19,514 research outputs found
Low-Energy Heavy-Ion Reactions and the Skyrme Effective Interaction
The Skyrme effective interaction, with its multitude of parameterisations,
along with its implemen- tation using the static and time-dependent density
functional (TDHF) formalism have allowed for a range of microscopic
calculations of low-energy heavy-ion collisions. These calculations allow
variation of the effective interaction along with an interpretation of the
results of this variation informed by a comparison to experimental data.
Initial progress in implementing TDHF for heavy-ion collisions necessarily used
many approximations in the geometry or the interaction. Over the last decade or
so, the implementations have overcome all restrictions, and studies have begun
to be made where details of the effective interaction are being probed. This
review surveys these studies in low energy heavy-ion reactions, finding
significant effects on observables from the form of the spin-orbit interaction,
the use of the tensor force, and the inclusion of time-odd terms in the density
functional.Comment: submitted to Prog. Part. Nucl. Phy
Rural land mobile radio market assessment and satellite and terrestrial system concepts
Market potential exists; the nature of the market in terms of service needs, usage characteristics, service requirements, and forecasting the demand to the year 2000; alternative system cncepts that show promise in addressing the identified needs, in a cost effective manner; and advanced technology requirements associated with these concepts are considered
Challenging the orthodoxy: union learning representatives as organic intellectuals
Teacher education and continuing professional development have become a key areas of controversy in England since the period of school sector restructuring following the 1988 Education Reform Act. More recently teacher training and professional development have often been used to promote and reinforce a narrow focus on the government’s ‘standards agenda’. However, the emerging discourse of ‘new professionalism’ has raised the profile of professional development in schools, and together with union learning representatives, there are opportunities to secure real improvements in teachers’ access to continuing professional development. This paper argues however that union learning representatives must go beyond advocating for better access to professional development and should raise more fundamental questions about the nature of professional development and the education system it serves. Drawing on Gramsci’s notion of the ‘organic intellectual’, the paper argues that union learning representatives have a key role as organisers of ideas – creating spaces in which the ideological dominance of current policy orthodoxy might be challenged
The clinical effectiveness and cost-effectiveness of inhaler devices used in the routine management of chronic asthma in older children: a systematic review and economic evaluation
Background:
This review examines the clinical effectiveness and
cost-effectiveness of hand-held inhalers to deliver
medication for the routine management of chronic
asthma in children aged between 5 and 15 years.
Asthma is a common disease of the airways, with a
prevalence of treated asthma in 5–15-year-olds of
around 12% and an actual prevalence in the community
as high as 23%. Treatment for the condition
is predominantly by inhalation of medication. There
are three main types of inhaler device, pressurised
metered dose, breath actuated, and dry powder, with
the option of the attachment of a spacer to the first
two devices under some prescribed circumstances.
Two recent reviews have examined the clinical and
cost-effectiveness evidence on inhaler devices, but
one was for children aged under 5 years and the
comparison in the second was made between pressurised
metered dose inhalers and other types only.
Objectives:
This review examines the clinical effectiveness and
cost-effectiveness of manual pressurised metered
dose inhalers, breath-actuated metered dose
inhalers, and breath-actuated dry powder inhalers,
with and without spacers as appropriate, to deliver
medication for the routine management of chronic
asthma in children aged between 5 and 15 years.
Methods:
Two previous HTA reviews have compared the
effectiveness of inhaler devices, one focusing on
asthma in children aged under 5 years and the
other on asthma and chronic obstructive airways
disease in all age groups. For the current review, a
literature search was carried out to identify all
evidence relating to the use of inhalers in older
children with chronic asthma. A search of in-vitro
studies undertaken for one of the previous reviews
was also updated.
The data sources used were: 15 electronic bibliographic
databases; the reference lists of one of the
previous HTA reports and other relevant articles;
health services research-related internet resources;
and all sponsor submissions.
Studies were selected according to strict inclusion
and exclusion criteria, and relevant information
concerning effectiveness and patient compliance
and preference was extracted directly on to an
extraction/evidence table. Quality assurance
was monitored.
Economic evaluation was undertaken by reviewing
existing cost-effective evidence. Further economic
modelling was carried out, and tables constructed
to determine device cost-minimisation and
incremental quality-adjusted life-year (QALY)
thresholds between devices.
Results:
Number and quality of studies, and
direction of evidence:
Fourteen randomised controlled studies were
identified relating to the clinical effectiveness of
inhaler devices for delivering β2-agonists. A further
five were on devices delivering corticosteroids and
one concerned the delivery of cromoglicate.
Overall, there were no differences in clinical
efficacy between inhaler devices, but a pressurised
metered dose inhaler with a spacer would appear
to be more effective than one without. These
findings endorse those of a previous HTA review
but extend them to other inhaler devices.
Seven randomised controlled trials examined the
impact on clinical effectiveness of using a nonchlorofluorocarbon
(CFC) propellant in place of
a CFC propellant in metered dose inhalers, both
pressurised and breath activated, although only one
study considered the latter type. No differences were
found between inhalers containing either propellant.
