Tricalcium phosphate endosseous implants in dentistry: ultrastructural findings

β-Tricalcium phosphate magnesium substitued (β-TCMP), consisting of one part small unsintered and one part large sintered granules was placed in upper and lower jaw surgical cavities of monkeys. At light and transmission electron microscope the biopsies taken at 2, 4, 8 and 24 weeks showed that both sintered and unsintered granules were well tolerated by the host tissue and result biodegradable over time.β-TCMP may stimulate the direction of bone growth enhancing osteoblasts activity and new bone deposition in direct contact and in the micropores of the biomaterial. β-TCMP containing Mg ions reabsorbs slowly when in sintered granules form and rapidly as unsintered granules. When it is placed in bone cavities, if bone reabsorption is biologically necessary, the biomaterial can be reabsorbed with bone, while if osteogenesis is required β-TCMP provides a more durable matrix to support new bone growth.Le β-phosphate tricalcique contenant à ions Mg (β-TCMP) et constitué à parts égales de fins granules non frittés et de larges granules frittés, est introduit dans des cavités chirurgicales pratiquées dans les maxillaires supérieurs et inférieurs de singes.Des biopsies pratiquées à 2, 4, 8 et 24 semaines ont été examinées au microscope optique et électronique à transmission.Les granules frittés et non frittés sont bien tolérés par les tissus hôtes et sont biodégradés avec le temps.Les observations histologiques montrent aussi que le β-TCMP peut orienter la direction de la croissance osseuse en stimulant l’activité des ostéoblastes et le dépôt d’os nouveau aussi bien autour des biomatériaux que dans leur micropores. Le β-TCMP contenant les ions Mg est réabsorbé lentement lorsqu’il se présente sous la forme de granules frittés, et rapidement lorsqu’il est sous la forme de granules non frittés.Lorsqu’il est introduit dans les cavités osseuses, si la réabsorption osseuse est biologiquement nécessaire, le biomatériau peut être réabsorbé avec l’os, tandis que si c’est l’ostéogenèse qui est sollicitée, β-TCMP fournit une matrice durable comme support à la croissance d’os nouveau

Probability density functions of photochemicals over a coastal area of Northern Italy

The present paper surveys the findings of experimental studies and analyses of statistical probability density functions (PDFs) applied to air pollutant concentrations to provide an interpretation of the ground-level distributions of photochemical oxidants in the coastal area of Ravenna (Italy). The atmospheric pollution data set was collected from the local environmental monitoring network for the period 1978-1989. Results suggest that the statistical distribution of surface ozone, once normalised over the solar radiation PDF for the whole measurement period, follows a log-normal law as found for other pollutants. Although the Weibull distribution also offers a good fit of the experimental data, the area’s meteorological features seem to favour the former distribution once the statistical index estimates have been analysed. Local transport phenomena are discussed to explain the data tail trends

Seasonal budgets of ozone and oxidant precursors in an industrial coastal area of northern Italy

The seasonal budgets and evolution of photochemical oxidants reported for greater Ravenna's urban-industrial area in the present study were calculated using the combined data from on-site systematic surveys (1978-1989) and from the monitoring network of the local environmental authorities. The notable differences in the concentrations of ozone and nitrogen oxides depended on season, and meteorological variables showed a marked correlation to the seasonal budget of trace constituents. The weak local circulation, the land-sea breeze system, and high solar radiation in summer, which may persist at length because of the anticyclonic conditions, can produce episodes of intense photochemical reactions. In winter, by contrast, low solar radiation and the absence of the breeze system results in very different evolutions of both pollutant concentrations and their seasonal budget

Topological mass mechanism and exact fields mapping

We present a class of mappings between models with topological mass mechanism and purely topological models in arbitrary dimensions. These mappings are established by directly mapping the fields of one model in terms of the fields of the other model in closed expressions. These expressions provide the mappings of their actions as well as the mappings of their propagators. For a general class of models in which the topological model becomes the BF model the mappings present arbitrary functions which otherwise are absent for Chern-Simons like actions. This work generalizes the results of [1] for arbitrary dimensions.Comment: 11 page

Synthesis of novel structural hybrids between aza-heterocycles and azelaic acid moiety with a specific activity on osteosarcoma cells

Nine compounds bearing pyridinyl (or piperidinyl, benzimidazolyl, benzotriazolyl) groups bound to an azelayl moiety through an amide bond were synthesized. The structural analogy with some histone deacetylase inhibitors inspired their syntheses, seeking new selective histone deacetylase inhibitors (HDACi). The azelayl moiety recalls part of 9-hydroxystearic acid, a cellular lipid showing antiproliferative activity toward cancer cells with HDAC as a molecular target. Azelayl derivatives bound to a benzothiazolyl moiety further proved to be active as HDACi. The novel compounds were tested on a panel of both normal and tumor cell lines. Non-specific induction of cytotoxicity was observed in the normal cell line, while three of them induced a biological effect only on the osteosarcoma (U2OS) cell line. One of them induced a change in nuclear shape and size. Cell-cycle alterations are associated with post-transcriptional modification of both H2/H3 and H4 histones. In line with recent studies, revealing unexpected HDAC7 function in osteoclasts, molecular docking studies on the active molecules predicted their proneness to interact with HDAC7. By reducing side effects associated with the action of the first-generation inhibitors, the herein reported compounds, thus, sound promising as selective HDACi

