88 research outputs found

    Do we forget to treat concussion?

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    Although the absolute definition is often debated, concussion can be defined as a temporary disruption in normal brain function after a mechanical impact or transmission of force through cerebral tissue. A frequent misconception in the diagnosis is that an individual must have ‘lost consciousness’ to have become concussed; this is not the case. A temporary loss of function may be manifested as blurring of vision, confusion or unsteadines

    A communication-free decentralized control for grid-connected cascaded pv inverters

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    This paper proposes a communication-free decentralized control for grid-connected cascaded PV inverter systems. The cascaded PV inverter system is an AC-stacked architecture, which promotes the integration of low voltage (LV) distributed photovoltaic (PV) generators into the medium/high voltage (MV/HV) power grid. The proposed decentralized control is fully free of communication links and phase-locked loop (PLL). All cascaded inverters are controlled as current controlled voltage sources locally and independently to achieve maximum power point tracking (MPPT) and frequency self-synchronization with the power grid. As a result, control complexity as well as communication costs are reduced, and the system’s reliability is greatly enhanced compared with existing communication-based methods. System stability and dynamic performance are evaluated by small-signal analysis to guide the design of system parameters. The feasibility and effectiveness of the proposed solution are verified by simulation tests

    Vitamin D deficiency in traumatic brain injury and its relationship with severity of injury and quality of life: a prospective, observational study

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    This single-centre prospective observational study aims to describe the prevalence of vitamin D deficiency (VDD) in the traumatic brain injury (TBI) population and identify any relationship between vitamin D and severity of head injury or quality of life. 124 TBI patients had serum vitamin D (25-OHD) levels measured at the local post-TBI endocrine screening clinic over 20 months. Quality of Life after Brain Injury (QOLIBRI) questionnaires were completed by the patient concurrently. A multivariate regressional analysis was performed, controlling for age, season, ethnicity, time since injury, TBI severity and gender. 34% (n=42) of the cohort were vitamin D deficient (25-OHD <25nmol/L) with a further 23% (n=29) having insufficient levels (25-OHD 25-50nmol/L). Vitamin D was significantly lower in severe TBI compared to mild TBI (n=95, p=0.03, CI 95% -23.60 to -1.21, mean effect size 12.40 nmol/L). There was a trend for self-reported quality of life to be better in patients with optimum vitamin D levels compared to patients with deficient vitamin D levels, controlling for severity of injury (n=81, p=0.05, CI 95% -0.07 to 21.27). This is the first study to identify a significant relationship between vitamin D levels and severity of head injury. Clinicians should actively screen for and treat VDD in head injured patients to reduce the risk of further morbidity such as osteomalacia and cardiovascular disease. Future research should establish the natural history of vitamin D levels following TBI to identify at which stage VDD develops and whether vitamin D replacement could have a beneficial effect on recovery and quality of life

    Investigation into repetitive concussion in sport (RECOS): study protocol of a prospective, exploratory, observational cohort study

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    Sport-related concussion management remains a diagnostic dilemma to clinicians in all strata of care, coaching staff and players alike. The lack of objective diagnostic and prognostic biomarkers and over-reliance on subjective clinical assessments carries a significant health risk of undiagnosed concussive episodes and early return to play before full recovery increasing the risk of sustaining additional concussion, and leading to long-term sequelae and/or unfavourable outcome. To identify a set of parameters (neuroimaging with neurophysiological, biological and neuropsychological tests) that may support pitch-side and outpatient clinical decision-making in order to objectively diagnose concussion, determine the severity of injury, guide a safe return to play and identify the potential predictors of the long-term sequelae of concussion. An exploratory, observational, prospective, cohort study recruiting between 2017 and 2020. The participants will have a baseline preseason screening (brain imaging, neuropsychological assessments, serum, urine and saliva sampling). If a screened player later suffers a concussion and/or multiple concussions then he/she will be assessed again with the same protocol within 72 hours, and their baseline data will be used as internal control as well as normative data. Inferential statistical analysis will be performed to determine correlations between biological, imaging techniques and neuropsychological assessments. This study was approved by the East of England-Essex Research Ethics Committee on 22 September 2017-REC 17/EE/0275; IRAS 216703. The results of this study will be presented at national and international conferences and submitted for publication in peer reviewed journals. ISRCTN16974791; Pre-results. [Abstract copyright: © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.
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