Studying the effects of in-vehicle information systems on driver visual behaviour – implications for design

In-vehicle information systems (IVIS) are a common feature in modern vehicles. The interaction of drivers with IVIS when driving must be considered to minimise distraction whilst maintaining the benefits provided. This research investigates the glance behaviours of drivers, assessed from video data, when using two functions – a personal navigation device (study 1) and a green driving advisory device (study 2). The main focus was to establish the number of glances of 2 seconds or more to the IVIS and relate this to driver safety (as stipulated in new guidelines for use of IVIS proposed by NHTSA). In study 1, the percentage of eyes- off-road time for drivers was much greater in the experimental (with device) condition compared to the baseline condition (14.3% compared to 6.7%) but, whilst glances to the personal navigation device accounted for the majority of the increase, there were very few which exceeded 2 seconds. Drivers in study 2 spent on average 4.3% of their time looking at the system, at an average of 0.43 seconds per glance; no glances exceeded 2 seconds. The research showed that ordinary use of IVIS (excluding manual interaction) does not lead to driver visual distraction and therefore the impact on safety is minimal. The results of the study have important design implications for future in-vehicle information systems

Ultrastructural Distribution of the 7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus

Acetylcholine (ACh) is an important neurotransmitter in the mammalian brain; it is implicated in arousal, learning, and other cognitive functions. Recent studies indicate that nicotinic receptors contribute to these cholinergic effects, in addition to the established role of muscarinic receptors. In the hippocampus, where cholinergic involvement in learning and memory is particularly well documented, 7 nicotinic acetylcholine receptor subunits (7 nAChRs) are highly expressed, but their precise ultrastructural localization has not been determined. Here, we describe the results of immunogold labeling of serial ultrathin sections through stratum radiatum of area CA1 in the rat. Using both anti-7 nAChR immunolabeling and -bungarotoxin binding, we find that 7 nAChRs are present at nearly all synapses in CA1 stratum radiatum, with immunolabeling present at both presynaptic and postsynaptic elements. Morphological considerations and double immunolabeling indicate that GABAergic as well as glutamatergic synapses bear 7 nAChRs, at densities approaching those observed for glutamate receptors in CA1 stratum radiatum. Postsynaptically, 7 nAChRs often are distributed at dendritic spines in a perisynaptic annulus. In the postsynaptic cytoplasm, immunolabeling is associated with spine apparatus and other membranous structures, suggesting that 7 nAChRs may undergo dynamic regulation, with insertion into the synapse and subsequent internalization. The widespread and substantial expression of 7 nAChRs at synapses in the hippocampus is consistent with an important role in mediating and/or modulating synaptic transmission, plasticity, and neurodegeneration

Distraction effects of navigation and green-driving systems – results from field operational tests (FOTs) in the UK

Navigation systems and green-driving advisory systems are now a common feature in modern vehicles. The interaction of drivers with such systems when driving must be considered to minimise distraction whilst maintaining the benefits provided. This research investigates the glance behaviours of drivers, assessed from video data, when using a navigation device (study 1) and a green-driving advisory device (study 2). The main research question addressed was ‘Does the device cause visual distraction that might be detrimental to safety?’ The main focus was to establish the number of glances of 2 s or more to the systems and relate this to driver safety (as stipulated in new guidelines for use of in-vehicle systems proposed by the National Highway Traffic Safety Administration (NHTSA) in the US)

The impact of interpersonal relationships on rural doctors’ clinical courage

Introduction: Clinical courage occurs when rural doctors push themselves to the limits of their scope of practice to provide the medical care needed by patients in their community. This mental strength to venture, persevere and act out of concern for one’s patient, despite a lack of formally recognised expertise, becomes necessary for doctors who work in relative professional isolation. Previous research by the authors suggested that the clinical courage of rural doctors relies on the relationships around them. This article explores in more depth how relationships with others can impact on clinical courage. Methods: At an international rural medicine conference in 2017, doctors who practised rural/remote medicine were invited to participate in the study. Twenty-seven semistructured interviews were conducted exploring experiences of clinical courage. Initial analysis of the material, using a hermeneutic phenomenological frame, sought to understand the meaning of clinical courage. In the original analysis, an emic question arose: ‘How do interpersonal relationships impact on clinical courage’. The material was re-analysed to explore this question, using Wenger’s community of practice as a theoretical framework. Results: This study found that clinical courage was affected by the relationships rural doctors had with their communities and patients, with each other, with the local members of their healthcare team and with other colleagues and health leaders outside their immediate community of practice. Conclusion: As a collective, rural doctors can learn, use and strengthen clinical courage and support its development in new members of the discipline. Relationships with rural communities, rural patients and urban colleagues can support the clinical courage of rural doctors. When detractors challenge the value of clinical courage, it requires individual rural doctors and their community of practice to champion rural doctors’ way of working

