2,456 research outputs found
A quantitative central limit theorem for linear statistics of random matrix eigenvalues
It is known that the fluctuations of suitable linear statistics of Haar
distributed elements of the compact classical groups satisfy a central limit
theorem. We show that if the corresponding test functions are sufficiently
smooth, a rate of convergence of order almost can be obtained using a
quantitative multivariate CLT for traces of powers that was recently proven
using Stein's method of exchangeable pairs.Comment: Title modified; main result stated under slightly weaker conditions;
accepted for publication in the Journal of Theoretical Probabilit
Reciprocal Inhibition of Adiponectin and Innate Lung Immune Responses to Chitin and Aspergillus fumigatus
Chitin is a structural biopolymer found in numerous organisms, including pathogenic fungi, and recognized as an immune-stimulating pathogen associated molecular pattern by pattern recognition molecules of the host immune system. However, programming and regulation of lung innate immunity to chitin inhalation in the context of inhalation of fungal pathogens such as Aspergillus fumigatus is complex and our understanding incomplete. Here we report that the systemic metabolism-regulating cytokine adiponectin is decreased in the lungs and serum of mice after chitin inhalation, with a concomitant decrease in surface expression of the adiponectin receptor AdipoR1 on lung leukocytes. Constitutive lung expression of acidic mammalian chitinase resulted in decreased inflammatory cytokine gene expression and neutrophil recruitment, but did not significantly affect lung adiponectin transcription. Exogenous recombinant adiponectin specifically dampened airway chitin-mediated eosinophil recruitment, while adiponectin deficiency resulted in increased airway eosinophils. The presence of adiponectin also resulted in decreased CCL11-mediated migration of bone marrow-derived eosinophils. In contrast to purified chitin, aspiration of viable conidia from the high chitin-expressing A. fumigatus isolate Af5517 resulted in increased neutrophil recruitment and inflammatory cytokine gene expression in adiponectin-deficient mice, while no significant changes were observed in response to the isolate Af293. Our results identify a novel role for the adiponectin pathway in inhibition of lung inflammatory responses to chitin and A. fumigatus inhalation
Single Proton Knock-Out Reactions from 24,25,26F
The cross sections of the single proton knock-out reactions from 24F, 25F,
and 26F on a 12C target were measured at energies of about 50 MeV/nucleon.
Ground state populations of 6.6+-.9 mb, 3.8+-0.6 mb for the reactions
12C(24F,23O) and 12C(25F,24O) were extracted, respectively. The data were
compared to calculations based on the many-body shell model and the eikonal
theory. In the reaction 12C(26F,25O) the particle instability of 25O was
confirmed
Excitonic Photoluminescence in Semiconductor Quantum Wells: Plasma versus Excitons
Time-resolved photoluminescence spectra after nonresonant excitation show a
distinct 1s resonance, independent of the existence of bound excitons. A
microscopic analysis identifies excitonic and electron-hole plasma
contributions. For low temperatures and low densities the excitonic emission is
extremely sensitive to even minute optically active exciton populations making
it possible to extract a phase diagram for incoherent excitonic populations.Comment: 9 pages, 4 figure
Comparison of Simulator Wear Measured by Gravimetric vs Optical Surface Methods for Two Million Cycles
Understanding wear mechanisms are key for better implants
Critical to the success of the simulation
Small amount of metal wear can have catastrophic effects in the patient such as heavy metal poisoning or deterioration of the bone/implant interface leading to implant failure
Difficult to measure in heavy hard-on-hard implants (metal-on-metal or ceramic-on-ceramic)
May have only fractions of a milligram of wear on a 200 g component
At the limit of detection of even high-end balances when the component is 200 g and the change in weight is on the order of 0.000 1 grams
Here we compare the standard gravimetric wear estimate with
A non-contact 3D optical profiling method at each weighing stop
A coordinate measuring machine (CMM) at the beginning and end of the ru
On the Coulomb-dipole transition in mesoscopic classical and quantum electron-hole bilayers
We study the Coulomb-to-dipole transition which occurs when the separation
of an electron-hole bilayer system is varied with respect to the
characteristic in-layer distances. An analysis of the classical ground state
configurations for harmonically confined clusters with reveals that
the energetically most favorable state can differ from that of two-dimensional
pure dipole or Coulomb systems. Performing a normal mode analysis for the N=19
cluster it is found that the lowest mode frequencies exhibit drastic changes
when is varied. Furthermore, we present quantum-mechanical ground states
for N=6, 10 and 12 spin-polarized electrons and holes. We compute the
single-particle energies and orbitals in self-consistent Hartree-Fock
approximation over a broad range of layer separations and coupling strengths
between the limits of the ideal Fermi gas and the Wigner crystal
Simplicity of eigenvalues in Anderson-type models
We show almost sure simplicity of eigenvalues for several models of
Anderson-type random Schr\"odinger operators, extending methods introduced by
Simon for the discrete Anderson model. These methods work throughout the
spectrum and are not restricted to the localization regime. We establish
general criteria for the simplicity of eigenvalues which can be interpreted as
separately excluding the absence of local and global symmetries, respectively.
The criteria are applied to Anderson models with matrix-valued potential as
well as with single-site potentials supported on a finite box.Comment: 20 page
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