11,844 research outputs found
Propagation of cosmic-ray nucleons in the Galaxy
We describe a method for the numerical computation of the propagation of
primary and secondary nucleons, primary electrons, and secondary positrons and
electrons. Fragmentation and energy losses are computed using realistic
distributions for the interstellar gas and radiation fields, and diffusive
reacceleration is also incorporated. The models are adjusted to agree with the
observed cosmic-ray B/C and 10Be/9Be ratios. Models with diffusion and
convection do not account well for the observed energy dependence of B/C, while
models with reacceleration reproduce this easily. The height of the halo
propagation region is determined, using recent 10Be/9Be measurements, as >4 kpc
for diffusion/convection models and 4-12 kpc for reacceleration models. For
convection models we set an upper limit on the velocity gradient of dV/dz < 7
km/s/kpc. The radial distribution of cosmic-ray sources required is broader
than current estimates of the SNR distribution for all halo sizes. Full details
of the numerical method used to solve the cosmic-ray propagation equation are
given.Comment: 15 pages including 23 ps-figures and 3 tables, latex2e, uses
emulateapj.sty (ver. of 11 May 1998, enclosed), apjfonts.sty, timesfonts.sty.
To be published in ApJ 1998, v.509 (December 10 issue). More details can be
found at http://www.gamma.mpe-garching.mpg.de/~aws/aws.html Some references
are correcte
Transonic wind tunnel test of a 14 percent thick oblique wing
An experimental investigation was conducted at the ARC 11- by 11-Foot Transonic Wind Tunnel as part of the Oblique Wing Research Aircraft Program to study the aerodynamic performance and stability characteristics of a 0.087-scale model of an F-8 airplane fitted with an oblique wing designed by Rockwell International. The 10.3 aspect ratio, straight-tapered wing of 0.14 thickness/chord ratio was tested at two different mounting heights above the fuselage. Additional tests were conducted to assess low-speed behavior with and without flaps, aileron effectiveness at representative flight conditions, and transonic drag divergence with 0 degree wing sweep. Longitudinal stability data were obtained at sweep angles of 0, 30, 45, 60, and 65 degrees, at Mach numbers ranging from 0.25 to 1.40. Test Reynolds numbers varied from 3.2 to 6.6 x 10 exp 6/ft. and angle of attack ranged from -5 to +18 degrees. Most data were taken at zero sideslip, but a few runs were at sideslip angles of +/- 5 degrees. The raised wing position proved detrimental overall, although side force and yawing moment were reduced at some conditions. Maximum lift coefficient with the flaps deflected was found to fall short of the value predicted in the preliminary design document. The performance and trim characteristics of the present wing are generally inferior to those obtained for a previously tested wing designed at ARC
Looking for a charge asymmetry in cosmic rays
We combine the data from PAMELA and FERMI-LAT cosmic ray experiments by
introducing a simple sum rule. This allows to investigate whether the lepton
excess observed by these experiments is charge symmetric or not. We also show
how the data can be used to predict the positron fraction at energies yet to be
explored by the AMS-02 experiment.Comment: Contribution to the proceedings of DISCRETE 2010, 5 pages, 2 figure
ECoG-based short-range recurrent stimulation techniques to stabilize tissue at risk of progressive damage: Theory based on clinical observations
We introduce theoretical concepts based on chaos control to stabilize in acute stroke the tissue at risk of progressive damage by preventing adverse effects of waves of mass neuronal depolarization. Moreover, we present clinical electrocorticography (ECoG) recordings of relevant signals suggested for the feedback control. The recordings are performed in combination with novel subdural opto-electrode technology for simultaneous laser-Doppler flowmetry in patients with aneurysmal subarachnoid haemorrhage (aSAH). In aSAH patients waves of spreading depolarization (SD) have a high incidence and cause hypoxia in tissue at risk, and, importantly, the haemodynamic response is the inverse of that seen in healthy tissue. In previous clinical studies, clusters of prolonged SDs have been measured in aSAH patients in close proximity to structural brain damage as assessed by neuroimaging, and, in theoretical studies, a mechanism was presented, suggesting how a failure of internal feedback could be a putative mechanism of such SD cluster patterns in acute stroke. 