Renormalization of the mass gap

The full gluon propagator relevant for the description of the truly non-perturbative QCD dynamics, the so-called intrinsically non-perturbative gluon propagator has been derived in our previous work. It explicitly depends on the regularized mass gap, which dominates its structure at small gluon momentum. It is automatically transversal in a gauge invariant way. It is characterized by the presence of severe infrared singularities at small gluon momentum, so the gluons remain massless, and this does not depend on the gauge choice. In this paper we have shown how precisely the renormalization program for the regularized mass gap should be performed. We have also shown how precisely severe infrared singularities should be correctly treated. This allowed to analytically formulate the exact and gauge-invariant criteria of gluon and quark confinement. After the renormalization program is completed, one can derive the gluon propagator applicable for the calculation of physical observables processes, etc., in low-energy QCD from first principles.Comment: 16 pages, no figures, no tables, some minor changes are introduce

Quantum control and the Strocchi map

Identifying the real and imaginary parts of wave functions with coordinates and momenta, quantum evolution may be mapped onto a classical Hamiltonian system. In addition to the symplectic form, quantum mechanics also has a positive-definite real inner product which provides a geometrical interpretation of the measurement process. Together they endow the quantum Hilbert space with the structure of a K\"{a}ller manifold. Quantum control is discussed in this setting. Quantum time-evolution corresponds to smooth Hamiltonian dynamics and measurements to jumps in the phase space. This adds additional power to quantum control, non unitarily controllable systems becoming controllable by ``measurement plus evolution''. A picture of quantum evolution as Hamiltonian dynamics in a classical-like phase-space is the appropriate setting to carry over techniques from classical to quantum control. This is illustrated by a discussion of optimal control and sliding mode techniques.Comment: 16 pages Late

On the symmetry of the vacuum in theories with spontaneous symmetry breaking

We review the usual account of the phenomena of spontaneous symmetry breaking (SSB), pointing out the common misunderstandings surrounding the issue, in particular within the context of quantum field theory. In fact, the common explanations one finds in this context, indicate that under certain conditions corresponding to the situation called SSB, the vacuum of the theory does not share the symmetries of the Lagrangian. We explain in detail why this statement is incorrect in general, and in what limited set of circumstances such situation could arise. We concentrate on the case of global symmetries, for which we found no satisfactory exposition in the existing literature, and briefly comment on the case of gauge symmetries where, although insufficiently publicized, accurate and complete descriptions exist. We briefly discuss the implications for the phenomenological manifestations usually attributed to the phenomena of spontaneous symmetry breaking, analyzing which might be affected by our analysis and which are not. In particular we describe the mass generation mechanism in a fully symmetric scheme (i.e., with a totally symmetric vacuum), and briefly discuss the implications of this analysis to the problem of formation of topological defects in the early universe

Geometrization of Quantum Mechanics

We show that it is possible to represent various descriptions of Quantum Mechanics in geometrical terms. In particular we start with the space of observables and use the momentum map associated with the unitary group to provide an unified geometrical description for the different pictures of Quantum Mechanics. This construction provides an alternative to the usual GNS construction for pure states.Comment: 16 pages. To appear in Theor. Math. Phys. Some typos corrected. Definition 2 in page 5 rewritte

Indole derivative interacts with estrogen receptor beta and inhibits human ovarian cancer cell growth

Ovarian cancer remains the leading cause of mortality among gynecological tumors. Estrogen receptor beta (ERβ) expression has been suggested to act as a tumor suppressor in epithelial ovarian cancer by reducing both tumor growth and metastasis. ERβ expression abnormalities represent a critical step in the development and progression of ovarian cancer: for these reasons, its re‐expression by genetic engineering, as well as the use of targeted ERβ therapies, still constitute an important therapeutic approach. 3‐{[2‐chloro‐1‐(4‐chlorobenzyl)‐5‐methoxy‐6-methyl‐1H‐indol‐3‐yl]methylene}‐5‐hydroxy‐6‐methyl‐1,3‐dihydro‐2H‐indol‐2‐one, referred to here as compound 3, has been shown to have cytostatic as well cytotoxic effects on various hormone-dependent cancer cell lines. However, the mechanism of its anti‐carcinogenic activity is not well understood. Here, we offer a possible explanation of such an effect in the human ovarian cancer cell line IGROV1. Chromatin binding protein assay and liquid chromatography mass spectrometry were exploited to localize and quantify compound 3 in cells. Molecular docking was used to prove compound 3 binding to ERβ. Mass spectrometry‐based approaches were used to analyze histone post‐translational modifications. Finally, gene expression analyses revealed a set of genes regulated by the ERβ/3 complex, namely CCND1, MYC, CDKN2A, and ESR2, providing possible molecular mechanisms that underline the observed antiproliferative effects