Analysis of the possibilities of influencing antibiotic prophylaxis on the basis of inflammatory markers II

Analýza možností ovlivnění antibiotické profylaxe na základě zánětlivých markerů II Autor: Gabriela Strnadová Vedoucí diplomové práce: doc. PharmDr. Josef Malý, Ph.D. Konzultant: PharmDr. Petr Domecký Katedra sociální a klinické farmacie, Farmaceutická fakulta v Hradci Králové, Univerzita Karlova Úvod a cíl: Infekce kloubních náhrad se považují za nejzávažnější komplikace provedení totálních endoprotéz, které lze redukovat mimo jiné sledováním zánětlivých a nutričních markerů. Cílem práce bylo analyzovat možnosti ovlivnění antibiotické profylaxe (AP) na základě těchto markerů u pacientů, kterým byla provedena primární implantace totální endoprotézy kyčelního kloubu (THA) a totální endoprotéza kolenního kloubu (TKA). Metodika: Data byla získána z prospektivní studie, která započala v březnu 2020 na Ortopedické klinice Fakultní nemocnice Hradec Králové. Do analýzy bylo zahrnuto 118 pacientů starších 18 let, kterým byla implantována primární THA nebo TKA v časovém období od května 2021 do června 2022. Analyzovaná data pocházela z listinné a elektronické podoby zdravotnické dokumentace pacientů. Údaje o pacientovi, provedeném výkonu, tromboprofylaxi (TP), AP a výsledcích fyzikálních a laboratorních vyšetření byly analyzovány a popsány pomocí metod deskriptivní statistiky. Hodnocení vztahu mezi...Analysis of the possibilities of influencing antibiotic prophylaxis on the basis of inflammatory markers II Author: Gabriela Strnadová Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Petr Domecký Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Periprosthetic joint infections are considered as the biggest complication of the implementation of the total arthroplasty which may be reduced by the observation of inflammatory and nutritional markers. The aim of this thesis is to analyse the possibilities of influencing the antibiotic prophylaxis (AP) on the basis of those markers observed on patients that underwent the total hip arthroplasty (THA) and the total knee arthroplasty (TKA). Methods: Data was collected from a prospective study which began in March 2020 at the Department of Orthopedics at the University Hospital Hradec Králové. There were 118 patients from May 2021 to June 2022 older than 18 years with THA and TKA included in the analysis. The analysed data were sourced from the paper and electronic forms of medical documentary materials of those patients. Patients'personal and medical details (including the information about the operation, the thromboprophylaxis (TP), AP, and the results of physical and...Katedra sociální a klinické farmacieDepartment of Social and Clinical PharmacyFarmaceutická fakulta v Hradci KrálovéFaculty of Pharmacy in Hradec Králov

Contemporary developments in the field of care for employees

Katedra pracovního práva a práva sociálního zabezpečeníDepartment of Labor Law and Social Security LawFaculty of LawPrávnická fakult

Analysis of the possibilities of influencing antibiotic prophylaxis on the basis of inflammatory markers II

Analysis of the possibilities of influencing antibiotic prophylaxis on the basis of inflammatory markers II Author: Gabriela Strnadová Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Petr Domecký Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Periprosthetic joint infections are considered as the biggest complication of the implementation of the total arthroplasty which may be reduced by the observation of inflammatory and nutritional markers. The aim of this thesis is to analyse the possibilities of influencing the antibiotic prophylaxis (AP) on the basis of those markers observed on patients that underwent the total hip arthroplasty (THA) and the total knee arthroplasty (TKA). Methods: Data was collected from a prospective study which began in March 2020 at the Department of Orthopedics at the University Hospital Hradec Králové. There were 118 patients from May 2021 to June 2022 older than 18 years with THA and TKA included in the analysis. The analysed data were sourced from the paper and electronic forms of medical documentary materials of those patients. Patients'personal and medical details (including the information about the operation, the thromboprophylaxis (TP), AP, and the results of physical and..

Contemporary developments in the field of care for employees

Katedra pracovního práva a práva sociálního zabezpečeníDepartment of Labor Law and Social Security LawFaculty of LawPrávnická fakult

RETRACTED: POSSIBILITY OF MONITORING OF PAHs DISTRIBUTION IN THE VERTICAL PROFILE AT THE BACKGROUND METEOROLOGICAL STATION KREŠÍN

This article has been retracted by Editorial Office, upon an approval of all authors. The Publisher apologized for any inconvenience this may cause. The contaminants present in the atmosphere have a substantial impact on public health. Among contaminants, the most important are polycyclic aromatic hydrocarbons (PAHs). This paper is focused on the possibility of continuous PAHs monitoring and the description of their vertical distribution using filters, which serve to purify the air before the determination of the greenhouse gases (CO2, CH4, N2O, CO, ozone) and Hg in air, continuously sampled at 8, 50 and 230m at the atmospheric station Krešín near Pacov and elaboration of a simple and economical method of extraction of these filters. The station serves as a point for monitoring the occurrence and remote transport of greenhouse gases and selected atmospheric pollutants and for the measurements of basic meteorological characteristics. In December, 17, 2014, a sampling of 16 priority PAHs started and lasted until December, 9, 2015. Samples were taken approximately once a month. The maximum concentration of ΣPAHs was 15.905 ng/m3, measured at the height of 8 meters in the period of 11. 2. 2015–11. 3. 2015, the concentration of benzo[a]pyrene exceeded the immission limit in the period by more than 50%. By the sampling, the hypothesis about decreasing concentration of PAHs with increasing height was confirmed, especially the decrease of heavier PAHs. The sampling has shown that it is highly desirable to use the meteorological tower for sampling of PAHs using PTFE filters either by including the active sampler itself, or by using pre-filters for tropospheric ozone and gaseous elemental mercury analysers