38 research outputs found
Propulsion challenges and opportunities for high-speed transport aircraft
For several years there was a growing interest in the subject of efficient sustained supersonic cruise technology applied to a high-speed transport aircraft. The major challenges confronting the propulsion community for supersonic transport (SST) applications are identified. Both past progress and future opportunities are discussed in relation to perceived technology shortfalls for an economically successful SST that satisfies environmental constraints. A very large improvement in propulsion system efficiency is needed both at supersonic and subsonic cruise conditions. Toward that end, several advanced engine concepts are being considered that, together with advanced discipline and component technologies, promise at least 40 percent better efficiency that the Concorde engine. The quest for higher productivity through higher speed is also thwarted by the lack of a conventional, low-priced fuel that is thermally stable at the higher temperatures associated with faster flight. Airport noise remains a tough challenge because previously researched concepts fall short of achieving FAR 36 Stage 3 noise levels. Innovative solutions may be necessary to reach acceptably low noise. While the technical challenges are indeed formidable, it is reasonable to assume that the current shortfalls in fuel economy and noise can be overcome through an aggressive propulsion research program
Propulsion challenges and opportunities for high-speed transport aircraft
The major challenges confronting the propulsion community for supersonic transport applications are identified. Both past progress and future opportunities are discussed in relation to perceived technology shortfalls for an economically successful SST that satisfies environmental constraint. A very large improvement in propulsion system efficiency is needed both at supersonic cruise and subsonic cruise conditions. Toward this end, several advanced engine concepts are being considered that promise up to 25 pct. better efficiency than the Concorde engine. The quest for high productivity through higher speed is also thwarted by the lack of a conventional, low priced fuel that is thermally stable at the higher temperatures associated with faster flight. Extending Jet A type fuel to higher temperatures and the adoption of liquid natural gas or methane are two possibilities requiring further study. Airport noise remains a tough challenge because previously researched concepts fall short of achieving FAR 36 Stage III noise levels. Innovative solutions may be necessary to reach acceptably low noise
The challenges and opportunities of supersonic transport propulsion technology
The major challenges confronting the propulsion community for civil supersonic transport applications are identified: high propulsion system efficiency at both supersonic and subsonic cruise conditions, low-cost fuel with adequate thermal stability at high temperatures, low noise cycles and exhaust systems, low emission combustion systems, and low drag installations. Both past progress and future opportunities are discussed in relation to perceived technology shortfalls for an economically successful airplane that satisfies environmental constraints
Probabilistic Design and Analysis Framework
PRODAF is a software package designed to aid analysts and designers in conducting probabilistic analysis of components and systems. PRODAF can integrate multiple analysis programs to ease the tedious process of conducting a complex analysis process that requires the use of multiple software packages. The work uses a commercial finite element analysis (FEA) program with modules from NESSUS to conduct a probabilistic analysis of a hypothetical turbine blade, disk, and shaft model. PRODAF applies the response surface method, at the component level, and extrapolates the component-level responses to the system level. Hypothetical components of a gas turbine engine are first deterministically modeled using FEA. Variations in selected geometrical dimensions and loading conditions are analyzed to determine the effects of the stress state within each component. Geometric variations include the cord length and height for the blade, inner radius, outer radius, and thickness, which are varied for the disk. Probabilistic analysis is carried out using developing software packages like System Uncertainty Analysis (SUA) and PRODAF. PRODAF was used with a commercial deterministic FEA program in conjunction with modules from the probabilistic analysis program, NESTEM, to perturb loads and geometries to provide a reliability and sensitivity analysis. PRODAF simplified the handling of data among the various programs involved, and will work with many commercial and opensource deterministic programs, probabilistic programs, or modules
The NASA sponsored HSCT propulsion studies
One objective of the NASA-sponsored High Speed Civil Transport (HSCT) propulsion studies is to determine the potential benefits of alternative advanced technologies. These benefits should be explicitly expressed in terms of meeting either environmental acceptability or economic viability. The potential benefit information is used to screen alternative technology candidates to the most promising technologies that, if successfully developed, will enable the propulsion system to achieve high performance and low weight without unduly sacrificing favorable emissions and noise characteristics. A second objective is the provision of key information to high-level decision makers--enabling them to make rational decisions concerning the technology program content. It will be necessary to pursue more than one concept/technology until experimental validity is convincingly demonstrated. Some technologies will likely fail to achieve their stated goals, and timely program redirection depends upon far-sighted system studies to provide such information
Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049