1,691 research outputs found
Control sideband generation for dual-recycled laser interferometric gravitational wave detectors
We present a discussion of the problems associated with generation of multiple control sidebands for length sensing and control of dual-recycled, cavity-enhanced Michelson interferometers and the motivation behind more complicated sideband generation methods. We focus on the Mach–Zehnder interferometer as a topological solution to the problem and present results from tests carried out at the Caltech 40 m prototype gravitational wave detector. The consequences for sensing and control for advanced interferometry are discussed, as are the implications for future interferometers such as Advanced LIGO
Demonstration of detuned dual recycling at the Garching 30m laser interferometer
Dual recycling is an advanced optical technique to enhance the
signal-to-noise ratio of laser interferometric gravitational wave detectors in
a limited bandwidth. To optimise the center of this band with respect to
Fourier frequencies of expected gravitational wave signals detuned dual
recycling has to be implemented. We demonstrated detuned dual recycling on a
fully suspended 30m prototype interferometer. A control scheme that allows to
tune the detector to different frequencies will be outlined. Good agreement
between the experimental results and numerical simulations has been achieved.Comment: 9 page
Time to do more
AbstractAimsClinical inertia, the tendency to maintain current treatment strategies despite results demanding escalation, is thought to substantially contribute to the disconnect between clinical aspirations for patients with diabetes and targets achieved. We wished to explore potential causes of clinical inertia among physicians and people with diabetes.MethodsA 20-min online survey of 652 adults with diabetes and 337 treating physicians in six countries explored opinions relating to clinical inertia from both perspectives, in order to correlate perceptions and expectations relating to diagnosis, treatment, diabetes complications and therapeutic escalation.ResultsPhysicians had low expectations for their patients, despite the belief that the importance of good glycaemic control through lifestyle and pharmacological interventions had been adequately conveyed. Conversely, people with diabetes had, at best, a rudimentary understanding of the risks of complications and the importance of good control; indeed, only a small proportion believed lifestyle changes were important and the majority did not intend to comply.ConclusionsThe principal findings of this survey suggest that impairments in communication are at the heart of clinical inertia. This manuscript lays out four key principles that we believe are achievable in all environments and can improve the lives of people with diabetes
Invited Article: CO_2 laser production of fused silica fibers for use in interferometric gravitational wave detector mirror suspensions
In 2000 the first mirror suspensions to use a quasi-monolithic final stage were installed at the GEO600 detector site outside Hannover, pioneering the use of fused silica suspension fibers in long baseline interferometric detectors to reduce suspension thermal noise. Since that time, development of the production methods of fused silica fibers has continued. We present here a review of a novel CO_2 laser-based fiber pulling machine developed for the production of fused silica suspensions for the next generation of interferometric gravitational wave detectors and for use in experiments requiring low thermal noise suspensions. We discuss tolerances, strengths, and thermal noise performance requirements for the next generation of gravitational wave detectors. Measurements made on fibers produced using this machine show a 0.8% variation in vertical stiffness and 0.05% tolerance on length, with average strengths exceeding 4 GPa, and mechanical dissipation which meets the requirements for Advanced LIGO thermal noise performance
The impact of COVID-19 on medical education and medical students. How and when can they return to placements?
This article was migrated. The article was marked as recommended.
The defining feature of 2020 will be the early and mid-stages of the covid-19 pandemic, declared by the World Health Organisation on 11th March. Rapid worldwide exponential spread continues and by 15 April, more than 1 900 000 cases and 123 000 deaths had been reported worldwide (WHO, 2020).
Health services have coped to varying degrees. One common feature has been the withdrawal of routine care (Iacobucci, 2020a) and 'non-essential' staff including learners, although many have returned to undertake care roles. As the likely timeframe for stabilisation of health services becomes clearer, certainly in the United Kingdom (UK) (Iacobucci, 2020b), medical educators need to rapidly get the teaching of the next generation of health care workers back on track if they are to enter health services as confident and competent practitioners in 2020 and 2021.
