Identifying and detecting facial expressions of emotion in peripheral vision

Facial expressions of emotion are signals of high biological value. Whilst recognition of facial expressions has been much studied in central vision, the ability to perceive these signals in peripheral vision has only seen limited research to date, despite the potential adaptive advantages of such perception. In the present experiment, we investigate facial expression recognition and detection performance for each of the basic emotions (plus neutral) at up to 30 degrees of eccentricity. We demonstrate, as expected, a decrease in recognition and detection performance with increasing eccentricity, with happiness and surprised being the best recognized expressions in peripheral vision. In detection however, while happiness and surprised are still well detected, fear is also a well detected expression. We show that fear is a better detected than recognized expression. Our results demonstrate that task constraints shape the perception of expression in peripheral vision and provide novel evidence that detection and recognition rely on partially separate underlying mechanisms, with the latter more dependent on the higher spatial frequency content of the face stimulus

Review of Gender and the Victorian Periodical

\u27We are dominated by Journalism\u27 \u27a really remarkable power\u27, Oscar Wilde observed, not entirely neutrally, in \u27The Soul of Man under Socialism\u27 published in the Fortnightly Review in 1891. Like many of his contemporaries, Wilde recognized not only the power of the press, but also its modernity. In this wide ranging and important study Hilary Fraser, Stephanie Green and Judith Johnston argue that precisely because of its power the periodical press occupied a central position in the construction of gender in Victorian cultural history. Journalism was gendered masculine by those who accorded it a lofty status within the profession of letters, they suggest. It was just as insistently gendered feminine by those who denigrated writing for the press. Hence Matthew Arnold\u27s description of the so-called \u27New Journalism\u27 in 1887 as \u27full of ability, novelty, variety, sensation, sympathy, generous instincts; its one great fault is that it is featherbrained\u27, - all attributes conventionally associated with women. Ironically the increasing number of women who joined the ranks of journalists as the century progressed served to downgrade the periodical press still further, by emphasizing its femininity. But for emerging writers like Marian Evans, Harriet Martineau, Margaret Oliphant and Eliza Lynn Linton earlier in the century the press provided a platform from which their careers were launched. Just as anonymity permitted men \u27never meant for authors\u27 to enter the writing profession, it gave women with literary ambitions an opportunity to write for publication. Fraser and Johnston quote Daniel Brown\u27s comment that the periodical essay became \u27the Trojan horse that allowed women writers to enter the male preserve of professional writing\u27. And their male counterparts were aware of their arrival. G. H. Lewes\u27s article \u27The Condition of Authors in England, Germany and France\u27 (1847) despite its jocular tone, reveals anxiety about the infiltration of the masculine writing profession by \u27speculators\u27 - \u27women, children, and ill-trained troops\u27. A subsequent article in The Leader, \u27A Gentle Hint to Writing Women\u27 (1850), continued the military metaphor, claiming that \u27women have made an invasion of our legitimate domain\u27 - \u27they are ruining our profession\u27 - \u27My idea of a perfect woman\u27, the article concludes, \u27is of one who can write but won\u27t\u27 , an unexpected comment, as the authors observe, by the man who was to become George Eliot\u27s consort

Highly active iridium(I) complexes for the selective hydrogenation of carbon-carbon multiple bonds

New iridium(I) complexes, bearing a bulky NHC/phosphine ligand combination, have been established as extremely efficient hydrogenation catalysts that can be used at low catalyst loadings, and are compatible with functional groups which are often sensitive to more routinely employed hydrogenation methods

Transdifferentiating Astrocytes Into Neurons Using ASCL1 Functionalized With a Novel Intracellular Protein Delivery Technology

Cellular transdifferentiation changes mature cells from one phenotype into another by altering their gene expression patterns. Manipulating expression of transcription factors, proteins that bind to DNA promoter regions, regulates the levels of key developmental genes. Viral delivery of transcription factors can efficiently reprogram somatic cells, but this method possesses undesirable side effects, including mutations leading to oncogenesis. Using protein transduction domains (PTDs) fused to transcription factors to deliver exogenous transcription factors serves as an alternative strategy that avoids the issues associated with DNA integration into the host genome. However, lysosomal degradation and inefficient nuclear localization pose significant barriers when performing PTD-mediated reprogramming. Here, we investigate a novel PTD by placing a secretion signal sequence next to a cleavage inhibition sequence at the end of the target transcription factor–achaete scute homolog 1 (ASCL1), a powerful regulator of neurogenesis, resulting in superior stability and nuclear localization. A fusion protein consisting of the amino acid sequence of ASCL1 transcription factor with this novel PTD added can transdifferentiate cerebral cortex astrocytes into neurons. Additionally, we show that the synergistic action of certain small molecules improves the efficiency of the transdifferentiation process. This study serves as the first step toward developing a clinically relevant in vivo transdifferentiation strategy for converting astrocytes into neurons

