Active Primary Care Physicians in Nebraska: Data Comparison, Supply, and Characteristics

https://digitalcommons.unmc.edu/coph_policy_reports/1020/thumbnail.jp

Geophysical characterization of derelict coalmine workings and mineshaft detection: a case study from Shrewsbury, United Kingdom

A study site of derelict coalmine workings near Shrewsbury, United Kingdom was the focus for multi‐phase, near‐surface geophysical investigations. Investigation objectives were: 1) site characterization for remaining relict infrastructure foundations, 2) locate an abandoned coalmine shaft, 3) determine if the shaft was open, filled or partially filled and 4) determine if the shaft was capped (and if possible characterize the capping material). Phase one included a desktop study and 3D microgravity modelling of the relict coalmine shaft thought to be on site. In phase two, electrical and electromagnetic surveys to determine site resistivity and conductivity were acquired together with fluxgate gradiometry and an initial microgravity survey. Phase three targeted the phase two geophysical anomalies and acquired high‐resolution self potential and ground penetrating radar datasets. The phased‐survey approach minimised site activity and survey costs. Geophysical results were compared and interpreted to characterize the site, the microgravity models were used to validate interpretations. Relict buildings, railway track remains with associated gravel and a partially filled coalmine shaft were located. Microgravity proved optimal to locate the mineshaft with radar profiles showing ‘side‐swipe’ effects from the mineshaft that did not directly underlie survey lines. Geophysical interpretations were then verified with subsequent geotechnical intrusive investigations. Comparisons of historical map records with intrusive geotechnical site investigations show care must be taken using map data alone, as the latter mineshaft locations was found to be inaccurate

Investigation of the role of morphology on the magnetic properties of Ca2Mn3O8 materials

Ca2Mn3O8 exhibits a complex layered structure comprised of Mn3O84- layers separated by Ca2+ ions. In contrast with the more traditional triangular Delafossite layered materials the Mn3O84- layers additionally exhibit an ordered vacancy which forms a 'bow-tie' like arrangement of the Mn4+ ions. We report a comprehensive study of the magnetic properties of a series of Ca2Mn3O8 materials with different morphologies. EXAFS and XANES analysis confirm no differences in either manganese environment or oxidation state between materials. Apparent differences in magnetic order from SQUID magnetometry can be rationalised by uncompensated surface spins arising as a result of changes to the surface:volume ratio between morphologies. Furthermore, these data suggest these materials are potentially frustrated in nature, due to the triangular connectivity of Mn4+ spins with a simple ‘spin-up/spin-down’ (↑↓) antiferromagnetic model unable to explain the data collected

A Model-Based Measure to Assess Operator Adherence to Procedures

Procedures play an important role in domains where humans interact with critical, complex systems. In such environments, the operator’s ability to correctly follow a given set of procedures can directly impact system safety. A quantitative measure of procedural adherence during training for complex system operation would be useful to assess trainee performance and evaluate a training program. This paper presents a novel model-based objective metric for quantifying procedural adherence in training. This metric is sensitive to both the number and nature of procedural deviations, and can be used with cluster analysis to classify trainee performance based on adherence. The metric was tested on an experimental data set gathered from volunteers using aircraft maintenance computer-based training (CBT). The properties of the metric are discussed, along with future possibilities

Primary Care Physician Assistants in Nebraska

https://digitalcommons.unmc.edu/coph_policy_reports/1022/thumbnail.jp

Primary Care Nurse Practitioners in Nebraska

https://digitalcommons.unmc.edu/coph_policy_reports/1021/thumbnail.jp

CD14 mediates the innate immune responses to arthritopathogenic peptidoglycan–polysaccharide complexes of Gram-positive bacterial cell walls

Bacterial infections play an important role in the multifactorial etiology of rheumatoid arthritis. The arthropathic properties of Gram-positive bacteria have been associated with peptidoglycan–polysaccharide complexes (PG-PS), which are major structural components of bacterial cell walls. There is little agreement as to the identity of cellular receptors that mediate innate immune responses to PG-PS. A glycosylphosphatidylinositol-linked cell surface protein, CD14, the lipopolysaccharide receptor, has been proposed as a PG-PS receptor, but contradictory data have been reported. Here, we examined the inflammatory and pathogenic responses to PG-PS in CD14 knockout mice in order to examine the role for CD14 in PG-PS-induced signaling. We found that PG-PS-induced responses in vitro, including transient increase in intracellular calcium, activation of nuclear factor-κB, and secretion of the cytokines tumor necrosis factor-α and interleukin-6, were all strongly inhibited in CD14 knockout macrophages. In vivo, the incidence and severity of PG-PS induced acute polyarthritis were significantly reduced in CD14 knockout mice as compared with their wild-type counterparts. Consistent with these findings, CD14 knockout mice had significantly inhibited inflammatory cell infiltration and synovial hyperplasia, and reduced expression of inflammatory cytokines in PG-PS arthritic joints. These results support an essential role for CD14 in the innate immune responses to PG-PS and indicate an important role for CD14 in PG-PS induced arthropathy

A 'large and valuable' Siwalik fossil collection in the archives of the Oxford University Museum of Natural History

This article describes results from a review of South Asian fossils in the Oxford University Museum of Natural History. These materials include two early 19th century collections of fossils from the Siwalik Hills in India. While this assemblage was summarised in 1837 by William Buckland as ‘large and valuable collections of fossil bones’, it has remained largely unstudied and unpublished in any detail since collection. Here, as a precursor to a comprehensive re-evaluation, we establish a chronological and geographical context of one collection event, provide details of its donor, and outline its history after arrival in Oxford. We then describe select taxa in the collection, including a well-preserved maxilla and toothrow of the large extinct giraffid, Sivatherium giganteum, as a basis to justify our current understanding of the biostratigraphic affinity of the assemblage. Conservatively, the collection is a ‘classic’ Upper Siwalik Plio-Pleistocene fauna, possibly the first to be transported to the UK. While further analyses will realise the scientific potential of the fossils, the narrative of their journey from India to Oxford remains incomplete. Further investigation of the hidden history of the collection is warranted

Tuning the excited state of water-soluble IrIII-based DNA intercalators that are isostructural with [RuII(NN)2(dppz)] light-switch complexes

The synthesis of two new IrIII complexes which are effectively isostructural with well-established [Ru(NN)2-(dppz)]2+ systems is reported (dppz = dipyridophenazine; NN = 2,2′-bipyridyl, or 1,10-phenanthroline). One of these IrIII complexes is tricationic and has a conventional N6 coordination sphere. The second dicationic complex has a N5C coordination sphere, incorporating a cyclometalated analogue of the dppz ligand. Both complexes show good water solubility. Experimental and computational studies show that the photoexcited states of the two complexes are very different from each other and also differ from their RuII analogues. Both of the complexes bind to duplex DNA with affinities that are two orders of magnitude higher than previously reported Ir(dppz)-based systems and are comparable with RuII(dppz) analogues