The Future of Education in Georgia : A+ Education Reform Act of 2000

[In 1999] the Governor of the State of Georgia issued a challenge to his newly formed Education Reform Study Commission. He said: I am counting on this group to shake up the educational system as it exists today in Georgia. We have been able to put together a group of people who are both experienced with and devoted to educational issues, and I know that they will be able to develop sound ideas that will help restore public confidence in our schools. And shake up they did. As a result of the Commission\u27s work, House Bill 1187 was introduced to the Georgia General Assembly [in 2000]. A hotly debated bill, the A+ Education Reform Act of 2000 will affect all aspects of the educational system. As a part of this reform the leaders of Georgia\u27s educational institutions will come together to form the Education Coordinating Council. Their purpose will be to improve public education through a seamless coordination among Georgia\u27s public education providers. On March 31, we will have three very important members of this council to discuss their outlook on education in Georgia: Governor Roy Barnes (J.D. \u2772), Chairman of the State School Board Otis Brumby (J.D. \u2765), and Chancellor Stephen Portch

Determination of an Interaction Network between an Extracellular Bacterial Pathogen and the Human Host

A major gap in understanding infectious diseases is the lack of information about molecular interaction networks between pathogens and the human host. Haemophilus ducreyi causes the genital ulcer disease chancroid in adults and is a leading cause of cutaneous ulcers in children in the tropics. We developed a model in which human volunteers are infected on the upper arm with H. ducreyi until they develop pustules. To define the H. ducreyi and human interactome, we determined bacterial and host transcriptomic and host metabolomic changes in pustules. We found that in vivo H. ducreyi transcripts were distinct from those in the inocula, as were host transcripts in pustule and wounded control sites. Many of the upregulated H. ducreyi genes were found to be involved in ascorbic acid and anaerobic metabolism and inorganic ion/nutrient transport. The top 20 significantly expressed human pathways showed that all were involved in immune responses. We generated a bipartite network for interactions between host and bacterial gene transcription; multiple positively correlated networks contained H. ducreyi genes involved in anaerobic metabolism and host genes involved with the immune response. Metabolomic studies showed that pustule and wounded samples had different metabolite compositions; the top ion pathway involved ascorbate and aldarate metabolism, which correlated with the H. ducreyi transcriptional response and upregulation of host genes involved in ascorbic acid recycling. These data show that an interactome exists between H. ducreyi and the human host and suggest that H. ducreyi exploits the metabolic niche created by the host immune response.IMPORTANCE Dual RNA sequencing (RNA-seq) offers the promise of determining an interactome at a transcriptional level between a bacterium and the host but has yet to be done on any bacterial infection in human tissue. We performed dual RNA-seq and metabolomics analyses on wounded and infected sites following experimental infection of the arm with H. ducreyi Our results suggest that H. ducreyi survives in an abscess by utilizing l-ascorbate as an alternative carbon source, possibly taking advantage of host ascorbic acid recycling, and that H. ducreyi also adapts by upregulating genes involved in anaerobic metabolism and inorganic ion and nutrient transport. To our knowledge, this is the first description of an interaction network between a bacterium and the human host at a site of infection

Economic Evaluation of Coastal Land Loss in Louisiana

Louisiana has lost approximately 1,880 square miles of land over the past eighty years. Projections suggest that in a future without action, the next fifty years could result in the loss of 1,750 additional square miles of land area. As land loss continues, a large portion of the natural and man-made capital stocks of coastal Louisiana will be at greater risk of damage, either from land loss or from the associated increase in storm damage. We estimate the replacement cost of capital stock directly at risk from land loss ranges from approximately $2.1 billion to$3.5 billion with economic activity at risk ranging from $2.4 billion to$3.1 billion in output. Increases in storm damage to capital stock range from $8.7 billion to as much as$133 billion with associated disruptions to economic activity ranging from an additional $1.9 billion to$23 billion in total lost output

Planetary Phase Variations of the 55 Cancri System

Characterization of the composition, surface properties, and atmospheric conditions of exoplanets is a rapidly progressing field as the data to study such aspects become more accessible. Bright targets, such as the multi-planet 55 Cancri system, allow an opportunity to achieve high signal-to-noise for the detection of photometric phase variations to constrain the planetary albedos. The recent discovery that that inner-most planet, 55 Cancri e, transits the host star introduces new prospects for studying this system. Here we calculate photometric phase curves at optical wavelengths for the system with varying assumptions for the surface and atmospheric properties of 55 Cancri e. We show that the large differences in geometric albedo allows one to distinguish between various surface models, that the scattering phase function cannot be constrained with foreseeable data, and that planet b will contribute significantly to the phase variation depending upon the surface of planet e. We discuss detection limits and how these models may be used with future instrumentation to further characterize these planets and distinguish between various assumptions regarding surface conditions.Comment: 7 pages, 3 figures, accepted for publication in Ap

