Within-Person Variation in Personality and Psychological Well-Being

Personality is one of the most broad and complex areas in psychology. This has led to many researchers attempting to reduce this complexity by focusing solely on how habitual personality differs between each individual (inter-individual differences). This is important to study, but it has been focused on so heavily that research into how each individual personality varies within the person (intra-individual differences) has been neglected in comparison. Recent research has started to examine intra-individual variation in personality more thoroughly. One research aim of this programme was to establish the nature of several different types of within person variability including inter-item variation (variation within the test responses for a personality trait), and cross-contextual variation in personality (variation according to context), to see whether these types of variability are associated with psychological outcomes. Three research questions were examined to this end: 1) What is the extent of meaningful variability in personality trait test responding? 2) What are the predictors of intra-individual variability in personality? 3) What is the relative importance of the person and situational factors in personality variability? The first question was developed to try and determine whether the individual can display meaningful inter-item variation in ratings of specific behaviours within personality trait measures. Trait questionnaires are usually only analysed at the between subject level, and within subject variation in inter-item ratings have not been extensively examined in relation to meaningful psychological outcomes. The second and third questions were developed to look into the nature of cross-contextual personality, and establish whether within person personality differences are influenced more strongly by the person or situation. The studies conducted towards answering these questions demonstrated a person-based capacity to display intra-individual variability. A second aim of the research programme was to see whether the capacity to display these types of variability can be utilised in behaviour change. The fourth research question was developed to try and understand how a person can display intra-individual variability, yet still be resistant to changing negative habits: 4) How do the different aspects in personality variability help explain why some people are resistant to change, especially with regard to behaviours that are bad for them? This question was answered by theoretically discussing the findings from the three previous studies which proposed that positive or problematic behaviour could be interpreted with a simple path to understand the process of behavioural action: The individual receives feedback from a behaviour response which either validates or invalidates their action in the situation context (does or does not receive a desired outcome). Reinforcement of the behaviour happens if it is validated by positive feedback. Alternately reconstruction of the situation happens if the behaviour is invalidated. This allows for two types of intra-individual variability. One is flexibility in behaviour responses to different situations under the individual’s control. The other is change according to the situation, where the behaviour is invalidated and an alternative is attempted. A problematic behaviour may have benefit in stopping something invalidating, but if repeated it may become a habit needed for psychological functioning. As part of the second research aim a behaviour change strategy was developed and piloted to try and bring the individual closer to their construct of the ideal self. Instructions were provided for the individual to experiment with that differed from their disposition. The programmes had varied degrees of success depending on the participant. The implications for personality research and behaviour change are discussed

Bone marrow senescence and the microenvironment of hematological malignancies

Senescence is the irreversible arrest of cell proliferation that has now been shown to play an important role in both health and disease. With increasing age senescent cells accumulate throughout the body, including the bone marrow and this has been associated with a number of age-related pathologies including malignancies. It has been shown that the senescence associated secretory phenotype (SASP) creates a pro-tumoural environment that supports proliferation and survival of malignant cells. Understanding the role of senescent cells in tumor development better may help us to identify new treatment targets to impair tumor survival and reduce treatment resistance. In this review, we will specifically discuss the role of senescence in the aging bone marrow (BM) microenvironment. Many BM disorders are age-related diseases and highly dependent on the BM microenvironment. Despite advances in drug development the prognosis particularly for older patients remains poor and new treatment approaches are needed to improve outcomes for patients. In this review, we will focus on the relationship of senescence and hematological malignancies, how senescence promotes cancer development and how malignant cells induce senescence

Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomized, double-blind, placebo controlled study

Background: It is well documented that exercise-induced muscle damage (EIMD) decreases muscle function and causes soreness and discomfort. Branched-chain amino acid (BCAA) supplementation has been shown to increase protein synthesis and decrease muscle protein breakdown, however, the effects of BCAAs on recovery from damaging resistance training are unclear. Therefore, the aim of this study was to examine the effects of a BCAA supplementation on markers of muscle damage elicited via a sport specific bout of damaging exercise in trained volunteers. Methods: Twelve males (mean ± SD age, 23 ± 2 y; stature, 178.3 ± 3.6 cm and body mass, 79.6 ± 8.4 kg) were randomly assigned to a supplement (n = 6) or placebo (n = 6) group. The damaging exercise consisted of 100 consecutive drop-jumps. Creatine kinase (CK), maximal voluntary contraction (MVC), muscle soreness (DOMS), vertical jump (VJ), thigh circumference (TC) and calf circumference (CC) were measured as markers of muscle damage. All variables were measured immediately before the damaging exercise and at 24, 48, 72 and 96 h post-exercise. Results: A significant time effect was seen for all variables. There were significant group effects showing a reduction in CK efflux and muscle soreness in the BCAA group compared to the placebo (P < 0.05). Furthermore, the recovery of MVC was greater in the BCAA group (P < 0.05). The VJ, TC and CC were not different between groups. Conclusion: The present study has shown that BCAA administered before and following damaging resistance exercise reduces indices of muscle damage and accelerates recovery in resistance-trained males. It seems likely that BCAA provided greater bioavailablity of substrate to improve protein synthesis and thereby the extent of secondary muscle damage associated with strenuous resistance exercise. Clinical Trial Registration Number: NCT01529281

