Algebraic Reduction of Feynman Diagrams to Scalar Integrals: a Mathematica implementation of LERG-I

A Mathematica implementation of the program LERG-I is presented that performs the reduction of tensor integrals, encountered in one-loop Feynman diagram calculations, to scalar integrals. The program was originally coded in REDUCE and in that incarnation was applied to a number of problems of physical interest.Comment: 16 page

Implementation of Magnetic Meters for Irrigation Volumetric Measurement

The irrigation industry is experiencing a growth in the use of magnetic meters for measuring the flow rate and volume in irrigation pipelines. Historically, propeller meters have been the device selected by users. New legislation in California (SB7x7) will require measurement devices at key locations for irrigation water delivery. Some users are very interested in the magnetic meter for making the measurement at the turnout or farm gate. The key feature of the new meter is the ability for the device to work in less than ideal flow conditions. Electromagnetic meters have been tested by the Irrigation Training and Research Center in lab and field pipelines located less than the 10 diameters upstream of disturbances with good results. There are several manufacturers that are selling units to the irrigation market as well as several types of magnetic meter designs. This paper discusses how a magnetic flow meter works, advantages/disadvantages of this type of meter, test results, and new guidelines for field applications

Strawberries: Effects of Modifying Irrigation Methods for Transplant Establishment

In 2009, the Cal Poly Irrigation Training and Research Center began a multi-year analysis of the current irrigation practices of strawberry growers on the Central Coast of California. Specifically, the project examines the impacts of salinity on young strawberry transplants and the current practice of sprinkler use during the establishment of transplants for salinity control in areas where drip irrigation is available. The overall goal of the project is to study current practices and determine any conditions where growers can minimize or eliminate sprinkler use on strawberries, thereby conserving water, saving pumping costs, and reducing runoff. Results from the first year of the study have suggested that, contrary to previous belief, using reduced sprinkler or only drip irrigation results in higher yields than conventional methods

Bio-inspired pulmonary surfactant-modified nanogels : a promising siRNA delivery system

Inhalation therapy with small interfering RNA (siRNA) is a promising approach in the treatment of pulmonary disorders. However, clinical translation is severely limited by the lack of suitable delivery platforms. In this study, we aim to address this limitation by designing a novel bioinspired hybrid nanoparticle with a core-shell nanoarchitecture, consisting of a siRNA-loaded dextran nanogel (siNG) core and a pulmonary surfactant (Curosurf (R)) outer shell. The decoration of siNGs with a surfactant shell enhances the colloidal stability and prevents siRNA release in the presence of competing polyanions, which are abundantly present in biofluids. Additionally, the impact of the surfactant shell on the biological efficacy of the siNGs is determined in lung cancer cells. The presence of the surfactants substantially reduces the cellular uptake of siNGs. Remarkably, the lowered intracellular dose does not impede the gene silencing effect, suggesting a crucial role of the pulmonary surfactant in the intracellular processing of the nanoparticles. In order to surmount the observed reduction in cellular dose, folate is incorporated as a targeting ligand in the pulmonary surfactant shell to incite receptor-mediated endocytosis. The latter substantially enhances both cellular uptake and gene silencing potential, achieving efficient knockdown at siRNA concentrations in the low nanomolar range. (C) 2015 Elsevier B.V. All rights reserved

Simulating large cosmology surveys with calibrated halo models

In this thesis I present a novel method for constructing large scale mock galaxy and halo catalogues and apply this model to a number of important topics in modern cosmology. Traditionally such mocks are created through first evolving a high resolution particle simulation from a set of initial conditions to the present epoch, identifying bound structures and their evolution, and finally applying a semi-analytic prescription for galaxy formation. In contrast to this computationally expensive procedure, I use low resolution simulations to obtain a density field that traces large scale modes. From this background I sample the population statistics of halos: the number of halos which are typically found within a region of a given overdensity, to produce a halo catalogue. From the halo catalogue I then produce galaxies by appealing to the halo model. In this model the expected number of galaxies within a halo and the distribution of their properties is dependent on halo mass alone. By sampling conditional luminosity functions for a number of populations of galaxies, I produce a galaxy catalogue with luminosity and colour properties. The aim of developing algorithm is not to probe the mechanics of galaxy formation in great detail. It is instead intended as a method of rapidly producing mock galaxy and halo catalogues rapidly on modern desktop computers. The approach we will take is to try to distill the minimal algorithm required to achieve this and still provide useful catalogues for observational cosmologists. Both the conditional mass function and conditional luminosity functions required for the algorithm are calibrated from the Millennium Simulation, one of the highest resolution cosmology simulations to date, and its associated semi-analytic catalogues. In Chapter 2 I examine these statistics and provide fits to the quantities of interest. As a test of the method, in Chapter 3 I produce a halo and galaxy catalogue from the same large scale modes as the Millennium Simulation. The clustering statistics of galaxies and halos within this re-simulation are calculated and compared with those of the original. Con dent of the accuracy of the method, in Chapter 4 I populate a number of simulations, each 8 times the volume of the Millennium Simulation, and study the evolution of the Baryon Acoustic Oscillation signal. For each population (dark matter, halos and galaxies) I fit the BAO in the power spectrum to obtain the shift in the BAO peak. In Chapter 5 I extend the algorithm to produce lightcones: simulated skies in which the evolution of the Universe along the line of sight is accounted for. I simulate the geometry and limitations of a major pending survey and calculate the expected clustering signature I expect to see in both. The redshift space distortions induced by peculiar velocities of galaxies along the line of sight are determined and their ability to distinguish between gravity models is also explored. In Chapter 6 I detail a further extension to the algorithm for simulating weak gravitational lensing surveys. I use the analytic 2D surface density pro files of NFW profiles to dress each dark matter halo on a lightcone. The sum of these pro files over the entire population can be used to construct high resolution maps of the convergence. From these maps I calculate the spectrum of the convergence and compare with theoretical predictions. Finally in Chapter 7 I discuss further possible applications and extensions of the algorithm I have developed in this thesis

