, birds of all species in later clinical stages (moribund and dead) had histopathologic lesions and systemic virus replication consistent with HPAI virus infection in gallinaceous poultry. These birds had widespread multifocal areas of necrosis, sometimes with heterophilic or lymphoplasmacytic inflammatory infiltrate, and viral antigen in parenchymal cells of most tissues. In general, lesions and antigen distribution were similar regardless of virus and species. However, endotheliotropism was the most striking difference among species, with only Pearl guinea fowl showing widespread replication of both viruses in endothelial cells of most tissues. The expression of IFN-γand IL-10 in Japanese quail, and IL-6 in chickens, were up-regulated in later clinical stages compared to asymptomatic birds

Procera Allceram: Two Year Evaluation of the Fixed Partial Denture

INTRODUCTION: The demand for all-ceramic restorations has increased substantially because of their esthetics and biocompatibility. However, the indication for a fixed partial denture has been limited by numerous problems such as low breaking strength of conventional dental ceramic and complex manufacturing techniques. Procera AllCeram is a CAD/CAM system for complete ceramic restorations with a dry-sintered high-purity aluminium oxide core.Purpose: The aim of this study was to determine whether the Procera ceramic fixed partial denture is an acceptable treatment modality.Material and methods: Nine patients were treated with a total of ten fixed partial dentures of three units. The restorations were constructed with bilateral support and one pontic, according to the Procera AllCeram technique. The California Dental Association quality evaluation system was used for assessment of marginal integrity and esthetics after two years. RESULTS: Nine of ten fixed partial dentures (90%) showed no defects and were functioning well after two years. No caries or signs of gingivitis or periodontitis exceeding those found. CONCLUSION: The study confirms that for the observation period of two years, fixed partial dentures made by the Procera AllCeram method seem to be an acceptable treatment alternative

Rapid Phenotype-Driven Gene Sequencing with the NeoSeq Panel: A Diagnostic Tool for Critically Ill Newborns with Suspected Genetic Disease

New genomic sequencing techniques have shown considerable promise in the field of neonatology, increasing the diagnostic rate and reducing time to diagnosis. However, several obstacles have hindered the incorporation of this technology into routine clinical practice. We prospectively evaluated the diagnostic rate and diagnostic turnaround time achieved in newborns with suspected genetic diseases using a rapid phenotype-driven gene panel (NeoSeq) containing 1870 genes implicated in congenital malformations and neurological and metabolic disorders of early onset (<2 months of age). Of the 33 newborns recruited, a genomic diagnosis was established for 13 (39.4%) patients (median diagnostic turnaround time, 7.5 days), resulting in clinical management changes in 10 (76.9%) patients. An analysis of 12 previous prospective massive sequencing studies (whole genome (WGS), whole exome (WES), and clinical exome (CES) sequencing) in newborns admitted to neonatal intensive care units (NICUs) with suspected genetic disorders revealed a comparable median diagnostic rate (37.2%), but a higher median diagnostic turnaround time (22.3 days) than that obtained with NeoSeq. Our phenotype-driven gene panel, which is specific for genetic diseases in critically ill newborns is an affordable alternative to WGS and WES that offers comparable diagnostic efficacy, supporting its implementation as a first-tier genetic test in NICUs

Ondansetron use in early pregnancy and the risk of late pregnancy outcomes

Background: The effects of ondansetron, used off-label to treat nausea and vomiting during pregnancy, on common pregnancy complications are understudied. Modest effects of a commonly used drug could result in adverse events for large numbers of pregnant women. Therefore, our objective was to compare the risk of stillbirth, preterm birth, gestational hypertensive disorders, small for gestational age, and differences in birth weight between women prescribed ondansetron and women prescribed alternative antiemetics in early pregnancy. Methods: A cohort of pregnant women receiving a prescription for ondansetron or comparator antiemetics (metoclopramide or promethazine) during the first 20 weeks of pregnancy was identified using electronic health record data from a health care system in North Carolina, USA. Confounding by multiple covariates was controlled using stabilized inverse probability of treatment weights. Weighted hazard ratios (HR) and 95% confidence intervals (CI) accounted for competing events. Results: We identified 2677 eligible pregnancies with antiemetic orders, 66% for ondansetron. The small number of stillbirths (n = 15) resulted in an imprecise estimate of the association with ondansetron (HR = 1.60; 95%CI 0.51, 4.97). No association was observed for preterm birth (HR = 0.90; 95%CI 0.67, 1.20) or gestational hypertensive disorders (HR = 0.87; 95%CI 0.68, 1.12). We observed an association with small for gestational age (HR = 1.37; 95%CI 0.98, 1.90), however mean birth weight among term births was similar between groups. Conclusions: Our results do not suggest that ondansetron increases the risk of preterm birth or gestational hypertensive disorders. The weak association observed between ondansetron use and small for gestational age warrants further investigation

Association of Systemic Lupus Erythematosus Clinical Features with European Population Genetic Substructure

Systemic Lupus Erythematosus (SLE) is an autoimmune disease with a very varied spectrum of clinical manifestations that could be partly determined by genetic factors. We aimed to determine the relationship between prevalence of 11 clinical features and age of disease onset with European population genetic substructure. Data from 1413 patients of European ancestry recruited in nine countries was tested for association with genotypes of top ancestry informative markers. This analysis was done with logistic regression between phenotypes and genotypes or principal components extracted from them. We used a genetic additive model and adjusted for gender and disease duration. Three clinical features showed association with ancestry informative markers: autoantibody production defined as immunologic disorder (P = 6.8×10(-4)), oral ulcers (P = 6.9×10(-4)) and photosensitivity (P = 0.002). Immunologic disorder was associated with genotypes more common in Southern European ancestries, whereas the opposite trend was observed for photosensitivity. Oral ulcers were specifically more common in patients of Spanish and Portuguese self-reported ancestry. These results should be taken into account in future research and suggest new hypotheses and possible underlying mechanisms to be investigated. A first hypothesis linking photosensitivity with variation in skin pigmentation is suggested