This failing internal feedback control is now suggested to be replaced by ECoG-based short-range recurrent functional stimulation that initiates the normal hyperperfusion haemodynamic response in a demand-controlled way and stabilizes the tissue at risk during the critical phase of SD passage. The suggested method has three key features: (i) it is short-range, i.e., in the order of the distance of the ECoG electrode strip, (ii) it is demand-controlled, and (iii) it uses no prior knowledge of the target state, in particular, it adapts to conditions in the healthy physiological range. On-demand type stimulation provides minimal invasive feedback as the control force is off when the target state is reached, i.e., the tissue at risk is without SD or it is back to the physiological range (out of risk). These last two features (ii-iii) are shared with classical methods of chaos control, where major progress was made in the last years with respect to extensions for spatio-temporal wave patterns. A detailed bifurcation analysis of the nonlinear model is presented, in particular, the SD cluster forming cortical state is suggested to be caused by a delay-induced saddle-node bifurcation.

Prospects For Detecting Dark Matter With GLAST In Light Of The WMAP Haze
Observations by the WMAP experiment have identified an excess of microwave
emission from the center of the Milky Way. It has previously been shown that
this "WMAP Haze" could be synchrotron emission from relativistic electrons and
positrons produced in the annihilations of dark matter particles. In
particular, the intensity, spectrum and angular distribution of the WMAP Haze
is consistent with an electroweak scale dark matter particle (such as a
supersymmetric neutralino or Kaluza-Klein dark matter in models with universal
extra dimensions) annihilating with a cross section on the order of sigma
v~3x10^-26 cm^3/s and distributed with a cusped halo profile. No further exotic
astrophysical or annihilation boost factors are required. If dark matter
annihilations are in fact responsible for the observed Haze, then other
annihilation products will also be produced, including gamma rays. In this
article, we study the prospects for the GLAST satellite to detect gamma rays
from dark matter annihilations in the Galactic Center region in this scenario.
We find that by studying only the inner 0.1 degrees around the Galactic Center,
GLAST will be able to detect dark matter annihilating to heavy quarks or gauge
bosons over astrophysical backgrounds with 5sigma (3sigma) significance if they
are lighter than approximately 320-500 GeV (500-750 GeV). If the angular window
is broadened to study the dark matter halo profile's angular extension (while
simultaneously reducing the astrophysical backgrounds), WIMPs as heavy as
several TeV can be identified by GLAST with high significance. Only if the dark
matter particles annihilate mostly to electrons or muons will GLAST be unable
to identify the gamma ray spectrum associated with the WMAP Haze.Comment: 10 pages, 6 figure
TEXES Observations of M Supergiants: Dynamics and Thermodynamics of Wind Acceleration
We have detected [Fe II] 17.94 um and 24.52 um emission from a sample of M
supergiants using TEXES on the IRTF. These low opacity emission lines are
resolved at R = 50, 000 and provide new diagnostics of the dynamics and
thermodynamics of the stellar wind acceleration zone. The [Fe II] lines, from
the first excited term, are sensitive to the warm plasma where energy is
deposited into the extended atmosphere to form the chromosphere and wind
outflow. These diagnostics complement previous KAO and ISO observations which
were sensitive to the cooler and more extended circumstellar envelopes. The
turbulent velocities, Vturb is about 12 to 13 km/s, observed in the [Fe II]
forbidden lines are found to be a common property of our sample, and are less
than that derived from the hotter chromospheric C II] 2325 Angstrom lines
observed in alpha Ori, where Vturb is about 17 to 19 km/s. For the first time,
we have dynamically resolved the motions of the dominant cool atmospheric
component discovered in alpha Ori from multi-wavelength radio interferometry by
Lim et al. (1998). Surprisingly, the emission centroids are quite Gaussian and
at rest with respect to the M supergiants. These constraints combined with
model calculations of the infrared emission line fluxes for alpha Ori imply
that the warm material has a low outflow velocity and is located close to the
star. We have also detected narrow [Fe I] 24.04 um emission that confirms that
Fe II is the dominant ionization state in alpha Ori's extended atmosphere.Comment: 79 pages including 10 figures and 2 appendices. Accepted by Ap
Positrons from particle dark-matter annihilation in the Galactic halo: propagation Green's functions
We have made a calculation of the propagation of positrons from dark-matter
particle annihilation in the Galactic halo in different models of the dark
matter halo distribution using our 3D code, and present fits to our numerical
propagation Green's functions. We show that the Green's functions are not very
sensitive to the dark matter distribution for the same local dark matter energy
density. We compare our predictions with computed cosmic ray positron spectra
(``background'') for the ``conventional'' CR nucleon spectrum which matches the
local measurements, and a modified spectrum which respects the limits imposed
by measurements of diffuse Galactic gamma-rays, antiprotons, and positrons. We
conclude that significant detection of a dark matter signal requires favourable
conditions and precise measurements unless the dark matter is clumpy which
would produce a stronger signal. Although our conclusion qualitatively agrees
with that of previous authors, it is based on a more realistic model of
particle propagation and thus reduces the scope for future speculations.
