Mentoring Exchange

This poster describes the progress and lessons learned as a result of newly implemented Faculty Mentoring Program in the Indiana University School of Informatics and Computing

Multidrug-Resistant Tuberculosis in Patients without HIV Infection

BACKGROUND Investigations of outbreaks of multidrug-resistant tuberculosis have found low rates of treatment response and very high mortality, and they have mainly involved patients with advanced human immunodeficiency virus (HIV) infection. For patients without HIV infection, one study reported an overall rate of response to treatment of 56 percent, and the mortality from tuberculosis was 22 percent. We investigated treatment response and mortality rates in 26 HIV-negative patients in New York with multidrug-resistant tuberculosis. METHODS We obtained detailed data from seven teaching hospitals in New York City on patients with multidrug-resistant tuberculosis--defined as tuberculosis resistant at least to isoniazid and rifampin--who were HIV-negative on serologic testing. Lengths of times from diagnosis to the initiation of appropriate therapy and from the initiation of appropriate therapy to conversion to negative cultures were assessed. Therapeutic responses were evaluated by both microbiologic and clinical criteria. RESULTS Between March 1991 and September 1994, 26 HIV-negative patients were identified and treated. Of the 25 patients for whom adequate data were available for analysis, 24 (96 percent) had clinical responses; all 17 patients for whom data on microbiologic response were available had such a response. The median times from diagnosis to the initiation of appropriate therapy and from the initiation of therapy to culture conversion were 44 days (range, 0 to 181) and 69 days (range, 2 to 705), respectively. Side effects requiring the discontinuation of medication occurred in 4 of 23 patients (17 percent) who were treated with second-line antituberculosis medications. The median follow-up for the 23 patients who responded and who received appropriate therapy was 91 weeks (range, 41 to 225). CONCLUSIONS In this report from New York City, HIV-negative patients with multidrug-resistant tuberculosis, contrary to previous reports, responded well to appropriate chemotherapy, both clinically and microbiologically

Higher quality of life and lower depression for people on art in Uganda as compared to a community control group

Provision of antiretroviral treatment (ART) to people living with HIV (PLWH) has increased globally. Research measuring whether ART restores subjective well-being to "normal" levels is lacking, particularly in resource limited settings. The study objectives are to compare quality of life and depression symptoms for PLWH on ART to a general community population and to explore factors to explain these differences, including socio-economic status and the impact of urban or rural residence. PLWH on ART (n = 263) were recruited from ART delivery sites and participants not on ART (n = 160) were recruited from communities in Wakiso District, Uganda. Participants were interviewed using the translated World Health Organisation Quality of Life brief measure, the Hopkins Symptom Checklist depression section, and questions about socioeconomic status, residence as urban or rural and, for PLWH on ART, self-reported adherence and use of HIV counselling. Compared to the community sample and controlling for location of residence, PLWH on ART had significantly higher quality of life (QOL) for physical, psychological and environment domains, but not the social domain. These differences were not due to socio-economic status alone. Depression scores were significantly lower for PLWH on ART. Both comparisons controlled for the effect of location of residence. People on ART self-reported high adherence and the majority had used HIV counselling services. Our findings show better QOL amongst PLWH on ART compared to a general community sample, which cannot be explained solely by differences in socio-economic status nor location of residence. The general community sample results point towards the challenges of life in this setting. Access to health services may underpin this difference and further research should explore this finding, in addition to identification of psychological mechanisms that relate to better QOL. ART provision infrastructure has clear benefits. Further work should consider sustainability and replication for other health conditions. © 2014 Martin et al

Development and Validation of the Personalized Sexual Health Promotion (SexPro) HIV Risk Prediction Model for Men Who Have Sex with Men in the United States.

Accurate HIV risk assessment among men who have sex with men (MSM) is important to help providers assess risk, and target HIV prevention interventions. We sought to develop an evidence-based HIV risk assessment tool for US MSM that is inclusive of Black MSM. Data from four large longitudinal cohorts of MSM were used to develop (EXPLORE), and validate (VAX004, HPTN061, and HVTN505). These data included visits in which participants self-reported HIV risk behavior and underwent HIV testing. We developed a pooled logistic model for incident HIV infection based on self-reported risk behaviors during the 6 months before each study visit. A total of 4069 MSM were used for the development cohort, and 8047 MSM in the three validation cohorts through 2013. The final model includes age (< 35, ≥ 35); Black race and Latino ethnicity; numbers of HIV-negative anal sex partners; number of insertive or receptive anal intercourse episodes; having 1 HIV-negative partner only; self-reported substance use; and bacterial sexually transmitted infection diagnosis. The model showed good discrimination in internal validation (C-statistic = 79.5). The external validation cohorts also showed good discrimination, with C-statistics of 73.1, 71.0, 71.9 in VAX004, HPTN061, and HVTN505 respectively, and acceptable calibration. We developed and validated an HIV risk assessment tool for MSM, which showed good predictive ability, including among the largest cohort of HIV-uninfected Black MSM in the US. This tool is available online (mysexpro.org) and can be used by providers to support targeting of HIV prevention interventions such as pre-exposure prophylaxis for MSM