A protocol to examine vision and gait in Parkinson’s disease: impact of cognition and response to visual cues

Background Cognitive and visual impairments are common in Parkinson's disease (PD) and contribute to gait deficit and falls. To date, cognition and vision in gait in PD have been assessed separately. Impact of both functions (which we term 'visuo-cognition') on gait however is likely interactive and can be tested using visual sampling (specifically saccadic eye movements) to provide an online behavioural measure of performance. Although experiments using static paradigms show saccadic impairment in PD, few studies have quantified visual sampling during dynamic motor tasks such as gait. This article describes a protocol developed for testing visuo-cognition during gait in order to examine the: 1) independent roles of cognition and vision in gait in PD, 2) interaction between both functions, and 3) role of visuo-cognition in gait in PD. Methods Two groups of older adults (≥50 years old) were recruited; non-demented people with PD (n=60) and age-matched controls (n=40). Participants attended one session and a sub-group (n=25) attended two further sessions in order to establish mobile eye-tracker reliability. Participants walked in a gait laboratory under different attentional (single and dual task), environmental (walk straight, through a door and turning), and cueing (no visual cues and visual cues) conditions. Visual sampling was recorded using synchronised mobile eye-tracker and electrooculography systems, and gait was measured using 3D motion analysis. Discussion This exploratory study examined visuo-cognitive processes and their impact on gait in PD. Improved understanding of the influence of cognitive and visual functions on visual sampling during gait and gait in PD will assist in development of interventions to improve gait and reduce falls risk. This study will also help establish robust mobile eye-tracking methods in older adults and people with PD

A protocol to examine vision and gait in Parkinson’s disease: impact of cognition and response to visual cues

Background Cognitive and visual impairments are common in Parkinson's disease (PD) and contribute to gait deficit and falls. To date, cognition and vision in gait in PD have been assessed separately. Impact of both functions (which we term 'visuo-cognition') on gait however is likely interactive and can be tested using visual sampling (specifically saccadic eye movements) to provide an online behavioural measure of performance. Although experiments using static paradigms show saccadic impairment in PD, few studies have quantified visual sampling during dynamic motor tasks such as gait. This article describes a protocol developed for testing visuo-cognition during gait in order to examine the: 1) independent roles of cognition and vision in gait in PD, 2) interaction between both functions, and 3) role of visuo-cognition in gait in PD. Methods Two groups of older adults (≥50 years old) were recruited; non-demented people with PD (n=60) and age-matched controls (n=40). Participants attended one session and a sub-group (n=25) attended two further sessions in order to establish mobile eye-tracker reliability. Participants walked in a gait laboratory under different attentional (single and dual task), environmental (walk straight, through a door and turning), and cueing (no visual cues and visual cues) conditions. Visual sampling was recorded using synchronised mobile eye-tracker and electrooculography systems, and gait was measured using 3D motion analysis. Discussion This exploratory study examined visuo-cognitive processes and their impact on gait in PD. Improved understanding of the influence of cognitive and visual functions on visual sampling during gait and gait in PD will assist in development of interventions to improve gait and reduce falls risk. This study will also help establish robust mobile eye-tracking methods in older adults and people with PD

Saccade frequency response to visual cues during gait in Parkinson's disease: the selective role of attention

Gait impairment is a core feature of Parkinson's disease (PD) with implications for falls risk. Visual cues improve gait in PD, but the underlying mechanisms are unclear. Evidence suggests that attention and vision play an important role; however, the relative contribution from each is unclear. Measurement of visual exploration (specifically saccade frequency) during gait allows for real-time measurement of attention and vision. Understanding how visual cues influence visual exploration may allow inferences of the underlying mechanisms to response which could help to develop effective therapeutics. This study aimed to examine saccade frequency during gait in response to a visual cue in PD and older adults and investigate the roles of attention and vision in visual cue response in PD. A mobile eye-tracker measured saccade frequency during gait in 55 people with PD and 32 age-matched controls. Participants walked in a straight line with and without a visual cue (50 cm transverse lines) presented under single task and dual-task (concurrent digit span recall). Saccade frequency was reduced when walking in PD compared to controls; however, visual cues ameliorated saccadic deficit. Visual cues significantly increased saccade frequency in both PD and controls under both single task and dual-task. Attention rather than visual function was central to saccade frequency and gait response to visual cues in PD. In conclusion, this study highlights the impact of visual cues on visual exploration when walking and the important role of attention in PD. Understanding these complex features will help inform intervention development

Gait in Parkinson’s disease: a visuo-cognitive challenge

Vision and cognition have both been related to gait impairment in Parkinson’s disease (PD) through separate strands of research. The cumulative and interactive effect of both (which we term visuo-cognition) has not been previously investigated and little is known about the influence of cognition on vision with respect to gait. Understanding the role of vision, cognition and visuo-cognition in gait in PD is critical for data interpretation and to infer and test underlying mechanisms. The purpose of this comprehensive narrative review was to examine the interdependent and interactive role of cognition and vision in gait in PD and older adults. Evidence from a broad range of research disciplines was reviewed and summarised. A key finding was that attention appears to play a pivotal role in mediating gait, cognition and vision, and should be considered emphatically in future research in this field