Analysis of the Research Projects in Relation to Analytical Hierarchy Process

Nowadays, the research projects are financed from private funds granted with the purpose of achieving certain potential results that involve a high effort, both financial and human. In order to increase the efficiency of all aspects of the projects it is highly important to detect their benefit during the performance and not only in terms of exploitation of the results at the end of the project. For maximization of the evaluation benefits of the research project it is recommended to invest a lot in planning (time and effort), to integrate the evaluation in an activity in course in the project performance, the personnel participation and implication showing that this participation is important, their implication should be as earlier and as much as possible, to realistically deal with the problems occurred. This paper examines how the impact AHP following that through further studies to develop a model for assessing the economic value of research project

Aspects regarding the efficiency of technology transfer from the national research institutes towards the industry in order to accelerate the development of Romanian economy

Currently, Romania is faced with problems regarding closing the deep economic gap between it and the rest of the EU members. In addition, Romania is concerned with overcoming the difficulties generated by the current economic crisis. The technology transfer of the research results from the scientific field towards the industry is one of the main leverages for the economic development, the innovation development and the competitiveness of the companies. At this point, Romania marks a very low transfer rate of technology between the research institutions and the economy. This is why, increasing and accelerating this rate becomes a vital element for the Romanian economy. The national research institutes are one of the most representative institutions of the national research and development system. With a high capacity of generating scientific results specific to certain national areas of expertise, their potential of transfering technology should be exploited and made more efficient. This paper presents a synthesis of the written works regarding the technology transfer, its role in the economic growth and the factors influencing its efficiency. The paper performs an analysis the current state of the national research institutes and formulates hypotheses regarding the causes leading to the low technology transfer rate, making suggestions on further research studies on how to turn this important process into a more efficient on

Aspects regarding the efficiency of technology transfer from the national research institutes towards the industry in order to accelerate the development of Romanian economy

Currently, Romania is faced with problems regarding closing the deep economic gap between it and the rest of the EU members. In addition, Romania is concerned with overcoming the difficulties generated by the current economic crisis. The technology transfer of the research results from the scientific field towards the industry is one of the main leverages for the economic development, the innovation development and the competitiveness of the companies. At this point, Romania marks a very low transfer rate of technology between the research institutions and the economy. This is why, increasing and accelerating this rate becomes a vital element for the Romanian economy. The national research institutes are one of the most representative institutions of the national research and development system. With a high capacity of generating scientific results specific to certain national areas of expertise, their potential of transfering technology should be exploited and made more efficient. This paper presents a synthesis of the written works regarding the technology transfer, its role in the economic growth and the factors influencing its efficiency. The paper performs an analysis the current state of the national research institutes and formulates hypotheses regarding the causes leading to the low technology transfer rate, making suggestions on further research studies on how to turn this important process into a more efficient on

Assessing the Efficiency of Triangular Gold Nanoparticles as NIR Photothermal Agents In Vitro and Melanoma Tumor Model

Photothermal therapy (PTT) is gaining a lot of interest as a cancer treatment option with minimal side effects due to the efficient photothermal agents employed. They are based on nanomaterials that, upon laser irradiation, absorb photon energy and convert it into heat to induce hyperthermia, which destroys the cancer cells. Here, the unique light-to-heat conversion features of three different gold nanotriangular nanoparticles (AuNTs) are evaluated with respect to their absorption properties to select the most efficient nanoheater with the highest potential to operate as an efficient photothermal agent. AuNTs with LSPR response in- and out- of resonance with the 785 nm near-infrared (NIR) excitation wavelength are investigated. Upon 15 min laser exposure, the AuNTs that exhibit a plasmonic response in resonance with the 785 nm laser line show the highest photothermal conversion efficacy of 80%, which correlates with a temperature increase of 22 °C. These photothermal properties are well-preserved in agarose-based skin biological phantoms that mimic the melanoma tumoral tissue and surrounding healthy tissue. Finally, in vitro studies on B16.F10 melanoma cells prove by fluorescence staining and MTT assay that the highest phototoxic effect after NIR laser exposure is induced by AuNTs with LSPR response in resonance with the employed laser line, thus demonstrating their potential implementation as efficient photothermal agents in PTT

Doxorubicin-Incorporated Nanotherapeutic Delivery System Based on Gelatin-Coated Gold Nanoparticles: Formulation, Drug Release, and Multimodal Imaging of Cellular Internalization

In this work, we developed a new pH- and temperature-responsive nanochemotherapeutic system based on Doxorubicin (DOX) noncovalently bound to biosynthesized gelatin-coated gold nanoparticles (DOX-AuNPs@gelatin). The real-time release profile of DOX was evaluated at different pH values (7.4, 5.3, and 4.6) and temperatures (22–45 °C) in aqueous solutions, and its therapeutic performance was examined <i>in vitro</i> against MCF-7 breast cancer cells. TEM, dark-field scattering, and wide-field fluorescence microscopy indicated the effective uptake of nanochemotherapeutics with the subsequent release and progressive accumulation of DOX in cell nuclei. MTT assays clearly showed the effectiveness of the treatment by inhibiting the growth of MCF-7 breast cancer cells for a loaded drug concentration of 5 μg/mL. The most informative data about the dynamic release and localization were provided by scanning confocal microscopy using time-resolved fluorescence and surface-enhanced Raman scattering (SERS) techniques. In particular, fluorescence-lifetime imaging (FLIM) recorded under 485 nm pulsed diode laser excitation revealed the bimodal distribution of DOX in cells. The shorter fluorescence lifetime of DOX localized in nuclei (1.52 ns) than in the cytoplasm (2.4 ns) is consistent with the cytotoxic mechanism induced by DOX–DNA intercalation. Remarkably, the few DOX molecules captured between nanoparticles (“electromagnetic hotspots”) after most drug is released act as SERS reporters for the localization of plasmonic nanocarriers in MCF-7 cells. The high drug loading capacity and effective drug release under pH control combined with the advantage of multimodal visualization inside cells clearly indicate the high potential of our DOX–AuNPs@gelatin delivery system for implementation in nanomedicine