On the Link between Martian Total Ozone and Potential Vorticity

AbstractWe demonstrate for the first time that total ozone in the martian atmosphere is highly correlated with the dynamical tracer, potential vorticity, under certain conditions. The degree of correlation is investigated using a Mars global circulation model including a photochemical model. Potential vorticity is the quantity of choice to explore the dynamical nature of polar vortices because it contains information on winds and temperature in a single scalar variable. The correlation is found to display a distinct seasonal variation, with a strong positive correlation in both northern and southern winter at poleward latitudes in the northern and southern hemisphere respectively.The identified strong correlation implies variations in polar total ozone during winter are predominantly controlled by dynamical processes in these spatio-temporal regions. The weak correlation in northern and southern summer is due to the dominance of photochemical reactions resulting from extended exposure to sunlight. The total ozone/potential vorticity correlation is slightly weaker in southern winter due to topographical variations and the preference for ozone to accumulate in Hellas basin. In northern winter, total ozone can be used to track the polar vortex edge.The ozone/potential vorticity ratio is calculated for both northern and southern winter on Mars for the first time. Using the strong correlation in total ozone and potential vorticity in northern winter inside the polar vortex, it is shown that potential vorticity can be used as a proxy to deduce the distribution of total ozone where satellites cannot observe for the majority of northern winter. Where total ozone observations are available on the fringes of northern winter at poleward latitudes, the strong relationship of total ozone and potential vorticity implies that total ozone anomalies in the surf zone of the northern polar vortex can potentially be used to determine the origin of potential vorticity filaments

The Exoplanet Eccentricity Distribution from Kepler Planet Candidates

The eccentricity distribution of exoplanets is known from radial velocity surveys to be divergent from circular orbits beyond 0.1 AU. This is particularly the case for large planets where the radial velocity technique is most sensitive. The eccentricity of planetary orbits can have a large effect on the transit probability and subsequently the planet yield of transit surveys. The Kepler mission is the first transit survey that probes deep enough into period-space to allow this effect to be seen via the variation in transit durations. We use the Kepler planet candidates to show that the eccentricity distribution is consistent with that found from radial velocity surveys to a high degree of confidence. We further show that the mean eccentricity of the Kepler candidates decreases with decreasing planet size indicating that smaller planets are preferentially found in low-eccentricity orbits.Comment: 6 pages, 4 figures, accepted for publication in MNRA

Nicotine Supplementation Does Not Influence Performance of a 1h Cycling Time-Trial in Trained Males

The use of nicotine amongst professional and elite athletes is high, with anecdotal evidence indicating increased prevalence amongst cycling sports. However, previous investigations into its effects on performance have not used high-validity or -reliability protocols nor trained cyclists. Therefore, the present study determined whether nicotine administration proved ergogenic during a ∼1 h self-paced cycling time-trial (TT). Ten well-trained male cyclists (34 ± 9 years; 71 ± 8 kg; O2max: 71 ± 6 ml ⋅ kg−1 ⋅ min−1) completed three work-dependent TT following ∼30 min administration of 2 mg nicotine gum (GUM), ∼10 h administration of 7 mg ⋅ 24 h−1 nicotine patch (PAT) or color- and flavor-matched placebos (PLA) in a randomized, crossover, and double blind design. Measures of nicotine’s primary metabolite (cotinine), core body temperature, heart rate, blood biochemistry (pH, HCO3−, La−) and Borg’s rating of perceived exertion (RPE) accompanied performance measures of time and power output. Plasma concentrations of cotinine were highest for PAT, followed by GUM, then PLA, respectively (p < 0.01). GUM and PAT resulted in no significant improvement in performance time compared to PLA (62.9 ± 4.1 min, 62.6 ± 4.5 min, and 63.3 ± 4.1 min, respectively; p = 0.73), with mean power outputs of 264 ± 31, 265 ± 32, and 263 ± 33 W, respectively (p = 0.74). Core body temperature was similar between trials (p = 0.33) whilst HR averaged 170 ± 10, 170 ± 11, and 171 ± 11 beats ⋅ min−1 (p = 0.60) for GUM, PAT, and PLA, respectively. There were no differences between trials for any blood biochemistry (all p > 0.46) or RPE with mean values of 16.7 ± 0.9, 16.8 ± 0.7, and 16.8 ± 0.8 (p = 0.89) for GUM, PAT, and PLA, respectively. In conclusion: (i) nicotine administration, whether via gum or transdermal patch, did not exert an ergogenic or ergolytic effect on self-paced cycling performance of ∼1 h; (ii) systemic delivery of nicotine was greatest when using a transdermal patch; and (iii) nicotine administration did not alter any of the psycho-physiological measures observed