Civil Service and Military Service Pensions In China

As quoted by Palacios and Whitehouse, there are separate pension schemes for civil servants in about half the world’s countries. This includes the People’s Republic of China. In some countries pension costs for public sector employees form a disproportionately large part of the total pension expenditure, and this applies to China. Whereas a considerable volume of material is available on the Chinese national pension systems, there has been far less study of the pension arrangements in place for the civil service, public service employees and military personnel in China. Indeed it has proven particularly difficult to obtain reliable and accurate information as to the pension arrangements for the People’s Liberation Army. Of course pension provision worldwide is attracting a great deal of attention because of its importance at a micro level, i.e. as replacement income for individuals after retirement, and at a macro level, viz. the impact on the overall economy of both funded and unfunded arrangements. The major pressures affecting the different pension systems in China, and indeed worldwide, include: - rapidly improving life expectancy; - changing work patterns, including greater labour mobility; - the effect of the global financial crisis on pension assets and on government budgets. This paper will describe the main elements of pension provision in China, i.e.: - state pension system for urban workers;- supplementary benefits for urban workers;- the National Social Security Fund;- the proposed rural pension system;- civil service and public servants pensions;- the military pension system. A description of certain reforms affecting public servants is given, together with comment on the desirability of further harmonising the various pension arrangements in China

A substrate mimic allows high-throughput assay of the FabA protein and consequently the identification of a novel inhibitor of <i>Pseudomonas aeruginosa</i> FabA

The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 223461, Senior Investigator Award WT100209MA (JHN), Swedish Science Council (GS), Wellcome Trust Strategic grant 100476/Z/12/Z (DWG) and National Institutes of Health R01GM095970 (MB). JHN & ADS are Royal Society Wolfson Merit Award holders.Eukaryotes and prokaryotes possess fatty acid synthase (FAS) biosynthetic pathway(s) that comprise iterative chain elongation, reduction, and dehydration reactions. The bacterial FASII pathway differs significantly from human FAS pathways and is a long-standing target for antibiotic development against Gram-negative bacteria due to differences from the human FAS, and several existing antibacterial agents are known to inhibit FASII enzymes. N-acetylcysteamine (NAC) fatty acid thioesters have been used as mimics of the natural acyl carrier protein (ACP) pathway intermediates to assay FASII enzymes, and we now report an assay of FabV from Pseudomonas aeruginosa using (E)-2-decenoyl-NAC. In addition, we have converted an existing UV absorbance assay for FabA, the bifunctional dehydration/epimerization enzyme and key target in the FAS II pathway, into a high throughput enzyme coupled fluorescence assay that has been employed to screen a library of diverse small molecules. With this approach, N-(4-chlorobenzyl)-3-(2-furyl)-1H-1,2,4-triazol-5-amine (N42FTA) was found to competitively inhibit (pIC50 = 5.7 ± 0.2) the processing of 3-hydroxydecanoyl-NAC by P. aeruginosa FabA. N42FTA was shown to be potent in blocking crosslinking of E. coli ACP and FabA, a direct mimic of the biological process. The co-complex structure of N42FTA with P. aeruginosa FabA protein rationalizes affinity and suggests future design opportunities. Employing NAC fatty acid mimics to developing further high throughput assays for individual enzymes in the FASII pathway should aid in the discovery of new antimicrobials.Publisher PDFPeer reviewe

Civil Service and Military Service Pensions In China

Workshop on Civil Service and Military Pension Arrangements in Selected Countries in Asia-Pacific Institute of Economic Research, Hitotsubashi University Tokyo, JapanAs quoted by Palacios and Whitehouse, there are separate pension schemes for civil servants in about half the world’s countries. This includes the People’s Republic of China. In some countries pension costs for public sector employees form a disproportionately large part of the total pension expenditure, and this applies to China. Whereas a considerable volume of material is available on the Chinese national pension systems, there has been far less study of the pension arrangements in place for the civil service, public service employees and military personnel in China. Indeed it has proven particularly difficult to obtain reliable and accurate information as to the pension arrangements for the People’s Liberation Army. Of course pension provision worldwide is attracting a great deal of attention because of its importance at a micro level, i.e. as replacement income for individuals after retirement, and at a macro level, viz. the impact on the overall economy of both funded and unfunded arrangements. The major pressures affecting the different pension systems in China, and indeed worldwide, include: - rapidly improving life expectancy; - changing work patterns, including greater labour mobility; - the effect of the global financial crisis on pension assets and on government budgets. This paper will describe the main elements of pension provision in China, i.e.: - state pension system for urban workers;- supplementary benefits for urban workers;- the National Social Security Fund;- the proposed rural pension system;- civil service and public servants pensions;- the military pension system. A description of certain reforms affecting public servants is given, together with comment on the desirability of further harmonising the various pension arrangements in China科学研究費補助金（特別推進研究） = Grant-in-Aid for Specially Promoted Research26 p

Structural insights into the mechanism and inhibition of the beta-Hydroxydecanoyl-Acyl carrier protein dehydratase from pseudomonas aeruginosa

Fatty acid biosynthesis is an essential component of metabolism in both eukaryotes and prokaryotes. The fatty acid biosynthetic pathway of Gram-negative bacteria is an established therapeutic target. Two homologous enzymes FabA and FabZ catalyze a key step in fatty acid biosynthesis; both dehydrate hydroxyacyl fatty acids that are coupled via a phosphopantetheine to an acyl carrier protein (ACP). The resulting trans-2-enoyl-ACP is further polymerized in a processive manner. FabA, however, carries out a second reaction involving isomerization of trans-2-enoyl fatty acid to cis-3-enoyl fatty acid. We have solved the structure of Pseudomonas aeruginosa FabA with a substrate allowing detailed molecular insight into the interactions of the active site. This has allowed a detailed examination of the factors governing the second catalytic step. We have also determined the structure of FabA in complex with small molecules (so-called fragments). These small molecules occupy distinct regions of the active site and form the basis for a rational inhibitor design program. (C) 2012 Elsevier Ltd. All rights reserved.Publisher PDFPeer reviewe