Although a 'whole world' experience, the effects of covid-19 sit in national contexts. We detail the issues for the UK in re-starting and re-inventing medical education, noting that the principles, if not necessarily the detail, will be common across the world
Weight change and sulfonylurea therapy are related to 3 year change in microvascular function in people with type 2 diabetes
Aims/hypothesis: Although cardiovascular disease is the biggest cause of death in people with diabetes, microvascular complications have a significant impact on quality of life and financial burden of the disease. Little is known about the progression of microvascular dysfunction in the early stages of type 2 diabetes before the occurrence of clinically apparent complications. We aimed to explore the determinants of endothelial-dependent and -independent microvascular function progression over a 3 year period, in people with and without both diabetes and few clinical microvascular complications.
Methods: Demographics were collected in 154 participants with type 2 diabetes and in a further 99 participants without type 2 diabetes. Skin microvascular endothelium-dependent response to iontophoresis of acetylcholine and endothelium-independent responses to sodium nitroprusside were measured using laser Doppler fluximetry. All assessments were repeated 3 years later.
Results: People with type 2 diabetes had impaired endothelial-dependent microvascular response compared with those without (AUC 93.9 [95% CI 88.1, 99.4] vs 111.9 [102.3, 121.4] arbitrary units [AU] × min, p < 0.001, for those with vs without diabetes, respectively). Similarly, endothelial-independent responses were attenuated in those with diabetes (63.2 [59.2, 67.2] vs 75.1 [67.8, 82.4] AU × min, respectively, p = 0.002). Mean microvascular function declined over 3 years in both groups to a similar degree (pinteraction 0.74 for response to acetylcholine and 0.69 for response to sodium nitroprusside). In those with diabetes, use of sulfonylurea was associated with greater decline (p = 0.022 after adjustment for co-prescriptions, change in HbA1c and weight), whereas improving glycaemic control was associated with less decline of endothelial-dependent microvascular function (p = 0.03). Otherwise, the determinants of microvascular decline were similar in those with and without diabetes. The principal determinant of change in microvascular function in the whole population was weight change over 3 years, such that those that lost ≥5% weight had very little decline in either endothelial-dependent or -independent function compared with those that were weight stable, whereas those who gained weight had a greater decline in function (change in endothelial-dependent function was 1.2 [95% CI -13.2, 15.7] AU × min in those who lost weight; -15.8 [-10.5, -21.0] AU × min in those with stable weight; and -37.8 [-19.4, -56.2] AU × min in those with weight gain; ptrend < 0.001). This association of weight change with change in endothelial function was driven by people with diabetes; in people without diabetes, the relationship was nonsignificant.
Conclusions/interpretation: Over 3 years, physiological change in weight was the greatest predictor of change in microvascular function.This article is freely available via Open Access. Click on the Publisher URL to access it via the publisher's site.This work was supported by the Innovative Medicines Initiative (the SUMMIT consortium, IMI-2008/115006).published version, accepted version (12 month embargo
Squeezed Light for the Interferometric Detection of High Frequency Gravitational Waves
The quantum noise of the light field is a fundamental noise source in
interferometric gravitational wave detectors. Injected squeezed light is
capable of reducing the quantum noise contribution to the detector noise floor
to values that surpass the so-called Standard-Quantum-Limit (SQL). In
particular, squeezed light is useful for the detection of gravitational waves
at high frequencies where interferometers are typically shot-noise limited,
although the SQL might not be beaten in this case. We theoretically analyze the
quantum noise of the signal-recycled laser interferometric gravitational-wave
detector GEO600 with additional input and output optics, namely
frequency-dependent squeezing of the vacuum state of light entering the dark
port and frequency-dependent homodyne detection. We focus on the frequency
range between 1 kHz and 10 kHz, where, although signal recycled, the detector
is still shot-noise limited. It is found that the GEO600 detector with present
design parameters will benefit from frequency dependent squeezed light.
