Advances in the design and development of oncolytic measles viruses.

A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has rapidly emerged as a potentially useful anticancer modality. Derivatives of the Edmonston MV vaccine strain possess a remarkable safety record in humans. Promising results in preclinical animal models and evidence of biological activity in early phase trials contribute to the enthusiasm. Genetic modifications have enabled MV to evolve from a vaccine agent to a potential anticancer therapy. Specifically, alterations of the MV genome have led to improved tumor selectivity and delivery, therapeutic potency, and immune system modulation. In this article, we will review the advancements that have been made in the design and development of MV that have led to its use as a cancer therapy. In addition, we will discuss the evidence supporting its use, as well as the challenges associated with MV as a potential cancer therapeutic

The impact of training and experience on the recovery of evidence in outdoor forensic scenes: implications for human remains recovery

The present study involves a multivariate assessment of the success of evidence recovery by searchers from various backgrounds and skill levels. Volunteers representing four experience levels (civilian volunteers, first year forensic anthropology graduate students, second year forensic anthropology graduate students, and first responders) conducted line searches of mock crime scenes, flagging items of forensic significance with pin flags. The groups were then briefly trained in human skeletal remains recovery, and implemented this training through a second set of mock scene searches. Recovery rates were compared across pre- and post-training trials and across searcher groups in order to determine the influence of searcher training and experience on search success. The results of this study reveal not only the percentage of evidence that was recovered by search teams, but exhibits the degree to which experience and training played a role in evidence recovery

Effect of temporal modulation rate on the intelligibility of phase-based speech

published_or_final_versio

Valuing Transgenic Cotton Technologies Using a Risk/Return Framework

Stochastic Efficiency with Respect to a Function (SERF) is used to rank transgenic cotton technology groups and place an upper and lower bound on their value. Yield and production data from replicated plot experiments are used to build cumulative distribution functions of returns for nontransgenic, Roundup Ready, Bollgard, and stacked gene cotton cultivars. Analysis of Arkansas data indicated that the stacked gene and Roundup Ready technologies would be preferred by a large number of risk neutral and risk averse producers as long as the costs of the technology and seed are below the lower bounds calculated in this manuscript.cotton, financial risk, market value, SERF, transgenic, Agribusiness, Crop Production/Industries, Risk and Uncertainty, Q12, Q16,

Review of: Life, Death, and In-Between on the U.S.-Mexico Border (Martha Oehmke Loustaunau & Mary Sanchez-Bane, eds.)

Review of the boo

2nd Place: Tattered Fiction

This is Murphy Studebaker\u27s submission essay, annotated bibliography, and annotated wishlist for the 206 John and Margaret Class Student Book Collection Contest, which won second place. Murphy is a freshman at Chapman University, majoring in Film Production

Saving the Sheep, Preserving the Fruit: A Plan of Christian Education for the Millennials and Beyond in the Midwest Wesleyan Church

This thesis involved a ministry plan for adequately preparing preteen youth in the Midwestern Wesleyan Church denomination. The goal was to ground those youth in their relationship with God until their relationship with Him and His Church will persist through their teenage years and beyond. The topic is crucial in view of the marked exodus of youth from the evangelical church by their late teenage years, often never to return. Data were collected to show what is actually being provided currently to preteen youth in Midwestern Wesleyan local churches through a mixed-methods survey of pastors or Christian education leaders in the denomination. In view of the research, a coherent, biblically based plan is offered to enhance local church ministry to preteen youth in Wesleyan churches by addressing the different avenues for their becoming and remaining active ministry participates in their local church