Viscoelastic deformation near active plate boundaries

Very Long Baseline Interferometry (VLBI) now has the capacity to monitor geodetic positions with precisions of a few 1 mm over continental baselines. For tectonic applications, one of the major products of the VLBI program is the determination of the rate of change of station locations. Vector site velocities are now routinely produced. One of the novel techniques, VLBI Euler poles, is discussed

Inflation from Geometrical Tachyons

We propose an alternative formulation of tachyon inflation using the geometrical tachyon arising from the time dependent motion of a BPS $D3$-brane in the background geometry due to $k$ parallel $NS$5-branes arranged around a ring of radius $R$. Due to the fact that the mass of this geometrical tachyon field is $\sqrt{2/k}$ times smaller than the corresponding open-string tachyon mass, we find that the slow roll conditions for inflation and the number of e-foldings can be satisfied in a manner that is consistent with an effective 4-dimensional model and with a perturbative string coupling. We also show that the metric perturbations produced at the end of inflation can be sufficiently small and do not lead to the inconsistencies that plague the open string tachyon models. Finally we argue for the existence of a minimum of the geometrical tachyon potential which could give rise to a traditional reheating mechanism.Comment: Latex, 20 pages, 4 figures; correction of algebraic errors in section 5 concerning the tachyon potential near its minimum. Conclusions unchange

Crustal deformation at the Sumatran Subduction Zone revealed by coral rings

Analyses of coral rings grown in the interval 1970–1997 reveal a geographically distinct pattern of interseismic uplift off Sumatra's western coast. At distances less than 110 km from the Sumatran trench, coral reefs are submerging as fast as 5 mm/y. At 130 and 180 km distance from the trench, they are emerging at similar rates. We suggest that a locked, or partially locked patch, located above 30 km depth on the upper surface of the subducting oceanic plate, generates this pattern

Lymphocyte subsets in healthy Malawians: Implications for immunologic assessment of HIV infection in Africa

BackgroundCD4+T lymphocyte measurements are the most important indicator of mortality in HIV-infected individuals in resource-limited settings. There is currently a lack of comprehensive immunophenotyping data from African populations to guide the immunologic assessment of HIV infection.ObjectiveTo quantify variation in absolute and relative lymphocyte subsets with age in healthy Malawians.MethodsLymphocyte subsets in peripheral blood of 539 healthy HIV-uninfected Malawians stratified by age were enumerated by flow cytometry.ResultsB and T–lymphocyte and T-lymphocyte subset absolute concentrations peaked in early childhood then decreased to adult levels, whereas lymphocyte subset proportions demonstrated much less variation with age. Adult lymphocyte subsets were similar to those in developed countries. In contrast, high B-lymphocyte and CD8+T-lymphocyte levels among children under 2 years, relative to those in developed countries, resulted in low CD4+T-lymphocyte percentages that varied little between 0 and 5 years (35% to 39%). The CD4+T-lymphocyte percentages in 35% of healthy children under 1 year and 18% of children age 1 to 3 years were below the World Health Organization threshold defining immunodeficiency in HIV-infected children in resource-limited settings. Thirteen percent of healthy children under 18 months old had a CD4:CD8T-lymphocyte ratio <1.0, which is commonly associated with HIV infection. All immunologic parameters except absolute natural killer lymphocyte concentration varied significantly with age, and percentage and overall absolute CD4+T-lymphocyte counts were higher in females than males.ConclusionAlthough lymphocyte subsets in Malawian adults are similar to those from developed countries, CD4+T-lymphocyte percentages in young children are comparatively low. These findings need to be considered when assessing the severity of HIV-related immunodeficiency in African children under 3 years

A molecular communication channel consisting of a single reversible chain of hydrogen bonds in a conformationally flexible oligomer

Communication of information through the global switching of conformation in synthetic molecules has hitherto entailed the inversion of chirality. Here, we report a class of oligomer through which information may be communicated through a global reversal of polarity. Ethylene-bridged oligoureas are constitutionally symmetrical, conformationally flexible molecules organized by a single chain of hydrogen bonds running the full length of the oligomer. NMR reveals that this hydrogen-bonded chain may undergo a coherent reversal of directionality. The directional uniformity of the hydrogen-bond chain allows it to act as a channel for the spatial communication of information on a molecular scale. A binding site at the terminus of an oligomer detects local information about changes in pH or anion concentration and transmits that information—in the form of a directionality switch in the hydrogen-bond chain—to a remote polarity-sensitive fluorophore. This propagation of polarity-encoded information provides a new mechanism for molecular communication

Proteomic profiling of urine for the detection of colon cancer.

BACKGROUND: Colorectal cancer is the second most common cause of cancer related death in the developed world. To date, no blood or stool biomarkers with both high sensitivity and specificity for potentially curable early stage disease have been validated for clinical use. SELDI and MALDI profiling are being used increasingly to search for biomarkers in both blood and urine. Both techniques provide information predominantly on the low molecular weight proteome (<15 kDa). There have been several reports that colorectal cancer is associated with changes in the serum proteome that are detectable by SELDI and we hypothesised that proteomic changes would also be detectable in urine. RESULTS: We collected urine from 67 patients with colorectal cancer and 72 non-cancer control subjects, diluted to a constant protein concentration and generated MALDI and SELDI spectra. The intensities of 19 peaks differed significantly between cancer and non-cancer patients by both t-tests and after adjusting for confounders using multiple linear regressions. Logistic regression classifiers based on peak intensities identified colorectal cancer with up to 78% sensitivity at 87% specificity. We identified and independently quantified 3 of the discriminatory peaks using synthetic stable isotope peptides (an 1885 Da fragment of fibrinogen and hepcidin-20) or ELISA (beta2-microglobulin). CONCLUSION: Changes in the urine proteome may aid in the early detection of colorectal cancer

D-Brane Dynamics and NS5 Rings

We consider the classical motion of a probe D-brane moving in the background geometry of a ring of NS5 branes, assuming that the latter are non-dynamical. We analyse the solutions to the Dirac-Born-Infield (DBI) action governing the approximate dynamics of the system. In the near horizon (throat) approximation we find several exact solutions for the probe brane motion. These are compared to numerical solutions obtained in more general cases. One solution of particular interest is when the probe undergoes oscillatory motion through the centre of the ring (and perpendicular to it). By taking the ring radius sufficiently large, this solution should remain stable to any stringy corrections coming from open-strings stretching between the probe and the NS5-branes along the ring.Comment: 17 pages, Latex, 8 figures; References adde

Non-Abelian (p,q) Strings in the Warped Deformed Conifold

We calculate the tension of $(p,q)$-strings in the warped deformed conifold using the non-Abelian DBI action. In the large flux limit, we find exact agreement with the recent expression obtained by Firouzjahi, Leblond and Henry-Tye up to and including order $1/M^2$ terms if $q$ is also taken to be large. Furthermore using the finite $q$ prescription for the symmetrised trace operation we anticipate the most general expression for the tension valid for any $(p,q)$. We find that even in this instance, corrections to the tension scale as $1/M^2$ which is not consistent with simple Casimir scaling.Comment: 18 pages, Latex, 1 figure; Added a discussion of the case when the warp factor parameter $b\neq 1$ and typos correcte