514 research outputs found
Clinical diagnosis of diabetic polyneuropathy with the diabetic neuropathy symptom and diabetic nueropathy examination scores
Response, relaxation and transport in unconventional superconductors
We investigate the collision-limited electronic Raman response and the
attenuation of ultrasound in spin-singlet d-wave superconductors at low
temperatures. The dominating elastic collisions are treated within a t-matrix
approximation, which combines the description of weak (Born) and strong
(unitary) impurity scattering. In the long wavelength limit a two-fluid
description of both response and transport emerges. Collisions are here seen to
exclusively dominate the relaxational dynamics of the (Bogoliubov)
quasiparticle system and the analysis allows for a clear connection of response
and transport phenomena. When applied to quasi-2-d superconductors like the
cuprates, it turns out that the transport parameter associated with the Raman
scattering intensity for B1g and B2g photon polarization is closely related to
the corresponding components of the shear viscosity tensor, which dominates the
attenuation of ultrasound. At low temperatures we present analytic solutions of
the transport equations, resulting in a non-power-law behavior of the transport
parameters on temperature.Comment: 22 pages, 3 figure
Formal change impact analyses for emulated control software
Processor emulators are a software tool for allowing legacy computer programs to be executed on a modern processor. In the past emulators have been used in trivial applications such as maintenance of video games. Now, however, processor emulation is being applied to safety-critical control systems, including military avionics. These applications demand utmost guarantees of correctness, but no verification techniques exist for proving that an emulated system preserves the original system’s functional and timing properties. Here we show how this can be done by combining concepts previously used for reasoning about real-time program compilation, coupled with an understanding of the new and old software architectures. In particular, we show how both the old and new systems can be given a common semantics, thus allowing their behaviours to be compared directly
Nonlinear Viscous Vortex Motion in Two-Dimensional Josephson-Junction Arrays
When a vortex in a two-dimensional Josephson junction array is driven by a
constant external current it may move as a particle in a viscous medium. Here
we study the nature of this viscous motion. We model the junctions in a square
array as resistively and capacitively shunted Josephson junctions and carry out
numerical calculations of the current-voltage characteristics. We find that the
current-voltage characteristics in the damped regime are well described by a
model with a {\bf nonlinear} viscous force of the form , where is the vortex velocity,
is the velocity dependent viscosity and and are
constants for a fixed value of the Stewart-McCumber parameter. This result is
found to apply also for triangular lattices in the overdamped regime. Further
qualitative understanding of the nature of the nonlinear friction on the vortex
motion is obtained from a graphic analysis of the microscopic vortex dynamics
in the array. The consequences of having this type of nonlinear friction law
are discussed and compared to previous theoretical and experimental studies.Comment: 14 pages RevTex, 9 Postscript figure
Involving patients and the public In sTatistIcal Analysis pLans (INITIAL): a delphi survey
Background
Patient and public involvement (PPI) in trials aims to enhance research by improving its relevance and transparency. Planning for statistical analysis begins at the design stage of a trial within the protocol and is refined and detailed in a Statistical Analysis Plan (SAP). While PPI is common in design and protocol development it is less common within SAPs. This study aimed to reach consensus on the most important and relevant statistical analysis items within an SAP to involve patients and the public.
Methods
We developed a UK-based, two-round Delphi survey through an iterative consultation with public partners, statisticians, and trialists. The consultation process started with 55 items from international guidance for statistical analysis plans. We aimed to recruit at least 20 participants per key stakeholder group for inclusion in the final analysis of the Delphi survey. Participants were asked to vote on each item using a Likert scale from 1 to 9, where a rating of 1 to 3 was labelled as having ‘limited importance’; 4 to 6 as ‘important but not critical’ and 7 to 9 as ‘critical’ to involve patients and the public. Results from the second round determined consensus on critical items for PPI.
Results
The consultation exercise led to the inclusion of 15 statistical items in the Delphi survey. We recruited 179 participants, of whom 72% (129: 36 statisticians, 29 patients or public partners, 25 clinical researchers or methodologists, 27 trial managers, and 12 PPI coordinators) completed both rounds. Participants were on average 48 years old, 60% were female, 84% were White, 64% were based in England and 84% had at least five years’ experience in trials. Four items reached consensus regarding critical importance for patient and public involvement: presentation of results to trial participants; summary and presentation of harms; interpretation and presentation of findings in an academic setting; factors impacting how well a treatment works. No consensus was reached for the remaining 11 items. In general, the results were consistent across stakeholder groups.