Incoherent broadband cavity-enhanced absorption spectroscopy in the near-ultraviolet: application to HONO and NO2

The first application of incoherent broadband cavity-enhanced absorption spectroscopy (IBBCEAS) in the near-ultraviolet for the simultaneous detection of two key atmospheric trace species, HONO and NO2, is reported. For both compounds the absorption is measured between 360 and 380 nm with a compact cavity-enhanced spectrometer employing a high power light-emitting diode. Detection limits of similar to 4 ppbv for HONO and similar to 14 ppbv for NO2 are reported for a static gas cell setup using a 20 s acquisition time. Based on an acquisition time of 10 min and an optical cavity length of 4.5 m detection limits of similar to 0.13 ppbv and similar to 0.38 ppbv were found for HONO and NO2 in a 4 m(3) atmospheric simulation chamber, demonstrating the usefulness of this approach for in situ monitoring of these important species in laboratory studies or field campaigns

Cytolytic toxin production by \u3ci\u3eStaphylococcus aureus\u3c/i\u3e is dependent upon the activity of the protoheme IX farnesyltransferase

Staphylococcus aureus is a medically important pathogen with an abundance of virulence factors that are necessary for survival within a host, including the production of cytolytic toxins. The regulation of toxin production is mediated by the Agr quorum sensing system, and a poorly defined post-exponential growth phase signal independent of Agr. As part of a recent genome wide association study (GWAS) to identify novel loci that alter the expression of cytolytic toxins, a polymorphism in the cyoE gene, which encodes a protoheme IX farnesyltransferase, was identified. This enzyme is essential for processing heme into the electron transport chain for use as an electron acceptor. Interestingly, without this enzyme S. aureus were repressed in their ability to secrete cytolytic toxins, and this appears to be mediated through repression of the Agr quorum sensing system. We hypothesize that the loss of electron transport is inducing feedback inhibition of metabolic capabilities that suppress the TCA cycle, and that this coupled with decreased RNAIII transcription prevents synthesis of cytolytic toxins

AFM imaging reveals the assembly of a P2X receptor complex containing P2X2, P2X4 and P2X6 subunits

Seven P2X purinergic receptor subunits have been identified: P2X1-P2X7. All except P2X6 assemble as homotrimers, and six heteromeric receptors (P2X1/2, P2X1/4, P2X1/5, P2X2/3, P2X2/6 and P2X4/6) have been described. In addition, P2X4 homomers associate with P2X2 or P2X7 homomers as dimers of trimers. The various P2X receptors show individual functional properties, suggesting distinct physiological roles. The overlapping expression of P2X2, P2X4 and P2X6 subunits has been shown in different cell types, and functional analysis of P2X receptors in Leydig cells suggests that the three subunits interact

Children\u27s Understanding of the Concept of Physical Activity

This study evaluated 4th-grade students\u27 understanding of the concept of physical activity and assessed the effects of two interventions to enhance the students\u27 understanding of this concept. Students were randomly assigned to 1 of 3 conditions: the video group (n=40) watched a 5-min video describing physical activity; the verbal group (n=42) listened to a generic description of physical activity; the control group received no instruction (n=45). Students completed a 17-item checklist testing their understanding of the concept of physical activity. Compared to controls, students in the verbal and video group demonstrated significantly higher checklist scores, with the video group scoring significantly higher than the verbal group. Only 35.6% of the controls compared to 52.4% and 70.0% of the verbal and video group respectively, could classify \u3e 15 of the checklist items correctly. The results indicate that, without intervention, children have a limited understanding of the concept of physical activity

Tracking of Physical Activity, Physical Inactivity, and Health-Related Physical Fitness in Rural Youth

This study examined the tracking of selected measures of physical activity, inactivity, and fitness in a cohort of rural youth. Students (N=181, 54.7% female, 63.5% African American) completed test batteries during their fifth- (age=10.7±0.7 years), sixth-, and seventh-grade years. The Previous Day Physical Activity Recall (PDPAR) was used to assess 30-min blocks of vigorous physical activity (VPA), moderate-to-vigorous physical activity (MVPA), TV watching and other sedentary activities, and estimated energy expenditure (EE). Fitness measures included the PWC 170 cycle ergometer test, strength tests, triceps skinfold thickness, and BMI. Intraclass correlation coefficients (ICCs) for VPA, MVPA, and after-school EE ranged from 0.63 to 0.78. ICCs ranged from 0.49 to 0.71 for measures of inactivity and from 0.78 to 0.82 for the fitness measures. These results indicate that measures of physical activity, inactivity, and physical fitness tend to track during the transition from elementary to middle school