Agile in Wonderland: Implementing a Virtual World Workshop Activity

For immersive 3D environments to be useful for specialist teaching, their programming facilities must be powerful enough to enable educators to create flexible learning tools. In this paper we describe the creation of a virtual environment designed to be used to host a workshop activity based on agile software development. Following an initial assessment of some available virtual world tools, the Java-based ‘Project Wonderland’ was used to create a proof of concept for running the workshop. We discuss the features that were implemented and a number of significant issues encountered during the process. In the light of our experiences, we assess the utility of Project Wonderland as a tool for creating an immersive workshop activity and describe the future work that would be needed to enable a robust and useable environment to be developed

If We Build It Will They Come? Creating a Virtual Classroom in Second Life

The Second Life Multi-User Virtual Environment (MUVE) has been used as an educational resource in many different ways, ranging from simulating the traditional classroom, though interactive experiences, to practical creational activities. Supporting resources can include traditional multimedia, simulation tools and programming languages. Learning experiences may vary from the wholly extrinsic, learning about the outside world, to more intrinsic study of Second Life’s ecosystems and its built environment, or wholly in-world creative work. Within this broad scope, there is an opportunity to support many types of learning, and distance learning in particular. In this paper we propose an analytical framework for virtual learning environments in Second Life based on current practice. We describe the creation of a learning space within Second Life designed to explore how we might support distance learners using traditional environments for extrinsic learning experiences. We reflect on the utility of the framework in understanding the various forces at work in virtual learning contexts and evaluate the student experience. We conclude that despite the potential for Second Life to support distance learners with a broad set of tools and resources, technical constraints suggest that a more effective option would be to provide focused creative tasks for students in a managed laboratory environment

Drug resistance outcomes of long-term ART with tenofovir disoproxil fumarate in the absence of virological monitoring

Objectives: The resistance profiles of patients receiving long-term ART in sub-Saharan Africa have been poorly described. This study obtained a sensitive assessment of the resistance patterns associated with long-term tenofovir-based ART in a programmatic setting where virological monitoring is yet to become part of routine care. Methods: We studied subjects who, after a median of 4.2 years of ART, replaced zidovudine or stavudine with tenofovir disoproxil fumarate while continuing lamivudine and an NNRTI. Using deep sequencing, resistance-associated mutations (RAMs) were detected in stored samples collected at tenofovir introduction (T0) and after a median of 4.0 years (T1). Results: At T0, 19/87 (21.8%) subjects showed a detectable viral load and 8/87 (9.2%) had one or more major NNRTI RAMs, whereas 82/87 (94.3%) retained full tenofovir susceptibility. At T1, 79/87 (90.8%) subjects remained on NNRTI-based ART, 5/87 (5.7%) had introduced lopinavir/ritonavir due to immunological failure, and 3/87 (3.4%) had interrupted ART. Whilst 68/87 (78.2%) subjects maintained or achieved virological suppression between T0 and T1, a detectable viral load with NNRTI RAMs at T0 predicted lack of virological suppression at T1. Each treatment interruption, usually reflecting unavailability of the dispensary, doubled the risk of T1 viraemia. Tenofovir, lamivudine and efavirenz selected for K65R, K70E/T, L74I/V and Y115F, alongside M184V and multiple NNRTI RAMs; this resistance profile was accompanied by high viral loads and low CD4 cell counts. Conclusions: Viraemia on tenofovir, lamivudine and efavirenz led to complex resistance patterns with implications for continued drug activity and risk of onward transmission

