Algorithmic Trading and Cryptocurrency- a literature review and key findings

Algorithmic and high-frequency trading gained significant popularity in traditional financial market transactions in the early 2000s. While cryptocurrency was introduced in 2009, it was not until 2015 that cryptocurrency trading experienced explosive growth due to advancements in technologies supporting the cryptocurrency ecosystem and economic uncertainties. Algorithmic trading strategies and high-frequency automated trading have been used in cryptocurrency trading. However, the lack of historical data and the volatility of the cryptocurrency market create unique challenges and impact the performance of these models and strategies. Additionally, cryptocurrency is an unregistered security, and cryptocurrency exchanges remain unregulated, which has generated significant concerns for global securities governing bodies. This research provides a literature review and document analysis of peer-reviewed journal articles and professional literature and identifies themes regarding algorithmic trading and the cryptocurrency ecosystem

The State of Digital Transformation: A Pilot Study

Although the COVID-19 pandemic has created many challenges for business operations, it has certainly driven businesses to deploy digital technologies in a variety of areas, including customer engagement, customer services, and workflow coordination. In addition to supporting overall business strategies, digital technologies have been shown to carry the capacity to trigger business innovations and renewal. This pilot study aims to understand the impact of COVID-19 on digitalization and further investigate the various paths of digital transformation at different businesses. Key findings will be discussed along with their implications for future research

COVID-19 Surveillance Testing of Healthcare Personnel Drives Universal Masking Practice

Health Care Professionals (HCP) are at increased risk of COVID-19 infection due to the unpredictable clinical presentation of COVID-19 disease, limited SARS-CoV-2 testing, personal protective equipment (PPE) shortages, and the inherent inability to distance from patients. Infected HCP may infect others including coworkers leading to a simultaneous increase of number of infections and decreased availability of HCP in a community. [1] Due to PPE shortages, many healthcare systems have faced difficult decisions regarding utilization of PPE to protect HCP and patients and the communities they serve. We describe Norton Healthcare’s success utilizing surveillance COVID-19 testing of HCP to inform the decision to increase the use of PPE during a PPE shortage in the form of universal masking. Many healthcare systems could benefit from surveillance COVID-19 testing of HCP and universal masking of HCP

Resilience in Nonmetropolitan Nebraska: Capacity to Overcome Disasters and Hardships. 2020 Nebraska Rural Poll Results

The definition of resilience is the capacity to recover quickly from difficulties. Synonyms include toughness, perseverance and grit. Last spring’s severe weather events and this year’s ongoing COVID-19 pandemic are likely testing the resilience of rural Nebraskans. Given that, how do rural Nebraskans rate their communities on dimensions that measure their resiliency? How confident are they that the federal government or local emergency management authorities can contain infectious disease outbreaks? How do they rate their ability to help their community handle adversities? How prepared are rural Nebraskans to deal with financial emergencies? This paper provides a detailed analysis of these questions. This report details 1,979 responses to the 2020 Nebraska Rural Poll, the 25th annual effort to understand rural Nebraskans’ perceptions. Respondents were asked a series of questions about resilience. Comparisons are made among different respondent subgroups, that is, comparisons by age, occupation, region, etc. Based on these analyses, some key findings emerged: • Most rural Nebraskans agree that their community contains most elements of resilience: trust among residents, ability to overcome an emergency situation, residents working together to improve the community, people that help each other, community information sharing and community priority and goal setting. • Rural Nebraskans are less likely to say their community treats everyone fairly, actively plans for future disasters, trusts public officials, and look at its successes and failures to learn from the past. • Most rural Nebraskans agree that infectious diseases will have a major impact in the country in the next few years. • Most rural Nebraskans assume that there will be limits on what federal and local governments can do to contain a widespread infectious disease outbreak. • Most rural Nebraskans believe they can help improve their communities when something bad happens and can take setbacks in their community’s progress in stride. • Savings, credit card(s) and a bank loan are the most accessible sources of emergency funds for rural Nebraskans

Exploring the Nebraska Rural Poll, 2020

The Nebraska Rural Poll was initiated in 1996. Over the past 24 years, input has been gathered from over 64,000 nonmetropolitan Nebraskans. 102 separate reports have been produced covering 31 unique topics Trend Analysis Subgroup Comparisons Some questions have been repeated at various intervals of tim

The Grizzly, April 9, 2015

Students Expose Racism on Yik Yak • English Honor Society Hosting Gatsby Party • Goss, Fulbright Winner, Plans to Travel to Turkey • HEART Lab Offers Unique Research • Annual Edible Book Festival Continues for Eleventh Year • New Minors Created for Fall • Opinion: A Fourth CIE Question That Breaks the Silence; Fourth Question Not True to Liberal Arts • Stick it to \u27em • On the Right Trackhttps://digitalcommons.ursinus.edu/grizzlynews/1930/thumbnail.jp

