624 research outputs found
Quality of life of chronic stable angina patients 4 years after coronary angioplasty or coronary artery bypass surgery
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72244/1/j.1365-2796.2001.00782.x.pd
The Evolution of Distorted Rotating Black Holes II: Dynamics and Analysis
We have developed a numerical code to study the evolution of distorted,
rotating black holes. This code is used to evolve a new family of black hole
initial data sets corresponding to distorted ``Kerr'' holes with a wide range
of rotation parameters, and distorted Schwarzschild black holes with odd-parity
radiation. Rotating black holes with rotation parameters as high as
are evolved and analyzed in this paper. The evolutions are generally carried
out to about , where is the ADM mass. We have extracted both the
even- and odd-parity gravitational waveforms, and find the quasinormal modes of
the holes to be excited in all cases. We also track the apparent horizons of
the black holes, and find them to be a useful tool for interpreting the
numerical results. We are able to compute the masses of the black holes from
the measurements of their apparent horizons, as well as the total energy
radiated and find their sum to be in excellent agreement with the ADM mass.Comment: 26 pages, LaTeX with RevTeX 3.0 macros. 27 uuencoded gz-compressed
postscript figures. Also available at http://jean-luc.ncsa.uiuc.edu/Papers/
Submitted to Physical Review
Role of Peroxisome Proliferator-Activated Receptor Gamma and Its Ligands in the Treatment of Hematological Malignancies
Peroxisome proliferator-activated receptor gamma (PPARγ) is a multifunctional transcription factor with important regulatory roles in inflammation, cellular growth, differentiation, and apoptosis. PPARγ is expressed in a variety of immune cells as well as in numerous leukemias and lymphomas. Here, we review recent studies that provide new insights into the mechanisms by which PPARγ ligands influence hematological malignant cell growth, differentiation, and survival. Understanding the diverse properties of PPARγ ligands is crucial for the development of new therapeutic approaches for hematological malignancies
The Evolution of Distorted Rotating Black Holes III: Initial Data
In this paper we study a new family of black hole initial data sets
corresponding to distorted ``Kerr'' black holes with moderate rotation
parameters, and distorted Schwarzschild black holes with even- and odd-parity
radiation. These data sets build on the earlier rotating black holes of Bowen
and York and the distorted Brill wave plus black hole data sets. We describe
the construction of this large family of rotating black holes. We present a
systematic study of important properties of these data sets, such as the size
and shape of their apparent horizons, and the maximum amount of radiation that
can leave the system during evolution. These data sets should be a very useful
starting point for studying the evolution of highly dynamical black holes and
can easily be extended to 3D.Comment: 16 page
Symmetry without Symmetry: Numerical Simulation of Axisymmetric Systems using Cartesian Grids
We present a new technique for the numerical simulation of axisymmetric
systems. This technique avoids the coordinate singularities which often arise
when cylindrical or polar-spherical coordinate finite difference grids are
used, particularly in simulating tensor partial differential equations like
those of 3+1 numerical relativity. For a system axisymmetric about the z axis,
the basic idea is to use a 3-dimensional Cartesian (x,y,z) coordinate grid
which covers (say) the y=0 plane, but is only one
finite-difference-molecule--width thick in the y direction. The field variables
in the central y=0 grid plane can be updated using normal (x,y,z)--coordinate
finite differencing, while those in the y \neq 0 grid planes can be computed
from those in the central plane by using the axisymmetry assumption and
interpolation. We demonstrate the effectiveness of the approach on a set of
fully nonlinear test computations in 3+1 numerical general relativity,
involving both black holes and collapsing gravitational waves.Comment: 17 pages, 4 figure
Integrating education into primary care quality and cost improvement at an academic medical center
Introduction: In 1996 the University of Michigan Health System created the Guidelines Utilization, Implementation, Development, and Evaluation Studies (GUIDES) unit to improve the quality and cost-effectiveness of primary care for common medical problems. GUIDES's primary functions are to oversee the development of evidence-based, practical clinical guidelines for common medical conditions; measure and provide feedback on physicians' performance; and facilitate systemic changes to support appropriate care. Various methods are used to improve care, including evidence reviews, formal education, informal clinical “opinion leaders,” feedback, reminders, and procedure changes. Twenty-four common medical conditions have been addressed through this process. More than 30 measures of clinical performance have been developed and reported. Methods: This case study describes a systematic, multifaceted program to improve the quality and cost-effectiveness of primary care. Results: Illustrative results for clinical performance are presented for 2 measures of chronic care, 2 measures of preventive care, and 2 measures of acute care. All 6 measures show general improvement in performance across years, with performance near or above the National Committee for Quality Assurance's 90th percentile for Health Plan Employer Data and Information Set measures. Discussion: A systematic approach involving all relevant components of a health system integrates the synthesis of information, education about the information and how to implement it, and addressing operational barriers. Benefits include a curriculum that is shared across faculty, residents, and medical students and more uniform quality of care that faculty model for physicians-in-training.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/49319/1/80_ftp.pd
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