Discussion
We identified four critical items to involve patients and the public in statistical analysis plans. The remaining 11 items did not reach consensus and need to be considered in a case-by-case basis with most responders considering patient and public involvement important (but not critical). Our research provides a platform to enable focused future efforts to improve patient and public involvement in trials and enhance the relevance of statistical analyses to patients and the public
Josephson Coupling and Fiske Dynamics in Ferromagnetic Tunnel Junctions
We report on the fabrication of Nb/AlO_x/Pd_{0.82}Ni_{0.18}/Nb
superconductor/insulator/ferromagnetic metal/superconductor (SIFS) Josephson
junctions with high critical current densities, large normal resistance times
area products, high quality factors, and very good spatial uniformity. For
these junctions a transition from 0- to \pi-coupling is observed for a
thickness d_F ~ 6 nm of the ferromagnetic Pd_{0.82}Ni_{0.18} interlayer. The
magnetic field dependence of the \pi-coupled junctions demonstrates good
spatial homogeneity of the tunneling barrier and ferromagnetic interlayer.
Magnetic characterization shows that the Pd_{0.82}Ni_{0.18} has an out-of-plane
anisotropy and large saturation magnetization, indicating negligible dead
layers at the interfaces. A careful analysis of Fiske modes provides
information on the junction quality factor and the relevant damping mechanisms
up to about 400 GHz. Whereas losses due to quasiparticle tunneling dominate at
low frequencies, the damping is dominated by the finite surface resistance of
the junction electrodes at high frequencies. High quality factors of up to 30
around 200 GHz have been achieved. Our analysis shows that the fabricated
junctions are promising for applications in superconducting quantum circuits or
quantum tunneling experiments.Comment: 15 pages, 9 figure
Signatures of Relativistic Neutrinos in CMB Anisotropy and Matter Clustering
We present a detailed analytical study of ultra-relativistic neutrinos in
cosmological perturbation theory and of the observable signatures of
inhomogeneities in the cosmic neutrino background. We note that a modification
of perturbation variables that removes all the time derivatives of scalar
gravitational potentials from the dynamical equations simplifies their solution
notably. The used perturbations of particle number per coordinate, not proper,
volume are generally constant on superhorizon scales. In real space an
analytical analysis can be extended beyond fluids to neutrinos.
The faster cosmological expansion due to the neutrino background changes the
acoustic and damping angular scales of the cosmic microwave background (CMB).
But we find that equivalent changes can be produced by varying other standard
parameters, including the primordial helium abundance. The low-l integrated
Sachs-Wolfe effect is also not sensitive to neutrinos. However, the gravity of
neutrino perturbations suppresses the CMB acoustic peaks for the multipoles
with l>~200 while it enhances the amplitude of matter fluctuations on these
scales. In addition, the perturbations of relativistic neutrinos generate a
*unique phase shift* of the CMB acoustic oscillations that for adiabatic
initial conditions cannot be caused by any other standard physics. The origin
of the shift is traced to neutrino free-streaming velocity exceeding the sound
speed of the photon-baryon plasma. We find that from a high resolution, low
noise instrument such as CMBPOL the effective number of light neutrino species
can be determined with an accuracy of sigma(N_nu) = 0.05 to 0.09, depending on
the constraints on the helium abundance.Comment: 38 pages, 7 figures. Version accepted for publication in PR
Determination of the Deep Inelastic Contribution to the Generalised Gerasimov-Drell-Hearn Integral for the Proton and Neutron
The virtual photon absorption cross section differences [sigma_1/2-sigma_3/2]
for the proton and neutron have been determined from measurements of polarised
cross section asymmetries in deep inelastic scattering of 27.5 GeV
longitudinally polarised positrons from polarised 1H and 3He internal gas
targets. The data were collected in the region above the nucleon resonances in
the kinematic range nu < 23.5 GeV and 0.8 GeV**2 < Q**2 < 12 GeV**2. For the
proton the contribution to the generalised Gerasimov-Drell-Hearn integral was
found to be substantial and must be included for an accurate determination of
the full integral. Furthermore the data are consistent with a QCD
next-to-leading order fit based on previous deep inelastic scattering data.
Therefore higher twist effects do not appear significant.Comment: 6 pages, 3 figures, 1 table, revte
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