Influence of subclinical hypothyroidism on endothel function, coronary microcirculation and the appearance of early atherosclerotic changes in the carotid arteries

Uvod: Iako je poznato da tiroidni hormoni imaju značajan efekat na kardiovaskularni sistem, uticaj blage tiroidne disfunkcije u pravcu subkliničke hipotireoze na funkcionalne kardiovaskularne promene i dalje je otvoreno pitanje. Ispitivali smo povezanost promene u tiroidnoj funkciji u pravcu subkliničke hipotireoze sa mikrovaskularnom disfunkcijom i ranim aterosklerotskim promenama na krvnim sudovima. Metodologija: istraživanje je uključilo je 78 ispitanika sa subkliničkom hipotireozom i 55 ispitanika sa urednom tiroidnom funkcijom. Određeni su tiroidni hormonski status, antropometrijski i metabolički parametri. Merene su i izračunate protokom posredovana dilatacija (PPD), debljina intima-medija kompleksa (IMK) i koronarna rezerva protoka (KRP). Rezultati: vrednosti PPD, debljina IMK i KRP se nisu značajno razlikovale među grupama i nije bilo povezanosti PPD, debljine IMK i KRP sa tiroidnim hormonskim statusom. Kod osoba sa subkliničkom hipotireozom, ali ne i kod eutiroidnih osoba nađena je značajna povezanost debljine IMK sa indeksom telesne mase, vrednostima glikemije, HOMA IR i fT4 i značajna povezanost KRP sa sa odnosom struka i kukova, hipertenzijom, pušenjem, markerima glikoregulacije, holesterolom, LDL-holesterolom i trigliceridima. Zaključak: Zaključili smo da postoji različit uticaj klasičnih kardiovaskularnih faktora rizika na debljinu IMK i KRP kod osoba sa subkliničkom hipotireozom u poređenju sa eutiroidnim osobama i da se ove dve grupe različito ponašaju u istim okolnostima, pod istim faktorima rizika. Osnova za ovu razliku bi mogla biti izmenjen „set point“ hipotalamo-hipofizno-tiroidne osovine koji menja osetljivost mikrovaskulature kod osoba sa subkliničkom hipotireozom na poznate faktore rizika u pravcu koji je proaterogen i čini ih podložnijim za hroničnu inflamaciju niskog stepena.Background: Although thyroid hormones have significant effect on cardiovascular system, the impact of subtle thyroid dysfunction such as subclinical hypothyroidism remains to be determined. We investigated possible association of microvascular dysfunction and early atherosclerotic changes with subclinical hypothyroidism. Methods: 78 subjects with subclinical hypothyroidism and 55 control subjects with normal serum thyroid hormonal status were included in the study. TSH, free thyroxine, free triiodothyronine, glucose, insulin, HbA1c, cholesterol, triglyceride and C-reactive protein were measured. Flow mediated dilatation (FMD), intima-media thickness (IMT) and coronary flow reserve were measured and calculated. Results: FMD, IMT and CFR were not significantly different between the two groups. and there was no association of FMD, IMT and CFR with thyroid hormonal status. In subjects with subclinical hypothyroidism, but not in euthyroid subjects, a significant association between IMT and body mass index, glycemia, HOMA IR and fT4 and a significant association between CFR and waist-hip ratio, hypertension, smoking, markers of glycoregulation, cholesterol, LDL-cholesterol and triglycerides was found. Conclusion: We concluded that there is a different impact of cardiovascular risk factors on IMT and CFR in subjects with subclinical hypothyroidism compared with euthyroid subjects and that these two groups behave differently in the same circumstances, under the same risk factors. The basis for this difference could be a modified "set point" of the hypothalamicpituitary- thyroid axis, which changes the sensitivity of the microvasculature in people with subclinical hypothyroidism to known risk factors in the direction that is proaterogenic and makes them more susceptible to low-grade chronic inflammatio

Psychopharmaco therapy in the tretment of psychiatric disorderds in breast

Contemporary research and clinical practice conform that half of oncologial patients have varions psychiatric comorbid disorders that require diagnosis and therapy. The aim of this paper is to highlight the need for the treatment of oncological patients at any stage of treatment, medication and psychotherapy, through a case report. CASE REPORT: Patient aged 44, married with two children (26, 20), unemployed, appearing for the first time one year after breast cancer surgery. She completed radiation and chemotherapy with a VI cycle. Comes flom unhappiness, sadness, tension,fears. 10 years ago, she was treated for depression. She has since been sporadically treated outpatienthy. Following pharmacological and psychotherapy treatment, withdrawal symptoms and recovery occurred. CONCLUSION: Breast cancer in half of the diseased patients was followed by comorbidity with psychiatrie disorders. For this reason, a psychiatrist is also present in the oncology team for the purpose of assessing the mental state and freating the diseased person