Comparative Study of Electoral Systems (2001-2006)

The module was administered as a post-election interview. The resulting data are provided along with voting, demographic, district and macro variables in a single dataset. CSES Variable List The list of variables is being provided on the CSES Website to help in understanding what content is available from CSES, and to compare the content available in each module. Themes: MICRO-LEVEL DATA: Identification and study administration variables: mode of interview; gender of interviewer; date questionnaire administered; election type; weighting factors; if multiple rounds: percent of vote selected parties received in first round; selection of head of state; direct election of head of state and process of direct election; threshold for first-round victory; selection of candidates for the final round; simple majority or absolute majority for 2nd round victory; primary electoral district of respondent; number of days the interview was conducted after the election Demography: age; gender; education; marital status; union membership; union membership of others in household; business association membership, farmers´ association membership; professional association membership; current employment status; main occupation; socio economic status; employment type - public or private; industrial sector; current employment status, occupation, socio economic status, employment type - public or private and industrial sector of spouse; household income; number of persons in household; number of children in household under the age of 18; attendance at religious services; race; ethnicity; religiosity; religious denomination; language usually spoken at home; region of residence; rural or urban residence Survey variables: political participation during the recent election campaign (persuade others, campaign activities) and frequency of political participation; contacted by candidate or party during the campaign; respondent cast a ballot at the current and the previous election; vote choice (presidential, lower house and upper house elections) at the current and the previous election; respondent cast candidate preference vote at the current election; most important issue; evaluation of governments performance concerning the most important issue and in general; satisfaction with the democratic process in the country; attitude towards selected statements: it makes a difference who is in power and who people vote for; democracy is better than any other form of government; respondent cast candidate preference vote at the previous election; judgement of the performance of the party the respondent voted for in the previous election; judgement how well voters´ views are represented in elections; party and leader that represent respondent´s view best; form of questionnaire (long or short); party identification; intensity of party identification; sympathy scale for selected parties; assessment of parties and political leaders on a left-right-scale; political participation during the last 5 years: contacted a politician or government, protest or demonstration, work with others who share the same concern; respect for individual freedom and human rights; assessment how much corruption is widespread in the country; self-placement on a left-right-scale; political information items DISTRICT-LEVEL DATA: number of seats contested in electoral district, number of candidates, number of party lists, percent vote of different parties, official voter turnout in electoral district MACRO-LEVEL DATA: percent of popular vote received by parties in current (lower house/upper house) legislative election; percent of seats in lower house received by parties in current lower house/upper house election; percentage of official voter turnout; number of portfolios held by each party in cabinet, prior to and after the most recent election; year of party foundation; ideological family the parties are closest to; European parliament political group and international organization the parties belong to; significant parties not represented before and after the election; left-right position of parties; general concensus on these left-right placements among informed observers in the country; alternative dimension placements; consensus on the alternative dimension placements; most salient factors in the election; consensus on the salience ranking; electoral alliances permitted during the election campaign; name of alliance and participant parties; number of elected legislative chambers; for lower house and upper house was asked: number of electoral segments; number of primary districts; number of seats; district magnitude (number of members elected from each district); number of secondary and tertiary electoral districts; compulsory voting; votes cast; voting procedure; transferrable votes; cumulated votes if more than one can be cast; party threshold; used electoral formula; party lists close, open, or flexible; parties can run joint lists; possibility of apparentement; multi-party endorsements; ally party support; requirements for joint party lists; types of apparentement agreements; multi-party endorsements on ballot; head of state (regime type); year of presidential election (before or after this legislative election); process if indirect election; if by electoral college: selection of electors, deliberates, and voting procedure; if by legislature: chambers of the legislature, voting procedure; power of the head of state (introduce legislation, expedited action, package veto, partial veto, legislate by decree, emergency powers, negotiate agreements, commander of forces, introduce referenda, refer legislation to judiciary, legislative sessions); head of government (elected independently, is the head of state, selection method if not elected independently); authorities of the head of government concerning the composition of the cabinet (name ministers, nominate ministers, review ministerial nominations, dismiss ministers); authorities of the head of government concerning the policy making process (chair cabinet meetings, legislature schedules, policy alternatives, refers policy to committee, votes of confidence); methods of cabinet dismissal (head of state acting alone, by head of government alone, majority of legislature, plurality of legislature, combination); dissolution of legislature prior to regularly scheduled elections; dissolution of legislature by: head of state, head of government, majority of legislature, combination; restrictions on dissolving legislature (on the timing, as a response to action/inaction by the legislature); second chamber of the legislature (method of election, composition, exclusive legislative powers, power over the cabinet); constitutional federal structure; central power over peripher

CSES Module 1-3 Harmonized Trend File

Für weitere Informationen zur Variablenliste siehe die Dokumentation (Codebook) des CSES Module 1-3 Harmonized Trend File. Informationen zum Inhalt können den Studiennummern ZA5179 CSES Module 1 Full Release, ZA5180 CSES Module 2 Full Release, und ZA5181 CSES Module 3 Full Release entnommen werden