Fra Ankara e Damasco, i fronti aperti dell'erdoganismo

Il fallito colpo di stato dello scorso luglio rappresenta il momento a partire dal quale, grazie soprattutto alle epurazioni di massa nei ran- ghi delle forze armate che lo hanno seguito, sono mutate non solo le dinamiche della politica interna turca, ma anche le principali diret- trici di politica estera. Disallineatasi rispetto agli Stati Uniti, contrari a un intervento di Ankara nello scenario siriano, la Turchia del post golpe ha anteposto il proprio interesse nazionale a ogni altra conside- razione, e appro ttando della fase conclusiva della presidenza Oba- ma ha scelto di inseguire proprio sulla partita siriana una complessa, disinvolta e disagevole convergenza con la Russia di Vladimir Putin

Innovative magnetic scaffolds for orthopedic tissue engineering

The use of magnetism in tissue engineering is a very promising approach, in fact magnetic scaffolds are able not only to support tissue regeneration, but they can be activated and work like a magnet attracting functionalized magnetic nanoparticles (MNPs) injected close to the scaffold enhancing tissue regeneration. This study aimed to assess the in vivo biocompatibility and osteointegrative properties of novel magnetic scaffolds. Two hydroxyapatite/collagen (70/30 wt %) magnetic scaffolds were magnetized with two different techniques: direct nucleation of biomimetic phase and superparamagnetic nanoparticles (MNPs) on self-assembling collagen fibers (MAG-A) and scaffold impregnation in ferro-fluid solution (MAG-B). Magnetic scaffolds were implanted in rabbit distal femoral epiphysis and tibial mid-diaphysis. Histopathological screening showed no inflammatory reaction due to MNPs. Significantly higher bone healing rate (ΔBHR) results were observed in MAG-A in comparison to MAG-B. Significant differences were also found between experimental times with an increase in ΔBHR from 2 to 4 weeks for both scaffolds in trabecular bone, while only for MAG-B (23%, p < 0.05) in cortical bone. The proposed magnetic scaffolds seem to be promising for magnetic guiding in orthopedic tissue engineering applications and they will be suitable to treat also several pathologies in regenerative medicine are

Approaches to Regional Stability and the Outlook for NATO

In recent years the international security environment within and around NATO perimeter has seen instability increasing and spreading in various ways, ranging from enduring conflicts and state failures, to sudden shifts in the strategic posture of relevant countries. Given the increasing connection between the local and international dynamics, the regional dimension of stability has gained importance for both experts and practitioners. At this level, interested states may find common ground in order to foster joint efforts to stabilisation, or at least to mitigate diverging national agendas which in turn contribute to instability. Focusing on the broad regional security complex encompassing Sahel, North Africa and Middle East, it is evident that it is increasingly unstable, as it represents the physical space where multiple forms of instability coalesce at local, national regional and global level. In order to understand such web of instabilities, the view on the relevant actors should be broadened by looking at both states and non-states, local and international ones including NATO and EU \u2013 and their role in terms of stabilisation/destabilisation. This publication is the result of the sixth academic conference organised in Bertinoro (Forl\uec) on 24-26 October 2018 by the NATO Allied Command Transformation (ACT), the University of Bologna and the Istituto Affari Internazionali (IAI)

Macroscopic Synovial Inflammation Correlates with Symptoms and Cartilage Lesions in Patients Undergoing Arthroscopic Partial Meniscectomy: A Clinical Study

Background: The aim of the study was to examine the relationship among patients' characteristics, intraoperative pathology and pre/post-operative symptoms in a cohort of patients undergoing arthroscopic partial meniscectomy for symptomatic meniscal tears. Methods: Clinical data were collected (age, sex, body mass index, time to surgery, trauma). Intraoperative cartilage pathology was assessed with Outerbridge score. Meniscal tears were graded with the ISAKOS classification. Synovial inflammation was scored using the Macro-score. Patient symptoms were assessed pre/post-operatively using the KOOS instrument. Results: In the series of 109 patients (median age 47 years), 50% of the meniscal tears were traumatic; 85% of patients showed mild to moderate synovitis; 52 (47.7%) patients had multiple cartilage defects and 31 (28.4%) exhibited a single focal chondral lesion. Outerbridge scores significantly correlated with patient age, BMI and synovial inflammation. There was a correlation between severity of chondral pathology and high-grade synovial hyperplasia. Pre-operative KOOS correlated with BMI, meniscal degenerative changes and symptom duration. Obesity, time to surgery, presence of high-grade synovial hyperplasia and high-grade cartilage lesions were independent predictors of worse post-operative pain and function. Conclusion: We demonstrated that pre-operative symptoms and post-operative outcomes correlate with synovitis severity and cartilage pathology, particularly in old and obese patients that underwent arthroscopic partial meniscectomy. Importantly, patients with a degenerative meniscal pattern and with longer time to surgery experienced more severe cartilage damage and, consequentially, pain and dysfunction. These findings are fundamental to identify patients suitable for earlier interventions