Beyond community engagement : perspectives on the meaningful involvement of people with HIV and affected communities (MIPA) in HIV cure research in The Netherlands

First, we express our heartfelt gratitude to all the participants who generously shared their experiences and insights, making this research possible. Your contributions are invaluable and we sincerely thank you for your time and openness. Special appreciation goes to the Dutch HIV Association of People with HIV and the HIV consultants for their collaboration and support in participant recruitment. We further thank Lissa Agema and Vaneza Paulo for their dedication to the detailed transcriptions. The PAB and CAB deserve profound acknowledgment for their efforts and significant contributions in the development and conducting of this research. Last, we acknowledge the use of the large-language model ChatGPT and Grammarly for improving clarity and conciseness.Peer reviewe

The Importance of Social Engagement in the Development of an HIV Cure : A Systematic Review of Stakeholder Perspectives

Funding Information: This research has been funded by Aidsfonds under Grant P-53001. Publisher Copyright: © 2023, The Author(s).Peer reviewedPublisher PD

Patient and Provider Perspectives on HIV and HIV-Related Stigma in Dutch Health Care Settings

Ensuring that people living with HIV (PLWH) feel accepted in health care settings is imperative. This mixed methods study explored the perspectives of PLWH and health professionals on their interactions. A total of 262 predominantly gay men of Dutch origin participated in a survey study of possible negative interactions with health professionals, and semi-structured interviews were subsequently conducted with 22 PLWH and 14 health professionals. Again, most PLWH were gay men of Dutch origin. All health professionals were Dutch. PLWH reported negative experiences with health professionals including awkward interactions, irrelevant questions, rude treatment, blame, pity, excessive or differential precautions, care refusal, unnecessary referrals, delayed treatment, poor support, and confidentiality breaches. They also reported positive experiences including equal treatment, being valued as a partner in one's health, social support provision, and confidentiality assurances. Health professionals reported having little experience with PLWH and only basic knowledge of HIV. They contended that PLWH are treated equally and that HIV is no longer stigmatized, but also reported fear of occupational infection, resulting in differential precautions. Additionally, they conveyed labeling PLWH's files to warn others, and curiosity regarding how patients acquired HIV. The findings suggest that there is a gap in perception between PLWH and health professionals regarding the extent to which negative interactions occur, and that these interactions should be improved. Implications for stigma reduction and care optimization are discussed

"What can her body do?" Reducing weight stigma by appreciating another person's body functionality.

Objective Weight stigma is prevalent across multiple life domains, and negatively affects both psychological and physical health. Yet, research into weight stigma reduction techniques is limited, and rarely results in reduced antipathy toward higher-weight individuals. The current pre-registered study investigated a novel weight stigma reduction intervention. We tested whether a writing exercise focusing on body functionality (i.e., everything the body can do, rather than how it looks) of another person leads to reductions in weight stigma. Method Participants were 98 women (Mage = 23.17, Range = 16–63) who viewed a photograph of a higher-weight woman, “Anne,” and were randomised to complete a writing exercise either describing what “Anne’s” body could do (experimental group) or describing her home (active control group). Facets of weight stigma were assessed at pretest and posttest. Results At posttest, the experimental group evidenced higher fat acceptance and social closeness to “Anne” compared with the active control group. However, no group differences were found in attribution complexity, responsibility, and likeability of “Anne”. Conclusions A brief body functionality intervention effectively reduced some, but not all, facets of weight stigma in women. This study provides evidence that functionality-focused interventions may hold promise as a means to reduce weight stigma

Role of Self-Stigma in Pathways from HIV-Related Stigma to Quality of Life among People Living with HIV

Funding Information: This study was supported by Viiv Healthcare, Gilead, and Aidsfonds (research Grant Number AF-P.42601). The funders had no role in decisions regarding the study design, data analysis, or publication. Acknowledgments We extend our gratitude to all PLHIV who completed the survey. We further thank the HIV specialist nurses and doctors at OLVG hospital for their effort in recruiting patients to complete the surveys.Peer reviewedPublisher PD

Epigenetic regulator genes direct lineage switching in MLL/AF4 leukaemia

The fusion gene MLL/AF4 defines a high-risk subtype of pro-B acute lymphoblastic leukaemia. Relapse can be associated with a lineage switch from acute lymphoblastic to acute myeloid leukaemia resulting in poor clinical outcomes due to resistance towards chemo- and immuno-therapies. Here we show that the myeloid relapses share oncogene fusion breakpoints with their matched lymphoid presentations and can originate from varying differentiation stages from immature progenitors through to committed B-cell precursors. Lineage switching is linked to substantial changes in chromatin accessibility and rewiring of transcriptional programmes, including alternative splicing. These findings indicate that the execution and maintenance of lymphoid lineage differentiation is impaired. The relapsed myeloid phenotype is recurrently associated with the altered expression, splicing or mutation of chromatin modifiers, including CHD4 coding for the ATPase/helicase of the nucleosome remodelling and deacetylation complex, NuRD. Perturbation of CHD4 alone or in combination with other mutated epigenetic modifiers induces myeloid gene expression in MLL/AF4-positive cell models indicating that lineage switching in MLL/AF4 leukaemia is driven and maintained by disrupted epigenetic regulation

Sarah E. Stutterheim's Quick Files

The Quick Files feature was discontinued and it’s files were migrated into this Project on March 11, 2022. The file URL’s will still resolve properly, and the Quick Files logs are available in the Project’s Recent Activity

HIV stigma in the Netherlands

HIV stigma in the Netherland

The Role of Support for Transgender and Nonbinary Employees:Perceived Co-Worker and Organizational Support's Associations With Job Attitudes and Work Behavior

The development of diverse and inclusive workforces is increasingly being prioritized by organizations. However, organizations often struggle to adequately address the unique issues faced by transgender and nonbinary (TNB) people, and this can result in workplace discrimination, with deleterious consequences on employees' job attitudes and behavior, and their well-being. Co-worker and organizational support may play an important role for TNB employees' job attitudes and behavior. In an online survey with 225 TNB employees, we investigated how perceived co-worker support relates to job attitudes and work behavior, specifically job satisfaction, affective commitment, turnover intentions, job anxiety, and counterproductive work behavior. We also investigated whether these relationships were mediated by perceived organizational support. We found significant associations between perceived co-worker support and all job attitudes and work behavior. We also found that all of these relationships were mediated by the extent to which the organization was considered supportive. The findings thus suggest that companies should focus on supporting TNB employees at both the organizational and interpersonal level.Public Significance Statement Perceived organizational and co-worker support interact and jointly promote positive job attitudes and work behavior in TNB employees, namely more job satisfaction and affective commitment, and less turnover intentions, job anxiety, and counterproductive work behavior. Companies should thus focus on supporting TNB employees at both the organizational and interpersonal level