Help-seeking online by young people : does the influence of others matter?

Help-seeking is an adaptive process whereby a person seeks external support for a problem. Help-seeking early in response to mental health concerns is thus important in preventing mental illness in later life. Recent developments in service provision such as online help services, have been identified as promoting help-seeking behaviours, but there are many barriers that work against a young person seeking effective help early on, including personal characteristics such as attitudes toward help sources. Further, the influence of others on a young person’s help-seeking behaviours is beginning to emerge in the youth help-seeking literature, and may be an important facilitator of help-seeking behaviours. The present mixed- method study explored young people’s attitudes toward help sources, and how receptive young people are to the influence of others on their help-seeking intentions. Critically, the study aims to determine whether these variables have varying effects on different types of help sources (formal, informal and online). It was found that the influence of others and attitudes toward help sources had little bearing on online help-seeking intentions, in contrast to help-seeking intentions from traditional modes of help-seeking. Recommendations are made as to how young people can be better informed about the benefits of online help-seeking, with the hopes of highlighting the potentially untapped resource of other people’s influence on a young person’s decision to seek help online.peer-reviewe

Preembryo Personhood: An Assessment of the President’s Council Arguments

The President’s Council on Bioethics has addressed the moral status of human preembryos in its reports on stem cell research and human therapeutic cloning. Although the Council has been criticized for being hand-picked to favor the right-to-life viewpoint concerning human preembryos, it has embraced the idea that the right-to-life position should be defended in secular terms. This is an important feature of the Council’s work, and it demonstrates a recognition of the need for genuine engagement between opposing sides in the debate over stem cell research. To promote this engagement, the Council has stated in secular terms several arguments for the personhood of human preembryos. This essay presents and critiques those arguments, and it concludes that they are unsuccessful. If the best arguments in support of the personhood of human preembryos have been presented by the Council, then there are no reasonable secular arguments in support of that view

The impact of brain-derived neurotrophic factor Val66Met polymorphism on cognition and functional brain networks in patients with intractable partial epilepsy

INTRODUCTION: Medial temporal lobe epilepsy (mTLE) is the most common refractory focal epilepsy in adults. Around 30%-40% of patients have prominent memory impairment and experience significant postoperative memory and language decline after surgical treatment. BDNF Val66Met polymorphism has also been associated with cognition and variability in structural and functional hippocampal indices in healthy controls and some patient groups. AIMS: We examined whether BDNF Val66Met variation was associated with cognitive impairment in mTLE. METHODS: In this study, we investigated the association of Val66Met polymorphism with cognitive performance (n = 276), postoperative cognitive change (n = 126) and fMRI activation patterns during memory encoding and language paradigms in 2 groups of patients with mTLE (n = 37 and 34). RESULTS: mTLE patients carrying the Met allele performed more poorly on memory tasks and showed reduced medial temporal lobe activation and reduced task-related deactivations within the default mode networks in both the fMRI memory and language tasks than Val/Val patients. CONCLUSIONS: Although cognitive impairment in epilepsy is the result of a complex interaction of factors, our results suggest a role of genetic factors on cognitive impairment in mTLE

Social pain and social gain in the adolescent brain: A common neural circuitry underlying both positive and negative social evaluation

Social interaction inherently involves the subjective evaluation of cues salient to social inclusion and exclusion. Testifying to the importance of such social cues, parts of the neural system dedicated to the detection of physical pain, the dorsal anterior cingulate cortex (dACC) and anterior insula (AI), have been shown to be equally sensitive to the detection of social pain experienced after social exclusion. However, recent work suggests that this dACC-AI matrix may index $\textit{any}$ socially pertinent information. We directly tested the hypothesis that the dACC-AI would respond to cues of $\textit{both}$ inclusion and exclusion, using a novel social feedback fMRI paradigm in a population-derived sample of adolescents. We show that the dACC and left AI are commonly activated by feedback cues of inclusion and exclusion. Our findings suggest that theoretical accounts of the dACC-AI network as a neural alarm system restricted within the social domain to the processing of signals of exclusion require significant revision.This work was supported by grants from Friends of Peterhouse Medical Fund Cambridge (RG 51114), the Wellcome Trust (RG 074296), and the UK Medical Research Council (MC US A060 0019)

OptiJ: Open-source optical projection tomography of large organ samples

The three-dimensional imaging of mesoscopic samples with Optical Projection Tomography (OPT) has become a powerful tool for biomedical phenotyping studies. OPT uses visible light to visualize the 3D morphology of large transparent samples. To enable a wider application of OPT, we present OptiJ, a low-cost, fully open-source OPT system capable of imaging large transparent specimens up to 13 mm tall and 8 mm deep with 50 µm resolution. OptiJ is based on off-the-shelf, easy-to-assemble optical components and an ImageJ plugin library for OPT data reconstruction. The software includes novel correction routines for uneven illumination and sample jitter in addition to CPU/GPU accelerated reconstruction for large datasets. We demonstrate the use of OptiJ to image and reconstruct cleared lung lobes from adult mice. We provide a detailed set of instructions to set up and use the OptiJ framework. Our hardware and software design are modular and easy to implement, allowing for further open microscopy developments for imaging large organ samples

Mood and neural responses to social rejection do not seem to be altered in resilient adolescents with a history of adversity

Childhood adversity (CA) increases the risk of subsequent mental health problems. Adolescent social support (from family and/or friends) reduces the risk of mental health problems after CA. However, the mechanisms of this effect remain unclear, and we speculate that they are manifested on neurodevelopmental levels. Therefore, we investigated whether family and/or friendship support at ages 14 and 17 function as intermediate variables for the relationship between CA before age 11 and affective or neural responses to social rejection feedback at age 18. We studied 55 adolescents with normative mental health at age 18 (26 with CA and therefore considered “resilient”), from a longitudinal cohort. Participants underwent a Social Feedback Task in the magnetic resonance imaging scanner. Social rejection feedback activated the dorsal anterior cingulate cortex and the left anterior insula. CA did not predict affective or neural responses to social rejection at age 18. Yet, CA predicted better friendships at age 14 and age 18, when adolescents with and without CA had comparable mood levels. Thus, adolescents with CA and normative mood levels have more adolescent friendship support and seem to have normal mood and neural responses to social rejection

Civil society mobilisation after Cyclone Tracy, Darwin 1974

Major disasters challenge or exceed the capacity of the official emergency management sector to provide needed rescue services, support and relief. Emergency services in most jurisdictions do not have the surge capacity for unusual or extreme events without drawing on other jurisdictions or local people from outside the formal emergency management organisations. In such circumstances, those in the affected area need to organise themselves and make maximum use of local resources to cope with the immediate aftermath of impact. To find the required surge capacity, this suggests a whole of society response with the official system working with the capacities of people, commerce and organisations outside the emergency sector. An example is provided by the destruction of the northern Australian capital city of Darwin by Cyclone Tracy in December 1974. Informal volunteering and emergent leadership in Darwin and across Australia were critical to the immediate response and relief. Volunteering was widespread and worked well alongside official emergency management. With today’s information and communication technologies and a strong national resilience narrative, we would expect to do at least as well. However, governments now exercise much more control over civil society. We examine the implications for surge capacity and adaptability