Tumor stiffness extends its grip on the metastatic microenvironment

The increased stiffness of a tumor triggers a multitude of responses that aid cancer cell dissemination. Stiffness-induced expression of CCN1 mediates autocrine signaling in the endothelium to upregulate N-Cadherin levels. This permits more stable interactions with cancer cells and increases their ability to spread into the circulation

Efficient Computation of Power, Force, and Torque in BEM Scattering Calculations

We present concise, computationally efficient formulas for several quantities of interest -- including absorbed and scattered power, optical force (radiation pressure), and torque -- in scattering calculations performed using the boundary-element method (BEM) [also known as the method of moments (MOM)]. Our formulas compute the quantities of interest \textit{directly} from the BEM surface currents with no need ever to compute the scattered electromagnetic fields. We derive our new formulas and demonstrate their effectiveness by computing power, force, and torque in a number of example geometries. Free, open-source software implementations of our formulas are available for download online

Modeling effects of nonbreeders on population growth estimates

Acknowledgements We thank the Beissinger lab and reviewers for helpful comments on manuscript drafts. This research was funded by a Marie Curie International Outgoing Fellowship within the 7th European Community Framework Programme (project NON- BREEDERS). The contents of this paper reflect the views of the researchers, not the views of the European Commission. Data Accessibility R-code available from the Dryad Digital Repository: http://dx.doi.org/10.5061/dryad.t56cn (Lee, Reid & Beissinger, 2016).Peer reviewedPostprin

Computation of Casimir Interactions between Arbitrary 3D Objects with Arbitrary Material Properties

We extend a recently introduced method for computing Casimir forces between arbitrarily--shaped metallic objects [M. T. H. Reid et al., Phys. Rev. Lett._103_ 040401 (2009)] to allow treatment of objects with arbitrary material properties, including imperfect conductors, dielectrics, and magnetic materials. Our original method considered electric currents on the surfaces of the interacting objects; the extended method considers both electric and magnetic surface current distributions, and obtains the Casimir energy of a configuration of objects in terms of the interactions of these effective surface currents. Using this new technique, we present the first predictions of Casimir interactions in several experimentally relevant geometries that would be difficult to treat with any existing method. In particular, we investigate Casimir interactions between dielectric nanodisks embedded in a dielectric fluid; we identify the threshold surface--surface separation at which finite--size effects become relevant, and we map the rotational energy landscape of bound nanoparticle diclusters

Education in post-Reformation Scotland : Andrew Melville and the University of St Andrews, 1560-1606

Andrew Melville (1545-1622) was the leader of the Presbyterian wing of the Scottish Kirk between 1574 and 1607, and he and his colleagues were a perpetual irritant to James VI and I in his attempts to establish a royal and Episcopal dominance over the Kirk. Yet much of Melville’s reputation has been based on the seventeenth-century Presbyterian historical narratives written by the likes of James Melville (Andrew’s nephew) and David Calderwood. These partisan accounts formed the basis of modern historiography in Thomas M’Crie’s monumentally influential Life of Andrew Melville. Modern historians broadly agree that Melville’s portrayal as a powerful and decisive church leader in these narratives is greatly exaggerated, and that he was at best an influential voice in the Kirk who was quickly marginalised by the adult James VI. However, only James Kirk has commented at any length on Melville’s other role in Jacobean Scotland—that of developing and reforming the Scottish universities. Melville revitalised the near-defunct Glasgow University between 1574 and 1580, and from 1580 to 1607 was principal of St Mary’s College, St Andrews, Scotland’s only divinity college. He was also rector of the University of St Andrews between 1590 and 1597. This thesis provides a detailed account of Melville’s personal role in the reform and expansion of the Scottish universities. This includes an analysis of his direct work at Glasgow, but focuses primarily on St Andrews, using the untapped archival sources held there and at the Scottish National Library and Archives to create a detailed picture of the development of the University after the Reformation. This thesis also evaluates the intellectual content of Melville’s reform programme, both as it developed during his time in Paris, Poitiers and Geneva, and as we see it in action in St Andrews

Fluctuating surface-current formulation of radiative heat transfer: theory and applications

We describe a novel fluctuating-surface current formulation of radiative heat transfer between bodies of arbitrary shape that exploits efficient and sophisticated techniques from the surface-integral-equation formulation of classical electromagnetic scattering. Unlike previous approaches to non-equilibrium fluctuations that involve scattering matrices---relating "incoming" and "outgoing" waves from each body---our approach is formulated in terms of "unknown" surface currents, laying at the surfaces of the bodies, that need not satisfy any wave equation. We show that our formulation can be applied as a spectral method to obtain fast-converging semi-analytical formulas in high-symmetry geometries using specialized spectral bases that conform to the surfaces of the bodies (e.g. Fourier series for planar bodies or spherical harmonics for spherical bodies), and can also be employed as a numerical method by exploiting the generality of surface meshes/grids to obtain results in more complicated geometries (e.g. interleaved bodies as well as bodies with sharp corners). In particular, our formalism allows direct application of the boundary-element method, a robust and powerful numerical implementation of the surface-integral formulation of classical electromagnetism, which we use to obtain results in new geometries, including the heat transfer between finite slabs, cylinders, and cones

Expressions of faith: religious writing

No abstract available

Survival Themed Video Games and Cultural Constructs of Power

Studies of the relationship between games and culture have often considered the empowering effect of games on the player. Studies have related this empowerment to individual character growth as well as broader geopolitical action (e.g., the conquering of nations). Few studies, however, have considered the emergent and increasingly popular survival genre of video games. In the current inquiry, through an analysis of past and current examples of games in this genre, we explore how survival games disempower players and discuss the potential implications for this shift in terms of cultural attitudes toward the current state of the world, individual prospects, and optimism/pessimism about the future. The goal of this piece is to explore and converse with the existing state of the literature and exemplars from the survival genre, creating a typological framework for future empirical and theoretical development in the area of games, culture, and (dis)empowerment dynamics