25 research outputs found

    Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study

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    Despite current guidelines, intraperitoneal drain placement after elective colorectal surgery remains widespread. Drains were not associated with earlier detection of intraperitoneal collections, but were associated with prolonged hospital stay and increased risk of surgical-site infections.Background Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice. Methods COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing elective colorectal surgery (February to March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included: rate and time to diagnosis of postoperative intraperitoneal collections; rate of surgical site infections (SSIs); time to discharge; and 30-day major postoperative complications (Clavien-Dindo grade at least III). After propensity score matching, multivariable logistic regression and Cox proportional hazards regression were used to estimate the independent association of the secondary outcomes with drain placement. Results Overall, 1805 patients from 22 countries were included (798 women, 44.2 per cent; median age 67.0 years). The drain insertion rate was 51.9 per cent (937 patients). After matching, drains were not associated with reduced rates (odds ratio (OR) 1.33, 95 per cent c.i. 0.79 to 2.23; P = 0.287) or earlier detection (hazard ratio (HR) 0.87, 0.33 to 2.31; P = 0.780) of collections. Although not associated with worse major postoperative complications (OR 1.09, 0.68 to 1.75; P = 0.709), drains were associated with delayed hospital discharge (HR 0.58, 0.52 to 0.66; P < 0.001) and an increased risk of SSIs (OR 2.47, 1.50 to 4.05; P < 0.001). Conclusion Intraperitoneal drain placement after elective colorectal surgery is not associated with earlier detection of postoperative collections, but prolongs hospital stay and increases SSI risk

    A rethink on Retropinna: conservation implications of new taxa and significant genetic sub-structure in Australian smelts (Pisces : Retropinnidae)

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    © CSIRO 2007The smelt genus Retropinna nominally includes three small (<150 mm) freshwater fish species endemic to south-eastern Australia and New Zealand. For the two Australian species, the broad range of R. semoni (Weber) on the mainland suggests some vulnerability to isolation and genetic divergence, whereas the apparent confinement of R. tasmanica McCulloch to Tasmania is curious if, as suspected, it is anadromous. Analyses of Australian material using allozyme electrophoresis show five genetically distinct species with contiguous ranges and no evidence of genetic exchange. Three occur along the eastern seaboard (including three instances of sympatry), another in coastal and inland south-eastern Australia and Tasmania, and a fifth species in the Lake Eyre Basin. There is no indication of a simple ‘tasmanica’ v. ‘semoni’ dichotomy, but instead a complex pattern involving discrete clusters for the Upper Murray plus Darling rivers, Lower Murray, Glenelg River and Tasmanian regions, with coastal western Victorian samples having varying affinity to these groups. The overall pattern is one of deep divergences among species and strong genetic sub-structuring within and provides a strong argument for extended studies to prepare for appropriate conservation measures.Michael P. Hammer, Mark Adams, Peter J. Unmack and Keith F. Walke
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