Experiments in farmers' collectives in Eastern India and Nepal: Process, benefits, and challenges

Do farmers' collectives, which pool land, labour, capital, and skills to create medium-sized production units, offer a more viable model of farming for resource-constrained smallholders than individual family farms? A participatory action research project in Eastern India and Nepal provides notable answers. Groups of marginal and tenant farmers, catalysed by the project, evolved into four different collective models with varying levels of cooperation, gender composition, and land ownership/tenancy status. Based on 3 years of action research, this paper examines how the models evolved and their differential outcomes. All groups have gained from cultivating contiguous plots in their efficiency of labour and machine use for land preparation and irrigation, and from economies in input purchase. Several collectives of tenant farmers have also enhanced their bargaining power vis-a-vis an entrenched landlord class and thus been able to negotiate lower rents and refuse long-standing feudal obligations. However, the models differ in their extent of economic gain and their ability to handle gender inequalities and conflicts over labour sharing. The paper explores the historical, regional, and cultural factors that could explain such differences across the models. It thus offers unique insights into the processes, benefits, and challenges of farmers' collectives and provides pointers for replication and further research

Amla enhances autophagy and modulates beta amyloid metabolism in an in vitro model of Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive, fatal neurodegenerative disease characterized by extensive neuronal loss associated with increased accumulation of the beta amyloid (Aβ) protein. Reducing production, preventing aggregation and improving clearance of Aβare areas of active research in the development of therapeutic agents to ameliorate neurodegeneration in AD. The Indian plant amla (Emblicaofficinalis), commonly known as Indian gooseberry, has widely been utilized in traditional Ayurvedic medicine preparations in the treatment of a variety of disease conditions including cardiovascular disease and diabetes: accumulating evidence also suggests that amla may be beneficial in AD. Amla exhibits antioxidant, anti-inflammatory, and anti-apoptotic mechanisms and more recently has been shown to modulate autophagy; a vital protein degradation pathway involved in the clearance of damaged organelles and aggregate proteins in cells. Our own recent in vitro work shows that amla extract enhances autophagy and modulates accumulation of proteolytic products of Amyloid precursor protein (APP) such as APP-C terminal fragments (C99, C83). Amla treatment (50-300 μg/ml) induced a dose-dependent increase in autophagic flux, as measured by Western blotting utilizing an LC3 directed antibody as an autophagosome marker. At similar concentrations, amla treatment also reduced accumulation of APP C-terminal fragment levels by 33 to 77%. However, no significant changes were observed in APP levels, indicating that amla did not alter APP production. Overall, our findings suggest that amla may confer beneficial effects through modulating autophagy and Aβ metabolism, and warrants further investigation as a potential therapeutic agent in ADhttps://ro.ecu.edu.au/ecuposters/1026/thumbnail.jp

Addressing road-river infrastructure gaps using a model-based approach

The world's rivers are covered over and fragmented by road infrastructure. Road-river infrastructure result in many socio-environmental questions and documenting where different types occur is challenged by their sheer numbers. Equally, the United Nations has committed the next decade to ecosystem restoration, and decision makers across government, non-government, and private sectors require information about where different types of road-river infrastructure occur to guide management decisions that promote both transport and river system resilience. Field-based efforts alone cannot address data and information needs at relevant scales, such as across river basins, nations, or regions to guide road-river infrastructure remediation. As a first step toward overcoming these data needs in Great Britain, we constructed a georeferenced database of road-river infrastructure, validated a subset of locations, and used a Boosted Regression Tree model-based approach with environmental data to predict which infrastructure are bridges and culverts. We mapped 110,406 possible road-river infrastructure locations and were able to either validate or predict which of 110,194 locations were bridges (n=60,385) or culverts (n=49,809). Upstream drainage area had the greatest contribution to determining infrastructure type: when <10 km2 our model correctly predicted culverts 73% of the time but only 60% of the time for bridges. Road type and stream gradient also influenced model results. Our model-based approach is readily applied to other locations and contexts and can be used to inform decisions about management of smaller infrastructure that are frequently overlooked worldwide

Convergent Evolution of Chromosomal Sex-Determining Regions in the Animal and Fungal Kingdoms

Sexual identity is governed by sex chromosomes in plants and animals, and by mating type (MAT) loci in fungi. Comparative analysis of the MAT locus from a species cluster of the human fungal pathogen Cryptococcus revealed sequential evolutionary events that fashioned this large, highly unusual region. We hypothesize that MAT evolved via four main steps, beginning with acquisition of genes into two unlinked sex-determining regions, forming independent gene clusters that then fused via chromosomal translocation. A transitional tripolar intermediate state then converted to a bipolar system via gene conversion or recombination between the linked and unlinked sex-determining regions. MAT was subsequently subjected to intra- and interallelic gene conversion and inversions that suppress recombination. These events resemble those that shaped mammalian sex chromosomes, illustrating convergent evolution in sex-determining structures in the animal and fungal kingdoms