124 research outputs found
Nitrate reduction and the occurrence of a deep nitrite maximum in the ocean off the west coast of South America
Between 10°S and 23°S off the coast of Peru, at depths where the oxygen concentration is less than 0.2 ml/l, a pronounced secondary nitrite maximum is found; for the same or gr eater depth range, results indicate a loss of nitrate in the water column. It has been assumed that either nitrate reduction has taken place or there has been an arrested oxidation of organic nitrogen...
Discussion of spectrophotometric determination of marine-plant pigments, with revised equations for ascertaining chlorophylls and carotenoids
A number of discrepancies in the spectrophotometric determination of plant pigments with the Richards with Thompson method have been reported. A revised set of equations for the determination of plant chlorophylls and a new equation for the approximate estimation of plant carotenoids are presented
Protection against neonatal respiratory viral infection via maternal treatment during pregnancy with the benign immune training agent OM‐85
Objectives
Incomplete maturation of immune regulatory functions at birth is antecedent to the heightened risk for severe respiratory infections during infancy. Our forerunner animal model studies demonstrated that maternal treatment with the microbial-derived immune training agent OM-85 during pregnancy promotes accelerated postnatal maturation of mechanisms that regulate inflammatory processes in the offspring airways. Here, we aimed to provide proof of concept for a novel solution to reduce the burden and potential long-term sequelae of severe early-life respiratory viral infection through maternal oral treatment during pregnancy with OM-85, already in widespread human clinical use.
Methods
In this study, we performed flow cytometry and targeted gene expression (RT-qPCR) analysis on lungs from neonatal offspring whose mothers received oral OM-85 treatment during pregnancy. We next determined whether neonatal offspring from OM-85 treated mothers demonstrate enhanced protection against lethal lower respiratory infection with mouse-adapted rhinovirus (vMC0), and associated lung immune changes.
Results
Offspring from mothers treated with OM-85 during pregnancy display accelerated postnatal seeding of lung myeloid populations demonstrating upregulation of function-associated markers. Offspring from OM-85 mothers additionally exhibit enhanced expression of TLR4/7 and the IL-1β/NLRP3 inflammasome complex within the lung. These treatment effects were associated with enhanced capacity to clear an otherwise lethal respiratory viral infection during the neonatal period, with concomitant regulation of viral-induced IFN response intensity.
Conclusion
These results demonstrate that maternal OM-85 treatment protects offspring against lethal neonatal respiratory viral infection by accelerating development of innate immune mechanisms crucial for maintenance of local immune homeostasis in the face of pathogen challenge
The First Magnetic Fields
We review current ideas on the origin of galactic and extragalactic magnetic
fields. We begin by summarizing observations of magnetic fields at cosmological
redshifts and on cosmological scales. These observations translate into
constraints on the strength and scale magnetic fields must have during the
early stages of galaxy formation in order to seed the galactic dynamo. We
examine mechanisms for the generation of magnetic fields that operate prior
during inflation and during subsequent phase transitions such as electroweak
symmetry breaking and the quark-hadron phase transition. The implications of
strong primordial magnetic fields for the reionization epoch as well as the
first generation of stars is discussed in detail. The exotic, early-Universe
mechanisms are contrasted with astrophysical processes that generate fields
after recombination. For example, a Biermann-type battery can operate in a
proto-galaxy during the early stages of structure formation. Moreover, magnetic
fields in either an early generation of stars or active galactic nuclei can be
dispersed into the intergalactic medium.Comment: Accepted for publication in Space Science Reviews. Pdf can be also
downloaded from http://canopus.cnu.ac.kr/ryu/cosmic-mag1.pd
Early origins of lung disease: Towards an interdisciplinary approach
The prenatal and perinatal environments can have profound effects on the development of
chronic inflammatory diseases. However, mechanistic insight into how the early-life microenvironment
can impact upon development of the lung and immune system and consequent initiation and progression
of respiratory diseases is still emerging. Recent studies investigating the developmental origins of lung
diseases have started to delineate the effects of early-life changes in the lung, environmental exposures and
immune maturation on the development of childhood and adult lung diseases. While the influencing
factors have been described and studied in mostly animal models, it remains challenging to pinpoint
exactly which factors and at which time point are detrimental in lung development leading to respiratory
disease later in life. To advance our understanding of early origins of chronic lung disease and to allow for
proper dissemination and application of this knowledge, we propose four major focus areas: 1) policy and
education; 2) clinical assessment; 3) basic and translational research; and 4) infrastructure and tools, and
discuss future directions for advancement. This review is a follow-up of the discussions at the European
Respiratory Society Research Seminar “Early origins of lung disease: towards an interdisciplinary
approach” (Lisbon, Portugal, November 2019)
D* Production in Deep Inelastic Scattering at HERA
This paper presents measurements of D^{*\pm} production in deep inelastic
scattering from collisions between 27.5 GeV positrons and 820 GeV protons. The
data have been taken with the ZEUS detector at HERA. The decay channel
(+ c.c.) has been used in the study. The
cross section for inclusive D^{*\pm} production with
and is 5.3 \pms 1.0 \pms 0.8 nb in the kinematic region
{ GeV and }. Differential cross
sections as functions of p_T(D^{*\pm}), and are
compared with next-to-leading order QCD calculations based on the photon-gluon
fusion production mechanism. After an extrapolation of the cross section to the
full kinematic region in p_T(D^{*\pm}) and (D^{*\pm}), the charm
contribution to the proton structure function is
determined for Bjorken between 2 10 and 5 10.Comment: 17 pages including 4 figure
Observation of Scaling Violations in Scaled Momentum Distributions at HERA
Charged particle production has been measured in deep inelastic scattering
(DIS) events over a large range of and using the ZEUS detector. The
evolution of the scaled momentum, , with in the range 10 to 1280
, has been investigated in the current fragmentation region of the Breit
frame. The results show clear evidence, in a single experiment, for scaling
violations in scaled momenta as a function of .Comment: 21 pages including 4 figures, to be published in Physics Letters B.
Two references adde
Relativistic Laser-Matter Interaction and Relativistic Laboratory Astrophysics
The paper is devoted to the prospects of using the laser radiation
interaction with plasmas in the laboratory relativistic astrophysics context.
We discuss the dimensionless parameters characterizing the processes in the
laser and astrophysical plasmas and emphasize a similarity between the laser
and astrophysical plasmas in the ultrarelativistic energy limit. In particular,
we address basic mechanisms of the charged particle acceleration, the
collisionless shock wave and magnetic reconnection and vortex dynamics
properties relevant to the problem of ultrarelativistic particle acceleration.Comment: 58 pages, 19 figure
Digestibilidade do fósforo em dietas como estratégia nutricional para redução de efluentes da tilapicultura
More than two decades after the introduction of Limnoperna fortunei (Dunker 1857) in La Plata Basin
- …