Konstrukcija i psihometrijska evaluacija kratke forme Upitnika šireg autističkog fenotipa

Broad Autism Phenotype (BAP) represents a group of personality traits expressed in limitations in social relations and pragmatic speech dimension, and rigid behavior. The Broad Autism Phenotype Questionnaire (BAPQ) measures personality traits which are crucial in defining the BAP. In the present research, three studies were conducted with the general aim to create a short form of the BAPQ. Study 1 was carried out to determine the factor structure of the BAPQ in a sample of 501 students and to select items for the short form. Obtained components: Aloofness, Rigidity, and Pragmatics, corresponding to the structure of the instrument proposed by authors, accounted for 26.61% of variance. Study 2 was conducted to examine factor structure of the BAPQ short form (BAPQ-SF), in a sample of 298 students. This solution explained 45.76% of the total variance. The aim of Study 3 was to determine psychometric characteristics of the BAPQ-SF in a sample of students (N = 294). Three-factor model of the BAPQ-SF was confirmed. Correlations of the BAPQ-SF with the Autism-Spectrum Quotient (AQ) and the Delta 10 suggest convergent and discriminant validity of the BAPQ-SF.Širi autistički fenotip (eng. Broad Autism Phenotype - BAP) predstavlja grupu crta ličnosti koje se manifestuju u vidu ograničenja u socijalnim odnosima, na dimenziji pragmatičnog govora i u rigidnom ponašanju. Upitnik šireg autističkog fenotipa (The Broad Autism Phenotype Questionnaire - BAPQ) meri crte ličnosti koje su ključne u definisanju šireg autističkog fenotipa. U ovom istraživanju su sprovedene tri studije sa opštim ciljem da se napravi kratka forma BAPQ. Prva studija je sprovedena da bi se utvrdila faktorska struktura upitnika na uzorku od 501 studenta i da se izaberu ajtemi za kratku formu. Dobijene su komponente Povučenost, Rigidnost i Pragmatika. Ove komponente odgovaraju strukturi instrumenta koju su predložili autori i objašanjavaju 26.61% varijanse. Druga studija je sprovedena da bi se ispitala faktorska struktura kratke forme BAPQ (BAPQ-SF) na uzorku od 298 studenata. Ovo rešenje objašnjava 45.76% ukupne varijanse. Cilj treće studije bio je da se utvrde psihometrijske karakteristike BAPQ-SF na uzorku studenata (N = 294). Potvrđena je trofaktorska struktura upitnika. Korelacije mera BAPQ-SF sa količnikom autističkog spektra (AQ) i Delta 10 merama govore u prilog konvergentne i diskriminativne validnosti upitnika

Synthesis temperature influence on the structure, morphology and electrochemical performance of NaxMnO2 as cathode materials for sodium-ion rechearchable batteries

The lithium-ion batteries are the most commonly used for energy storage in portable devices. Since lithium is relatively rare on earth but rapidly consumed, it is necessary to find an adequate replacement. Owing to the similar chemical properties of sodium and lithium, but much higher availability, sodium ion batteries are one of the best candidates to replace lithium-ion batteries. A variety of materials such as manganese oxide, vanadium oxide or phosphate can be used as an electrode material (anode and cathode) in sodium ion batteries due to the high ability of intercalation of sodium. In this work, NaxMnO2 powder was synthesized by glycine nitrate method. The precursor powder was annealed for four hours at different temperatures: 800, 850, 900 and 950 °C. The characterization of the obtained materials was carried out using following methods: X-ray diffraction (XRD), scanning electron spectroscopy with energy dispersive X-ray spectroscopy (SEM/EDS) and transmission electron spectroscopy with energy dispersive Xray spectroscopy (TEM/EDS). Electrochemical properties were studied using cyclic voltammetry and chronopotentiometry in an aqueous solution of NaNO3. The layer structured Na0.7MnO2.05 with sheet-like morphology and Na0.4MnO2 with 3-D tunnel structure and rod-like morphology was obtained at 800 oC and 900 oC respectively. Na0.44MnO2 with rod-like morphology was annealed at 900 and 950 oC. 3D-tunnel structure Na0.44MnO2 obtained at 900 oC showed the best electrochemical behaviour in aqueous NaNO3 solution