Reliable background evaluation requires new accurate positron measurements and
further developments in modelling production and propagation of cosmic ray
species in the Galaxy.Comment: 8 pages, 6 ps-figures, 3 tables, uses revtex. Accepted for
publication in Physical Review D. More details can be found at
http://www.gamma.mpe-garching.mpg.de/~aws/aws.htm
The HTA risk analysis chart: visualising the need for and potential value of managed entry agreements in health technology assessment
Background
Recent changes to the regulatory landscape of pharmaceuticals may sometimes require reimbursement authorities to issue guidance on technologies that have a less mature evidence base. Decision makers need to be aware of risks associated with such health technology assessment (HTA) decisions and the potential to manage this risk through managed entry agreements (MEAs).
Objective
This work develops methods for quantifying risk associated with specific MEAs and for clearly communicating this to decision makers.
Methods
We develop the ‘HTA risk analysis chart’, in which we present the payer strategy and uncertainty burden (P-SUB) as a measure of overall risk. The P-SUB consists of the payer uncertainty burden (PUB), the risk stemming from decision uncertainty as to which is the truly optimal technology from the relevant set of technologies, and the payer strategy burden (PSB), the additional risk of approving a technology that is not expected to be optimal. We demonstrate the approach using three recent technology appraisals from the UK National Institute for Health and Clinical Excellence (NICE), each of which considered a price-based MEA.
Results
The HTA risk analysis chart was calculated using results from standard probabilistic sensitivity analyses. In all three HTAs, the new interventions were associated with substantial risk as measured by the P-SUB. For one of these technologies, the P-SUB was reduced to zero with the proposed price reduction, making this intervention cost effective with near complete certainty. For the other two, the risk reduced substantially with a much reduced PSB and a slightly increased PUB.
Conclusions
The HTA risk analysis chart shows the risk that the healthcare payer incurs under unresolved decision uncertainty and when considering recommending a technology that is not expected to be optimal given current evidence. This allows the simultaneous consideration of financial and data-collection MEA schemes in an easily understood format. The use of HTA risk analysis charts will help to ensure that MEAs are considered within a standard utility-maximising health economic decision-making framework
Treatment of Retinitis Pigmentosa-Associated Cystoid Macular Oedema Using Intravitreal Aflibercept (Eylea) despite Minimal Response to Ranibizumab (Lucentis): A Case Report.
BACKGROUND: We present an interesting case of bilateral retinitis pigmentosa (RP)-associated cystoid macular oedema that responded on two separate occasions to intravitreal injections of aflibercept, despite previously demonstrating only minimal response to intravitreal ranibizumab. This unique case would support a trial of intravitreal aflibercept for the treatment of RP-associated cystoid macular oedema.
CASE PRESENTATION: A 38-year-old man from Dubai, United Arab Emirates, presented to the UK with a 3-year history of bilateral RP-associated cystoid macular oedema. Previous treatment with topical dorzolamide, oral acetazolamide, and intravitreal ranibizumab had demonstrated only minimal reduction of cystoid macular oedema. Following re-confirmation of the diagnosis by clinical examination and optical coherence tomography imaging, bilateral loading doses of intravitreal aflibercept were given. Central macular thickness reduced and the patient returned to Dubai. After 6 months, the patient was treated with intravitreal ranibizumab due to re-accumulation of fluid and the unavailability of aflibercept in Dubai. Only minimal reduction of central macular thickness was observed. Once available in Dubai, intravitreal aflibercept was administered bilaterally with further reduction of central macular thickness observed. Visual acuity remained stable throughout.
CONCLUSIONS: This is the first case report to demonstrate a reduction of RP-associated CMO following intravitreal aflibercept, despite inadequate response to ranibizumab on two separate occasions. Aflibercept may provide superior action to other anti-VEGF medications due to its intermediate size (115 kDa) and higher binding affinity. This is worthy of further investigation in a large prospective cohort over an extended time to determine the safety and efficacy of intravitreal aflibercept for use in this condition
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