Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts.

[This corrects the article DOI: 10.1038/s42003-018-0226-0.]

Field observations of canopy flows over complex terrain

The investigation of airflow over and within forests in complex terrain has been, until recently, limited to a handful of modelling and laboratory studies. Here, we present an observational dataset of airflow measurements inside and above a forest situated on a ridge on the Isle of Arran, Scotland. The spatial coverage of the observations all the way across the ridge makes this a unique dataset. Two case studies of across-ridge flow under near-neutral conditions are presented and compared with recent idealized two-dimensional modelling studies. Changes in the canopy profiles of both mean wind and turbulent quantities across the ridge are broadly consistent with these idealized studies. Flow separation over the lee slope is seen as a ubiquitous feature of the flow. The three-dimensional nature of the terrain and the heterogeneous forest canopy does however lead to significant variations in the flow separation across the ridge, particularly over the less steep western slope. Furthermore, strong directional shear with height in regions of flow separation has a significant impact on the Reynolds stress terms and other turbulent statistics. Also observed is a decrease in the variability of the wind speed over the summit and lee slope, which has not been seen in previous studies. This dataset should provide a valuable resource for validating models of canopy flow over real, complex terrain

Harnessing the Creative Potential of Consumers: Money, Participation and Creativity in Idea Crowdsourcing

Given the growing importance of innovation and consumer engagement, many firms are strongly interested in finding ways to encourage their consumers to generate creative new product ideas for them in their crowdsourcing initiatives. To that end, managers often use monetary rewards – one of the most commonly used managerial tools to stimulate desired behaviors. A critical question in this respect is whether the use of monetary rewards is effective in stimulating creativity and, if so, how large those rewards should be. This study aims to answer these questions. The results of an experiment suggest that introducing monetary rewards does not contribute to the number of new product ideas generated by a single consumer or the novelty of his/her ideas, and when the reward is relatively small it can even be harmful. Monetary rewards, however, are effective in encouraging widespread participation in crowdsourcing initiatives and improving the appropriateness of the new product ideas. As a whole, these findings take us a step further toward better understanding the motivational mechanisms of consumer creativity in new product ideation

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction

The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In humans, over 150 non-syndromic loci have been identified, and there are more than 400 human genetic syndromes with a hearing loss component. Over 100 non-syndromic hearing loss genes have been identified in mouse and human, but we remain ignorant of the full extent of the genetic landscape involved in auditory dysfunction. As part of the International Mouse Phenotyping Consortium, we undertook a hearing loss screen in a cohort of 3006 mouse knockout strains. In total, we identify 67 candidate hearing loss genes. We detect known hearing loss genes, but the vast majority, 52, of the candidate genes were novel. Our analysis reveals a large and unexplored genetic landscape involved with auditory function

Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Despite advances in next generation sequencing technologies, determining the genetic basis of ocular disease remains a major challenge due to the limited access and prohibitive cost of human forward genetics. Thus, less than 4,000 genes currently have available phenotype information for any organ system. Here we report the ophthalmic findings from the International Mouse Phenotyping Consortium, a large-scale functional genetic screen with the goal of generating and phenotyping a null mutant for every mouse gene. Of 4364 genes evaluated, 347 were identified to influence ocular phenotypes, 75% of which are entirely novel in ocular pathology. This discovery greatly increases the current number of genes known to contribute to ophthalmic disease, and it is likely that many of the genes will subsequently prove to be important in human ocular development and disease

Identification of genes required for eye development by high-throughput screening of mouse knockouts

International audienc

Imaging of firn isochrones across an Antarctic ice rise and implications for patterns of snow accumulation rate

It has been an underlying assumption in many studies that near-surface layers imaged by ground-penetrating radar (GPR) can be interpreted as depositional markers or isochrones. It has been shown that GPR layers can be approximately reproduced from the measured electrical properties of ice, but these material layers are generally narrower and more closely spaced than can be resolved by typical GPR systems operating in the range 50-400 MHz. Thus GPR layers should be interpreted as interference patterns produced from closely spaced and potentially discontinuous material layers, and should not be assumed to be interpretable as precise markers of isochrones. We present 100 MHz GPR data from Lyddan Ice Rise, Antarctica, in which near-surface (< 50 m deep) layers are clearly imaged. The growth of the undulations in these layers with depth is approximately linear, implying that, rather than resulting from a pattern of vertical strain rate, they do correspond to some pattern of snowfall variation. Furthermore, comparison of the GPR layers with snow-stake measurements suggests that around 80% of the rms variability in mean annual accumulation is present in the GPR layers. The observations suggest that, at least in this case, the GPR layers do approximate isochrones, and that patterns of snow accumulation over Lyddan Ice Rise are dominated by extremely persistent spatial variations with only a small residual spatial variability. If this condition is shown to be widely applicable it may reduce the period required for measurements of surface elevation change to be taken as significant indications of mass imbalance

Development of ice particles in convective clouds observed over the Black Forest mountains during COPS

A combination of modelling studies and ground-based and aircraft measurements is used to examine the development of ice particles in convective clouds observed over the Black Forest mountains during the Convective and Orographically-induced Precipitation Study (COPS). High concentrations of relatively small ice particles were observed in the weaker northern cell that developed on convergence lines over the mountains in the much-studied 15 July 2007 case. The conditions in the cloud were not conducive for the Hallett�Mossop process. Instead, the explanation for such high concentrations of ice is likely associated with the type of ice nuclei ingested into the cloud. Biological nuclei, oxidised organic aerosol particles in the polluted air vented from the Murg valley into the cloud base, and desert dust are all possible candidates. A model sensitivity test with biological nuclei produced similar concentrations of ice particles to the observations. In contrast, the high concentration of ice particles measured in clouds that advected over the Black Forest mountains on 11 July 2007 were likely due to the Hallett�Mossop process. The deep convective cell at the southern end of the COPS domain on 15 July 2007 developed in less polluted air than the shallower northern cloud. A model sensitivity test with lower aerosol loading produced a more vigorous cloud with a higher top, more precipitation, and greater reflectivity, more similar to the radar observations. The results suggest that aerosol particles vented out of the valleys could have a significant impact on orographically induced precipitation

The terrain-induced rotor experiment: A field campaign overview including observational highlights

The Terrain-Induced Rotor Experiment (T-REX) is a coordinated international project, comprised of an observational field campaign and a research program, focused on the investigation of atmospheric rotors and closely related phenomena in complex terrain. The T-REX field campaign took place during March and April 2006 in the lee of the southern Sierra Nevada in eastern California. Atmospheric rotors have been traditionally defined as quasi-two-dimensional atmospheric vortices that form parallel to and downwind of a mountain ridge under conditions conducive to the generation of large-amplitude mountain waves. Intermittency, high-levels of turbulence, and complex small-scale internal structure characterize rotors, which are known hazards to general aviation. The objective of the T-REX field campaign was to provide an unprecedented comprehensive set of in situ and remotely-sensed meteorological observations from the ground to upper troposphere-lower stratosphere (UTLS) altitudes for the documentation of the spatio-temporal characteristics and internal structure of a tightly coupled system consisting of an atmospheric rotor, terrain-induced internal gravity waves, and a complex-terrain boundary layer. In addition, T-REX had several ancillary objectives including the studies of UTLS chemical distribution in the presence of mountain waves and complex-terrain boundary layer in the absence of waves and rotors. This overview provides a background of the project including the information on its science objectives, experimental design and observational systems, along with highlights of key observations obtained during the field campaign