A further 30 studies of varying quality, from 12 randomised
controlled trials to non-controlled studies,
were identified that concerned the impact of use
by, and preference for, inhaler type, and treatment
adherence in children. Differences between the
studies, and limitations in comparative data between
various inhaler device types, make it difficult to draw
any firm conclusions from this evidence.
Summary of benefits:
No obvious benefits for one inhaler device type
over another for use in children aged 5–15 years
were identified.
Costs and cost per quality-adjusted
life-year:
Two approaches have been taken: cost-minimisation
and QALY threshold. In the QALY threshold
approach, additional QALYs that each device must
produce compared with a cheaper device to achieve
an acceptable cost per QALY were calculated. Using
the cheapest and most expensive devices for delivering
200 μg of beclometasone per day, assuming no
cost offset for any device, and a threshold of £5000,
the largest QALY needed was 0.00807. With such
a small QALY increase, no intervention can be
categorically rejected as not cost-effective.
Conclusions:
Generalisability of findings:
On the available evidence there are no obvious
benefits for one inhaler device over another
when used by children aged 5–15 years with
chronic asthma. However, the evidence, in the
majority of cases, was compiled on children
with mild to moderate asthma and restricted
to a limited number of drugs. Therefore the
findings may not be generalisable to those at
the more severe end of the spectrum of the
disease or to inhaler devices delivering some
of the drugs used in the management of asthma.
Need for further research:
Many of the previous studies are likely to
have been underpowered. Further clinical
trials with a robust methodology, sufficient
power and qualitative components are needed
to demonstrate any differences in clinical
resource use and patients’ asthma symptoms.
Further studies should also include the
behavioural aspects of patients towards their
medication and its delivery mechanisms.
It is acknowledged that sufficient power may
prove impractical owing to the large numbers
of patients required
Gemini/GMOS Transmission Spectral Survey: Complete Optical Transmission Spectrum of the hot Jupiter WASP-4b
We present the complete optical transmission spectrum of the hot Jupiter
WASP-4b from 440-940 nm at R ~ 400-1500 obtained with the Gemini Multi-Object
Spectrometers (GMOS); this is the first result from a comparative
exoplanetology survey program of close-in gas giants conducted with GMOS.
WASP-4b has an equilibrium temperature of 1700 K and is favorable to study in
transmission due to a large scale height (370 km). We derive the transmission
spectrum of WASP-4b using 4 transits observed with the MOS technique. We
demonstrate repeatable results across multiple epochs with GMOS, and derive a
combined transmission spectrum at a precision about twice above photon noise,
which is roughly equal to to one atmospheric scale height. The transmission
spectrum is well fitted with a uniform opacity as a function of wavelength. The
uniform opacity and absence of a Rayleigh slope from molecular hydrogen suggest
that the atmosphere is dominated by clouds with condensate grain size of ~1 um.
This result is consistent with previous observations of hot Jupiters since
clouds have been seen in planets with similar equilibrium temperatures to
WASP-4b. We describe a custom pipeline that we have written to reduce GMOS
time-series data of exoplanet transits, and present a thorough analysis of the
dominant noise sources in GMOS, which primarily consist of wavelength- and
time- dependent displacements of the spectra on the detector, mainly due to a
lack of atmospheric dispersion correction.Comment: 23 pages, 12 figures, accepted for publication in AJ, 2017 July
Density distributions of superheavy nuclei
We employed the Skyrme-Hartree-Fock model to investigate the density
distributions and their dependence on nuclear shapes and isospins in the
superheavy mass region. Different Skyrme forces were used for the calculations
with a special comparison to the experimental data in Pb. The
ground-state deformations, nuclear radii, neutron skin thicknesses and
-decay energies were also calculated. Density distributions were
discussed with the calculations of single-particle wavefunctions and shell
fillings. Calculations show that deformations have considerable effects on the
density distributions, with a detailed discussion on the 120 nucleus.
Earlier predictions of remarkably low central density are not supported when
deformation is allowed for.Comment: 7 pages, 10 figure
Two stage superconducting quantum interference device amplifier in a high-Q gravitational wave transducer
We report on the total noise from an inductive motion transducer for a
gravitational-wave antenna. The transducer uses a two-stage SQUID amplifier and
has a noise temperature of 1.1 mK, of which 0.70 mK is due to back-action noise
from the SQUID chip. The total noise includes thermal noise from the transducer
mass, which has a measured Q of 2.60 X 10^6. The noise temperature exceeds the
expected value of 3.5 \mu K by a factor of 200, primarily due to voltage noise
at the input of the SQUID. Noise from flux trapped on the chip is found to be
the most likely cause.Comment: Accepted by Applied Physics Letters tentatively scheduled for March
13, 200
Tropospheric ozone and El Niño–Southern Oscillation: Influence of atmospheric dynamics, biomass burning emissions, and future climate change
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