Analysis of the possibilities of influencing antibiotic prophylaxis on the basis of inflammatory markers II

Abstract

Analysis of the possibilities of influencing antibiotic prophylaxis on the basis of inflammatory markers II Author: Gabriela Strnadová Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Petr Domecký Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Periprosthetic joint infections are considered as the biggest complication of the implementation of the total arthroplasty which may be reduced by the observation of inflammatory and nutritional markers. The aim of this thesis is to analyse the possibilities of influencing the antibiotic prophylaxis (AP) on the basis of those markers observed on patients that underwent the total hip arthroplasty (THA) and the total knee arthroplasty (TKA). Methods: Data was collected from a prospective study which began in March 2020 at the Department of Orthopedics at the University Hospital Hradec Králové. There were 118 patients from May 2021 to June 2022 older than 18 years with THA and TKA included in the analysis. The analysed data were sourced from the paper and electronic forms of medical documentary materials of those patients. Patients'personal and medical details (including the information about the operation, the thromboprophylaxis (TP), AP, and the results of physical and..