Drought

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The Long Winter of 1880-1881

The story of the winter of 1880-1881 in the central United States has been retold in historical fiction, including Laura Ingalls Wilder’s The Long Winter, as well as in local histories and folklore. What story does the meteorological data tell, and how does it measure up when compared to the fiction and folklore? What were the contributing factors to the severity of the Long Winter, and has it been or could it be repeated? Examining historical and meteorological data, reconstructions, and reanalysis, including the Accumulated Winter Season Severity Index, the Long Winter emerges as one of the most severe since European-descended settlers arrived to the central United States and began documenting weather. Contributing factors to its severity include an extremely negative North Atlantic Oscillation pattern, a mild to moderate El Niño, and a background climate state that was much colder than the twentieth-century average. The winter began early and was particularly cold and snowy throughout its duration, with a sudden spring melt that caused subsequent record-setting flooding. Historical accounts of the winter, including The Long Winter, prove to be largely accurate in describing its severity, as well as its impacts on transportation, fuel availability, food supplies, and human and livestock health. Being just one of the most severe winters on record, there are others in the modern historical record that do compare in severity, providing opportunity for comparing and contrasting the impacts of similarly severe winters

The Accumulated Winter Season Severity Index (AWSSI)

The character of a winter can be defined by many of its features, including temperature averages and extremes, snowfall totals, snow depth, and the duration between onset and cessation of winter-weather conditions. The accumulated winter season severity index incorporates these elements into one site-specific value that defines the severity of a particular winter, especially when examined in the context of climatological values for that site. Thresholds of temperature, snowfall, and snow depth are assigned points that accumulate through the defined winter season; a parallel index uses temperature and precipitation to provide a snow proxy where snow data are unavailable or unreliable. The results can be analyzed like any other meteorological parameter to examine relationships to teleconnection patterns, determine trends, and create sector-specific applications, as well as to analyze an ongoing winter or any individual winter season to place its severity in context

The Accumulated Winter Season Severity Index (AWSSI)

The character of a winter can be defined by many of its features, including temperature averages and extremes, snowfall totals, snow depth, and the duration between onset and cessation of winter-weather conditions. The accumulated winter season severity index incorporates these elements into one site-specific value that defines the severity of a particular winter, especially when examined in the context of climatological values for that site. Thresholds of temperature, snowfall, and snow depth are assigned points that accumulate through the defined winter season; a parallel index uses temperature and precipitation to provide a snow proxy where snow data are unavailable or unreliable. The results can be analyzed like any other meteorological parameter to examine relationships to teleconnection patterns, determine trends, and create sector-specific applications, as well as to analyze an ongoing winter or any individual winter season to place its severity in context

The Severe Winter of 1981-1982 in Illinois

The winter of 1981-1982 was Illinois' fourth severe winter in six years and the second most severe on record. Eighteen severe winter storms equalled the record number set in the winter of 1977-1978. The winter was unusually long, lasting from late November through early April. This report examines the climatology of the winter in regard to storm characteristics, snowfall, and temperature and contains a general synoptic analysis of each storm. Mean upper atmospheric circulation patterns of this and three previous severe winters are compared. Impacts of the severe storms and the winter in general are discussed in terms of transportation, utilities, public health, government, agriculture, and the environment. The winter of 1981-1982 had the greatest impact in central and southern Illinois. Up to 20 inches of snow and blizzard-like conditions in south central Illinois during the storm of 29-31 January led to it being classified as the most damaging of the winter. The storms and cold of the winter were responsible for 34 deaths and at least 550 injuries statewide. Transportation and energy usage and costs were most affected by the winter weather. Serious agricultural damage resulted from the severe cold, and both the snow and cold had detrimental effects on wildlife.publishedpeer reviewedOpe

The 1980-1981 drought in Illinois causes, dimensions, and impact

Hydrologic, meteorological, and climatological aspects of the 1980-1981 drought in Illinois are addressed. The drought is evaluated in terms of precipitation, streamflow, lakes and reservoirs, and groundwater resources of the state. The meteorological conditions that produced the drought also are addressed. Impacts and problems resulting from the drought are discussed along with various actions taken to ameliorate the problems. Although the primary goal of the study was to quantify the drought, primarily in a physical sense, an important secondary goal was to assess the impacts and the actions employed, to derive information needed in future planning and handling of Illinois droughts. The report thus ends with a set of recommendations for coping with future droughts. The 1980-1981 drought was not one of the extreme droughts of record; however, it is important in that it was the most severe drought since those of the early 1950’s. As such, it reflects some new types of impacts on the state’s water resources due to technological, hydrological, and institutional changes since the 1950’s.publishedpeer reviewedOpe