Aggressive intraabdominal fibromatosis

Background. Intraabdominal or mesenteric fibromatosis is a rare benign nonmetastatic neoplasm that appears as a sporadic lesion or in patients with familiar polyposis. Its evolution is unpredictable. About 10% of the cases show a very aggressive growth. Case report. We presented a 22-year-old woman in whom an aggressive intraabdominal fibromatosis had appeared during the first pregnancy as a well circumscribed ovoid tumor, involving the terminal ileum, the caecum, the ascending colon, the right kidney, the ureter, and the right common iliac artery. The tumor was excised with right colectomy, nephroureterectomy and resection of the involved artery using arterial reconstruction with graft interposition. Two years after the surgery the patient developed an inoperable tumor recurrence with a fatal outcome. Conclusion. In spite of a successful surgical excision during the original surgery intraabdominal or mesenteric fibromatosis might have an aggressive evolution leading to an inoperable tumor recurrency and a fatal outcome

Synthesis and Characterization of Na0.4MnO2 as a Positive Electrode Material for an Aqueous Electrolyte Sodium-ion Energy Storage Device

Due to the increasing use of batteries in everyday life and in industry, there is a need for developing cheaper batteries than the widely used lithium ion batteries. Lower price and higher abundance of sodium compared to lithium mineral resources intensified the development of Na-ion batteries. Aqueous lithium/ sodium rechargeable batteries have attracted considerable attention for energy storage because they do not contain flammable organic electrolytes as commercial batteries do, the ionic conductivity of the aqueous electrolyte is about two orders of magnitude higher than in non-aqueous electrolyte and the electrolyte salt and solvent are cheaper. Various materials such as manganese oxides, vanadium oxide and phosphates have been used as electrode materials (cathodic and anodic) in sodium batteries due to high sodium intercalation ability in both, organic and aqueous electrolytes. The most frequently used type of manganese oxides are Li–Mn–O or Na–Mn–O systems due to their tunnel or layered crystal structures which facilitate the lithium/sodium intercalation-deintercalation. In this work, a glycine-nitrate method (GNM) was applied for the synthesis of cathode material Na0.4MnO2

Reviewing the potential of Sentinel-2 in assessing the drought

This paper systematically reviews the potential of the Sentinel-2 (A and B) in assessing drought. Research findings, including the IPCC reports, highlighted the increasing trend in drought over the decades and the need for a better understanding and assessment of this phenomenon. Continuous monitoring of the Earth’s surface is an efficient method for predicting and identifying the early warnings of drought, which enables us to prepare and plan the mitigation procedures. Considering the spatial, temporal, and spectral characteristics, the freely available Sentinel-2 data products are a promising option in this area of research, compared to Landsat and MODIS. This paper evaluates the recent developments in this field induced by the launch of Sentinel-2, as well as the comparison with other existing data products. The objective of this paper is to evaluate the potential of Sentinel-2 in assessing drought through vegetation characteristics, soil moisture, evapotranspiration, surface water including wetland, and land use and land cover analysis. Furthermore, this review also addresses and compares various data fusion methods and downscaling methods applied to Sentinel-2 for retrieving the major bio-geophysical variables used in the analysis of drought. Additionally, the limitations of Sentinel-2 in its direct applicability to drought studies are also evaluated

The Optimization of Metals and Metalloids Extraction From Fly Ash

Fly ash originating from coal combustion in thermal power plants is generated in landfills in large amounts, and due to the high content of heavy metals and metalloids whose mobility is hazardous to the environment and human health, it causes soil and groundwater pollution. Scientific research in the field of "alternative mining" is significant, where heavy metals and rare earth elements would be recovered from waste materials such as fly ash using various extraction methods. The aim of this paper is to determine the optimal extraction process of the examined elements: V, Cr, Mn, Co, Ni, Cu, Zn, As, Cd, and Pb from fly ash. Two extraction agents were used: sulfuric and acetic acid. In the first set of experiments, the fly ash was immersed immediately in acids, and in the second set, this process was preceded by the addition of sodium hydroxide, which effectively destroys the alumina-silicate matrix. Several different parameters were also monitored: ratio of fly ash and acid/acid mixture (1:5, 1:30), temperature (25 and 45°C), duration of the process (4 and 24 h), and stirring. For the extraction of Pb - H2SO4, temperature and time were shown as significant parameters, while for Cd, only H2SO4 was an effective extractant. Concerning the As metalloid, the acetic acid, solid/liquid ratio, and time were significant, while for Zn, Cu, Co, Mn, and V metals only the solid/liquid ratio was significant. Determination of the content of heavy metals and metalloids was done by the ICP-MS.5th Metallurgical & Materials Engineering Congress of South-East Europe : Congress Proceedings ; 7-10th June 2023 ; Trebinje, Bosnia and Herzegovin