Employment status and mental health care use in times of economic contraction: a repeated cross-sectional study in Europe, using a three-level model

Introduction: Framed within the recent economic crisis, in this study we investigate the medical mental health care use of the unemployed compared with that of the employed in Europe, and whether the relationship between employment status and mental health care use varies across macro-economic conditions. We examine whether the macro-economic context and changes therein are related to mental health care use, via their impact on mental health, or more directly, irrespective of mental health. Methods: We use data from three waves of the Eurobarometer (2002, 2005/2006, and 2010), which has a repeated cross-sectional and cross-national design. Linear and logistic multilevel regression analyses are performed with mental health, contacting a general practitioner, and contacting a psychiatrist for mental health problems as dependent variables. The multilevel design has three levels (the individual, the period-country, and the country), which allows us to estimate both longitudinal and cross-sectional macro-effects. The macro-economic context and changes therein are assessed using national unemployment rates and growth rates in Gross Domestic Product (GDP). Results: The mean unemployment rate is negatively related to mental health, although for women, this effect only applies to the employed. Among women, no relationship is found between changes in the macro-economic context and mental health. The unemployment rate, and changes in both the unemployment rate and the real GDP growth rate, are associated with men’s care use, regardless of their mental health, whereas this does not hold for women. In countries with an increase in the unemployment rate, both unemployed and employed men tend to medicalize their problems more by contacting a general practitioner, irrespective of their mental health, while the likelihood of contacting a psychiatrist is lower among employed men. Conclusions: Our findings stress the importance of taking the macro-economic context and changes therein into account when studying the mental health care use of unemployed people compared with the employed, in particular among men. Moreover, it is important to make the distinction between primary and specialized medical care use, as the impact of macro-economic conditions is dependent on the type of care, which also applies when controlling for mental health

Machine learning: statistical physics based theory and smart industry applications

The increasing computational power and the availability of data have made it possible to train ever-bigger artificial neural networks. These so-called deep neural networks have been used for impressive applications, like advanced driver assistance and support in medical diagnoses. However, various vulnerabilities have been revealed and there are many open questions concerning the workings of neural networks. Theoretical analyses are therefore essential for further progress. One current question is: why is it that networks with Rectified Linear Unit (ReLU) activation seemingly perform better than networks with sigmoidal activation?We contribute to the answer to this question by comparing ReLU networks with sigmoidal networks in diverse theoretical learning scenarios. In contrast to analysing specific datasets, we use a theoretical modelling using methods from statistical physics. They give the typical learning behaviour for chosen model scenarios. We analyse both the learning behaviour on a fixed dataset and on a data stream in the presence of a changing task. The emphasis is on the analysis of the network’s transition to a state wherein specific concepts have been learnt. We find significant benefits of ReLU networks: they exhibit continuous increases of their performance and adapt more quickly to changing tasks.In the second part of the thesis we treat applications of machine learning: we design a quick quality control method for material in a production line and study the relationship with product faults. Furthermore, we introduce a methodology for the interpretable classification of time series data

Cold exposure induces dynamic changes in circulating triacylglycerol species, which is dependent on intracellular lipolysis: A randomized cross-over trial

Background The application of cold exposure has emerged as an approach to enhance whole-body lipid catabolism. The global effect of cold exposure on the lipidome in humans has been reported with mixed results depending on intensity and duration of cold. Methods This secondary study was based on data from a previous randomized cross-over trial (ClinicalTrials.gov ID: NCT03012113). We performed sequential lipidomic profiling in serum during 120 min cold exposure of human volunteers. Next, the intracellular lipolysis was blocked in mice (eighteen 10-week-old male wild-type mice C57BL/ 6J) using a small-molecule inhibitor of adipose triglyceride lipase (ATGL; Atglistatin), and mice were exposed to cold for a similar duration. The quantitative lipidomic profiling was assessed in-depth using the Lipidyzer platform. Findings In humans, cold exposure gradually increased circulating free fatty acids reaching a maximum at 60 min, and transiently decreased total triacylglycerols (TAGs) only at 30 min. A broad range of TAG species was initially decreased, in particular unsaturated and polyunsaturated TAG species with ≤5 double bonds, while after 120 min a significant increase was observed for polyunsaturated TAG species with ≥6 double bonds in humans. The mechanistic study in mice revealed that the cold-induced increase in polyunsaturated TAGs was largely prevented by blocking adipose triglyceride lipase. Interpretation We interpret these findings as that cold exposure feeds thermogenic tissues with TAG-derived fatty acids for combustion, resulting in a decrease of circulating TAG species, followed by increased hepatic production of polyunsaturated TAG species induced by liberation of free fatty acids stemming from adipose tissue.Netherlands CardioVascular Research Initiative: `the Dutch Heart FoundationDutch Federation of University Medical CentersNetherlands Organization for Health Research and Development Royal Netherlands Academy of Sciences' CVON201720 GENIUS-IIFundacion Alfonso Martin EscuderoMaria Zambrano - Ministerio de Universidades y la Union Europea -NextGenerationEU RR_C_2021_04Spanish Government FPU19/01609European Foundation for the Study of Diabetes (EFSD)NWO XOmics project 184.034.01

Complete genome sequences of escherichia coli phages vB_EcoM-EP75 and vB_EcoP-EP335

Phages vB_EcoM-EP75 (EP75) and vB_EcoP-EP335 (EP335) specifically infect Shiga toxin (Stx)-producing Escherichia coli (STEC) O157 strains. EP75 has a genome size of 158,143 bp and belongs to the genus Vi1virus The genome size of EP335 is 76,622 bp, and it belongs to the genus Phieco32virus

Medicalization of sleep problems in an aging population : a longitudinal cross-national study of medication use for sleep problems in older European adults

OBJECTIVE: The association between age and sleep problems is considered to be positive, and medication use is a common health care intervention among older individuals. Because daytime consequences are often stated as a reason to seek care, we study to what extent the medicalization of sleep problems is found in an aging European population, with a focus on daily activities. METHOD: Data from the Survey of Health Ageing and Retirement in Europe are used in three-level, generalized linear mixed models. Medicalization is operationalized as the use of medication for sleep problems at least once per week. RESULTS: Men are more likely than women to use medication for sleep problems, and the process of aging is associated with a decrease in medicalization. DISCUSSION: Sleep problems seem to be medicalized particularly when they prevent aging individuals from engaging in work-related responsibilities, as medication is especially used by employed individuals with sleep problems.status: publishe

Evidence for metabolic activity of airborne bacteria

Aerosols of the bacterium Serratia marcescens, and of uniformly labelled C-14 glucose, were created simultaneously and mixed in tubing leading to an aerosol chamber. During a subsequent period of about 5 hrs, C-14O2 was produced unequivocally within the chamber, and insoluble, labelled material within the suspended particles first increased, then decreased