In vitro and in vivo antifungal profile of a novel and long acting inhaled azole, PC945, on Aspergillus fumigatus infection

The profile of PC945, a novel triazole antifungal, designed for administration via inhalation, hasbeen assessed in a range of in vitro and in vivo studies. PC945 was characterized as a potent, tight-binding inhibitor of Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B)activity.In addition, when A. fumigatus hyphae or human bronchial cells were treated with PC945, and thenwashed, PC945 was found to be quickly absorbed into both target and non-target cells and toproduce persistent antifungal effects. In temporarily neutropenic immunocompromised miceinfected with A. fumigatus intranasally, 50% of the animals survived until day 7 when treatedintranasally with PC945 at 0.56 μg/mouse, while posaconazole showed similar effects (44%) at14 μg/mouse. This profile affirms that topical treatment with PC945 should provide potentantifungal activity in the lung

Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy

Background: The phase IIIb, randomized, parallel-group, placebo-controlled ANDHI double-blind (DB) study extended understanding of the efficacy of benralizumab for patients with severe eosinophilic asthma. Patients from ANDHI DB could join the 56-week ANDHI in Practice (IP) single-arm, open-label extension substudy. Objective: Assess potential for standard-of-care background medication reductions while maintaining asthma control with benralizumab. Methods: Following ANDHI DB completion, eligible adults were enrolled in ANDHI IP. After an 8-week run-in with benralizumab, there were 5 visits to potentially reduce background asthma medications for patients achieving and maintaining protocol-defined asthma control with benralizumab. Main outcome measures for non-oral corticosteroid (OCS)-dependent patients were the proportions with at least 1 background medication reduction (ie, lower inhaled corticosteroid dose, background medication discontinuation) and the number of adapted Global Initiative for Asthma (GINA) step reductions at end of treatment (EOT). Main outcomes for OCS-dependent patients were reductions in daily OCS dosage and proportion achieving OCS dosage of 5 mg or lower at EOT. Results: For non-OCS-dependent patients, 53.3% (n = 208 of 390) achieved at least 1 background medication reduction, increasing to 72.6% (n = 130 of 179) for patients who maintained protocol-defined asthma control at EOT. A total of 41.9% (n = 163 of 389) achieved at least 1 adapted GINA step reduction, increasing to 61.8% (n = 110 of 178) for patients with protocol-defined EOT asthma control. At ANDHI IP baseline, OCS dosages were 5 mg or lower for 40.4% (n = 40 of 99) of OCS-dependent patients. Of OCS-dependent patients, 50.5% (n = 50 of 99) eliminated OCS and 74.7% (n = 74 of 99) achieved dosages of 5 mg or lower at EOT. Conclusions: These findings demonstrate benralizumab's ability to improve asthma control, thereby allowing background medication reduction

Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy

peer reviewedBackground: The phase IIIb, randomized, parallel-group, placebo-controlled ANDHI double-blind (DB) study extended understanding of the efficacy of benralizumab for patients with severe eosinophilic asthma. Patients from ANDHI DB could join the 56-week ANDHI in Practice (IP) single-arm, open-label extension substudy. Objective: Assess potential for standard-of-care background medication reductions while maintaining asthma control with benralizumab. Methods: Following ANDHI DB completion, eligible adults were enrolled in ANDHI IP. After an 8-week run-in with benralizumab, there were 5 visits to potentially reduce background asthma medications for patients achieving and maintaining protocol-defined asthma control with benralizumab. Main outcome measures for non–oral corticosteroid (OCS)-dependent patients were the proportions with at least 1 background medication reduction (ie, lower inhaled corticosteroid dose, background medication discontinuation) and the number of adapted Global Initiative for Asthma (GINA) step reductions at end of treatment (EOT). Main outcomes for OCS-dependent patients were reductions in daily OCS dosage and proportion achieving OCS dosage of 5 mg or lower at EOT. Results: For non–OCS-dependent patients, 53.3% (n = 208 of 390) achieved at least 1 background medication reduction, increasing to 72.6% (n = 130 of 179) for patients who maintained protocol-defined asthma control at EOT. A total of 41.9% (n = 163 of 389) achieved at least 1 adapted GINA step reduction, increasing to 61.8% (n = 110 of 178) for patients with protocol-defined EOT asthma control. At ANDHI IP baseline, OCS dosages were 5 mg or lower for 40.4% (n = 40 of 99) of OCS-dependent patients. Of OCS-dependent patients, 50.5% (n = 50 of 99) eliminated OCS and 74.7% (n = 74 of 99) achieved dosages of 5 mg or lower at EOT. Conclusions: These findings demonstrate benralizumab's ability to improve asthma control, thereby allowing background medication reduction. © 202