Duration channels mediate human time perception

The task of deciding how long sensory events seem to last is one that the human nervous system appears to perform rapidly and, for sub-second intervals, seemingly without conscious effort. That these estimates can be performed within and between multiple sensory and motor domains suggest time perception forms one of the core, fundamental processes of our perception of the world around us. Given this significance, the current paucity in our understanding of how this process operates is surprising. One candidate mechanism for duration perception posits that duration may be mediated via a system of duration-selective ‘channels’, which are differentially activated depending on the match between afferent duration information and the channels' ‘preferred’ duration. However, this model awaits experimental validation. In the current study, we use the technique of sensory adaptation, and we present data that are well described by banks of duration channels that are limited in their bandwidth, sensory-specific, and appear to operate at a relatively early stage of visual and auditory sensory processing. Our results suggest that many of the computational principles the nervous system applies to coding visual spatial and auditory spectral information are common to its processing of temporal extent

Soldiering on: a survey on the lived experience of tinnitus in aged military veterans in the UK

Tinnitus has long been interrogated as a medical conundrum, with little discourse between medicine and other disciplines. It involves the perception of sound in the ears or head without any external sound source, most likely a natural consequence of some form of hearing loss. For many people, tinnitus is bothersome and associated with various problems such as insomnia, difficulty concentrating and impaired listening ability. Nevertheless, with little attention from humanities or the social sciences, our understanding of the wider perspectives and psychosocial context of adults with tinnitus is limited, especially among UK military veterans. The aim of this study was to explore the impact of tinnitus on aged UK veterans, and to consider the support they receive and require to live well with tinnitus. In all, 120 aged UK veterans took part in this study. Data revealed similarities and differences between UK veteran and other study populations. For example, tinnitus symptom severity was higher in aged veterans than a general (younger) research population, particularly so on measures of intrusiveness and the effect of tinnitus on listening ability. Veterans had mixed views on social support. Many did not want to talk about tinnitus with others and/or did not want to burden their family, preferring to deal with their tinnitus ‘backstage’. Others appreciated empathy or sympathy; many implied a desire that their family and/or friends could better understand their experience of living with tinnitus and the problems it caused them. These complexities support a need for cross-disciplinary work to understand and respond to tinnitus-related problems in veterans

Mobile applications for management of tinnitus: users' survey, quality assessment and content analysis

Background: Tinnitus is the perception of a sound without any outside source. It affects 6 million people in the UK. Sound therapy is a core component of many tinnitus management programmes. Potential mechanisms of benefit include making tinnitus less noticeable, habituation, distracting attention from tinnitus, relaxation, and promoting neuroplastic changes within the brain. In recent years there has been a substantial increase in the use of mobile technology. This provided an additional medium via which people with tinnitus can access different tinnitus management options including sound therapy. Objective: The purpose of this study was to: 1) generate the list of apps that people use for management of their tinnitus; 2) explore reasons for apps use and non-use; 3) perform quality assessment of the most cited apps; 4) perform content analysis to explore and describe options and management techniques available in the most cited apps.Methods: An online survey consisting of 33 open and closed questions captured: i) demographic information about respondents, information about tinnitus, hearing loss; ii) mobile apps specific questions asked about the motivation to use an app to manage tinnitus, the apps which respondents used for managing tinnitus, important factors when choosing an app, devices used to access apps, reasons for not using apps. The quality of the most cited apps listed by respondents was assessed using the Mobile Apps Rating Scale (MARS) Content and features of the most cited apps were analysed. Results: Data from 643 respondents were analysed. The majority of respondents (75%) had never used an app for management of tinnitus mainly due to lack of awareness (79%). The list of the 55 apps that people use for the management of their tinnitus was generated. These included apps which were developed specifically for the management of tinnitus, however the majority of cited apps were developed for other problems (e.g. sleep, depression/anxiety, relaxation). Quality assessment of the 18 most popular apps, using MARS resulted in a range of mean scores from 1.6 to 4.2 (out of 5). In line with the current model of tinnitus management, sound was the main focus of the majority of the apps. Other components included relaxation exercises, elements of cognitive behaviour therapy, information and education and hypnosis. Conclusions: People use apps for the management of their tinnitus, however this was done mostly as a self-help option without conjunction with management provided by hearing healthcare professionals. Further research should consider the place for apps in the tinnitus management (standalone self-management intervention vs part of the management by a hearing professional). As the content of the apps varies in respect to sound options, information and management strategies it seems that the choice of the best management app should be guided by individual patient needs and preferences

