Accounting for practice in an age of theory: Charles Taylor’s theory of social imaginaries

No abstract available

Are lasers justified in everyday clinical dental practice

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Interactive ray tracing for volume visualization

Journal ArticleWe present a brute-force ray tracing system for interactive volume visualization, The system runs on a conventional (distributed) shared-memory multiprocessor machine. For each pixel we trace a ray through a volume to compute the color for that pixel. Although this method has high intrinsic computational cost, its simplicity and scalability make it ideal for large datasets on current high-end parallel systems

Interactive manipulation of contour data using the layers program

Journal ArticleThe "layers" program is useful for visualizing and editing large sets of contour data. These datasets arise frequently when trying to extract geometry from MRI slices. Due to the imprecise nature of the MR imaging and segmentation processes, the contours extracted may not accurately reflect the human geometry. The "layers" program has been designed to allow the efficient editing of these contours in order to provide human control over the contour generation process

An Analysis of Critical Thinking and Motivation in a Korean University EFL Classroom

This study was designed to determine what kinds of motivation students at a Korean university had for learning English, how the students would respond to intervention lessons with strong critical thinking components, and to what extent, if any, did those students feel that critical thinking would be advantageous to the study of English. It utilized a mixed-methods approach. Quantitative data was collected in the form of Likert questionnaire items and analyzed in terms of Dörnyei’s L2 Motivational Self System. Qualitative data was collected using open-ended questionnaire items. The findings were that the students’ strongest source of motivation was their Ideal L2 Self, followed by the L2 Learning Environment. The Ought-to Self played the smallest part. Additionally, though the students’ opinion of certain critical thinking focused behaviors differed from that of the author, there was a generally favorable response to the use of critical thinking in the English classroo

Parker Scott Honor Portfolio

Parker Scott\u27s honors portfolio captured in November 2017

Loss-of-Function ROX1 Mutations Suppress the Fluconazole Susceptibility of upc2AΔ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis

wo of the major classes of antifungal drugs in clinical use target ergosterol biosynthesis. Despite its importance, our understanding of the transcriptional regulation of ergosterol biosynthesis genes in pathogenic fungi is essentially limited to the role of hypoxia and sterol-stress-induced transcription factors such as Upc2 and Upc2A as well as homologs of sterol response element binding (SREB) factors. To identify additional regulators of ergosterol biosynthesis in Candida glabrata, an important human fungal pathogen with reduced susceptibility to ergosterol biosynthesis inhibitors relative to other Candida spp., we used a serial passaging strategy to isolate suppressors of the fluconazole hypersusceptibility of a upc2AΔ deletion mutant. This led to the identification of loss-of-function mutations in two genes: ROX1, the homolog of a hypoxia gene transcriptional suppressor in Saccharomyces cerevisiae, and CST6, a transcription factor that is involved in the regulation of carbon dioxide response in C. glabrata. Here, we describe a detailed analysis of the genetic interaction of ROX1 and UPC2A. In the presence of fluconazole, loss of Rox1 function restores ERG11 expression to the upc2AΔ mutant and inhibits the expression of ERG3 and ERG6, leading to increased levels of ergosterol and decreased levels of the toxic sterol 14α methyl-ergosta-8,24(28)-dien-3β, 6α-diol, relative to the upc2AΔ mutant. Our observations establish that Rox1 is a negative regulator of ERG gene biosynthesis and indicate that a least one additional positive transcriptional regulator of ERG gene biosynthesis must be present in C. glabrata

Relationships Among Student Type, GPA, and Retention Within a Proprietary Career College

Researchers have suggested that the college student population in the United States is evolving and the number of nontraditional students is rising. New student retention and academic success were ongoing concerns at a college in the southern United States and the association of those outcomes with instructional delivery model and student type was not known. In an effort to improve new student outcomes, this study examined differences in first-quarter student retention and academic success, as measured by GPA, for courses taught strictly online or on campus, and for traditional versus nontraditional students. Guided by Bean and Metzner\u27s conceptual model of nontraditional student attrition, this quasi-experimental study used data from 1,304 first-quarter students divided into 4 equal groups (n = 326). Groups were compared for GPA using 2x2 factorial ANOVA and for retention using chi-square tests of association. Findings showed no significant differences in retention or in the interaction between instructional delivery model and student type for GPA. A significant difference in GPA between traditional and nontraditional students, with the latter earning higher grades, was found. In addition, a bimodal grade distribution was identified in all 4 sample groups indicating the highest frequencies of students earning As and Fs, suggesting that new students either do very well or very poorly academically. Based on these findings, a white paper and presentation for campus officials was developed. The implementation of rubrics in all campus-based courses along with continuous evaluation of student performance was recommended. Positive social change may result from the use of rubrics with the new student population by increasing consistency of grading and improving understanding of expectations which may lead to better student outcomes over time

Accounting for practice in an age of theory: Charles Taylor’s theory of social imaginaries

No abstract available

A giant mystery in giant cell myocarditis: navigating diagnosis, immunosuppression, and mechanical circulatory support.

Giant cell myocarditis is a rare but often devastating diagnosis. Advances in cardiac imaging and mechanical circulatory support have led to earlier and more frequent diagnoses and successful management. This disease state has wide variation in acuity of presentation, and consequently, optimal treatment ranging from intensity and type of immunosuppression to mechanical circulatory support is not well defined. The following case describes the management of a patient with an unusual presentation of giant cell myocarditis over a 10 year course of advanced heart failure therapies and immunomodulatory support. This case highlights emerging concepts in the management of giant cell myocarditis including sub-acute presentations, challenges in diagnosis, and treatment modalities in the modern era