3,604 research outputs found
Classifying RI/FS Costs Under a Policy of Comprehensive General Liability Insurance: Indemnity or Defense
Classifying RI/FS Costs Under a Policy of Comprehensive General Liability Insurance: Indemnity or Defense
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Functional and Psychiatric Correlates of Comorbid Post-Traumatic Stress Disorder and Alcohol Use Disorder.
Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are common comorbid conditions that affect large segments of the population. Individuals with comorbid PTSD/AUD face greater clinical and functional stressors than those with diagnoses of either PTSD or AUD alone. The purpose of this article is to review the phenomenology and functional associations of PTSD/AUD and address the common social, occupational, and psychological concerns associated with both disorders. Given the increased problems associated with comorbid PTSD/AUD, clinical and research efforts should focus on targeting functional and psychosocial problems in conjunction with psychiatric symptoms
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Purpose in Life and Conscientiousness Protect Against the Development of Suicidal Ideation in U.S. Military Veterans With PTSD and MDD: Results From the National Health and Resilience in Veterans Study.
Background:Although several studies have examined risk factors for suicidal ideation among veterans, little is known about risk and protective factors for suicidal ideation in high-risk veteran samples. Thus, this study examined a broad range of risk and protective factors associated with the development of suicidal ideation in a high-risk sample of U.S. veterans who screened positive for current posttraumatic stress disorder (PTSD) and/or major depressive disorder (MDD). Methods:Data were analyzed from the National Health and Resilience in Veterans Study, a nationally representative, prospective cohort study of U.S. veterans. Veterans completed self-report measures to screen for PTSD and MDD and to assess for risk and protective factors. The sample included 222 veterans with PTSD and/or MDD who did not endorse suicidal ideation at baseline and completed at least one assessment over a seven-year follow-up period. A multivariable binary logistic regression analysis was conducted to examine baseline factors associated with incident suicidal ideation. Results:Nearly one in three (27.1%) of veterans with PTSD and/or MDD developed suicidal ideation over the seven-year follow-up period. Non-Caucasian race and lower scores on measures of purpose in life, conscientiousness, and frequency of religious service attendance were independently associated with incident suicidal ideation. Lower purpose in life (52.3%) and conscientiousness (33.2%) explained the vast majority of variance in incident suicidal ideation. Conclusion:Nearly 30% of veterans with PTSD and/or MDD who did not endorse suicidal ideation at baseline developed suicidal ideation over a seven-year period. Prevention and treatment efforts designed to bolster purpose in life and conscientiousness may help mitigate risk for suicidal ideation in this high-risk population
On the Formation Height of the SDO/HMI Fe 6173 Doppler Signal
The Helioseismic and Magnetic Imager (HMI) onboard the Solar Dynamics
Observatory (SDO) is designed to study oscillations and the mag- netic field in
the solar photosphere. It observes the full solar disk in the Fe I absorption
line at 6173\AA . We use the output of a high-resolution 3D, time- dependent,
radiation-hydrodynamic simulation based on the CO5BOLD code to calculate
profiles F({\lambda},x,y,t) for the Fe I 6173{\AA} line. The emerging profiles
F({\lambda},x,y,t) are multiplied by a representative set of HMI filter
transmission profiles R_i({\lambda},1 \leq i \leq 6) and filtergrams
I_i(x,y,t;1 \leq i \leq 6) are constructed for six wavelengths. Doppler
velocities V_HMI(x,y,t) are determined from these filtergrams using a
simplified version of the HMI pipeline. The Doppler velocities are correlated
with the original velocities in the simulated atmosphere. The cross-
correlation peaks near 100 km, suggesting that the HMI Doppler velocity signal
is formed rather low in the solar atmosphere. The same analysis is performed
for the SOHO/MDI Ni I line at 6768\AA . The MDI Doppler signal is formed
slightly higher at around 125 km. Taking into account the limited spatial
resolution of the instruments, the apparent formation height of both the HMI
and MDI Doppler signal increases by 40 to 50 km. We also study how
uncertainties in the HMI filter-transmission profiles affect the calculated
velocities.Comment: 15 pages, 11 Figure
Thermodynamics of Heat Shock Response
Production of heat shock proteins are induced when a living cell is exposed
to a rise in temperature. The heat shock response of protein DnaK synthesis in
E.coli for temperature shifts from temperature T to T plus 7 degrees,
respectively to T minus 7 degrees is measured as function of the initial
temperature T. We observe a reversed heat shock at low T. The magnitude of the
shock increases when one increase the distance to the temperature , thereby mimicking the non monotous stability of proteins at low
temperature. Further we found that the variation of the heat shock with T
quantitatively follows the thermodynamic stability of proteins with
temperature. This suggest that stability related to hot as well as cold
unfolding of proteins is directly implemented in the biological control of
protein folding. We demonstrate that such an implementation is possible in a
minimalistic chemical network.Comment: To be published in Physical Review Letter
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