Refighting Pickett’s Charge: mathematical modeling of the Civil War battlefield

Objective. We model Pickett’s Charge at the Battle of Gettysburg to see whether the Confederates could have achieved victory by committing more infantry, executing a better barrage, or facing a weaker defense. Methods. Our mathematical modeling is based on Lanchester equations, calibrated using historical army strengths. We weight the Union artillery and infantry two different ways using two sources of data, and so have four versions of the model. Results. The models estimate that a successful Confederate charge would have required at least 1 to 3 additional brigades. An improved artillery barrage would have reduced these needs by about 1 brigade. A weaker Union defense could have allowed the charge to succeed as executed. Conclusions. The Confederates plausibly had enough troops to take the Union position and alter the battle’s outcome, but likely too few to further exploit such a success

Self-Assessment of Knowledge: a cognitive learning or affective measure? Perspectives from the management learning and education community

The article presents a response to the article "Self-Assessment of Knowledge: A Cognitive Learning or Affective Measure?," by Traci Sitzmann, Katherine Ely, Kenneth G. brown and Kristina N. Bauer. In the response the authors offer their opinions on the article, on self-assessment in education and on the role that self-assessment plays in the management learning and education communities. A discussion of research which has evaluated the psychology of learning and the psychology of personal growth is presented

Metamorphosis of the Mushroom Bodies; Large-Scale Rearrangements of the Neural Substrates for Associative Learning and Memory in Drosophila

Paired brain centers known as mushroom bodies are key features of the circuitry for insect associative learning, especially when evoked by olfactory cues. Mushroom bodies have an embryonic origin, and unlike most other brain structures they exhibit developmental continuity, being prominent components of both the larval and the adult CNS. Here, we use cell-type-specific markers, provided by the P{GAL4} enhancer trap system, to follow specific subsets of mushroom body intrinsic and extrinsic neurons from the larval to the adult stage. We find marked structural differences between the larval and adult mushroom bodies, arising as the consequence of large-scale reorganization during metamorphosis. Extensive, though incomplete, degradation of the larval structure is followed by establishment of adult specific α and β lobes. Kenyon cells of embryonic origin, by contrast, were found to project selectively to the adult γ lobe. We propose that the γ lobe stores information of relevance to both developmental stages, whereas the α and β lobes have uniquely adult roles

Activation of lateral hypothalamus-projecting parabrachial neurons by intraorally delivered gustatory stimuli

The present study investigated a subpopulation of neurons in the mouse parabrachial nucleus (PbN), a gustatory and visceral relay area in the brainstem, that project to the lateral hypothalamus (LH). We made injections of the retrograde tracer Fluorogold (FG) into LH, resulting in fluorescent labeling of neurons located in different regions of the PbN. Mice were stimulated through an intraoral cannula with one of seven different taste stimuli, and PbN sections were processed for immunohistochemical detection of the immediate early gene c-Fos, which labels activated neurons. LH projection neurons were found in all PbN subnuclei, but in greater concentration in lateral subnuclei, including the dorsal lateral subnucleus (dl). Fos-like immunoreactivity (FLI) was observed in the PbN in a stimulus-dependent pattern, with the greatest differentiation between intraoral stimulation with sweet (0.5 M sucrose) and bitter (0.003 M quinine) compounds. In particular, sweet and umami-tasting stimuli evoked robust FLI in cells in the dl, whereas quinine evoked almost no FLI in cells in this subnucleus. Double-labeled cells were also found in the greatest quantity in the dl. Overall, these results support the hypothesis that the dl contains direct a projection to the LH that is activated preferentially by appetitive compounds; this projection may be mediated by taste and/or postingestive mechanisms

The effects of cognitive style on research supervision: a study of student-supervisor dyads in management education

Whilst attention has been paid to many aspects of teaching and learning in management education, one facet that has been seriously overlooked is the process of research supervision. Research at both the graduate and the undergraduate level suggests that the relationship between the student and the supervisor is a significant predictor of success and failure in independent research projects. One personality variable that has been shown to be partly responsible for shaping the overall effectiveness of such relationships is cognitive style, defined as consistent individual differences in how we perceive, organize and process information, solve problems, learn and relate to others. This study examined the effects of differences and similarities in the analytic-intuitive dimension of cognitive style on the supervision process. Data were collected from both partners in 421 dyadic relationships, each comprising an academic supervisor and a management student undertaking a major research project. Findings suggest that analytic supervisors were perceived to be significantly more nurturing and less dominant than their more intuitive counterparts, indicating a higher degree of closeness in their relationships. This led to increased liking in the relationship, and significantly higher performance outcomes for the student. These effects were highest in dyads whose students and supervisors were more analytic