X-Ray emission from SN 2004dj: A Tale of Two Shocks

Type IIP (Plateau) Supernovae are the most commonly observed variety of core collapse events. They have been detected in a wide range of wavelengths from radio, through optical to X-rays. The standard picture of a type IIP supernova has the blastwave interacting with the progenitor's circumstellar matter to produce a hot region bounded by a forward and a reverse shock. This region is thought to be responsible for most of the X-ray and radio emission from these objects. Yet the origin of X-rays from these supernovae is not well understood quantitatively. The relative contributions of particle acceleration and magnetic field amplification in generating the X-ray and radio emission need to be determined. In this work we analyze archival Chandra observations of SN 2004dj, the nearest supernova since SN 1987A, along with published radio and optical information. We determine the pre-explosion mass loss rate, blastwave velocity, electron acceleration and magnetic field amplification efficiencies. We find that a greater fraction of the thermal energy goes into accelerating electrons than into amplifying magnetic fields. We conclude that the X-ray emission arises out of a combination of inverse Compton scattering by non-thermal electrons accelerated in the forward shock and thermal emission from supernova ejecta heated by the reverse shock.Comment: 9 pages, 7 figures, 1 tabl

Boron Phosphate and Aluminum Phosphate Aerogels

Anhydrous sol-gel condensation of triethyl phosphate [(CH3CH2O)3PO] with boron trichloride (BCL3 ) or triethyl aluminum [(CH3CH2 ) 3A1] in organic solvents, led to formation of metallophosphate gels. The pore fluid of the gels was removed under supercritical conditions in a pressurized vessel to form aerogels. The aerogels were then calcined at progressively higher temperatures to produce high surface area phosphates. Since the initial gel reagent mixtures contained several NMR active nuclei, the condensation chemistry prior to the gel point was monitored by solution nB NMR. The surface areas, distribution of pore sizes, and total pore volumes of the aerogel products were determined using nitrogen gas physisorption methods

Why Is There No Cure for Tinnitus?

Tinnitus is unusual for such a common symptom in that there are few treatment options and those that are available are aimed at reducing the impact rather than specifically addressing the tinnitus percept. In particular, there is no drug recommended specifically for the management of tinnitus. Whilst some of the currently available interventions are effective at improving quality of life and reducing tinnitus-associated psychological distress, most show little if any effect on the primary symptom of subjective tinnitus loudness. Studies of the delivery of tinnitus services have demonstrated considerable end-user dissatisfaction and a marked disconnect between the aims of healthcare providers and those of tinnitus patients: patients want their tinnitus loudness reduced and would prefer a pharmacological solution over other modalities. Several studies have shown that tinnitus confers a significant financial burden on healthcare systems and an even greater economic impact on society as a whole. Market research has demonstrated a strong commercial opportunity for an effective pharmacological treatment for tinnitus, but the amount of tinnitus research and financial investment is small compared to other chronic health conditions. There is no single reason for this situation, but rather a series of impediments: tinnitus prevalence is unclear with published figures varying from 5.1 to 42.7%; there is a lack of a clear tinnitus definition and there are multiple subtypes of tinnitus, potentially requiring different treatments; there is a dearth of biomarkers and objective measures for tinnitus; treatment research is associated with a very large placebo effect; the pathophysiology of tinnitus is unclear; animal models are available but research in animals frequently fails to correlate with human studies; there is no clear definition of what constitutes meaningful change or “cure”; the pharmaceutical industry cannot see a clear pathway to distribute their products as many tinnitus clinicians are non-prescribing audiologists. To try and clarify this situation, highlight important areas for research and prevent wasteful duplication of effort, the British Tinnitus Association (BTA) has developed a Map of Tinnitus. This is a repository of evidence-based tinnitus knowledge, designed to be free to access, intuitive, easy to use, adaptable and expandable