Coherent Captain Mills: The Search for Sterile Neutrinos

The observation of neutrino oscillations confirms that the active neutrinos (νe, νμ, ντ) are comprised of three mass eigenstates with Δm2 values between 10-3 to 10-5 eV2 . However, a persistent phenomenon has been observed at LSND, MiniBooNE and other shortbaseline experiments (SBE) where Δm2 ~ 1eV2 and is not compatible with the current mixing between mass eigenstates. However, a 4th neutrino, a sterile neutrino (νs) that doesn’t participate in weak interactions could explain the phenomena observed as SBE’s. An experiment has been constructed at TA-53 at Los Alamos National Laboratory to investigate this large Δm2 ~ 1eV2 and determine conclusively whether or not this large Δm2 is due to a “new” sterile neutrino. POSTER PRESENTATION IGNITE AWAR

Vision impossible

Vision Impossible was designed to help promote vision awareness to the general public as well as to help bring various health professions together and educate them as to the different visual demands that each profession may experience. Vision Impossible was also intended to be a fundraising event to help raise money for the renovation of Jefferson Hall. Ninety-four subjects, consisting mainly of optometry students, took part in two trial runs of a ten-event course, designed to challenge the visual system in various ways. The trial runs were conducted at Pacific University and were used to assess the efficiency of the event design and data was collected for normative purposes. However, Vision Impossible was unable to implement the originally designed fundraising event. Factors which contributed to this included flaws with some of the event designs as well as unavailability of equipment, inability to obtain donations for prize incentives, and logistical problems concerning the event location and timing. However, Vision Impossible did succeed in developing a final course design as well as obtaining normative results for these course events should this endeavor be attempted in the future

Documenting ---- in Bloomington-Normal: A Community Report on Intolerance, Segregation, Accessibility, Inclusion, and Progress, and Improvement

For the local chapter of Not In Our Town, we document intolerance, discrimination, segregation, disparities of access, and disparities in the criminal justice system in Bloomington-Normal, IL. Using archival material, secondary data, and primary data, we examine these issues from the mid-1990s to the present. We also assess the position of the organization in the community and provide strategies for future success. In sum, Bloomington-Normal was and is intolerant; discrimination did and does take place in this community; there are disparities of access and in the criminal justice system; we are segregated. The community is also less of these things than it used to be and is less of these things than other places. Fifteen undergraduate students in Sociology 300, twelve graduate students in Sociology 477, a teaching assistant, and an instructor conducted this study in spring 2017

Coherent Captain Mills: The Search for Sterile Neutrinos

The observation of neutrino oscillations confirms that the active neutrinos (νe, νμ, ντ) are comprised of three mass eigenstates with Δm2 values between 10-3 to 10-5 eV2. However, a persistent phenomenon has been observed at LSND, MiniBooNE and other shortbaseline experiments (SBE) where Δm2 ~ 1eV2 is not compatible with the current mixing between mass eigenstates. However, a 4th neutrino, a sterile neutrino (νs) that doesn’t participate in weak interactions could explain the phenomena observed as SBE’s. An experiment has been constructed at TA-53 at Los Alamos National Laboratory to investigate this large Δm2 ~ 1eV2 and determine conclusively whether or not this large Δm2 is due to a “new” sterile neutrino. POSTER PRESENTATIO

Changes in the Na D-1 Absorption Components of eta Carinae Provide Clues on the Location of the Dissipating Central Occulter

The Na D absorption doublet in the spectrum of eta Carinae is complex, with multiple absorption features associated with the Great Eruption (1840s), the Lesser Eruption (1890s), and the interstellar clouds. The velocity profile is further complicated by the P Cygni profile originating in the system's stellar winds and blending with the He i lambda 5876 profile. The Na D profile contains a multitude of absorption components, including those at velocities of -145 km s(-1), -168 km s(-1), and +87 km s(-1), which we concentrate on in this analysis. Ground-based spectra recorded from 2008 to 2021 show significant variability of the -145 km s(-1) absorption throughout long-term observations. In the high-ionization phases of eta Carinae prior to the 2020 periastron passage, this feature disappeared completely but briefly reappeared across the 2020 periastron, along with a second absorption at -168 km s(-1). Over the past few decades, eta Carinae has been gradually brightening, which is shown to be caused by a dissipating occulter. The decreasing absorption of the -145 km s(-1) component, coupled with similar trends seen in absorptions of ultraviolet resonant lines, indicate that this central occulter was possibly a large clump associated with the Little Homunculus or another clump between the Little Homunculus and the star. We also report on a foreground absorption component at +87 km s(-1). Comparison of Na D absorption in the spectra of nearby systems demonstrates that this redshifted component likely originates in an extended foreground structure consistent with a previous ultraviolet spectral survey in the Carina Nebula

An integrated technology for quantitative wide mutational scanning of human antibody Fab libraries

Abstract Antibodies are engineerable quantities in medicine. Learning antibody molecular recognition would enable the in silico design of high affinity binders against nearly any proteinaceous surface. Yet, publicly available experiment antibody sequence-binding datasets may not contain the mutagenic, antigenic, or antibody sequence diversity necessary for deep learning approaches to capture molecular recognition. In part, this is because limited experimental platforms exist for assessing quantitative and simultaneous sequence-function relationships for multiple antibodies. Here we present MAGMA-seq, an integrated technology that combines multiple antigens and multiple antibodies and determines quantitative biophysical parameters using deep sequencing. We demonstrate MAGMA-seq on two pooled libraries comprising mutants of nine different human antibodies spanning light chain gene usage, CDR H3 length, and antigenic targets. We demonstrate the comprehensive mapping of potential antibody development pathways, sequence-binding relationships for multiple antibodies simultaneously, and identification of paratope sequence determinants for binding recognition for broadly neutralizing antibodies (bnAbs). MAGMA-seq enables rapid and scalable antibody engineering of multiple lead candidates because it can measure binding for mutants of many given parental antibodies in a single experiment