First scientific VLBI observations using New Zealand 30 metre radio telescope WARK30M

We report the results of a successful 24 hour 6.7 GHz VLBI experiment using the 30 meter radio telescope WARK30M near Warkworth, New Zealand, recently converted from a radio telecommunications antenna, and two radio telescopes located in Australia: Hobart 26-m and Ceduna 30-m. The geocentric position of WARK30M is determined with a 100 mm uncertainty for the vertical component and 10 mm for the horizontal components. We report correlated flux densities at 6.7 GHz of 175 radio sources associated with Fermi gamma-ray sources. A parsec scale emission from the radio source 1031-837 is detected, and its association with the gamma-ray object 2FGL J1032.9-8401 is established with a high likelihood ratio. We conclude that the new Pacific area radio telescope WARK30M is ready to operate for scientific projects.Comment: Accepted for publication by the Publications of the Astronomical Society of the Pacific on April 8, 2015; 7 pages, 6 figures, 3 tables. Table 3 is machine-readable. It can be found in the source of this submissio

Fractional flow reserve-guided management in stable coronary disease and acute myocardial infarction: recent developments

Coronary artery disease (CAD) is a leading global cause of morbidity and mortality, and improvements in the diagnosis and treatment of CAD can reduce the health and economic burden of this condition. Fractional flow reserve (FFR) is an evidence-based diagnostic test of the physiological significance of a coronary artery stenosis. Fractional flow reserve is a pressure-derived index of the maximal achievable myocardial blood flow in the presence of an epicardial coronary stenosis as a ratio to maximum achievable flow if that artery were normal. When compared with standard angiography-guided management, FFR disclosure is impactful on the decision for revascularization and clinical outcomes. In this article, we review recent developments with FFR in patients with stable CAD and recent myocardial infarction. Specifically, we review novel developments in our understanding of CAD pathophysiology, diagnostic applications, prognostic studies, clinical trials, and clinical guidelines

The effect of high intensity interval exercise on postprandial triacylglycerol and leukocyte activation - monitored for 48h post exercise

Peer reviewedPublisher PD

Preliminary observations of muscle fibre cross sectional area of flexor digitorum brevis in cadaver feet with and without claw toes

<p>Abstract</p> <p>Background</p> <p>In order to facilitate normal gait, toes require to be in a rectus position during the propulsive phase. This requires a correct balance and sequence of activity of the intrinsic musculature of the feet. Alteration of this balance and sequence may lead to the development of claw toes. Atrophy of the lumbricals occurs in the development of claw toes, but it is not known if changes occur in any other intrinsic muscles, including flexor digitorum brevis. This study set out to investigate whether hypertrophic changes were evident in flexor digitorum brevis in feet with claw toes.</p> <p>Methods</p> <p>Four cadaver feet were investigated, two with rectus toes and two with claw toes. Flexor digitorum brevis was removed from each, and seven anatomically significant tissue sections from each muscle were routinely processed, cut and stained. One hundred and sixty muscle fibre cross sectional areas were measured from each section.</p> <p>Results</p> <p>The mean age of the donors was 81.5 years, and three of the four were female. Results showed that the cross sectional area of fibres from feet with claw toes was 417 μg²significantly greater (p < 0.01) than the cross sectional area of fibres from feet with rectus toes, which was 263 μg².</p> <p>Conclusions</p> <p>Although this study has several limitations, preliminary observations reveal that flexor digitorum brevis muscle fibre cross sectional area is significantly reduced in feet with claw toes. This would indicate a relationship between muscle fibre atrophy of flexor digitorum brevis and clawing of the lesser toes.</p