The bend stiffness of S-DNA

We formulate and solve a two-state model for the elasticity of nicked, double-stranded DNA that borrows features from both the Worm Like Chain and the Bragg--Zimm model. Our model is computationally simple, and gives an excellent fit to recent experimental data through the entire overstretching transition. The fit gives the first value for the bending stiffness of the overstretched state as about 10 nm*kbt, a value quite different from either B-form or single-stranded DNA.Comment: 7 pages, 1 figur

The Experiences of Mental Illness and Addiction among Men and Women with Co-occurring Disorders

The study presented used empirical phenomenological methods to gain insight into the experiences of chemical dependence and mental illness among men and women with co-occurring disorders. The literature review discussed issues concerning: gender with the self-construal, traditional gender norms, and gender as a factor in the co-occurring disorder population. The results of this study include the following themes: catalysts for change, positive and negative self-concept, substance use as a means of self-medication, and therapeutic factors. Implications for the counseling profession, and implications for further research were discussed

Off-lattice Monte Carlo Simulation of Supramolecular Polymer Architectures

We introduce an efficient, scalable Monte Carlo algorithm to simulate cross-linked architectures of freely-jointed and discrete worm-like chains. Bond movement is based on the discrete tractrix construction, which effects conformational changes that exactly preserve fixed-length constraints of all bonds. The algorithm reproduces known end-to-end distance distributions for simple, analytically tractable systems of cross-linked stiff and freely jointed polymers flawlessly, and is used to determine the effective persistence length of short bundles of semi-flexible worm-like chains, cross-linked to each other. It reveals a possible regulatory mechanism in bundled networks: the effective persistence of bundles is controlled by the linker density.Comment: 4 pages, 4 figure

Evaluation of SIR-A space radar for geologic interpretation: United States, Panama, Colombia, and New Guinea

Comparisons between LANDSAT MSS imagery, and aircraft and space radar imagery from different geologic environments in the United States, Panama, Colombia, and New Guinea demonstrate the interdependence of radar system geometry and terrain configuration for optimum retrieval of geologic information. Illustrations suggest that in the case of space radars (SIR-A in particular), the ability to acquire multiple look-angle/look-direction radar images of a given area is more valuable for landform mapping than further improvements in spatial resolution. Radar look-angle is concluded to be one of the most important system parameters of a space radar designed to be used for geologic reconnaissance mapping. The optimum set of system parameters must be determined for imaging different classes of landform features and tailoring the look-angle to local topography

Infrared Surface Brightness Distances to Cepheids: a comparison of Bayesian and linear-bisector calculations

We have compared the results of Bayesian statistical calculations and linear-bisector calculations for obtaining Cepheid distances and radii by the infrared surface brightness method. We analyzed a set of 38 Cepheids using a Bayesian Markov Chain Monte Carlo method that had been recently studied with a linear-bisector method. The distances obtained by the two techniques agree to 1.5 \pm 0.6% with the Bayesian distances being larger. The radii agree to 1.1% \pm 0.7% with the Bayesian determinations again being larger. We interpret this result as demonstrating that the two methods yield the same distances and radii. This implies that the short distance to the LMC found in recent linear-bisector studies of Cepheids is not caused by deficiencies in the mathematical treatment. However, the computed uncertainties in distance and radius for our dataset are larger in the Bayesian calculation by factors of 1.4-6.7. We give reasons to favor the Bayesian computations of the uncertainties. The larger uncertainties can have a significant impact upon interpretation of Cepheid distances and radii obtained from the infrared surface brightness method.Comment: 27 pages with 9 figure

Social Circuits: Peptidergic Regulation of Mammalian Social Behavior

Mammals have developed patterns of social relationships that enhance the survival of individuals and maximize the reproductive success of species. Although social stimuli and social responses are highly complex, recent studies are providing substantial insights into their neural substrates. Neural pathways employing the nonapeptides vasopressin and oxytocin play a particularly prominent role both in social recognition and the expression of appropriate social responses. New insights into social neuroscience are discussed, along with the relevance of this rapidly developing field to human relationships and disease processes

Glomerulonephritis and malignancy: A population-based analysis

Glomerulonephritis and malignancy: A population-based analysis.BackgroundAn association between glomerulonephritis and malignant tumors has previously both been found and discarded in clinical series, but to our knowledge never has been tested in a population-based setting.MethodsThe Danish Kidney Biopsy Registry includes all kidney biopsies performed from 1985. Using a unique personal identification number, each person in the registry to the National Population Registry and the Danish Cancer Registry were linked. Cancer occurrence after the biopsy was compared in patients with morphological, glomerular diseases with that of the general Danish population, taking into account sex, age, calendar period and time since biopsy, and the 95% confidence interval (95% CI) for the observed-to-expected rates was calculated, assuming a Poisson distribution. Cancer occurrence was stratified to <1 year, 1 to 4, and ≥5 years after a biopsy.ResultsA total of 102 de novo cancers were found in 1958 patients. These cancers represent a two- to threefold excess of the expected number at <1 and 1 to 4, but not ≥5 years after a biopsy. Non-Hodgkin's lymphomas were observed six to eight times more than expected. Cancer excess was seen in glomerulonephritides with a known or suspected virus etiology.ConclusionsThe excess cancer rate could be the result of underlying undiagnosed tumors whose antigens have initiated glomerulonephritis, or the immunosuppressive therapy that initiated or energized tumor cells. Based on the findings in our study, there is some support for an association to persistent viruses causing first the glomerulonephritides and then the malignancies, perhaps through a common pathogenesis. This calls for other studies to be done that are specifically designed to investigate this issue, with more data on patient characteristics and confounders

Critical behaviour in the nonlinear elastic response of hydrogels

In this paper we study the elastic response of synthetic hydrogels to an applied shear stress. The hydrogels studied here have previously been shown to mimic the behaviour of biopolymer networks when they are sufficiently far above the gel point. We show that near the gel point they exhibit an elastic response that is consistent with the predicted critical behaviour of networks near or below the isostatic point of marginal stability. This point separates rigid and floppy states, distinguished by the presence or absence of finite linear elastic moduli. Recent theoretical work has also focused on the response of such networks to finite or large deformations, both near and below the isostatic point. Despite this interest, experimental evidence for the existence of criticality in such networks has been lacking. Using computer simulations, we identify critical signatures in the mechanical response of sub-isostatic networks as a function of applied shear stress. We also present experimental evidence consistent with these predictions. Furthermore, our results show the existence of two distinct critical regimes, one of which arises from the nonlinear stretch response of semi-flexible polymers.