Why Every Hospital Needs a COVID-19 Clinical Case Review Team

A hospital’s response to a global pandemic requires a coordinated effort to provide consistent guidance as information rapidly changes. In the early months of the COVID-19 pandemic, diagnosis and subsequent containment was challenging due to unfamiliarity with disease presentation, unknown reverse transcription-polymerase chain reaction sensitivity and inconsistent access to testing supplies. A centralized COVID-19 clinical case review team can provide guidance on test interpretation, isolation, resource coordination and more

Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model

NOTICE: this is the author’s version of a work that was accepted for publication in Neurobiology of Disease. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication.Friedreich ataxia (FRDA) is an inherited neurodegenerative disorder caused by GAA repeat expansion within the FXN gene, leading to epigenetic changes and heterochromatin-mediated gene silencing that result in a frataxin protein deficit. Histone deacetylase (HDAC) inhibitors, including pimelic o-aminobenzamide compounds 106, 109 and 136, have previously been shown to reverse FXN gene silencing in short-term studies of FRDA patient cells and a knock-in mouse model, but the functional consequences of such therapeutic intervention have thus far not been described. We have now investigated the long-term therapeutic effects of 106, 109 and 136 in our GAA repeat expansion mutation-containing YG8R FRDA mouse model. We show that there is no overt toxicity up to 5 months of treatment and there is amelioration of the FRDA-like disease phenotype. Thus, while the neurological deficits of this model are mild, 109 and 106 both produced an improvement of motor coordination, whereas 109 and 136 produced increased locomotor activity. All three compounds increased global histone H3 and H4 acetylation of brain tissue, but only 109 significantly increased acetylation of specific histone residues at the FXN locus. Effects on FXN mRNA expression in CNS tissues were modest, but 109 significantly increased frataxin protein expression in brain tissue. 109 also produced significant increases in brain aconitase enzyme activity, together with reduction of neuronal pathology of the dorsal root ganglia (DRG). Overall, these results support further assessment of HDAC inhibitors for treatment of Friedreich ataxia.This work was supported by Repligen Corporation; Muscular Dystrophy Association (MDA) USA; Ataxia UK; Friedreich's Ataxia Research Alliance (FARA); GoFAR; and the Wellcome Trust [089757]

In Vitro and In Vivo Neurotoxicity of Prion Protein Oligomers

The mechanisms underlying prion-linked neurodegeneration remain to be elucidated, despite several recent advances in this field. Herein, we show that soluble, low molecular weight oligomers of the full-length prion protein (PrP), which possess characteristics of PrP to PrPsc conversion intermediates such as partial protease resistance, are neurotoxic in vitro on primary cultures of neurons and in vivo after subcortical stereotaxic injection. Monomeric PrP was not toxic. Insoluble, fibrillar forms of PrP exhibited no toxicity in vitro and were less toxic than their oligomeric counterparts in vivo. The toxicity was independent of PrP expression in the neurons both in vitro and in vivo for the PrP oligomers and in vivo for the PrP fibrils. Rescue experiments with antibodies showed that the exposure of the hydrophobic stretch of PrP at the oligomeric surface was necessary for toxicity. This study identifies toxic PrP species in vivo. It shows that PrP-induced neurodegeneration shares common mechanisms with other brain amyloidoses like Alzheimer disease and opens new avenues for neuroprotective intervention strategies of prion diseases targeting PrP oligomers

Crop Updates 2006 - Katanning

This session covers sixteen papers from different authors 2006 SEASONAL OUTLOOK, David Stephens and Michael Meuleners, Department of Agriculture Review of climate model summaries reported in the Department of Agriculture’s growing season outlooks, Meredith Fairbanks, Department of Agriculture Farmers commodity outlook 2006, Thomas Schulz, Department of Agriculture Why is salinity such a difficult problem for plant breeders? T J Flowers, TD Colmer, University of Western Australia Matching nitrogen supply to wheat demand in 2005, Narelle Simpson, Ron McTaggart, Wal Anderson, Lionel Martin and Dave Allen, Department of Agriculture Wheat varieties in 2006, Brenda Shackley, Department of Agriculture Performance of dwarf potential milling oat varieties in Western Australian environments, Raj Malik and Kellie Winfield, Department of Agriculture Field pea lessons for 2006, Rodger Beermir, Department of Agriculture Better returns from Durum wheat, Shahahan Miyan, Department of Agriculture Summer weeds can reduce grain yield and protein, Dr. Abul Hashem, Department of Agriculture, Dr Shahab Pathan, Department of Agriculture, Vikki Osten, Queensland Department of Primary Industries and Fisheries Management of Summer Weeds, Alex Douglas, Department of Agriculture Frost or Friction, Garren Knell, Steve Curtin, Wade Longmuir, Consult Ag Pty Ltd PROFITING FROM MARGINAL LAND SEMINAR Producing Bio-Diesel and rubber from marginal land?? Dr Henry Brockman, Department of Agriculture SGSL Producer network – on ground implementation of saltbush based pastures, Justin Hardy, Arjen Ryder, John Paul Collins and Jessica Johns, Department of Agriculture Enhancing the profitability of “Edenia” using saltbush and perenials, SGSL Producer case study, John Pepall, Jinka’s Hill LCDC Investment in saltland pastures, Allan Herbert, Department of Agricultur