An EMG preamplifier system for biomechanical studies

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24560/1/0000840.pd

Objectively measured physical activity and fat mass in a large cohort of children

Background Previous studies have been unable to characterise the association between physical activity and obesity, possibly because most relied on inaccurate measures of physical activity and obesity. Methods and Findings We carried out a cross sectional analysis on 5,500 12-year-old children enrolled in the Avon Longitudinal Study of Parents and Children. Total physical activity and minutes of moderate and vigorous physical activity (MVPA) were measured using the Actigraph accelerometer. Fat mass and obesity (defined as the top decile of fat mass) were measured using the Lunar Prodigy dual x-ray emission absorptiometry scanner. We found strong negative associations between MVPA and fat mass that were unaltered after adjustment for total physical activity. We found a strong negative dose-response association between MVPA and obesity. The odds ratio for obesity in adjusted models between top and the bottom quintiles of minutes of MVPA was 0.03 (95% confidence interval [CI] 0.01-0.13, p-value for trend < 0.0001) in boys and 0.36 (95% CI 0.17-0.74, p-value for trend = 0.006) in girls. Conclusions We demonstrated a strong graded inverse association between physical activity and obesity that was stronger in boys. Our data suggest that higher intensity physical activity may be more important than total activity

Implications of the PEGASUS-TIMI 54 Trial for US Clinical Practice

Objectives This study aims to determine the proportion of real-world patients with myocardial infarction (MI) who would have been eligible for the PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54) trial, to characterise their current use of P2Y12 inhibitors and to explore the estimated costs and ischaemic event consequences of increasing P2Y12 inhibitor use among these patients. Methods In the US national ACTION Registry–GWTG (Acute Coronary Treatment and Intervention Outcomes Network Registry–Get With The Guidelines), we identified 273 328 patients with MI and determined the proportion that would have met the eligibility criteria for the PEGASUS trial. We described longitudinal P2Y12 inhibitor use among patients eligible for PEGASUS and estimated the cost and ischaemic consequences of increasing P2Y12 use among eligible patients. Results A total of 112 222 (41.1%) patients with MI in ACTION Registry–GWTG met eligibility for the PEGASUS trial. Among 83 871 eligible patients with pharmacy claims data, 23 042 (27.5%) were on a P2Y12 inhibitor at 1 year, 9661 (11.5%) at 2 years and 5246 (6.3%) at 3 years, with the majority (79.2%) of these patients on clopidogrel. The use of ticagrelor in eligible patients not yet on a P2Y12 inhibitor at 1 year post-MI would cost an estimated US$885 000 per MI, stroke or cardiovascular death averted over a 3-year time horizon, while the use of clopidogrel would cost an estimated US$19 800 per ischaemic event averted. Conclusion In contemporary clinical practice, a minority of patients are on a P2Y12 inhibitor beyond 1-year post-MI. Applying PEGASUS trial findings to clinical practice would result in a large increase in P2Y12 inhibitor use, with a cost per ischaemic event averted that is strongly influenced by the choice of therapy

A second case of outbursts in a pulsating white dwarf observed by Kepler

We present observations of a new phenomenon in pulsating white dwarf stars: large-amplitude outbursts at timescales much longer than the pulsation periods. The cool (${T}_{\mathrm{eff}}$ = 11,060 K), hydrogen-atmosphere pulsating white dwarf PG 1149+057 was observed nearly continuously for more than 78.8 day by the extended Kepler mission in K2 Campaign 1. The target showed 10 outburst events, recurring roughly every 8 day and lasting roughly 15 hr, with maximum flux excursions up to 45% in the Kepler bandpass. We demonstrate that the outbursts affect the pulsations and therefore must come from the white dwarf. Additionally, we argue that these events are not magnetic reconnection flares, and are most likely connected to the stellar pulsations and the relatively deep surface convection zone. PG 1149+057 is now the second cool pulsating white dwarf to show this outburst phenomenon, after the first variable white dwarf observed in the Kepler mission, KIC 4552982. Both stars have the same effective temperature, within the uncertainties, and are among the coolest known pulsating white dwarfs of typical mass. These outbursts provide fresh observational insight into the red edge of the DAV instability strip and the eventual cessation of pulsations in cool white dwarfs