Assuming a squeezing strength of -6 dB in quantum noise variance, the
interferometer will become thermal noise limited up to 4 kHz without further
reduction of bandwidth. At higher frequencies the linear noise spectral density
of GEO600 will still be dominated by shot-noise and improved by a factor of
10^{6dB/20dB}~2 according to the squeezing strength assumed. The interferometer
might reach a strain sensitivity of 6x10^{-23} above 1 kHz (tunable) with a
bandwidth of around 350 Hz. We propose a scheme to implement the desired
frequency dependent squeezing by introducing an additional optical component to
GEO600s signal-recycling cavity.Comment: Presentation at AMALDI Conference 2003 in Pis
Photon pressure induced test mass deformation in gravitational-wave detectors
A widely used assumption within the gravitational-wave community has so far
been that a test mass acts like a rigid body for frequencies in the detection
band, i.e. for frequencies far below the first internal resonance. In this
article we demonstrate that localized forces, applied for example by a photon
pressure actuator, can result in a non-negligible elastic deformation of the
test masses. For a photon pressure actuator setup used in the gravitational
wave detector GEO600 we measured that this effect modifies the standard
response function by 10% at 1 kHz and about 100% at 2.5 kHz
Robust vetoes for gravitational-wave burst triggers using known instrumental couplings
The search for signatures of transient, unmodelled gravitational-wave (GW)
bursts in the data of ground-based interferometric detectors typically uses
`excess-power' search methods. One of the most challenging problems in the
burst-data-analysis is to distinguish between actual GW bursts and spurious
noise transients that trigger the detection algorithms. In this paper, we
present a unique and robust strategy to `veto' the instrumental glitches. This
method makes use of the phenomenological understanding of the coupling of
different detector sub-systems to the main detector output. The main idea
behind this method is that the noise at the detector output (channel H) can be
projected into two orthogonal directions in the Fourier space -- along, and
orthogonal to, the direction in which the noise in an instrumental channel X
would couple into H. If a noise transient in the detector output originates
from channel X, it leaves the statistics of the noise-component of H orthogonal
to X unchanged, which can be verified by a statistical hypothesis testing. This
strategy is demonstrated by doing software injections in simulated Gaussian
noise. We also formulate a less-rigorous, but computationally inexpensive
alternative to the above method. Here, the parameters of the triggers in
channel X are compared to the parameters of the triggers in channel H to see
whether a trigger in channel H can be `explained' by a trigger in channel X and
the measured transfer function.Comment: 14 Pages, 8 Figures, To appear in Class. Quantum Gra
Lunar Outgassing, Transient Phenomena and The Return to The Moon, I: Existing Data
Herein the transient lunar phenomena (TLP) report database is subjected to a
discriminating statistical filter robust against sites of spurious reports, and
produces a restricted sample that may be largely reliable. This subset is
highly correlated geographically with the catalog of outgassing events seen by
the Apollo 15, 16 and Lunar Prospector alpha-particle spectrometers for
episodic Rn-222 gas release. Both this robust TLP sample and even the larger,
unfiltered sample are highly correlated with the boundary between mare and
highlands, as are both deep and shallow moonquakes, as well as Po-210, a
long-lived product of Rn-222 decay and a further tracer of outgassing. This
offers another significant correlation relating TLPs and outgassing, and may
tie some of this activity to sagging mare basalt plains (perhaps mascons).
Additionally, low-level but likely significant TLP activity is connected to
recent, major impact craters (while moonquakes are not), which may indicate the
effects of cracks caused by the impacts, or perhaps avalanches, allowing
release of gas. The majority of TLP (and Rn-222) activity, however, is confined
to one site that produced much of the basalt in the Procellarum Terrane, and it
seems plausible that this TLP activity may be tied to residual outgassing from
the formerly largest volcanic ffusion sites from the deep lunar interior. With
the coming in the next few years of robotic spacecraft followed by human
exploration, the study of TLPs and outgassing is both promising and imperiled.
We will have an unprecedented pportunity to study lunar outgassing, but will
also deal with a greater burden of anthropogenic lunar gas than ever produced.
There is a pressing need to study lunar atmosphere and its sources while still
pristine. [Abstract abridged.]Comment: 35 pages, 3 figures, submitted to Icarus. Other papers in series
found at http://www.astro.columbia.edu/~arlin/TLP
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